Aliases for NFAT5 Gene
External Ids for NFAT5 Gene
Previous GeneCards Identifiers for NFAT5 Gene
The product of this gene is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for NFAT5 Gene
NFAT5 (Nuclear Factor Of Activated T-Cells 5, Tonicity-Responsive) is a Protein Coding gene. Among its related pathways are GPCR Pathway and Activation of cAMP-Dependent PKA. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is NFATC4.
UniProtKB/Swiss-Prot for NFAT5 Gene
Transcription factor involved in the transcriptional regulation of osmoprotective and inflammatory genes. Regulates hypertonicity-induced cellular accumulation of osmolytes