Aliases for MASP2 Gene
- Mannan-Binding Lectin Serine Peptidase 2 2 3
- Mannan-Binding Lectin Serine Peptidase 1 Pseudogene 1 2 3
- Mannan-Binding Lectin Serine Protease 1 Pseudogene 1 2 3
- Mannose-Binding Protein-Associated Serine Protease 2 3 4
- Mannan-Binding Lectin Serine Protease 2 2 3
- MBL-Associated Serine Protease 2 3 4
- MASP-2 3 4
- MBL-Associated Plasma Protein Of 19 KD 3
External Ids for MASP2 Gene
Previous Symbols for MASP2 Gene
The Ra-reactive factor (RARF) is a complement-dependent bactericidal factor that binds to the Ra and R2 polysaccharides expressed by certain enterobacteria. Alternate splicing of this gene results in two transcript variants encoding two RARF components that are involved in the mannan-binding lectin pathway of complement activation. The longer isoform is cleaved into two chains which form a heterodimer linked by a disulfide bond. The encoded proteins are members of the trypsin family of peptidases. [provided by RefSeq, Jul 2008]
GeneCards Summary for MASP2 Gene
MASP2 (Mannan-Binding Lectin Serine Peptidase 2) is a Protein Coding gene. Diseases associated with MASP2 include masp2 deficiency and immunodeficiency due to masp-2 deficiency. Among its related pathways are Complement and coagulation cascades and Complement and coagulation cascades. GO annotations related to this gene include calcium ion binding and peptidase activity. An important paralog of this gene is HP.
UniProtKB/Swiss-Prot for MASP2 Gene
Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase.