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Aliases for RBBP9 Gene

Aliases for RBBP9 Gene

  • RB Binding Protein 9, Serine Hydrolase 2 3 5
  • Retinoblastoma-Binding Protein 9 2 3 4
  • Retinoblastoma-Binding Protein 10 3 4
  • RBBP-10 3 4
  • RBBP-9 3 4
  • RBBP10 3 4
  • BOG 3 4
  • Retinoblastoma Binding Protein 9 2
  • B5T Overexpressed Gene Protein 3
  • B5T-Overexpressed Gene Protein 4
  • Retinoma-Binding Protein 9 3
  • Putative Hydrolase RBBP9 3
  • Protein BOG 4
  • EC 3.-.-.- 4

External Ids for RBBP9 Gene

Previous GeneCards Identifiers for RBBP9 Gene

  • GC20M018455
  • GC20M018462

Summaries for RBBP9 Gene

Entrez Gene Summary for RBBP9 Gene

  • The protein encoded by this gene is a retinoblastoma binding protein that may play a role in the regulation of cell proliferation and differentiation. Two alternatively spliced transcript variants of this gene with identical predicted protein products have been reported, one of which is a nonsense-mediated decay candidate. [provided by RefSeq, Jul 2008]

GeneCards Summary for RBBP9 Gene

RBBP9 (RB Binding Protein 9, Serine Hydrolase) is a Protein Coding gene. Diseases associated with RBBP9 include Retinoblastoma and Corneal Dystrophy, Posterior Polymorphous, 1. GO annotations related to this gene include hydrolase activity.

UniProtKB/Swiss-Prot for RBBP9 Gene

  • May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta1 through interaction with retinoblastoma and the subsequent displacement of E2F-1.

Gene Wiki entry for RBBP9 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBBP9 Gene

Genomics for RBBP9 Gene

Regulatory Elements for RBBP9 Gene

Enhancers for RBBP9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G018566 1.1 ENCODE 13.2 -70.2 -70242 2.0 HDGF PKNOX1 MLX ZFP64 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SEC23B SMIM26 RBBP9 DTD1 POLR3F DZANK1 RN7SL638P
GH20G018428 0.9 ENCODE 11.7 +68.3 68284 0.2 FEZF1 RAD21 YY1 ZNF366 ZSCAN5C KLF7 ZNF680 YY2 CEBPB OVOL3 POLR3F DZANK1 RBBP9 RNA5SP476 GCNT1P1
GH20G018527 0.8 ENCODE 11.4 -30.6 -30621 0.6 HDAC1 RBBP5 ZNF2 RAD21 ZNF335 GLIS2 POLR2A ZNF207 PRDM10 PHF8 DZANK1 POLR3F RBBP9 SEC23B GC20P018562
GH20G018543 0.7 ENCODE 11.4 -47.0 -46974 0.9 BHLHE40 MAX FEZF1 ZIC2 RAD21 NR2F2 GABPA YY1 FOXA1 JUND SEC23B RBBP9 POLR3F DZANK1 DTD1 GC20P018562
GH20G018523 0.6 ENCODE 11.2 -27.3 -27326 2.8 TFAP4 BHLHE40 CEBPB MAX PRDM1 YY1 SEC23B SMIM26 DTD1 RBBP9 GC20P018562
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RBBP9 on UCSC Golden Path with GeneCards custom track

Promoters for RBBP9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000135238 255 1201 HDGF CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207

Genomic Location for RBBP9 Gene

Chromosome:
20
Start:
18,486,540 bp from pter
End:
18,497,255 bp from pter
Size:
10,716 bases
Orientation:
Minus strand

Genomic View for RBBP9 Gene

Genes around RBBP9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBBP9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBBP9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBBP9 Gene

Proteins for RBBP9 Gene

  • Protein details for RBBP9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75884-RBBP9_HUMAN
    Recommended name:
    Putative hydrolase RBBP9
    Protein Accession:
    O75884
    Secondary Accessions:
    • D3DW31
    • Q5JPH9
    • Q9H1D8

    Protein attributes for RBBP9 Gene

    Size:
    186 amino acids
    Molecular mass:
    21000 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Interacts with the serine hydrolase-directed activity-based probe fluorophosphonate-rhodamine (FP-rhodamine). This interaction is inhibited selectively and reversibly by emetine, a compound with cytotoxic activity.

    Three dimensional structures from OCA and Proteopedia for RBBP9 Gene

    Alternative splice isoforms for RBBP9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RBBP9 Gene

Post-translational modifications for RBBP9 Gene

  • Ubiquitination at isoforms=156
  • Modification sites at PhosphoSitePlus

Other Protein References for RBBP9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RBBP9 Gene

Domains & Families for RBBP9 Gene

Protein Domains for RBBP9 Gene

Suggested Antigen Peptide Sequences for RBBP9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75884

UniProtKB/Swiss-Prot:

RBBP9_HUMAN :
  • Belongs to the RBBP9 family.
Family:
  • Belongs to the RBBP9 family.
genes like me logo Genes that share domains with RBBP9: view

No data available for Gene Families for RBBP9 Gene

Function for RBBP9 Gene

Molecular function for RBBP9 Gene

GENATLAS Biochemistry:
Bog,retinoblastoma binding protein,murine Bog homolog,inhibiting TGFB1 activity by displacing E2F1 when overexpressed
UniProtKB/Swiss-Prot Function:
May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta1 through interaction with retinoblastoma and the subsequent displacement of E2F-1.

