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Aliases for PLAC1 Gene

Aliases for PLAC1 Gene

  • Placenta-Specific 1 2 3
  • Cancer/Testis Antigen 92 2 3
  • Placenta-Specific Protein 1 3
  • OOSP2L 3
  • CT92 3

External Ids for PLAC1 Gene

Previous GeneCards Identifiers for PLAC1 Gene

  • GC0XM128345
  • GC0XM130545
  • GC0XM131644
  • GC0XM132405
  • GC0XM133425
  • GC0XM133527
  • GC0XM133699
  • GC0XM123098

Summaries for PLAC1 Gene

GeneCards Summary for PLAC1 Gene

PLAC1 (Placenta-Specific 1) is a Protein Coding gene. An important paralog of this gene is OOSP2.

UniProtKB/Swiss-Prot for PLAC1 Gene

  • May play a role in placental development.

Gene Wiki entry for PLAC1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLAC1 Gene

Genomics for PLAC1 Gene

Regulatory Elements for PLAC1 Gene

Genomic Location for PLAC1 Gene

Start:
134,565,838 bp from pter
End:
134,764,322 bp from pter
Size:
198,485 bases
Orientation:
Minus strand

Genomic View for PLAC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLAC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLAC1 Gene

Proteins for PLAC1 Gene

  • Protein details for PLAC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBJ0-PLAC1_HUMAN
    Recommended name:
    Placenta-specific protein 1
    Protein Accession:
    Q9HBJ0
    Secondary Accessions:

    Protein attributes for PLAC1 Gene

    Size:
    212 amino acids
    Molecular mass:
    23616 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PLAC1 Gene

Proteomics data for PLAC1 Gene at MOPED

Post-translational modifications for PLAC1 Gene

  • Ubiquitination at Lys108
  • Modification sites at PhosphoSitePlus

Other Protein References for PLAC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PLAC1 Gene

Domains for PLAC1 Gene

Protein Domains for PLAC1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PLAC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HBJ0

UniProtKB/Swiss-Prot:

PLAC1_HUMAN :
  • Q9HBJ0
Family:
  • Belongs to the PLAC1 family.
genes like me logo Genes that share domains with PLAC1: view

No data available for Gene Families for PLAC1 Gene

Function for PLAC1 Gene

Molecular function for PLAC1 Gene

UniProtKB/Swiss-Prot Function: May play a role in placental development.
UniProtKB/Swiss-Prot Induction: Up-regulated during trophoblast differentiation and by FGF7 in trophoblast cells.

Gene Ontology (GO) - Molecular Function for PLAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with PLAC1: view

Phenotypes for PLAC1 Gene

genes like me logo Genes that share phenotypes with PLAC1: view

Animal Models for PLAC1 Gene

MGI Knock Outs for PLAC1:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PLAC1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for PLAC1 Gene

Localization for PLAC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLAC1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLAC1 Gene COMPARTMENTS Subcellular localization image for PLAC1 gene
Compartment Confidence
extracellular 4

Gene Ontology (GO) - Cellular Components for PLAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with PLAC1: view

Pathways for PLAC1 Gene

SuperPathways for PLAC1 Gene

No Data Available

Interacting Proteins for PLAC1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000352173%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000352173 for PLAC1 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for PLAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001890 placenta development IEP 10995572
GO:0090214 spongiotrophoblast layer developmental growth IEA --
genes like me logo Genes that share ontologies with PLAC1: view

No data available for Pathways by source for PLAC1 Gene

Transcripts for PLAC1 Gene

Unigene Clusters for PLAC1 Gene

Placenta-specific 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PLAC1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLAC1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for PLAC1 Gene

GeneLoc Exon Structure for
PLAC1
ECgene alternative splicing isoforms for
PLAC1

Expression for PLAC1 Gene

mRNA expression in normal human tissues for PLAC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLAC1 Gene

This gene is overexpressed in Testis (14.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PLAC1 Gene

