Aliases for PLAC1 Gene
Aliases for PLAC1 Gene
External Ids for PLAC1 Gene
- HGNC: 9044
- Entrez Gene: 10761
- Ensembl: ENSG00000170965
- OMIM: 300296
- UniProtKB: Q9HBJ0
Previous GeneCards Identifiers for PLAC1 Gene
- GC0XM128345
- GC0XM130545
- GC0XM131644
- GC0XM132405
- GC0XM133425
- GC0XM133527
- GC0XM133699
- GC0XM123098
Summaries for PLAC1 Gene
GeneCards Summary for PLAC1 Gene
PLAC1 (Placenta Specific 1) is a Protein Coding gene. Diseases associated with PLAC1 include Pre-Eclampsia. An important paralog of this gene is OOSP2.
UniProtKB/Swiss-Prot for PLAC1 Gene
-
May play a role in placental development.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLAC1 Gene
Genomics for PLAC1 Gene
GeneHancer (GH) Regulatory Elements for PLAC1 Gene
Promoters and enhancers for PLAC1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH0XI134659 | Promoter | 0.8 | EPDnew | 550.1 | +105.8 | 105834 | 0.1 | ZNF217 CTBP1 ATF4 PKNOX1 GATA3 CEBPB EP300 | PLAC1 GC0XP134651 RNU4-44P GC0XM134761 | |
| GH0XI134745 | Enhancer | 0.7 | Ensembl ENCODE | 0.4 | +18.0 | 18032 | 1.3 | MEIS2 JUND TEAD4 SPI1 | RNU4-44P GC0XM134761 PLAC1 GC0XP134651 | |
| GH0XI134751 | Enhancer | 0.6 | ENCODE | 0.4 | +11.4 | 11389 | 2.5 | CTCF ZNF654 REST RAD21 GATA3 SCRT2 HMBOX1 SMC3 PRDM10 ZBTB17 | LINC00629 MIR503 MIR503HG MIR450A1 MIR450A2 MIR450B MIR542 GC0XM134761 RNU4-44P PLAC1 | |
| GH0XI134732 | Enhancer | 0.8 | Ensembl ENCODE | 0.3 | +30.1 | 30112 | 3.2 | ZNF398 ZIC2 OSR2 ZFHX2 JUND VEZF1 ZNF341 GLIS1 EGR2 CHD2 | RNU4-44P GC0XM134761 PLAC1 GC0XP134651 | |
| GH0XI134714 | Enhancer | 1.2 | Ensembl ENCODE | 0.2 | +47.2 | 47188 | 4.9 | CLOCK FOXA2 ARNT SIN3A FEZF1 ZNF2 ZNF766 GLIS2 GATA2 KLF7 | RNU4-44P GC0XM134761 PLAC1 GC0XP134651 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around PLAC1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the PLAC1 gene promoter:
Regulatory Element Products
Genomic Locations for PLAC1 Gene
Genomic Locations for PLAC1 Gene
- chrX:134,565,838-134,764,322
- (GRCh38/hg38)
- Size:
- 198,485 bases
- Orientation:
- Minus strand
- chrX:133,699,868-133,898,352
- (GRCh37/hg19)
Genomic View for PLAC1 Gene
Genes around PLAC1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xq26.3 by Ensembl
- Xq26.3 by Entrez Gene
- Xq26.3 by HGNC
PLAC1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PLAC1 Gene
Proteins for PLAC1 Gene
-
Protein details for PLAC1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9HBJ0-PLAC1_HUMAN
- Recommended name:
- Placenta-specific protein 1
- Protein Accession:
- Q9HBJ0
Protein attributes for PLAC1 Gene
- Size:
- 212 amino acids
- Molecular mass:
- 23616 Da
- Quaternary structure:
- No Data Available
Protein Expression for PLAC1 Gene
Post-translational modifications for PLAC1 Gene
- Ubiquitination at Lys108
Other Protein References for PLAC1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for PLAC1
-
Abcam antibodies for PLAC1
- Invitrogen Antibodies for PLAC1
- Search GeneTex for Antibodies for PLAC1
-
Custom Antibody ServicesProSci Antibodies for PLAC1
-
Santa Cruz Biotechnology (SCBT) Antibodies for PLAC1
Protein Products
-
OriGene Purified Proteins for PLAC1
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- antibodies-online: Search results for 4 available PLAC1 Proteins ranked by validation data
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-
Quality Products:
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-
Abcam proteins for PLAC1
Assay Products
- antibodies-online: Search results for 6 available PLAC1 Elisa Kits ranked by validation data
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-
Quality Products:
No data available for DME Specific Peptides for PLAC1 Gene
Domains & Families for PLAC1 Gene
Gene Families for PLAC1 Gene
- Human Protein Atlas (HPA):
-
- Predicted secreted proteins
Suggested Antigen Peptide Sequences for PLAC1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9HBJ0- Family:
-
- Belongs to the PLAC1 family.
