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Aliases for PTGES3 Gene

Aliases for PTGES3 Gene

  • Prostaglandin E Synthase 3 (Cytosolic) 2 3
  • CPGES 3 4 6
  • P23 3 4 6
  • Cytosolic Prostaglandin E2 Synthase 3 4
  • Progesterone Receptor Complex P23 3 4
  • Telomerase-Binding Protein P23 3 4
  • Hsp90 Co-Chaperone 3 4
  • EC 5.3.99.3 4 63
  • TEBP 3 4
  • Unactive Progesterone Receptor, 23 KD 3
  • Cytosolic Prostaglandin E Synthase 3
  • Prostaglandin E Synthase 3 3

External Ids for PTGES3 Gene

Summaries for PTGES3 Gene

GeneCards Summary for PTGES3 Gene

PTGES3 (Prostaglandin E Synthase 3 (Cytosolic)) is a Protein Coding gene. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and AhR pathway (WikiPathways). GO annotations related to this gene include unfolded protein binding and prostaglandin-E synthase activity. An important paralog of this gene is PTGES3L-AARSD1.

UniProtKB/Swiss-Prot for PTGES3 Gene

  • Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448).

Gene Wiki entry for PTGES3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTGES3 Gene

Genomics for PTGES3 Gene

Genomic Location for PTGES3 Gene

Start:
56,663,341 bp from pter
End:
56,688,408 bp from pter
Size:
25,068 bases
Orientation:
Minus strand

Genomic View for PTGES3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PTGES3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTGES3 Gene

Regulatory Elements for PTGES3 Gene

Proteins for PTGES3 Gene

  • Protein details for PTGES3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15185-TEBP_HUMAN
    Recommended name:
    Prostaglandin E synthase 3
    Protein Accession:
    Q15185
    Secondary Accessions:
    • A8K7D0
    • B4DHP2
    • B4DP11
    • B4DP21
    • Q8WU70

    Protein attributes for PTGES3 Gene

    Size:
    160 amino acids
    Molecular mass:
    18697 Da
    Quaternary structure:
    • Binds to the progesterone receptor. Interacts with TERT; the interaction, together with HSP90AA1, is required for correct assembly and stabilization of the telomerase holoenzyme complex. Interacts (via PXLE motif) with EGLN1/PHD2, recruiting EGLN1/PHD2 to the HSP90 pathway to facilitate HIF alpha proteins hydroxylation.

    Three dimensional structures from OCA and Proteopedia for PTGES3 Gene

    Alternative splice isoforms for PTGES3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTGES3 Gene

Proteomics data for PTGES3 Gene at MOPED

Post-translational modifications for PTGES3 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys48, Lys79, and Lys95

Domains for PTGES3 Gene

Gene Families for PTGES3 Gene

Protein Domains for PTGES3 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q15185

UniProtKB/Swiss-Prot:

TEBP_HUMAN
Domain:
  • The PXLE motif mediates interaction with EGLN1/PHD2.:
    • Q15185
  • Contains 1 CS domain.:
    • Q15185
Family:
  • Belongs to the p23/wos2 family.:
    • Q15185
genes like me logo Genes that share domains with PTGES3: view

Function for PTGES3 Gene

Molecular function for PTGES3 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=14 uM for PGH2 {ECO:0000269 PubMed:10922363}; Vmax=190 nmol/min/mg enzyme toward PGH2 {ECO:0000269 PubMed:10922363};
UniProtKB/Swiss-Prot CatalyticActivity: (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate.
UniProtKB/Swiss-Prot Function: Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448).

Enzyme Numbers (IUBMB) for PTGES3 Gene

Gene Ontology (GO) - Molecular Function for PTGES3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003720 telomerase activity IDA 12135483
GO:0005515 protein binding IPI 19875381
GO:0050220 prostaglandin-E synthase activity IDA 10922363
GO:0051082 unfolded protein binding IDA 12077419
genes like me logo Genes that share ontologies with PTGES3: view
genes like me logo Genes that share phenotypes with PTGES3: view

Animal Models for PTGES3 Gene

MGI Knock Outs for PTGES3:

miRNA for PTGES3 Gene

miRTarBase miRNAs that target PTGES3

No data available for Transcription Factor Targeting and HOMER Transcription for PTGES3 Gene

Localization for PTGES3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTGES3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTGES3 Gene COMPARTMENTS Subcellular localization image for PTGES3 gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PTGES3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000781 chromosome, telomeric region IC 12135483
GO:0005634 nucleus IDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005697 telomerase holoenzyme complex IDA 12135483
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with PTGES3: view

Pathways for PTGES3 Gene

genes like me logo Genes that share pathways with PTGES3: view

UniProtKB/Swiss-Prot Q15185-TEBP_HUMAN

  • Pathway: Lipid metabolism; prostaglandin biosynthesis.

