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Aliases for NRG3 Gene

Aliases for NRG3 Gene

  • Neuregulin 3 2 3 5
  • Pro-NRG3 3 4
  • Neuregulin-3-Like Polypeptide 3
  • Neuregulin 3 Variant 10 3
  • Neuregulin 3 Variant 11 3
  • Neuregulin 3 Variant 12 3
  • Neuregulin 3 Variant 13 3
  • Neuregulin 3 Variant 14 3
  • Neuregulin 3 Variant 1 3
  • Neuregulin 3 Variant 3 3
  • Neuregulin 3 Variant 4 3
  • Neuregulin 3 Variant 5 3
  • Neuregulin 3 Variant 6 3
  • Neuregulin 3 Variant 7 3
  • Neuregulin 3 Variant 8 3
  • Neuregulin 3 Variant 9 3
  • HRG3 3

External Ids for NRG3 Gene

Previous GeneCards Identifiers for NRG3 Gene

  • GC10U990072
  • GC10P083766
  • GC10P083299
  • GC10P083625
  • GC10P077483

Summaries for NRG3 Gene

Entrez Gene Summary for NRG3 Gene

  • This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified.[provided by RefSeq, Sep 2009]

GeneCards Summary for NRG3 Gene

NRG3 (Neuregulin 3) is a Protein Coding gene. Diseases associated with NRG3 include schizophrenia. Among its related pathways are ErbB signaling pathway and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include receptor binding and receptor tyrosine kinase binding. An important paralog of this gene is NRG1.

UniProtKB/Swiss-Prot for NRG3 Gene

  • Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes.

Gene Wiki entry for NRG3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRG3 Gene

Genomics for NRG3 Gene

Regulatory Elements for NRG3 Gene

Enhancers for NRG3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NRG3 on UCSC Golden Path with GeneCards custom track

Genomic Location for NRG3 Gene

Chromosome:
10
Start:
81,875,309 bp from pter
End:
82,987,179 bp from pter
Size:
1,111,871 bases
Orientation:
Plus strand

Genomic View for NRG3 Gene

Genes around NRG3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRG3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRG3 Gene

Proteins for NRG3 Gene

  • Protein details for NRG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56975-NRG3_HUMAN
    Recommended name:
    Pro-neuregulin-3, membrane-bound isoform
    Protein Accession:
    P56975
    Secondary Accessions:
    • A4D7U1
    • Q0PEH2
    • Q5VYH3

    Protein attributes for NRG3 Gene

    Size:
    720 amino acids
    Molecular mass:
    77901 Da
    Quaternary structure:
    • Interacts with ERBB4.

    Alternative splice isoforms for NRG3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NRG3 Gene

Proteomics data for NRG3 Gene at MOPED

Post-translational modifications for NRG3 Gene

  • Extensive glycosylation precedes the proteolytic cleavage (By similarity). Isoform 3 is glycosylated.
  • Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.
  • Glycosylation at Thr 276, Thr 277, Thr 278, Ser 280, and Thr 281
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for NRG3 (Neuregulin-3/NRG3)

No data available for DME Specific Peptides for NRG3 Gene

Domains & Families for NRG3 Gene

Protein Domains for NRG3 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P56975

UniProtKB/Swiss-Prot:

NRG3_HUMAN :
  • The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity).
  • Belongs to the neuregulin family.
Domain:
  • The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity).
  • ERBB receptor binding is elicited entirely by the EGF-like domain.
  • Contains 1 EGF-like domain.
Family:
  • Belongs to the neuregulin family.
genes like me logo Genes that share domains with NRG3: view

No data available for Gene Families for NRG3 Gene

Function for NRG3 Gene

Molecular function for NRG3 Gene

UniProtKB/Swiss-Prot Function:
Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes.

Gene Ontology (GO) - Molecular Function for NRG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030971 receptor tyrosine kinase binding NAS 9275162
genes like me logo Genes that share ontologies with NRG3: view
genes like me logo Genes that share phenotypes with NRG3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NRG3

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NRG3 Gene

Localization for NRG3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRG3 Gene

Pro-neuregulin-3, membrane-bound isoform: Cell membrane; Single-pass type I membrane protein. Note=Does not seem to be active. {ECO:0000250}.
Neuregulin-3: Secreted.
Isoform 3: Cell membrane; Single-pass type I membrane protein. Note=Isoform 3 is also proteolytically released as a soluble form.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NRG3 Gene COMPARTMENTS Subcellular localization image for NRG3 gene
Compartment Confidence
extracellular 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for NRG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 9275162
GO:0005887 integral component of plasma membrane NAS 9275162
genes like me logo Genes that share ontologies with NRG3: view