Function for PLAC1 Gene
Molecular function for PLAC1 Gene
- UniProtKB/Swiss-Prot Function:
- May play a role in placental development.
- UniProtKB/Swiss-Prot Induction:
- Up-regulated during trophoblast differentiation and by FGF7 in trophoblast cells.
Phenotypes From GWAS Catalog for PLAC1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003674 | molecular_function | ND | -- |
Phenotypes for PLAC1 Gene
- MGI mutant phenotypes for PLAC1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for PLAC1:
Animal Models for PLAC1 Gene
- MGI Knock Outs for PLAC1:
-
- Plac1 tm1(KOMP)Vlcg
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for PLAC1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PLAC1 gene
- Search ViGene Biosciences for PLAC1
CRISPR Products
-
OriGene CRISPR knockouts for PLAC1
- genomics-online: gRNA clones - Search results for available PLAC1 gene related products
- Applied Biological Materials CRISPR for PLAC1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PLAC1
- GenScript: Design CRISPR guide RNA sequences for PLAC1
miRNA Products
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Inhibitory RNA Products
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- genomics-online: shRNA clones - Search results for available PLAC1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PLAC1 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for PLAC1
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available PLAC1 gene related products
- orf clones - Search results for available PLAC1 gene related products
- Applied Biological Materials Clones for PLAC1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for PLAC1
-
ViGene Biosciences adenoviral particle packaged cDNA for PLAC1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PLAC1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PLAC1 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PLAC1 Gene
Localization for PLAC1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PLAC1 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005575 | cellular_component | ND | -- |
| GO:0005576 | extracellular region | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for PLAC1 Gene
Pathways & Interactions for PLAC1 Gene
No Data Available
Interacting Proteins for PLAC1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001890 | placenta development | IEP | 10995572 |
| GO:0007275 | multicellular organism development | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for PLAC1 Gene
Transcripts for PLAC1 Gene
mRNA/cDNA for PLAC1 Gene
- (7) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (78) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for PLAC1
- genomics-online: gRNA clones - Search results for available PLAC1 gene related products
- Applied Biological Materials CRISPR for PLAC1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PLAC1
- GenScript: Design CRISPR guide RNA sequences for PLAC1
miRNA Products
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Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PLAC1
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- genomics-online: shRNA clones - Search results for available PLAC1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PLAC1 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for PLAC1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PLAC1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available PLAC1 gene related products
- orf clones - Search results for available PLAC1 gene related products
- Applied Biological Materials Clones for PLAC1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b |
|---|---|---|---|---|---|---|---|
| SP1: | |||||||
| SP2: | - |
Expression for PLAC1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Mature Endothelial Cells Blood Brain Barrier
- Lateral Ventricle
-
Endothelium (Cardiovascular System)
- Mature Endothelial Cells Blood Brain Barrier
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
-
Epiblast (Early Embryonic Tissues)
- Epiblast Cells Epiblast
-
Extraembryonic Mesoderm (Extraembryonic Tissues)
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
- Germ Cells (Reproductive System)
- Gonad
-
Placenta (Extraembryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for PLAC1 Gene
This gene is overexpressed in Testis (x14.4).
