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Aliases for PTGES3 Gene

Aliases for PTGES3 Gene

  • Prostaglandin E Synthase 3 2 3 5
  • Prostaglandin E Synthase 3 (Cytosolic) 2 3
  • Cytosolic Prostaglandin E2 Synthase 3 4
  • Progesterone Receptor Complex P23 3 4
  • Telomerase-Binding Protein P23 3 4
  • Hsp90 Co-Chaperone 3 4
  • EC 5.3.99.3 4 63
  • CPGES 3 4
  • TEBP 3 4
  • P23 3 4
  • Unactive Progesterone Receptor, 23 KD 3
  • Cytosolic Prostaglandin E Synthase 3

External Ids for PTGES3 Gene

Previous GeneCards Identifiers for PTGES3 Gene

  • GC12M055344
  • GC12M057057
  • GC12M054096

Summaries for PTGES3 Gene

Entrez Gene Summary for PTGES3 Gene

  • This gene encodes an enzyme that converts prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). This protein functions as a co-chaperone with heat shock protein 90 (HSP90), localizing to response elements in DNA and disrupting transcriptional activation complexes. Alternative splicing results in multiple transcript variants. There are multiple pseudogenes of this gene on several different chromosomes. [provided by RefSeq, Feb 2016]

GeneCards Summary for PTGES3 Gene

PTGES3 (Prostaglandin E Synthase 3) is a Protein Coding gene. Among its related pathways are Arachidonic acid metabolism and Cellular response to heat stress. GO annotations related to this gene include unfolded protein binding and prostaglandin-E synthase activity. An important paralog of this gene is PTGES3L-AARSD1.

UniProtKB/Swiss-Prot for PTGES3 Gene

  • Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448).

Gene Wiki entry for PTGES3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTGES3 Gene

Genomics for PTGES3 Gene

Regulatory Elements for PTGES3 Gene

Enhancers for PTGES3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PTGES3 on UCSC Golden Path with GeneCards custom track

Promoters for PTGES3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PTGES3 on UCSC Golden Path with GeneCards custom track

Genomic Location for PTGES3 Gene

Chromosome:
12
Start:
56,663,341 bp from pter
End:
56,688,408 bp from pter
Size:
25,068 bases
Orientation:
Minus strand

Genomic View for PTGES3 Gene

Genes around PTGES3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTGES3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTGES3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTGES3 Gene

Proteins for PTGES3 Gene

  • Protein details for PTGES3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15185-TEBP_HUMAN
    Recommended name:
    Prostaglandin E synthase 3
    Protein Accession:
    Q15185
    Secondary Accessions:
    • A8K7D0
    • B4DHP2
    • B4DP11
    • B4DP21
    • Q8WU70

    Protein attributes for PTGES3 Gene

    Size:
    160 amino acids
    Molecular mass:
    18697 Da
    Quaternary structure:
    • Binds to the progesterone receptor. Interacts with TERT; the interaction, together with HSP90AA1, is required for correct assembly and stabilization of the telomerase holoenzyme complex. Interacts (via PXLE motif) with EGLN1/PHD2, recruiting EGLN1/PHD2 to the HSP90 pathway to facilitate HIF alpha proteins hydroxylation.

    Three dimensional structures from OCA and Proteopedia for PTGES3 Gene

    Alternative splice isoforms for PTGES3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTGES3 Gene

Proteomics data for PTGES3 Gene at MOPED

Post-translational modifications for PTGES3 Gene

  • Ubiquitination at Lys 7, Lys 48, Lys 79, and Lys 95
  • Modification sites at PhosphoSitePlus

Domains & Families for PTGES3 Gene

Gene Families for PTGES3 Gene

IUPHAR :

Protein Domains for PTGES3 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q15185

UniProtKB/Swiss-Prot:

