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Aliases for PTGES3 Gene

Aliases for PTGES3 Gene

  • Prostaglandin E Synthase 3 (Cytosolic) 2 3
  • Cytosolic Prostaglandin E2 Synthase 3 4
  • Progesterone Receptor Complex P23 3 4
  • Telomerase-Binding Protein P23 3 4
  • Hsp90 Co-Chaperone 3 4
  • EC 5.3.99.3 4 63
  • CPGES 3 4
  • TEBP 3 4
  • P23 3 4
  • Unactive Progesterone Receptor, 23 KD 3
  • Cytosolic Prostaglandin E Synthase 3

External Ids for PTGES3 Gene

Previous GeneCards Identifiers for PTGES3 Gene

  • GC12M055344
  • GC12M057057
  • GC12M054096

Summaries for PTGES3 Gene

GeneCards Summary for PTGES3 Gene

PTGES3 (Prostaglandin E Synthase 3 (Cytosolic)) is a Protein Coding gene. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and AhR pathway (WikiPathways). GO annotations related to this gene include unfolded protein binding and prostaglandin-E synthase activity. An important paralog of this gene is PTGES3L-AARSD1.

UniProtKB/Swiss-Prot for PTGES3 Gene

  • Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448).

Gene Wiki entry for PTGES3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTGES3 Gene

Genomics for PTGES3 Gene

Regulatory Elements for PTGES3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PTGES3 Gene

Chromosome:
12
Start:
56,663,341 bp from pter
End:
56,688,408 bp from pter
Size:
25,068 bases
Orientation:
Minus strand

Genomic View for PTGES3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PTGES3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTGES3 Gene

Proteins for PTGES3 Gene

  • Protein details for PTGES3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15185-TEBP_HUMAN
    Recommended name:
    Prostaglandin E synthase 3
    Protein Accession:
    Q15185
    Secondary Accessions:
    • A8K7D0
    • B4DHP2
    • B4DP11
    • B4DP21
    • Q8WU70

    Protein attributes for PTGES3 Gene

    Size:
    160 amino acids
    Molecular mass:
    18697 Da
    Quaternary structure:
    • Binds to the progesterone receptor. Interacts with TERT; the interaction, together with HSP90AA1, is required for correct assembly and stabilization of the telomerase holoenzyme complex. Interacts (via PXLE motif) with EGLN1/PHD2, recruiting EGLN1/PHD2 to the HSP90 pathway to facilitate HIF alpha proteins hydroxylation.

    Three dimensional structures from OCA and Proteopedia for PTGES3 Gene

    Alternative splice isoforms for PTGES3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTGES3 Gene

Proteomics data for PTGES3 Gene at MOPED

Post-translational modifications for PTGES3 Gene

  • Ubiquitination at Lys 7, Lys 48, Lys 79, and Lys 95
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for PTGES3 Gene

Gene Families for PTGES3 Gene

IUPHAR :

Protein Domains for PTGES3 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q15185

UniProtKB/Swiss-Prot:

TEBP_HUMAN :
  • The PXLE motif mediates interaction with EGLN1/PHD2.
  • Belongs to the p23/wos2 family.
Domain:
  • The PXLE motif mediates interaction with EGLN1/PHD2.
  • Contains 1 CS domain.
Family:
  • Belongs to the p23/wos2 family.
genes like me logo Genes that share domains with PTGES3: view

Function for PTGES3 Gene

Molecular function for PTGES3 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=14 uM for PGH2 {ECO:0000269 PubMed:10922363}; Vmax=190 nmol/min/mg enzyme toward PGH2 {ECO:0000269 PubMed:10922363};
UniProtKB/Swiss-Prot CatalyticActivity:
(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate.
UniProtKB/Swiss-Prot Function:
Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448).

