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Aliases for PLAC1 Gene

Aliases for PLAC1 Gene

  • Placenta Specific 1 2 3 5
  • Cancer/Testis Antigen 92 2 3
  • Placenta-Specific 1 3
  • OOSP2L 3
  • CT92 3

External Ids for PLAC1 Gene

Previous GeneCards Identifiers for PLAC1 Gene

  • GC0XM128345
  • GC0XM130545
  • GC0XM131644
  • GC0XM132405
  • GC0XM133425
  • GC0XM133527
  • GC0XM133699
  • GC0XM123098

Summaries for PLAC1 Gene

GeneCards Summary for PLAC1 Gene

PLAC1 (Placenta Specific 1) is a Protein Coding gene. Diseases associated with PLAC1 include Preeclampsia/Eclampsia 1. An important paralog of this gene is OOSP2.

UniProtKB/Swiss-Prot for PLAC1 Gene

  • May play a role in placental development.

Gene Wiki entry for PLAC1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLAC1 Gene

Genomics for PLAC1 Gene

Regulatory Elements for PLAC1 Gene

Enhancers for PLAC1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PLAC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PLAC1 Gene

134,565,838 bp from pter
134,764,322 bp from pter
198,485 bases
Minus strand

Genomic View for PLAC1 Gene

Genes around PLAC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLAC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLAC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLAC1 Gene

Proteins for PLAC1 Gene

  • Protein details for PLAC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Placenta-specific protein 1
    Protein Accession:

    Protein attributes for PLAC1 Gene

    212 amino acids
    Molecular mass:
    23616 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PLAC1 Gene

Proteomics data for PLAC1 Gene at MOPED

Post-translational modifications for PLAC1 Gene

  • Ubiquitination at Lys 108
  • Modification sites at PhosphoSitePlus

Other Protein References for PLAC1 Gene

Antibody Products

  • Abcam antibodies for PLAC1

No data available for DME Specific Peptides for PLAC1 Gene

Domains & Families for PLAC1 Gene

Protein Domains for PLAC1 Gene


Suggested Antigen Peptide Sequences for PLAC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PLAC1 family.
  • Belongs to the PLAC1 family.
genes like me logo Genes that share domains with PLAC1: view

No data available for Gene Families for PLAC1 Gene

Function for PLAC1 Gene

Molecular function for PLAC1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in placental development.
UniProtKB/Swiss-Prot Induction:
Up-regulated during trophoblast differentiation and by FGF7 in trophoblast cells.
genes like me logo Genes that share phenotypes with PLAC1: view

Animal Models for PLAC1 Gene

MGI Knock Outs for PLAC1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PLAC1 Gene

Localization for PLAC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLAC1 Gene


Subcellular locations from

Jensen Localization Image for PLAC1 Gene COMPARTMENTS Subcellular localization image for PLAC1 gene
Compartment Confidence
extracellular 5
nucleus 1

Gene Ontology (GO) - Cellular Components for PLAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with PLAC1: view

Pathways & Interactions for PLAC1 Gene

SuperPathways for PLAC1 Gene

No Data Available

Interacting Proteins for PLAC1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000352173 for PLAC1 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for PLAC1 Gene


No data available for Pathways by source and SIGNOR curated interactions for PLAC1 Gene

Drugs & Compounds for PLAC1 Gene

No Compound Related Data Available

Transcripts for PLAC1 Gene

Unigene Clusters for PLAC1 Gene

Placenta-specific 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLAC1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b
SP2: -

Relevant External Links for PLAC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PLAC1 Gene

mRNA expression in normal human tissues for PLAC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLAC1 Gene

This gene is overexpressed in Testis (x14.4).