Pathways & Interactions for NRG3 Gene

SuperPathways for NRG3 Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 Apoptotic Pathways in Synovial Fibroblasts
3 PI3K events in ERBB4 signaling
4 GPCR Pathway
5 Signaling by ERBB2
genes like me logo Genes that share pathways with NRG3: view

SIGNOR curated interactions for NRG3 Gene

Activates:

Gene Ontology (GO) - Biological Process for NRG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity NAS 9275162
GO:0007389 pattern specification process IEA --
GO:0035556 intracellular signal transduction IBA --
GO:0060596 mammary placode formation IEA --
genes like me logo Genes that share ontologies with NRG3: view

Drugs & Compounds for NRG3 Gene

(2) Drugs for NRG3 Gene - From: PharmGKB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Iloperidone Approved Pharma Antagonist Dopamine (D2) and serotonin (5HT2) receptor antagonist 0
genes like me logo Genes that share compounds with NRG3: view

Transcripts for NRG3 Gene

Unigene Clusters for NRG3 Gene

Neuregulin 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NRG3 Gene

No ASD Table

Relevant External Links for NRG3 Gene

GeneLoc Exon Structure for
NRG3
ECgene alternative splicing isoforms for
NRG3

Expression for NRG3 Gene

mRNA expression in normal human tissues for NRG3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NRG3 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x7.1), Brain - Anterior cingulate cortex (BA24) (x6.5), Brain - Cortex (x6.1), Brain - Amygdala (x5.1), Brain - Hippocampus (x4.7), and Brain - Hypothalamus (x4.0).

Protein differential expression in normal tissues from HIPED for NRG3 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NRG3 Gene



SOURCE GeneReport for Unigene cluster for NRG3 Gene Hs.125119

mRNA Expression by UniProt/SwissProt for NRG3 Gene

P56975-NRG3_HUMAN
Tissue specificity: Highly expressed in most regions of the brain with the exception of corpus callosum. Expressed at lower level in testis. Not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with NRG3: view

Protein tissue co-expression partners for NRG3 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for NRG3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NRG3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NRG3 35
  • 93.85 (n)
  • 94.77 (a)
NRG3 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NRG3 35
  • 91.08 (n)
  • 90.92 (a)
NRG3 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nrg3 35
  • 90.12 (n)
  • 91.98 (a)
Nrg3 16
Nrg3 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nrg3 35
  • 88.62 (n)
  • 90.99 (a)
oppossum
(Monodelphis domestica)
Mammalia NRG3 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NRG3 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves NRG3 35
  • 80.27 (n)
  • 81.6 (a)
NRG3 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NRG3 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nrg3 35
  • 71.31 (n)
  • 71.84 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.31978 35
zebrafish
(Danio rerio)
Actinopterygii LOC101882495 35
  • 53.27 (n)
  • 46.73 (a)
NRG3 36
  • 23 (a)
OneToOne
Species with no ortholog for NRG3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NRG3 Gene

ENSEMBL:
Gene Tree for NRG3 (if available)
TreeFam:
Gene Tree for NRG3 (if available)

Paralogs for NRG3 Gene

Paralogs for NRG3 Gene

genes like me logo Genes that share paralogs with NRG3: view

Variants for NRG3 Gene

Sequence variations from dbSNP and Humsavar for NRG3 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs2295934 - 82,978,951(-) TAGAC(G/T)CCTGC reference, missense
rs17101193 - 82,985,170(+) ACAAA(A/C)CCCTA reference, missense
rs1474869 -- 82,030,764(-) TTTTA(C/T)ATTCA intron-variant
rs1475706 -- 82,925,488(-) ATGAA(C/G/T)ATTTA intron-variant
rs1475707 -- 82,925,176(-) ATCCT(A/C)CTTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NRG3 Gene

