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Aliases for SLC12A7 Gene

Aliases for SLC12A7 Gene

  • Solute Carrier Family 12 Member 7 2 3
  • Solute Carrier Family 12 (Potassium/Chloride Transporter), Member 7 2 3 5
  • Electroneutral Potassium-Chloride Cotransporter 4 3 4
  • K-Cl Cotransporter 4 3 4
  • KCC4 3 4
  • Solute Carrier Family 12 (Potassium/Chloride Transporters), Member 7 3
  • Potassium/Chloride Transporter KCC4 3

External Ids for SLC12A7 Gene

Previous GeneCards Identifiers for SLC12A7 Gene

  • GC05M001254
  • GC05P001115
  • GC05M001083
  • GC05M001103
  • GC05M001032

Summaries for SLC12A7 Gene

GeneCards Summary for SLC12A7 Gene

SLC12A7 (Solute Carrier Family 12 Member 7) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Insulin receptor recycling. GO annotations related to this gene include protein kinase binding and potassium:chloride symporter activity. An important paralog of this gene is SLC12A2.

UniProtKB/Swiss-Prot for SLC12A7 Gene

  • Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+) uptake into Deiters cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity).

Gene Wiki entry for SLC12A7 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC12A7 Gene

Genomics for SLC12A7 Gene

Regulatory Elements for SLC12A7 Gene

Enhancers for SLC12A7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC12A7 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC12A7 Gene

1,050,374 bp from pter
1,155,747 bp from pter
105,374 bases
Minus strand

Genomic View for SLC12A7 Gene

Genes around SLC12A7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC12A7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC12A7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC12A7 Gene

Proteins for SLC12A7 Gene

  • Protein details for SLC12A7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier family 12 member 7
    Protein Accession:
    Secondary Accessions:
    • A6NDS8
    • Q4G0F3
    • Q96I81
    • Q9H7I3
    • Q9H7I7
    • Q9UFW2

    Protein attributes for SLC12A7 Gene

    1083 amino acids
    Molecular mass:
    119106 Da
    Quaternary structure:
    • Homomultimer and heteromultimer with other K-Cl cotransporters.

    Alternative splice isoforms for SLC12A7 Gene


neXtProt entry for SLC12A7 Gene

Proteomics data for SLC12A7 Gene at MOPED

Post-translational modifications for SLC12A7 Gene

  • Ubiquitination at Lys 937, Lys 976, Lys 1002, and Lys 1008
  • Glycosylation at Asn 312 and Asn 360
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC12A7 Gene

Antibody Products

  • R&D Systems Antibodies for SLC12A7 (KCC4/SLC12A7)
  • Abcam antibodies for KCC4

No data available for DME Specific Peptides for SLC12A7 Gene

Domains & Families for SLC12A7 Gene

Gene Families for SLC12A7 Gene

Protein Domains for SLC12A7 Gene

Suggested Antigen Peptide Sequences for SLC12A7 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SLC12A transporter family.
  • Belongs to the SLC12A transporter family.
genes like me logo Genes that share domains with SLC12A7: view

Function for SLC12A7 Gene

Molecular function for SLC12A7 Gene

GENATLAS Biochemistry:
solute carrier family 12 (sodium/potassium/chloride cotransporter),highly expressed in muscle,brain,heart,lung and kidney,regulated in vascular endothelial cells by EGF
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by N-ethylmaleimide (NEM). Inhibited by furosemide, DIDS and bumetanide. The inhibition is much stronger in the presence of 50 mM K(+) in the uptake medium. Inhibited by DIOA. Inhibited by WNK3.
UniProtKB/Swiss-Prot Function:
Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+) uptake into Deiters cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity).
genes like me logo Genes that share phenotypes with SLC12A7: view

Animal Models for SLC12A7 Gene

MGI Knock Outs for SLC12A7:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC12A7

CRISPR Products

miRNA for SLC12A7 Gene

miRTarBase miRNAs that target SLC12A7

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC12A7 Gene

Localization for SLC12A7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC12A7 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC12A7 Gene COMPARTMENTS Subcellular localization image for SLC12A7 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SLC12A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SLC12A7: view

Pathways & Interactions for SLC12A7 Gene

genes like me logo Genes that share pathways with SLC12A7: view

Interacting Proteins for SLC12A7 Gene

Gene Ontology (GO) - Biological Process for SLC12A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA,TAS --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC12A7: view

