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Aliases for PLAC1 Gene

Aliases for PLAC1 Gene

  • Placenta-Specific 1 2 3
  • Cancer/Testis Antigen 92 2 3
  • OOSP2L 3
  • CT92 3

External Ids for PLAC1 Gene

Previous GeneCards Identifiers for PLAC1 Gene

  • GC0XM128345
  • GC0XM130545
  • GC0XM131644
  • GC0XM132405
  • GC0XM133425
  • GC0XM133527
  • GC0XM133699
  • GC0XM123098

Summaries for PLAC1 Gene

GeneCards Summary for PLAC1 Gene

PLAC1 (Placenta-Specific 1) is a Protein Coding gene. Diseases associated with PLAC1 include preeclampsia/eclampsia 1. An important paralog of this gene is OOSP2.

UniProtKB/Swiss-Prot for PLAC1 Gene

  • May play a role in placental development.

Gene Wiki entry for PLAC1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLAC1 Gene

Genomics for PLAC1 Gene

Regulatory Elements for PLAC1 Gene

Genomic Location for PLAC1 Gene

Chromosome:
X
Start:
134,565,838 bp from pter
End:
134,764,322 bp from pter
Size:
198,485 bases
Orientation:
Minus strand

Genomic View for PLAC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLAC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLAC1 Gene

Proteins for PLAC1 Gene

  • Protein details for PLAC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBJ0-PLAC1_HUMAN
    Recommended name:
    Placenta-specific protein 1
    Protein Accession:
    Q9HBJ0

    Protein attributes for PLAC1 Gene

    Size:
    212 amino acids
    Molecular mass:
    23616 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PLAC1 Gene

Proteomics data for PLAC1 Gene at MOPED

Post-translational modifications for PLAC1 Gene

  • Ubiquitination at Lys 108
  • Modification sites at PhosphoSitePlus

Other Protein References for PLAC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PLAC1 Gene

Domains & Families for PLAC1 Gene

Protein Domains for PLAC1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for PLAC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HBJ0

UniProtKB/Swiss-Prot:

PLAC1_HUMAN :
  • Belongs to the PLAC1 family.
Family:
  • Belongs to the PLAC1 family.
genes like me logo Genes that share domains with PLAC1: view

No data available for Gene Families for PLAC1 Gene

Function for PLAC1 Gene

Molecular function for PLAC1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in placental development.
UniProtKB/Swiss-Prot Induction:
Up-regulated during trophoblast differentiation and by FGF7 in trophoblast cells.

Gene Ontology (GO) - Molecular Function for PLAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with PLAC1: view
genes like me logo Genes that share phenotypes with PLAC1: view

Animal Models for PLAC1 Gene

MGI Knock Outs for PLAC1:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PLAC1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for PLAC1 Gene

Localization for PLAC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLAC1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLAC1 Gene COMPARTMENTS Subcellular localization image for PLAC1 gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for PLAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with PLAC1: view

Pathways & Interactions for PLAC1 Gene

SuperPathways for PLAC1 Gene

No Data Available

Interacting Proteins for PLAC1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000352173%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000352173 for PLAC1 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for PLAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001890 placenta development IEP 10995572
GO:0090214 spongiotrophoblast layer developmental growth IEA --
genes like me logo Genes that share ontologies with PLAC1: view

No data available for Pathways by source and SIGNOR curated interactions for PLAC1 Gene

Drugs & Compounds for PLAC1 Gene

No Compound Related Data Available

Transcripts for PLAC1 Gene

Unigene Clusters for PLAC1 Gene

Placenta-specific 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PLAC1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLAC1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for PLAC1 Gene

GeneLoc Exon Structure for
PLAC1
ECgene alternative splicing isoforms for
PLAC1

Expression for PLAC1 Gene

mRNA expression in normal human tissues for PLAC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLAC1 Gene

This gene is overexpressed in Testis (x14.4).