Gene Ontology (GO) - Biological Process for PTGES3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000723 telomere maintenance TAS 12135483
GO:0001516 prostaglandin biosynthetic process IDA 10922363
GO:0005978 glycogen biosynthetic process --
GO:0006278 RNA-dependent DNA replication IDA 12135483
GO:0007165 signal transduction TAS 8114727
genes like me logo Genes that share ontologies with PTGES3: view

Compounds for PTGES3 Gene

(3) HMDB Compounds for PTGES3 Gene

Compound Synonyms Cas Number PubMed IDs
PGH3
  • prostaglandin H(,3)
42935-17-1
Progesterone
  • 17a-Progesterone
57-83-0
Prostaglandin H1
  • PGH(,1)
Not Available

(13) Novoseek inferred chemical compound relationships for PTGES3 Gene

Compound -log(P) Hits PubMed IDs
geldanamycin 82.3 5
pgh2 72.7 2
pge2 70.9 17
novobiocin 61.5 2
prostaglandin 60 6
genes like me logo Genes that share compounds with PTGES3: view

Transcripts for PTGES3 Gene

Unigene Clusters for PTGES3 Gene

Prostaglandin E synthase 3 (cytosolic):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PTGES3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8
SP1: - - - -
SP2: - - - - -
SP3: - - - -
SP4: - -
SP5: -

Relevant External Links for PTGES3 Gene

GeneLoc Exon Structure for
PTGES3
ECgene alternative splicing isoforms for
PTGES3

Expression for PTGES3 Gene

mRNA expression in normal human tissues for PTGES3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PTGES3 Gene

SOURCE GeneReport for Unigene cluster for PTGES3 Gene Hs.50425

genes like me logo Genes that share expressions with PTGES3: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PTGES3 Gene

Orthologs for PTGES3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PTGES3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTGES3 35
  • 100 (n)
  • 100 (a)
PTGES3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PTGES3 35
  • 97.69 (n)
  • 100 (a)
PTGES3 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTGES3 35
  • 98.54 (n)
  • 99.37 (a)
PTGES3 36
  • 33 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptges3 35
  • 94.97 (n)
  • 98.74 (a)
Ptges3 16
Ptges3 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PTGES3 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTGES3 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptges3 35
  • 95.18 (n)
  • 98.74 (a)
chicken
(Gallus gallus)
Aves PTGES3 35
  • 90.15 (n)
  • 96.23 (a)
lizard
(Anolis carolinensis)
Reptilia PTGES3 36
  • 94 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia tebp-pending-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ptges3 35
  • 84.91 (n)
  • 88.05 (a)
zebrafish
(Danio rerio)
Actinopterygii ptges3a 35
  • 77.28 (n)
  • 78.34 (a)
ptges3a 36
  • 75 (a)
OneToMany
ptges3b 36
  • 75 (a)
OneToMany
ptges3b 36
  • 75 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ZC395.10 36
  • 25 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 4 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10501 36
  • 27 (a)
ManyToMany
Species with no ortholog for PTGES3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PTGES3 Gene

ENSEMBL:
Gene Tree for PTGES3 (if available)
TreeFam:
Gene Tree for PTGES3 (if available)

Paralogs for PTGES3 Gene

Paralogs for PTGES3 Gene

Selected SIMAP similar genes for PTGES3 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for PTGES3 Gene

genes like me logo Genes that share paralogs with PTGES3: view

Variants for PTGES3 Gene

Sequence variations from dbSNP and Humsavar for PTGES3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs9290 -- 56,663,783(+) GGACT(A/T)AATGT utr-variant-3-prime, nc-transcript-variant
rs15258 -- 56,663,710(+) GGAAA(A/T)AAAAA utr-variant-3-prime, nc-transcript-variant
rs1020848 -- 56,669,675(+) ggcac(C/G)atctc intron-variant
rs1049900 -- 56,663,421(-) GATGC(A/C)CTTTG utr-variant-3-prime, nc-transcript-variant
rs1049902 -- 56,663,401(-) GAAAA(A/G)AAAGT utr-variant-3-prime, nc-transcript-variant

Relevant External Links for PTGES3 Gene

HapMap Linkage Disequilibrium report
PTGES3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PTGES3 Gene

Disorders for PTGES3 Gene

(3) Novoseek inferred disease relationships for PTGES3 Gene

Disease -log(P) Hits PubMed IDs
shock 54.6 13
tumors 0 8
cancer 0 3

Relevant External Links for PTGES3

Genetic Association Database (GAD)
PTGES3
Human Genome Epidemiology (HuGE) Navigator
PTGES3
genes like me logo Genes that share disorders with PTGES3: view

No data available for UniProtKB/Swiss-Prot for PTGES3 Gene

Publications for PTGES3 Gene

  1. Characterization of a novel 23-kilodalton protein of unactive progesterone receptor complexes. (PMID: 8114727) Johnson J.L. … Toft D.O. (Mol. Cell. Biol. 1994) 2 3 4 23
  2. Crystal structure and activity of human p23, a heat shock protein 90 co-chaperone. (PMID: 10811660) Weaver A.J. … Toft D.O. (J. Biol. Chem. 2000) 3 4 23
  3. Stable association of hsp90 and p23, but Not hsp70, with active human telomerase. (PMID: 11274138) Forsythe H.L. … Holt S.E. (J. Biol. Chem. 2001) 3 4 23
  4. Disassembly of transcriptional regulatory complexes by molecular chaperones. (PMID: 12077419) Freeman B.C. … Yamamoto K.R. (Science 2002) 2 3 4
  5. Molecular identification of cytosolic prostaglandin E2 synthase that is functionally coupled with cyclooxygenase-1 in immediate prostaglandin E2 biosynthesis. (PMID: 10922363) Tanioka T. … Kudo I. (J. Biol. Chem. 2000) 3 4

Products for PTGES3 Gene

Sources for PTGES3 Gene

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