No data available for SIGNOR curated interactions for SLC12A7 Gene

Drugs & Compounds for SLC12A7 Gene

(3) Drugs for SLC12A7 Gene - From: DrugBank, DGIdb, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Potassium Chloride Approved, Withdrawn Pharma Target, Transporter, substrate 0
DIOA Pharma Inhibition, Inhibitor 0

(3) Additional Compounds for SLC12A7 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Chloride ion
  • Bertholite
  • Chloor
  • Chlor
  • Chlore
  • Chloride
genes like me logo Genes that share compounds with SLC12A7: view

Transcripts for SLC12A7 Gene

Unigene Clusters for SLC12A7 Gene

Solute carrier family 12 (potassium/chloride transporters), member 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC12A7 Gene

No ASD Table

Relevant External Links for SLC12A7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC12A7 Gene

mRNA expression in normal human tissues for SLC12A7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC12A7 Gene

This gene is overexpressed in Heart - Left Ventricle (x4.2).

Protein differential expression in normal tissues from HIPED for SLC12A7 Gene

This gene is overexpressed in Nasal epithelium (28.0), Testis (12.9), Adrenal (7.8), and Ovary (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC12A7 Gene

SOURCE GeneReport for Unigene cluster for SLC12A7 Gene Hs.172613

mRNA Expression by UniProt/SwissProt for SLC12A7 Gene

Tissue specificity: Detected in muscle, brain, lung, heart and kidney.
genes like me logo Genes that share expression patterns with SLC12A7: view

Primer Products

No data available for Protein tissue co-expression partners for SLC12A7 Gene

Orthologs for SLC12A7 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC12A7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SLC12A7 35
  • 84.05 (n)
  • 83.51 (a)
SLC12A7 36
  • 81 (a)
(Canis familiaris)
Mammalia SLC12A7 35
  • 86.78 (n)
  • 89.42 (a)
SLC12A7 36
  • 89 (a)
(Mus musculus)
Mammalia Slc12a7 35
  • 84.64 (n)
  • 91.04 (a)
Slc12a7 16
Slc12a7 36
  • 91 (a)
(Pan troglodytes)
Mammalia SLC12A7 35
  • 96.7 (n)
  • 96.17 (a)
SLC12A7 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Slc12a7 35
  • 85.29 (n)
  • 91.23 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 79 (a)
-- 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia SLC12A7 36
  • 54 (a)
(Gallus gallus)
Aves SLC12A7 35
  • 70.03 (n)
  • 82.59 (a)
SLC12A7 36
  • 83 (a)
(Anolis carolinensis)
Reptilia SLC12A7 36
  • 79 (a)
(Danio rerio)
Actinopterygii slc12a7a 35
  • 68.49 (n)
  • 73.19 (a)
slc12a7a 36
  • 69 (a)
slc12a7b 36
  • 74 (a)
fruit fly
(Drosophila melanogaster)
Insecta kcc 36
  • 54 (a)
(Caenorhabditis elegans)
Secernentea H16O14.1 37
  • 46 (a)
K02A2.3 37
  • 38 (a)
R13A1.2 37
  • 41 (a)
kcc-2 36
  • 44 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2084 36
  • 53 (a)
Species with no ortholog for SLC12A7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC12A7 Gene

Gene Tree for SLC12A7 (if available)
Gene Tree for SLC12A7 (if available)

Paralogs for SLC12A7 Gene

Paralogs for SLC12A7 Gene

(4) SIMAP similar genes for SLC12A7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLC12A7: view

Variants for SLC12A7 Gene

Sequence variations from dbSNP and Humsavar for SLC12A7 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_028748 -
rs737154 -- 1,065,284(-) TTTGT(A/G)GGTAG nc-transcript-variant, reference, synonymous-codon
rs15627 -- 1,051,420(+) TGGCT(A/G)TCGTG nc-transcript-variant, utr-variant-3-prime
rs1058508 -- 1,051,572(-) CATCC(A/G)CCTTT nc-transcript-variant, utr-variant-3-prime
rs1058542 -- 1,050,600(-) TGCTT(C/T)TGAGG nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SLC12A7 Gene