Protein differential expression in normal tissues from HIPED for PLAC1 Gene

This gene is overexpressed in Ovary (36.0), Testis (22.0), and Esophagus (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PLAC1 Gene



SOURCE GeneReport for Unigene cluster for PLAC1 Gene Hs.496811

mRNA Expression by UniProt/SwissProt for PLAC1 Gene

Q9HBJ0-PLAC1_HUMAN
Tissue specificity: Expressed in placenta. Localizes primarily to differentiated syncytiotrophoblast throughout gestation as well as to a small population of villous cytotrophoblasts. Also detected in maternal blood and rapidly disappears following delivery, but is not detected in other adult or fetal tissues examined.
genes like me logo Genes that share expression patterns with PLAC1: view

Protein tissue co-expression partners for PLAC1 Gene

Primer Products

In Situ Assay Products

Orthologs for PLAC1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PLAC1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PLAC1 35
  • 81.94 (n)
  • 70.39 (a)
PLAC1 36
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLAC1 35
  • 81.29 (n)
  • 74.06 (a)
PLAC1 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Plac1 35
  • 71.35 (n)
  • 60.23 (a)
Plac1 16
Plac1 36
  • 60 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Plac1 35
  • 72.9 (n)
  • 61.99 (a)
chimpanzee
(Pan troglodytes)
Mammalia PLAC1 36
  • 99 (a)
OneToOne
Species with no ortholog for PLAC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PLAC1 Gene

ENSEMBL:
Gene Tree for PLAC1 (if available)
TreeFam:
Gene Tree for PLAC1 (if available)

Paralogs for PLAC1 Gene

Paralogs for PLAC1 Gene

genes like me logo Genes that share paralogs with PLAC1: view

Variants for PLAC1 Gene

Sequence variations from dbSNP and Humsavar for PLAC1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1982 -- 134,565,930(+) AGGTT(G/T)CTCTT utr-variant-3-prime
rs871865 -- 134,735,319(+) GTCTC(A/G)TATCT intron-variant, upstream-variant-2KB
rs1905791 -- 134,700,772(-) ttgaa(A/T)agtgg intron-variant
rs1905792 -- 134,700,742(-) aggtc(A/T)ttcat intron-variant
rs2355307 -- 134,719,175(-) TCACA(A/G)TGTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLAC1 Gene

Variant ID Type Subtype PubMed ID
nsv517076 CNV Gain 19592680
nsv521470 CNV Gain 19592680
nsv525660 CNV Gain 19592680
nsv521365 CNV Gain 19592680
nsv7102 CNV Insertion 18451855

Variation tolerance for PLAC1 Gene

Residual Variation Intolerance Score: 63.46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.26; 5.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLAC1 Gene

HapMap Linkage Disequilibrium report
PLAC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLAC1 Gene

Disorders for PLAC1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PLAC1 Gene - From: NovoSeek

Disorder Aliases PubMed IDs
preeclampsia/eclampsia 1
  • preeclampsia
- elite association
Search PLAC1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PLAC1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLAC1
genes like me logo Genes that share disorders with PLAC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLAC1 Gene

Publications for PLAC1 Gene

  1. PLAC1, an Xq26 gene with placenta-specific expression. (PMID: 10995572) Cocchia M. … Schlessinger D. (Genomics 2000) 2 23 67
  2. Selective activation of trophoblast-specific PLAC1 in breast cancer by CCAAT/enhancer-binding protein beta (C/EBPbeta) isoform 2. (PMID: 19652226) Koslowski M. … Sahin U. (J. Biol. Chem. 2009) 23 67
  3. The evolution, regulation, and function of placenta-specific genes. (PMID: 18616428) Rawn S.M. … Cross J.C. (Annu. Rev. Cell Dev. Biol. 2008) 23 67
  4. Plac1 is a tumor-specific antigen capable of eliciting spontaneous antibody responses in human cancer patients. (PMID: 18183594) Dong X.Y. … Chen W.F. (Int. J. Cancer 2008) 23 67
  5. PLAC1 mRNA levels in maternal blood at induction of labor correlate negatively with induction-delivery interval. (PMID: 16860456) Rizzo N. … Farina A. (Eur. J. Obstet. Gynecol. Reprod. Biol. 2007) 23 67

Products for PLAC1 Gene

Sources for PLAC1 Gene

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