Protein differential expression in normal tissues from HIPED for PLAC1 Gene

This gene is overexpressed in Ovary (36.0), Testis (22.0), and Esophagus (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PLAC1 Gene

SOURCE GeneReport for Unigene cluster for PLAC1 Gene Hs.496811

mRNA Expression by UniProt/SwissProt for PLAC1 Gene

Tissue specificity: Expressed in placenta. Localizes primarily to differentiated syncytiotrophoblast throughout gestation as well as to a small population of villous cytotrophoblasts. Also detected in maternal blood and rapidly disappears following delivery, but is not detected in other adult or fetal tissues examined.
genes like me logo Genes that share expression patterns with PLAC1: view

Protein tissue co-expression partners for PLAC1 Gene

Primer Products

Orthologs for PLAC1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PLAC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PLAC1 35
  • 81.94 (n)
  • 70.39 (a)
PLAC1 36
  • 70 (a)
(Canis familiaris)
Mammalia PLAC1 35
  • 81.29 (n)
  • 74.06 (a)
PLAC1 36
  • 74 (a)
(Mus musculus)
Mammalia Plac1 35
  • 71.35 (n)
  • 60.23 (a)
Plac1 16
Plac1 36
  • 60 (a)
(Rattus norvegicus)
Mammalia Plac1 35
  • 72.9 (n)
  • 61.99 (a)
(Pan troglodytes)
Mammalia PLAC1 36
  • 99 (a)
Species with no ortholog for PLAC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PLAC1 Gene

Gene Tree for PLAC1 (if available)
Gene Tree for PLAC1 (if available)

Paralogs for PLAC1 Gene

Paralogs for PLAC1 Gene

genes like me logo Genes that share paralogs with PLAC1: view

Variants for PLAC1 Gene

Sequence variations from dbSNP and Humsavar for PLAC1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs747701853 -- 134,593,989(+) TCTAA(A/G)GGTGA intron-variant
rs747702245 -- 134,607,802(+) AGGGG(C/G)AGCCT intron-variant
rs747715337 -- 134,698,310(+) TAGCC(A/G)GGTGT intron-variant
rs747716685 -- 134,765,019(+) ACTAT(A/G)CAACT upstream-variant-2KB
rs747736774 -- 134,714,723(+) CTTCA(C/T)GTAAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PLAC1 Gene

Variant ID Type Subtype PubMed ID
nsv517076 CNV Gain 19592680
nsv521470 CNV Gain 19592680
nsv525660 CNV Gain 19592680
nsv521365 CNV Gain 19592680
nsv7102 CNV Insertion 18451855

Variation tolerance for PLAC1 Gene

Residual Variation Intolerance Score: 63.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.26; 5.70% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PLAC1 Gene

Disorders for PLAC1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PLAC1 Gene - From: Novoseek

Disorder Aliases PubMed IDs
preeclampsia/eclampsia 1
  • preeclampsia
- elite association - COSMIC cancer census association via MalaCards
Search PLAC1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PLAC1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PLAC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLAC1 Gene

Publications for PLAC1 Gene

  1. PLAC1, an Xq26 gene with placenta-specific expression. (PMID: 10995572) Cocchia M. … Schlessinger D. (Genomics 2000) 2 3 4 23 67
  2. Selective activation of trophoblast-specific PLAC1 in breast cancer by CCAAT/enhancer-binding protein beta (C/EBPbeta) isoform 2. (PMID: 19652226) Koslowski M. … Sahin U. (J. Biol. Chem. 2009) 3 23
  3. Plac1 is a tumor-specific antigen capable of eliciting spontaneous antibody responses in human cancer patients. (PMID: 18183594) Dong X.Y. … Chen W.F. (Int. J. Cancer 2008) 3 23
  4. PLAC1 mRNA levels in maternal blood at induction of labor correlate negatively with induction-delivery interval. (PMID: 16860456) Rizzo N. … Farina A. (Eur. J. Obstet. Gynecol. Reprod. Biol. 2007) 3 23
  5. The PLAC1 protein localizes to membranous compartments in the apical region of the syncytiotrophoblast. (PMID: 17186554) Fant M. … Bick R. (Mol. Reprod. Dev. 2007) 3 23

Products for PLAC1 Gene

Sources for PLAC1 Gene