Enzyme Numbers (IUBMB) for RBBP9 Gene

Gene Ontology (GO) - Molecular Function for RBBP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21044950
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with RBBP9: view
genes like me logo Genes that share phenotypes with RBBP9: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBBP9 Gene

Localization for RBBP9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBBP9 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RBBP9 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 4
plasma membrane 2

Gene Ontology (GO) - Cellular Components for RBBP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with RBBP9: view

Pathways & Interactions for RBBP9 Gene

SuperPathways for RBBP9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBBP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042127 regulation of cell proliferation IEA --
genes like me logo Genes that share ontologies with RBBP9: view

No data available for Pathways by source and SIGNOR curated interactions for RBBP9 Gene

Transcripts for RBBP9 Gene

Unigene Clusters for RBBP9 Gene

Retinoblastoma binding protein 9:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBBP9 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d
SP1:
SP2: -
SP3: - -
SP4: - -

Relevant External Links for RBBP9 Gene

GeneLoc Exon Structure for
RBBP9
ECgene alternative splicing isoforms for
RBBP9

Expression for RBBP9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RBBP9 Gene

Protein differential expression in normal tissues from HIPED for RBBP9 Gene

This gene is overexpressed in Oral epithelium (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RBBP9 Gene



Protein tissue co-expression partners for RBBP9 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RBBP9 Gene:

RBBP9

SOURCE GeneReport for Unigene cluster for RBBP9 Gene:

Hs.69330

mRNA Expression by UniProt/SwissProt for RBBP9 Gene:

O75884-RBBP9_HUMAN
Tissue specificity: Widely expressed. Expressed at higher levels in tumor tissues than in normal tissues.

Evidence on tissue expression from TISSUES for RBBP9 Gene

  • Liver(4.3)
  • Skin(4.2)
  • Nervous system(4.2)
  • Lymph node(4.1)
genes like me logo Genes that share expression patterns with RBBP9: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RBBP9 Gene

Orthologs for RBBP9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RBBP9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RBBP9 34 35
  • 99.64 (n)
mouse
(Mus musculus)
Mammalia Rbbp9 34 16 35
  • 92.07 (n)
dog
(Canis familiaris)
Mammalia RBBP9 34 35
  • 90.86 (n)
rat
(Rattus norvegicus)
Mammalia Rbbp9 34
  • 90.84 (n)
cow
(Bos Taurus)
Mammalia RBBP9 34 35
  • 87.16 (n)
oppossum
(Monodelphis domestica)
Mammalia RBBP9 35
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491567 34
  • 69.83 (n)
zebrafish
(Danio rerio)
Actinopterygii rbbp9 34 35
  • 67.8 (n)
wufd05g11 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.792 34
Species where no ortholog for RBBP9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RBBP9 Gene

ENSEMBL:
Gene Tree for RBBP9 (if available)
TreeFam:
Gene Tree for RBBP9 (if available)

Paralogs for RBBP9 Gene

No data available for Paralogs for RBBP9 Gene

Variants for RBBP9 Gene

Sequence variations from dbSNP and Humsavar for RBBP9 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000027169 -- 18,493,291(+) GACAC(A/C)ATCTA intron-variant
rs1000490220 -- 18,494,608(+) CCCAG(A/G)AGGCA intron-variant
rs1000621488 -- 18,486,457(+) TATAG(C/G)TAAAG downstream-variant-500B
rs1000817341 -- 18,498,320(+) ACTTA(C/T)GGGGT upstream-variant-2KB
rs1000842832 -- 18,494,273(+) AGTTT(G/T)TCTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RBBP9 Gene

Variant ID Type Subtype PubMed ID
dgv4283n100 CNV loss 25217958
nsv1062244 CNV gain 25217958

Variation tolerance for RBBP9 Gene

Residual Variation Intolerance Score: 70.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.79; 16.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RBBP9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RBBP9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBBP9 Gene

Disorders for RBBP9 Gene

MalaCards: The human disease database

(2) MalaCards diseases for RBBP9 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
retinoblastoma
  • retinoblastoma, trilateral
corneal dystrophy, posterior polymorphous, 1
  • corneal endothelial dystrophy 1, autosomal dominant
- elite association - COSMIC cancer census association via MalaCards
Search RBBP9 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RBBP9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RBBP9
genes like me logo Genes that share disorders with RBBP9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RBBP9 Gene

Publications for RBBP9 Gene

  1. A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability. (PMID: 9697699) Woitach J.T. … Thorgeirsson S.S. (Nat. Genet. 1998) 2 3 4 22 64
  2. RBBP9: a tumor-associated serine hydrolase activity required for pancreatic neoplasia. (PMID: 20080647) Shields D.J. … Cheresh D.A. (Proc. Natl. Acad. Sci. U.S.A. 2010) 2 3 22 64
  3. Cloning and expression of a novel retinoblastoma binding protein cDNA, RBBP10. (PMID: 12296629) Chen J.-Z. … Mao Y.-M. (Biochem. Genet. 2002) 3 4 22 64
  4. Assignment of the Bog gene (RBBP9) to syntenic regions of mouse chromosome 2G1-H1 and human chromosome 20p11.2 by fluorescence in situ hybridization. (PMID: 10449909) Woitach J.T. … Thorgeirsson S.S. (Cytogenet. Cell Genet. 1999) 2 3 22 64
  5. Crystal structure of human retinoblastoma binding protein 9. (PMID: 19004028) Vorobiev S.M. … Tong L. (Proteins 2009) 3 4 64

Products for RBBP9 Gene

Sources for RBBP9 Gene

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