TEBP_HUMAN :
  • The PXLE motif mediates interaction with EGLN1/PHD2.
  • Belongs to the p23/wos2 family.
Domain:
  • The PXLE motif mediates interaction with EGLN1/PHD2.
  • Contains 1 CS domain.
Family:
  • Belongs to the p23/wos2 family.
genes like me logo Genes that share domains with PTGES3: view

Function for PTGES3 Gene

Molecular function for PTGES3 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=14 uM for PGH2 {ECO:0000269 PubMed:10922363}; Vmax=190 nmol/min/mg enzyme toward PGH2 {ECO:0000269 PubMed:10922363};
UniProtKB/Swiss-Prot CatalyticActivity:
(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate.
UniProtKB/Swiss-Prot Function:
Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448).

Enzyme Numbers (IUBMB) for PTGES3 Gene

Gene Ontology (GO) - Molecular Function for PTGES3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051082 unfolded protein binding IDA 12077419
genes like me logo Genes that share ontologies with PTGES3: view
genes like me logo Genes that share phenotypes with PTGES3: view

Animal Models for PTGES3 Gene

MGI Knock Outs for PTGES3:

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTGES3 Gene

Localization for PTGES3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTGES3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTGES3 Gene COMPARTMENTS Subcellular localization image for PTGES3 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5

Gene Ontology (GO) - Cellular Components for PTGES3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with PTGES3: view

Pathways & Interactions for PTGES3 Gene

genes like me logo Genes that share pathways with PTGES3: view

Pathways by source for PTGES3 Gene

2 KEGG pathways for PTGES3 Gene
1 GeneGo (Thomson Reuters) pathway for PTGES3 Gene

UniProtKB/Swiss-Prot Q15185-TEBP_HUMAN

  • Pathway: Lipid metabolism; prostaglandin biosynthesis.

SIGNOR curated interactions for PTGES3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PTGES3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001516 prostaglandin biosynthetic process IEA,IDA 10922363
GO:0005978 glycogen biosynthetic process IEA --
GO:0019369 arachidonic acid metabolic process TAS --
GO:0034605 cellular response to heat TAS --
GO:0042921 glucocorticoid receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with PTGES3: view

Drugs & Compounds for PTGES3 Gene

(10) Drugs for PTGES3 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Progesterone Approved Pharma Full agonist, Activator Endogenous progesterone receptor agonist 511
Dinoprostone Approved Pharma Major endogenous prostanoid 78
Grn163l Investigational Pharma Target 0

(6) Additional Compounds for PTGES3 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Prostaglandin H2
  • (15S)Hydroxy-9alpha,11alpha-(epoxymethano)prosta-5,13-dienoate
  • (15S)Hydroxy-9alpha,11alpha-(epoxymethano)prosta-5,13-dienoic acid
  • (5Z)-7-{(1R,4S,5R,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2,3-dioxabicyclo[2.2.1]hept-5-yl}hept-5-enoate
  • (5Z)-7-{(1R,4S,5R,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2,3-dioxabicyclo[2.2.1]hept-5-yl}hept-5-enoic acid
  • (5Z,13E)-(15S)-9,11-epidioxy-15-hydroxyprosta-5,13-dienoate
42935-17-1
genes like me logo Genes that share compounds with PTGES3: view

Transcripts for PTGES3 Gene

Unigene Clusters for PTGES3 Gene

Prostaglandin E synthase 3 (cytosolic):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PTGES3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8
SP1: - - - -
SP2: - - - - -
SP3: - - - -
SP4: - -
SP5: -

Relevant External Links for PTGES3 Gene

GeneLoc Exon Structure for
PTGES3
ECgene alternative splicing isoforms for
PTGES3

Expression for PTGES3 Gene

mRNA expression in normal human tissues for PTGES3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PTGES3 Gene

This gene is overexpressed in Tlymphocyte (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PTGES3 Gene



SOURCE GeneReport for Unigene cluster for PTGES3 Gene Hs.50425

genes like me logo Genes that share expression patterns with PTGES3: view

Protein tissue co-expression partners for PTGES3 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PTGES3 Gene