Enzyme Numbers (IUBMB) for PTGES3 Gene

Gene Ontology (GO) - Molecular Function for PTGES3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003720 telomerase activity IDA 12135483
GO:0005515 protein binding IPI 9817749
GO:0050220 prostaglandin-E synthase activity IDA 10922363
GO:0051082 unfolded protein binding IDA 12077419
genes like me logo Genes that share ontologies with PTGES3: view
genes like me logo Genes that share phenotypes with PTGES3: view

Animal Models for PTGES3 Gene

MGI Knock Outs for PTGES3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTGES3

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for PTGES3 Gene

Localization for PTGES3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTGES3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTGES3 Gene COMPARTMENTS Subcellular localization image for PTGES3 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for PTGES3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000781 chromosome, telomeric region IC 12135483
GO:0005634 nucleus IDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005697 telomerase holoenzyme complex IDA 12135483
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with PTGES3: view

Pathways & Interactions for PTGES3 Gene

genes like me logo Genes that share pathways with PTGES3: view

Pathways by source for PTGES3 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q15185-TEBP_HUMAN

  • Pathway: Lipid metabolism; prostaglandin biosynthesis.

SIGNOR curated interactions for PTGES3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PTGES3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000723 telomere maintenance TAS 12135483
GO:0001516 prostaglandin biosynthetic process IDA 10922363
GO:0005978 glycogen biosynthetic process --
GO:0006278 RNA-dependent DNA replication IDA 12135483
GO:0007165 signal transduction TAS 8114727
genes like me logo Genes that share ontologies with PTGES3: view

Drugs & Compounds for PTGES3 Gene

(10) Drugs for PTGES3 Gene - From: NovoSeek, HMDB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Progesterone Approved Pharma Inhibition, Pore Blocker Endogenous progesterone receptor agonist 473
Dinoprostone Approved Pharma 67
Dexamethasone Approved, Investigational Pharma Agonist 1806
Novobiocin Approved Pharma 0
Geldanamycin Experimental Pharma Hsp90 inhibitor,potent and specific, Selective Hsp90 inhibitor 0

(6) Additional Compounds for PTGES3 Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Prostaglandin H2
  • (15S)Hydroxy-9alpha,11alpha-(epoxymethano)prosta-5,13-dienoate
  • (15S)Hydroxy-9alpha,11alpha-(epoxymethano)prosta-5,13-dienoic acid
  • (5Z)-7-{(1R,4S,5R,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2,3-dioxabicyclo[2.2.1]hept-5-yl}hept-5-enoate
  • (5Z)-7-{(1R,4S,5R,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2,3-dioxabicyclo[2.2.1]hept-5-yl}hept-5-enoic acid
  • (5Z,13E)-(15S)-9,11-epidioxy-15-hydroxyprosta-5,13-dienoate
42935-17-1
molybdate
  • Molybdate ion
pge2
PGH2
Prostaglandin
genes like me logo Genes that share compounds with PTGES3: view

Transcripts for PTGES3 Gene

Unigene Clusters for PTGES3 Gene

Prostaglandin E synthase 3 (cytosolic):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTGES3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTGES3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8
SP1: - - - -
SP2: - - - - -
SP3: - - - -
SP4: - -
SP5: -

Relevant External Links for PTGES3 Gene

GeneLoc Exon Structure for
PTGES3
ECgene alternative splicing isoforms for
PTGES3

Expression for PTGES3 Gene

mRNA expression in normal human tissues for PTGES3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PTGES3 Gene

This gene is overexpressed in Tlymphocyte (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PTGES3 Gene



SOURCE GeneReport for Unigene cluster for PTGES3 Gene Hs.50425

genes like me logo Genes that share expression patterns with PTGES3: view

Protein tissue co-expression partners for PTGES3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PTGES3 Gene

