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Aliases for PLK4 Gene

Aliases for PLK4 Gene

  • Polo-Like Kinase 4 2 3 4
  • STK18 3 4 6
  • SAK 3 4 6
  • Serine/Threonine-Protein Kinase Sak 3 4
  • Serine/Threonine-Protein Kinase 18 3 4
  • Serine/Threonine-Protein Kinase PLK4 3
  • Polo-Like Kinase 4 (Drosophila) 2
  • Serine/Threonine Kinase 18 2
  • Snk Akin Kinase 3
  • EC 2.7.11.21 4
  • MCCRP2 3
  • PLK-4 4

External Ids for PLK4 Gene

Previous Symbols for PLK4 Gene

  • STK18

Summaries for PLK4 Gene

Entrez Gene Summary for PLK4 Gene

  • This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

GeneCards Summary for PLK4 Gene

PLK4 (Polo-Like Kinase 4) is a Protein Coding gene. Diseases associated with PLK4 include microcephaly and chorioretinopathy, autosomal recessive, 2. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include protein serine/threonine kinase activity and protein tyrosine kinase activity. An important paralog of this gene is PLK5.

UniProtKB/Swiss-Prot for PLK4 Gene

  • Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates Ser-151 of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2.

Gene Wiki entry for PLK4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLK4 Gene

Genomics for PLK4 Gene

Genomic Location for PLK4 Gene

Start:
127,880,861 bp from pter
End:
127,899,224 bp from pter
Size:
18,364 bases
Orientation:
Plus strand

Genomic View for PLK4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLK4 Gene

Regulatory Elements for PLK4 Gene

Proteins for PLK4 Gene

  • Protein details for PLK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00444-PLK4_HUMAN
    Recommended name:
    Serine/threonine-protein kinase PLK4
    Protein Accession:
    O00444
    Secondary Accessions:
    • B2RAL0
    • B7Z837
    • B7Z8G7
    • Q8IYF0
    • Q96Q95
    • Q9UD84
    • Q9UDE2

    Protein attributes for PLK4 Gene

    Size:
    970 amino acids
    Molecular mass:
    108972 Da
    Quaternary structure:
    • Homodimer (By similarity). Interacts with CEP152 (via N-terminus).

    Three dimensional structures from OCA and Proteopedia for PLK4 Gene

    Alternative splice isoforms for PLK4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLK4 Gene

Proteomics data for PLK4 Gene at MOPED

Post-translational modifications for PLK4 Gene

Other Protein References for PLK4 Gene

No data available for DME Specific Peptides for PLK4 Gene

Domains for PLK4 Gene

Gene Families for PLK4 Gene

Suggested Antigen Peptide Sequences for PLK4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O00444

UniProtKB/Swiss-Prot:

PLK4_HUMAN
Domain:
  • Contains 1 POLO box domain.:
    • O00444
  • Contains 1 protein kinase domain.:
    • O00444
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.:
    • O00444
genes like me logo Genes that share domains with PLK4: view

Function for PLK4 Gene

Molecular function for PLK4 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot Function: Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates Ser-151 of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2.
UniProtKB/Swiss-Prot Induction: Down-regulated in HCT 116 colorectal cancer cells, leading to aberrant centrioles composed of disorganized cylindrical microtubules and displaced appendages. Down-regulated by p53/TP53.

Enzyme Numbers (IUBMB) for PLK4 Gene

Gene Ontology (GO) - Molecular Function for PLK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity ISS --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 16189514
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with PLK4: view
genes like me logo Genes that share phenotypes with PLK4: view

Animal Models for PLK4 Gene

MGI Knock Outs for PLK4:

miRNA for PLK4 Gene

miRTarBase miRNAs that target PLK4

No data available for Transcription Factor Targeting and HOMER Transcription for PLK4 Gene

Localization for PLK4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLK4 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus, nucleolus. Cleavage furrow. Note=Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles. Associates with centrioles throughout the cell cycle. According to PubMed:16244668, it is not present at cleavage furrows.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLK4 Gene COMPARTMENTS Subcellular localization image for PLK4 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 4
extracellular 1

Gene Ontology (GO) - Cellular Components for PLK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus ISS --
GO:0005813 centrosome IDA 21399614
GO:0005814 centriole IDA 16244668
GO:0005829 cytosol TAS --
GO:0032154 cleavage furrow IEA --
genes like me logo Genes that share ontologies with PLK4: view

Pathways for PLK4 Gene

genes like me logo Genes that share pathways with PLK4: view

Pathways by source for PLK4 Gene

Gene Ontology (GO) - Biological Process for PLK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0006468 protein phosphorylation IEA --
GO:0006996 organelle organization TAS --
GO:0007099 centriole replication IMP 21725316
genes like me logo Genes that share ontologies with PLK4: view

Compounds for PLK4 Gene

(8) ApexBio Compounds for PLK4 Gene

Compound Action Cas Number
BI 2536 PLK1 inhibitor [755038-02-9]
BI6727 (Volasertib) highly potent Polo-like kinase inhibitor. [755038-65-4]
GSK461364 inhibits purified Plk1. [929095-18-1]
GW843682X selective inhibitor of PLK1 and PLK3 [660868-91-7]
HMN-214 potent inhibitor of Polo-like kinase (Plk) [173529-46-9]
MLN0905 small-molecule PLK1 inhibitor. [1228960-69-7]
Poloxin non-ATP competitive Polo-like Kinase 1 (PLK1) inhibitor [321688-88-4]
Rigosertib (ON-01910) PLK1 Inhibitor [1225497-78-8]