Orthologs for PTGES3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PTGES3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PTGES3 35
  • 97.69 (n)
  • 100 (a)
PTGES3 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTGES3 35
  • 98.54 (n)
  • 99.37 (a)
PTGES3 36
  • 33 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptges3 35
  • 94.97 (n)
  • 98.74 (a)
Ptges3 16
Ptges3 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PTGES3 35
  • 100 (n)
  • 100 (a)
PTGES3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptges3 35
  • 95.18 (n)
  • 98.74 (a)
oppossum
(Monodelphis domestica)
Mammalia PTGES3 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTGES3 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves PTGES3 35
  • 90.15 (n)
  • 96.23 (a)
lizard
(Anolis carolinensis)
Reptilia PTGES3 36
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ptges3 35
  • 84.91 (n)
  • 88.05 (a)
African clawed frog
(Xenopus laevis)
Amphibia tebp-pending-prov 35
zebrafish
(Danio rerio)
Actinopterygii ptges3a 35
  • 77.28 (n)
  • 78.34 (a)
ptges3a 36
  • 75 (a)
OneToMany
ptges3b 36
  • 75 (a)
OneToMany
ptges3b 36
  • 75 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ZC395.10 36
  • 25 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 4 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10501 36
  • 27 (a)
ManyToMany
Species with no ortholog for PTGES3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PTGES3 Gene

ENSEMBL:
Gene Tree for PTGES3 (if available)
TreeFam:
Gene Tree for PTGES3 (if available)

Paralogs for PTGES3 Gene

Paralogs for PTGES3 Gene

(2) SIMAP similar genes for PTGES3 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for PTGES3 Gene

genes like me logo Genes that share paralogs with PTGES3: view

Variants for PTGES3 Gene

Sequence variations from dbSNP and Humsavar for PTGES3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1962963 -- 56,669,502(+) ggtct(C/T)gaact intron-variant
rs9290 -- 56,663,783(+) GGACT(A/T)AATGT nc-transcript-variant, utr-variant-3-prime
rs15258 -- 56,663,710(+) GGAAA(A/T)AAAAA nc-transcript-variant, utr-variant-3-prime
rs7295377 -- 56,687,122(+) TAAAA(C/T)GAAGA intron-variant
rs7297289 -- 56,682,703(+) taaga(C/T)cccgt intron-variant

Variation tolerance for PTGES3 Gene

Residual Variation Intolerance Score: 47.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.98; 20.19% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for PTGES3 Gene

Disorders for PTGES3 Gene

Relevant External Links for PTGES3

Genetic Association Database (GAD)
PTGES3
Human Genome Epidemiology (HuGE) Navigator
PTGES3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTGES3

No disorders were found for PTGES3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PTGES3 Gene

Publications for PTGES3 Gene

  1. Characterization of a novel 23-kilodalton protein of unactive progesterone receptor complexes. (PMID: 8114727) Johnson J.L. … Toft D.O. (Mol. Cell. Biol. 1994) 2 3 4 23 67
  2. Curcumin inhibits nuclear localization of telomerase by dissociating the Hsp90 co-chaperone p23 from hTERT. (PMID: 19751963) Lee J.H. … Chung I.K. (Cancer Lett. 2010) 3 23
  3. The terminal prostaglandin synthases mPGES-1, mPGES-2, and cPGES are all overexpressed in human gliomas. (PMID: 19347995) Mattila S. … StenbAock F. (Neuropathology 2009) 3 23
  4. A truncated form of p23 down-regulates telomerase activity via disruption of Hsp90 function. (PMID: 19740745) Woo S.H. … Park I.C. (J. Biol. Chem. 2009) 3 23
  5. Prostaglandin metabolism in human hair follicle. (PMID: 17697149) Colombe L. … Bernard B.A. (Exp. Dermatol. 2007) 3 23

Products for PTGES3 Gene

Sources for PTGES3 Gene

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