Variant ID Type Subtype PubMed ID
nsv831925 CNV Gain 17160897
esv22050 CNV Loss 19812545
esv2738873 CNV Deletion 23290073
esv2738884 CNV Deletion 23290073
nsv507565 CNV Insertion 20534489
nsv825483 CNV Loss 20364138
nsv831927 CNV Gain 17160897
nsv7398 CNV Insertion 18451855
esv2676643 CNV Deletion 23128226
nsv527301 CNV Loss 19592680
dgv7n50 CNV Loss 21212237
esv2669227 CNV Deletion 23128226
esv2738895 CNV Deletion 23290073
esv28936 CNV Loss 19812545
esv33611 CNV Loss 17666407
esv2422053 CNV Deletion 20811451
nsv442196 CNV CNV 18776908
nsv516182 CNV Loss 19592680
nsv514578 CNV Loss 21397061
esv2738906 CNV Deletion 23290073
esv1787554 CNV Insertion 17803354
nsv895808 CNV Loss 21882294
nsv518939 CNV Loss 19592680
dgv158e199 CNV Deletion 23128226
dgv786n71 CNV Gain 21882294
nsv516167 CNV Loss 19592680
dgv787n71 CNV Loss 21882294
nsv7410 CNV Insertion 18451855
dgv307e1 CNV Complex 17122850
esv2738918 CNV Deletion 23290073
esv2738929 CNV Deletion 23290073
esv2304405 CNV Deletion 18987734
nsv24927 CNV Loss 16902084
esv2738940 CNV Deletion 23290073
nsv517782 CNV Loss 19592680
esv2427309 CNV Loss 19546169
esv2526609 CNV Deletion 19546169
nsv436117 CNV Deletion 17901297
esv1981738 CNV Deletion 18987734
esv2738951 CNV Deletion 23290073
esv2678481 CNV Deletion 23128226
dgv165n67 CNV Loss 20364138
esv24251 CNV Loss 19812545
nsv527270 CNV Loss 19592680
nsv467402 CNV Loss 19166990
nsv526120 CNV Loss 19592680
esv4025 CNV Deletion 18987735
esv2738962 CNV Deletion 23290073
esv7990 CNV Loss 19470904
esv1370318 CNV Deletion 17803354
nsv895813 CNV Loss 21882294
esv2738973 CNV Deletion 23290073
nsv895814 CNV Loss 21882294
dgv788n71 CNV Loss 21882294
nsv895816 CNV Loss 21882294
nsv895818 CNV Loss 21882294
esv2738984 CNV Deletion 23290073
esv2738995 CNV Deletion 23290073
esv2739006 CNV Deletion 23290073
esv35106 CNV Gain 17911159
esv2739017 CNV Deletion 23290073
esv2287780 CNV Deletion 18987734
esv5009 CNV Deletion 18987735
esv2739029 CNV Deletion 23290073
dgv308e1 CNV Complex 17122850
esv1006949 CNV Deletion 20482838
esv1211637 CNV Deletion 17803354
nsv24044 CNV Loss 16902084
nsv467403 CNV Gain 19166990
nsv517505 CNV Gain+Loss 19592680
nsv895819 CNV Gain 21882294
nsv8711 CNV Gain 18304495
nsv442197 CNV CNV 18776908
essv20465 CNV CNV 17122850
nsv818776 CNV Gain 17921354
nsv516267 CNV Loss 19592680
esv34368 CNV Loss 17911159
esv2665966 CNV Deletion 23128226
dgv309e1 CNV Complex 17122850
nsv527348 CNV Loss 19592680
nsv516930 CNV Loss 19592680
esv2671454 CNV Deletion 23128226
esv2660411 CNV Deletion 23128226
esv24433 CNV Loss 19812545
esv2421719 CNV Deletion 20811451
nsv442198 CNV CNV 18776908
nsv818779 CNV Loss 17921354
nsv514579 CNV Loss 21397061
nsv895820 CNV Loss 21882294
nsv831928 CNV Gain 17160897

Variation tolerance for NRG3 Gene

Residual Variation Intolerance Score: 19.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.74; 73.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NRG3 Gene

HapMap Linkage Disequilibrium report
NRG3
Human Gene Mutation Database (HGMD)
NRG3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRG3 Gene

Disorders for NRG3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NRG3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
schizophrenia
  • schizophrenia 12
- elite association - COSMIC cancer census association via MalaCards
Search NRG3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NRG3

Genetic Association Database (GAD)
NRG3
Human Genome Epidemiology (HuGE) Navigator
NRG3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NRG3
genes like me logo Genes that share disorders with NRG3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NRG3 Gene

Publications for NRG3 Gene

  1. Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4. (PMID: 9275162) Zhang D. … Godowski P.J. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 23 67
  2. Fine mapping on chromosome 10q22-q23 implicates Neuregulin 3 in schizophrenia. (PMID: 19118813) Chen P.L. … Valle D. (Am. J. Hum. Genet. 2009) 3 23
  3. Neuregulin 3 genetic variations and susceptibility to schizophrenia in a Chinese population. (PMID: 18708184) Wang Y.C. … Liou Y.J. (Biol. Psychiatry 2008) 3 23
  4. Characterization of a neural-specific splicing form of the human neuregulin 3 gene involved in oligodendrocyte survival. (PMID: 16478787) Carteron C. … Cabedo H. (J. Cell Sci. 2006) 3 23
  5. Effects of neuregulin 3 genotype on human prefrontal cortex physiology. (PMID: 24431462) Tost H. … Law A.J. (J. Neurosci. 2014) 3

Products for NRG3 Gene

Sources for NRG3 Gene

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