This gene is overexpressed in Ovary (36.0), Testis (22.0), and Esophagus (8.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PLAC1 Gene
NURSA nuclear receptor signaling pathways regulating expression of PLAC1 Gene:
PLAC1SOURCE GeneReport for Unigene cluster for PLAC1 Gene:
Hs.496811mRNA Expression by UniProt/SwissProt for PLAC1 Gene:
Q9HBJ0-PLAC1_HUMAN
Tissue specificity:
Expressed in placenta. Localizes primarily to differentiated syncytiotrophoblast throughout gestation as well as to a small population of villous cytotrophoblasts. Also detected in maternal blood and rapidly disappears following delivery, but is not detected in other adult or fetal tissues examined.
Primer Products
-
OriGene qPCR primer pairs for PLAC1
-
OriGene qPCR primer pairs and template standards for PLAC1
- genomics-online: primer clones - Search results for available PLAC1 gene related products
No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLAC1 Gene
Orthologs for PLAC1 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PLAC1 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | PLAC1 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | PLAC1 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | LOC102550080 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Plac1 33 16 34 |
|
- Species where no ortholog for PLAC1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for PLAC1 Gene
Variants for PLAC1 Gene
| SNP ID | Clin | Chr 0X pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000002593 | -- | 134,573,673(-) | G/A | intron_variant | |
| rs1000071479 | -- | 134,672,344(-) | C/A | genic_upstream_transcript_variant, intron_variant | |
| rs1000082839 | -- | 134,745,196(-) | C/A | genic_upstream_transcript_variant, intron_variant | |
| rs1000084419 | -- | 134,660,352(-) | C/T | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000086268 | -- | 134,678,702(-) | G/T | genic_upstream_transcript_variant, intron_variant |
Residual Variation Intolerance Score:
63.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.26;
5.70% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PLAC1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PLAC1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLAC1 Gene
Disorders for PLAC1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| pre-eclampsia |
|
Search PLAC1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PLAC1
No data available for UniProtKB/Swiss-Prot and Genatlas for PLAC1 Gene
Publications for PLAC1 Gene
- PLAC1, an Xq26 gene with placenta-specific expression. (PMID: 10995572) Cocchia M … Schlessinger D (Genomics 2000) 2 3 4 22 58
- Rapid clearance of mRNA for PLAC1 gene in maternal blood after delivery. (PMID: 15608456) Concu M … Carinci P (Fetal diagnosis and therapy 2005) 3 4 22 58
- PLAC1 expression increases during trophoblast differentiation: evidence for regulatory interactions with the fibroblast growth factor-7 (FGF-7) axis. (PMID: 15803460) Massabbal E … Fant M (Molecular reproduction and development 2005) 3 4 22 58
- PLAC1, a trophoblast-specific gene, is expressed throughout pregnancy in the human placenta and modulated by keratinocyte growth factor. (PMID: 12412044) Fant M … Schlessinger D (Molecular reproduction and development 2002) 3 4 22 58
- Selective activation of trophoblast-specific PLAC1 in breast cancer by CCAAT/enhancer-binding protein beta (C/EBPbeta) isoform 2. (PMID: 19652226) Koslowski M … Sahin U (The Journal of biological chemistry 2009) 3 22 58
Products for PLAC1 Gene
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- Invitrogen Antibodies for PLAC1
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- VectorBuilder custom plasmid, inducible vectors for PLAC1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PLAC1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 21 available PLAC1 Antibodies ranked by validation data
- Compare Top PLAC1 Antibodies
- antibodies-online: Search results for 6 available PLAC1 Elisa Kits ranked by validation data
- Compare Top PLAC1 Elisa Kits
- Quality Products:
- antibodies-online: Search results for 4 available PLAC1 Proteins ranked by validation data
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- Quality Products:
- Search GeneTex for Antibodies for PLAC1
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- Search ViGene Biosciences for PLAC1
- Santa Cruz Biotechnology (SCBT) Antibodies for PLAC1
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- Santa Cruz Biotechnology (SCBT) CRISPR for PLAC1
- Custom Antibody ServicesProSci Antibodies for PLAC1
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- Horizon Cell Lines for PLAC1
- genomics-online: cdna clones - Search results for available PLAC1 gene related products
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- genomics-online: primer clones - Search results for available PLAC1 gene related products
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Sources for PLAC1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
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