Aliases for PTGES3 Gene
External Ids for PTGES3 Gene
Previous GeneCards Identifiers for PTGES3 Gene
GeneCards Summary for PTGES3 Gene
PTGES3 (Prostaglandin E Synthase 3 (Cytosolic)) is a Protein Coding gene. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and AhR pathway (WikiPathways). GO annotations related to this gene include unfolded protein binding and prostaglandin-E synthase activity. An important paralog of this gene is PTGES3L-AARSD1.
UniProtKB/Swiss-Prot for PTGES3 Gene
Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448).