SOURCE GeneReport for Unigene cluster for PLAC1 Gene Hs.496811

mRNA Expression by UniProt/SwissProt for PLAC1 Gene

Q9HBJ0-PLAC1_HUMAN
Tissue specificity: Expressed in placenta. Localizes primarily to differentiated syncytiotrophoblast throughout gestation as well as to a small population of villous cytotrophoblasts. Also detected in maternal blood and rapidly disappears following delivery, but is not detected in other adult or fetal tissues examined.
genes like me logo Genes that share expressions with PLAC1: view

In Situ Assay Products

Orthologs for PLAC1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PLAC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLAC1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PLAC1 35
  • 81.94 (n)
  • 70.39 (a)
PLAC1 36
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLAC1 35
  • 81.29 (n)
  • 74.06 (a)
PLAC1 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Plac1 35
  • 71.35 (n)
  • 60.23 (a)
Plac1 16
Plac1 36
  • 60 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Plac1 35
  • 72.9 (n)
  • 61.99 (a)
Species with no ortholog for PLAC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PLAC1 Gene

ENSEMBL:
Gene Tree for PLAC1 (if available)
TreeFam:
Gene Tree for PLAC1 (if available)

Paralogs for PLAC1 Gene

Paralogs for PLAC1 Gene

genes like me logo Genes that share paralogs with PLAC1: view

Variants for PLAC1 Gene

Sequence variations from dbSNP and Humsavar for PLAC1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1982 -- 134,565,930(+) AGGTT(G/T)CTCTT utr-variant-3-prime
rs2428567 -- 134,567,486(+) AGGgg(C/T)ggctt intron-variant
rs2503989 -- 134,567,117(+) TACTT(C/G)CCTCT intron-variant
rs3003875 -- 134,568,241(+) TAACC(C/T)CTGCA intron-variant
rs3003876 -- 134,568,254(+) Aattc(A/T)ttctt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLAC1 Gene

Variant ID Type Subtype PubMed ID
nsv517076 CNV Gain 19592680
nsv521470 CNV Gain 19592680
nsv525660 CNV Gain 19592680
nsv521365 CNV Gain 19592680
nsv7102 CNV Insertion 18451855

Relevant External Links for PLAC1 Gene

HapMap Linkage Disequilibrium report
PLAC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLAC1 Gene

Disorders for PLAC1 Gene

(1) University of Copenhagen DISEASES for PLAC1 Gene

(1) Novoseek inferred disease relationships for PLAC1 Gene

Disease -log(P) Hits PubMed IDs
preeclampsia 49.5 3
genes like me logo Genes that share disorders with PLAC1: view

No data available for UniProtKB/Swiss-Prot for PLAC1 Gene

Publications for PLAC1 Gene

  1. PLAC1, an Xq26 gene with placenta-specific expression. (PMID: 10995572) Cocchia M. … Schlessinger D. (Genomics 2000) 2 3 4 23
  2. PLAC1, a trophoblast-specific gene, is expressed throughout pregnancy in the human placenta and modulated by keratinocyte growth factor. (PMID: 12412044) Fant M. … Schlessinger D. (Mol. Reprod. Dev. 2002) 3 4 23
  3. Rapid clearance of mRNA for PLAC1 gene in maternal blood after delivery. (PMID: 15608456) Concu M. … Carinci P. (Fetal Diagn. Ther. 2005) 3 4 23
  4. PLAC1 expression increases during trophoblast differentiation: evidence for regulatory interactions with the fibroblast growth factor-7 (FGF-7) axis. (PMID: 15803460) Massabbal E. … Fant M. (Mol. Reprod. Dev. 2005) 3 4 23
  5. Increased plasma mRNAs of placenta-specific 1 (PLAC1) and glial cells-missing 1 (GCM1) in mothers with pre-eclampsia. (PMID: 16594548) Fujito N. … Kudo Y. (Hiroshima J. Med. Sci. 2006) 3 23

Products for PLAC1 Gene

Sources for PLAC1 Gene

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