(2) HMDB Compounds for PLK4 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(4) Novoseek inferred chemical compound relationships for PLK4 Gene

Compound -log(P) Hits PubMed IDs
microplasmin 82.5 8
serine 21 4
fibrinogen 11.4 2
cysteine 2.31 1
genes like me logo Genes that share compounds with PLK4: view

Transcripts for PLK4 Gene

Unigene Clusters for PLK4 Gene

Polo-like kinase 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLK4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1:
SP2:
SP3: -
SP4: -
SP5:
SP6: -

Relevant External Links for PLK4 Gene

GeneLoc Exon Structure for
PLK4
ECgene alternative splicing isoforms for
PLK4

Expression for PLK4 Gene

mRNA expression in normal human tissues for PLK4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLK4 Gene

This gene is overexpressed in Testis (8.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PLK4 Gene

SOURCE GeneReport for Unigene cluster for PLK4 Gene Hs.172052

genes like me logo Genes that share expressions with PLK4: view

No data available for mRNA Expression by UniProt/SwissProt for PLK4 Gene

Orthologs for PLK4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PLK4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLK4 35
  • 99.6 (n)
  • 99.24 (a)
PLK4 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PLK4 35
  • 91.59 (n)
  • 89.78 (a)
PLK4 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLK4 35
  • 91.96 (n)
  • 89.13 (a)
PLK4 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Plk4 35
  • 85.25 (n)
  • 82.97 (a)
Plk4 16
Plk4 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PLK4 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLK4 36
  • 50 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Plk4 35
  • 85.33 (n)
  • 82.1 (a)
chicken
(Gallus gallus)
Aves LOC422497 35
  • 71.24 (n)
  • 68.57 (a)
PLK4 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLK4 36
  • 64 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68791 35
tropical clawed frog
(Silurana tropicalis)
Amphibia plk4 35
  • 66.31 (n)
  • 63.41 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9557 35
zebrafish
(Danio rerio)
Actinopterygii Dr.11503 35
plk4 35
  • 58.55 (n)
  • 55.92 (a)
plk4 36
  • 52 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012499 35
  • 55.34 (n)
  • 52.26 (a)
fruit fly
(Drosophila melanogaster)
Insecta SAK 35
  • 52 (n)
  • 47.41 (a)
SAK 36
  • 38 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC5 36
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3490 36
  • 37 (a)
OneToOne
Species with no ortholog for PLK4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLK4 Gene

ENSEMBL:
Gene Tree for PLK4 (if available)
TreeFam:
Gene Tree for PLK4 (if available)

Paralogs for PLK4 Gene

Paralogs for PLK4 Gene

Pseudogenes.org Pseudogenes for PLK4 Gene

genes like me logo Genes that share paralogs with PLK4: view

Variants for PLK4 Gene

Sequence variations from dbSNP and Humsavar for PLK4 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs3811740 - 127,886,064(-) AAAAG(A/T)TGGCA missense, reference
rs3811741 -- 127,882,004(-) GTAGA(C/T)AAGGA intron-variant
rs4279228 -- 127,881,526(+) TGACC(A/G)AGCCC intron-variant
rs5861839 -- 127,882,996(+) TGGGA(-/T)TTTTT intron-variant
rs6812947 -- 127,897,341(+) TGAAA(A/G)ACTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLK4 Gene

Variant ID Type Subtype PubMed ID
nsv879915 CNV Gain 21882294
dgv5711n71 CNV Loss 21882294
nsv879923 CNV Loss 21882294

Relevant External Links for PLK4 Gene

HapMap Linkage Disequilibrium report
PLK4
Human Gene Mutation Database (HGMD)
PLK4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLK4 Gene

Disorders for PLK4 Gene

UniProtKB/Swiss-Prot

PLK4_HUMAN
  • Microcephaly and chorioretinopathy, autosomal recessive, 2 (MCCRP2) [MIM:616171]: A severe disorder characterized by microcephaly, delayed psychomotor development, growth retardation with dwarfism, and ocular abnormalities. {ECO:0000269 PubMed:25344692}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(4) Novoseek inferred disease relationships for PLK4 Gene

Disease -log(P) Hits PubMed IDs
acute myocardial infarction 5.22 1
stroke 0 1
tumors 0 3
cancer 0 1

Relevant External Links for PLK4

Genetic Association Database (GAD)
PLK4
Human Genome Epidemiology (HuGE) Navigator
PLK4
genes like me logo Genes that share disorders with PLK4: view

Publications for PLK4 Gene

  1. Sak serine-threonine kinase acts as an effector of Tec tyrosine kinase. (PMID: 11489907) Yamashita Y. … Mano H. (J. Biol. Chem. 2001) 3 4 23
  2. SAK, a new polo-like kinase, is transcriptionally repressed by p53 and induces apoptosis upon RNAi silencing. (PMID: 15967108) Li J. … Sun Y. (Neoplasia 2005) 3 4 23
  3. SAK/PLK4 is required for centriole duplication and flagella development. (PMID: 16326102) Bettencourt-Dias M. … Glover D.M. (Curr. Biol. 2005) 3 4 23
  4. Plk4 is required for cytokinesis and maintenance of chromosomal stability. (PMID: 20348415) Rosario C.O. … Swallow C.J. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 23
  5. Sak kinase gene structure and transcriptional regulation. (PMID: 10607900) Hudson J.W. … Dennis J.W. (Gene 2000) 3 23

Products for PLK4 Gene

  • Addgene plasmids for PLK4

Sources for PLK4 Gene

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