Orthologs for PTGES3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PTGES3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PTGES3 35
  • 97.69 (n)
  • 100 (a)
PTGES3 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTGES3 35
  • 98.54 (n)
  • 99.37 (a)
PTGES3 36
  • 33 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptges3 35
  • 94.97 (n)
  • 98.74 (a)
Ptges3 16
Ptges3 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PTGES3 35
  • 100 (n)
  • 100 (a)
PTGES3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptges3 35
  • 95.18 (n)
  • 98.74 (a)
oppossum
(Monodelphis domestica)
Mammalia PTGES3 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTGES3 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves PTGES3 35
  • 90.15 (n)
  • 96.23 (a)
lizard
(Anolis carolinensis)
Reptilia PTGES3 36
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ptges3 35
  • 84.91 (n)
  • 88.05 (a)
African clawed frog
(Xenopus laevis)
Amphibia tebp-pending-prov 35
zebrafish
(Danio rerio)
Actinopterygii ptges3a 35
  • 77.28 (n)
  • 78.34 (a)
ptges3a 36
  • 75 (a)
OneToMany
ptges3b 36
  • 75 (a)
OneToMany
ptges3b 36
  • 75 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ZC395.10 36
  • 25 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 4 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10501 36
  • 27 (a)
ManyToMany
Species with no ortholog for PTGES3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PTGES3 Gene

ENSEMBL:
Gene Tree for PTGES3 (if available)
TreeFam:
Gene Tree for PTGES3 (if available)

Paralogs for PTGES3 Gene

Paralogs for PTGES3 Gene

(2) SIMAP similar genes for PTGES3 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for PTGES3 Gene

genes like me logo Genes that share paralogs with PTGES3: view

Variants for PTGES3 Gene

Sequence variations from dbSNP and Humsavar for PTGES3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs181915658 -- 56,689,379(+) CAGGA(C/T)CAGCC upstream-variant-2KB
rs182066220 -- 56,679,799(+) CCTCC(C/G)GAGTA intron-variant
rs181847170 -- 56,666,837(+) GCCCA(A/G)GCTGG intron-variant
rs181667184 -- 56,690,136(+) AACAT(A/G)GCAAA upstream-variant-2KB
rs182115311 -- 56,686,951(+) CTTAA(C/T)TGTTC intron-variant

Variation tolerance for PTGES3 Gene

Residual Variation Intolerance Score: 47.35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.98; 20.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTGES3 Gene

HapMap Linkage Disequilibrium report
PTGES3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PTGES3 Gene

Disorders for PTGES3 Gene

Relevant External Links for PTGES3

Genetic Association Database (GAD)
PTGES3
Human Genome Epidemiology (HuGE) Navigator
PTGES3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTGES3
genes like me logo Genes that share disorders with PTGES3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PTGES3 Gene

Publications for PTGES3 Gene

  1. Characterization of a novel 23-kilodalton protein of unactive progesterone receptor complexes. (PMID: 8114727) Johnson J.L. … Toft D.O. (Mol. Cell. Biol. 1994) 2 23 67
  2. Curcumin inhibits nuclear localization of telomerase by dissociating the Hsp90 co-chaperone p23 from hTERT. (PMID: 19751963) Lee J.H. … Chung I.K. (Cancer Lett. 2010) 23 67
  3. Signal pathways JNK and NF-kappaB, identified by global gene expression profiling, are involved in regulation of TNFalpha-induced mPGES-1 and COX-2 expression in gingival fibroblasts. (PMID: 20398340) BAYge T. … Yucel-Lindberg T. (BMC Genomics 2010) 23 67
  4. La protein required for internal ribosome entry site-directed translation is a potential therapeutic target for hepatitis C virus replication. (PMID: 20497049) Shirasaki T. … Kaneko S. (J. Infect. Dis. 2010) 23 67
  5. Celastrol: Molecular targets of Thunder God Vine. (PMID: 20226165) Salminen A. … Kaarniranta K. (Biochem. Biophys. Res. Commun. 2010) 23 67

Products for PTGES3 Gene

Sources for PTGES3 Gene

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