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Aliases for RBBP9 Gene

Aliases for RBBP9 Gene

  • Retinoblastoma Binding Protein 9 2 3
  • Retinoblastoma-Binding Protein 9 2 3 4
  • BOG 3 4 6
  • Retinoblastoma-Binding Protein 10 3 4
  • B5T-Overexpressed Gene Protein 3 4
  • RBBP-10 3 4
  • RBBP-9 3 4
  • RBBP10 3 4
  • B5T Overexpressed Gene Protein 3
  • Retinoma-Binding Protein 9 3
  • Putative Hydrolase RBBP9 3
  • Protein BOG 4
  • EC 3.-.-.- 4

External Ids for RBBP9 Gene

Previous GeneCards Identifiers for RBBP9 Gene

  • GC20M018455
  • GC20M018462

Summaries for RBBP9 Gene

Entrez Gene Summary for RBBP9 Gene

  • The protein encoded by this gene is a retinoblastoma binding protein that may play a role in the regulation of cell proliferation and differentiation. Two alternatively spliced transcript variants of this gene with identical predicted protein products have been reported, one of which is a nonsense-mediated decay candidate. [provided by RefSeq, Jul 2008]

GeneCards Summary for RBBP9 Gene

RBBP9 (Retinoblastoma Binding Protein 9) is a Protein Coding gene. Diseases associated with RBBP9 include retinoblastoma. GO annotations related to this gene include hydrolase activity.

UniProtKB/Swiss-Prot for RBBP9 Gene

  • May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta1 through interaction with retinoblastoma and the subsequent displacement of E2F-1

Gene Wiki entry for RBBP9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBBP9 Gene

Genomics for RBBP9 Gene

Regulatory Elements for RBBP9 Gene

Genomic Location for RBBP9 Gene

Start:
18,486,540 bp from pter
End:
18,497,255 bp from pter
Size:
10,716 bases
Orientation:
Minus strand

Genomic View for RBBP9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RBBP9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBBP9 Gene

Proteins for RBBP9 Gene

  • Protein details for RBBP9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75884-RBBP9_HUMAN
    Recommended name:
    Putative hydrolase RBBP9
    Protein Accession:
    O75884
    Secondary Accessions:
    • D3DW31
    • Q5JPH9
    • Q9H1D8

    Protein attributes for RBBP9 Gene

    Size:
    186 amino acids
    Molecular mass:
    21000 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Interacts with the serine hydrolase-directed activity-based probe fluorophosphonate-rhodamine (FP-rhodamine). This interaction is inhibited selectively and reversibly by emetine, a compound with cytotoxic activity

    Three dimensional structures from OCA and Proteopedia for RBBP9 Gene

    Alternative splice isoforms for RBBP9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RBBP9 Gene

Proteomics data for RBBP9 Gene at MOPED

Post-translational modifications for RBBP9 Gene

  • Ubiquitination at Lys156
  • Modification sites at PhosphoSitePlus

Other Protein References for RBBP9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RBBP9 Gene

Domains for RBBP9 Gene

Protein Domains for RBBP9 Gene

Suggested Antigen Peptide Sequences for RBBP9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75884

UniProtKB/Swiss-Prot:

RBBP9_HUMAN :
  • O75884
Family:
  • Belongs to the RBBP9 family.
genes like me logo Genes that share domains with RBBP9: view

No data available for Gene Families for RBBP9 Gene

Function for RBBP9 Gene

Molecular function for RBBP9 Gene

GENATLAS Biochemistry:
Bog,retinoblastoma binding protein,murine Bog homolog,inhibiting TGFB1 activity by displacing E2F1 when overexpressed
UniProtKB/Swiss-Prot Function:
May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta1 through interaction with retinoblastoma and the subsequent displacement of E2F-1

Enzyme Numbers (IUBMB) for RBBP9 Gene

Gene Ontology (GO) - Molecular Function for RBBP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with RBBP9: view
genes like me logo Genes that share phenotypes with RBBP9: view

Animal Model Products

miRNA for RBBP9 Gene

miRTarBase miRNAs that target RBBP9

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for RBBP9 Gene

Localization for RBBP9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBBP9 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RBBP9 Gene COMPARTMENTS Subcellular localization image for RBBP9 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for RBBP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with RBBP9: view