Variant ID Type Subtype PubMed ID
dgv1736e1 CNV Complex 17122850
nsv428459 CNV Gain+Loss 18775914
nsv10654 CNV Gain+Loss 18304495
nsv880488 CNV Gain 21882294
nsv881169 CNV Loss 21882294
nsv880554 CNV Gain 21882294
dgv5907n71 CNV Loss 21882294
dgv5908n71 CNV Loss 21882294
nsv469577 CNV Loss 16826518
nsv880538 CNV Gain 21882294
nsv470985 CNV Gain 18288195
nsv461896 CNV Loss 19166990
nsv470984 CNV Loss 18288195
nsv527182 CNV Loss 19592680
nsv880941 CNV Gain+Loss 21882294
nsv822953 CNV Gain 20364138
dgv686n27 CNV Loss 19166990
dgv5909n71 CNV Loss 21882294
dgv5910n71 CNV Loss 21882294
nsv880448 CNV Gain 21882294
nsv461900 CNV Loss 19166990
dgv5911n71 CNV Loss 21882294
nsv881170 CNV Loss 21882294
dgv5912n71 CNV Gain 21882294
nsv513209 CNV Loss 21212237
esv2729398 CNV Deletion 23290073
esv7694 CNV Loss 19470904
esv27870 CNV Gain+Loss 19812545
esv987527 CNV Deletion 20482838
dgv959e201 CNV Deletion 23290073
esv2740954 CNV Deletion 23290073
esv1017705 CNV Deletion 17803354
nsv327933 CNV Loss 16902084
esv2729399 CNV Deletion 23290073
esv2729400 CNV Deletion 23290073
nsv881632 CNV Loss 21882294
nsv880275 CNV Loss 21882294
nsv881117 CNV Loss 21882294
esv2729401 CNV Deletion 23290073
esv2729402 CNV Deletion 23290073
nsv820935 CNV Deletion 20802225
esv2729403 CNV Deletion 23290073
nsv513210 CNV Loss 21212237
esv1595100 CNV Insertion 17803354
dgv960e201 CNV Deletion 23290073
esv1484370 CNV Deletion 17803354
esv2729405 CNV Deletion 23290073
nsv329413 CNV Loss 16902084
nsv329780 CNV Insertion 16902084
esv1013230 CNV Deletion 17803354
esv2729408 CNV Deletion 23290073
esv2729409 CNV Deletion 23290073
esv2729410 CNV Deletion 23290073
esv2729411 CNV Deletion 23290073
esv2729412 CNV Deletion 23290073
esv3216 CNV Deletion 18987735
esv2658162 CNV Deletion 23128226
nsv328577 CNV Loss 16902084
esv2729413 CNV Deletion 23290073
esv2729414 CNV Deletion 23290073
esv2729415 CNV Deletion 23290073
esv2729416 CNV Deletion 23290073
esv2729418 CNV Deletion 23290073
esv29930 CNV Loss 19812545
esv2729419 CNV Deletion 23290073
esv2674154 CNV Deletion 23128226
esv2239100 CNV Deletion 18987734
esv2729420 CNV Deletion 23290073
esv2729421 CNV Deletion 23290073
esv2729422 CNV Deletion 23290073

Variation tolerance for SLC12A7 Gene

Residual Variation Intolerance Score: 2.75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.13; 51.33% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SLC12A7 Gene

Disorders for SLC12A7 Gene

Relevant External Links for SLC12A7

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SLC12A7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC12A7 Gene

Publications for SLC12A7 Gene

  1. Cloning and characterization of KCC3 and KCC4, new members of the cation-chloride cotransporter gene family. (PMID: 10347194) Mount D.B. … Gamba G. (J. Biol. Chem. 1999) 2 3 4 23 67
  2. Functional association between K+-Cl- cotransporter-4 and H+,K+-ATPase in the apical canalicular membrane of gastric parietal cells. (PMID: 18984587) Fujii T. … Sakai H. (J. Biol. Chem. 2009) 3 23
  3. Motor protein-dependent membrane trafficking of KCl cotransporter-4 is important for cancer cell invasion. (PMID: 19887603) Chen Y.F. … Shen M.R. (Cancer Res. 2009) 3 23
  4. IGF-1 upregulates electroneutral K-Cl cotransporter KCC3 and KCC4 which are differentially required for breast cancer cell proliferation and invasiveness. (PMID: 17133354) Hsu Y.M. … Shen M.R. (J. Cell. Physiol. 2007) 3 23
  5. Functional and molecular characterization of multiple K-Cl cotransporter isoforms in corneal epithelial cells. (PMID: 17418819) CapA^-Aponte J.E. … Reinach P.S. (Exp. Eye Res. 2007) 23 25

Products for SLC12A7 Gene

Sources for SLC12A7 Gene