Pathways for RBBP9 Gene

SuperPathways for RBBP9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBBP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:0042127 regulation of cell proliferation IEA --
genes like me logo Genes that share ontologies with RBBP9: view

No data available for Pathways by source for RBBP9 Gene

Transcripts for RBBP9 Gene

Unigene Clusters for RBBP9 Gene

Retinoblastoma binding protein 9:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RBBP9

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBBP9 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d
SP1:
SP2: -
SP3: - -
SP4: - -

Relevant External Links for RBBP9 Gene

GeneLoc Exon Structure for
RBBP9
ECgene alternative splicing isoforms for
RBBP9

Expression for RBBP9 Gene

mRNA expression in normal human tissues for RBBP9 Gene

Protein differential expression in normal tissues for RBBP9 Gene

This gene is overexpressed in Oral epithelium (8.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RBBP9 Gene

SOURCE GeneReport for Unigene cluster for RBBP9 Gene Hs.69330

mRNA Expression by UniProt/SwissProt for RBBP9 Gene

O75884-RBBP9_HUMAN
Tissue specificity: Widely expressed. Expressed at higher levels in tumor tissues than in normal tissues
genes like me logo Genes that share expressions with RBBP9: view

Expression partners for RBBP9 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RBBP9 Gene

Orthologs for RBBP9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RBBP9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RBBP9 35
  • 87.16 (n)
  • 89.08 (a)
RBBP9 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RBBP9 35
  • 90.86 (n)
  • 90.32 (a)
RBBP9 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rbbp9 35
  • 92.07 (n)
  • 91.89 (a)
Rbbp9 16
Rbbp9 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RBBP9 35
  • 99.64 (n)
  • 100 (a)
RBBP9 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rbbp9 35
  • 90.84 (n)
  • 90.66 (a)
oppossum
(Monodelphis domestica)
Mammalia RBBP9 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491567 35
  • 69.83 (n)
  • 75.42 (a)
zebrafish
(Danio rerio)
Actinopterygii rbbp9 35
  • 67.8 (n)
  • 71.02 (a)
wufd05g11 35
rbbp9 36
  • 68 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.792 35
Species with no ortholog for RBBP9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RBBP9 Gene

ENSEMBL:
Gene Tree for RBBP9 (if available)
TreeFam:
Gene Tree for RBBP9 (if available)

Paralogs for RBBP9 Gene

No data available for Paralogs for RBBP9 Gene

Variants for RBBP9 Gene

Sequence variations from dbSNP and Humsavar for RBBP9 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs1065444 -- 18,497,123(-) GGAGG(A/C/T)GGGGA synonymous-codon, reference, utr-variant-5-prime
rs1130201 -- 18,487,182(-) TAGCC(A/T)TATTT utr-variant-3-prime
rs1143100 -- 18,497,115(-) GGATG(A/T)GACCA missense, reference, utr-variant-5-prime
rs2247746 -- 18,496,970(+) TTGCT(A/G)GAGGG intron-variant
rs2247757 -- 18,497,226(+) CCTGC(A/T)CCCGC utr-variant-5-prime

Relevant External Links for RBBP9 Gene

HapMap Linkage Disequilibrium report
RBBP9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RBBP9 Gene

Disorders for RBBP9 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for RBBP9 Gene in MalaCards »

(1) Diseases for RBBP9 Gene including...

genes like me logo Genes that share disorders with RBBP9: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for RBBP9 Gene

Publications for RBBP9 Gene

  1. A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability. (PMID: 9697699) Woitach J.T. … Thorgeirsson S.S. (Nat. Genet. 1998) 2 3 4 23
  2. Assignment of the Bog gene (RBBP9) to syntenic regions of mouse chromosome 2G1-H1 and human chromosome 20p11.2 by fluorescence in situ hybridization. (PMID: 10449909) Woitach J.T. … Thorgeirsson S.S. (Cytogenet. Cell Genet. 1999) 2 3 23
  3. Cloning and expression of a novel retinoblastoma binding protein cDNA, RBBP10. (PMID: 12296629) Chen J.-Z. … Mao Y.-M. (Biochem. Genet. 2002) 3 4 23
  4. RBBP9: a tumor-associated serine hydrolase activity required for pancreatic neoplasia. (PMID: 20080647) Shields D.J. … Cheresh D.A. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 23
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4

Products for RBBP9 Gene

Sources for RBBP9 Gene

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