External Ids for TBR1 Gene
Previous GeneCards Identifiers for TBR1 Gene
This gene is a member of a conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. A similar protein has been disrupted in mice and shown to be critical for early cortical development, and causes loss of projection neurons in the olfactory bulbs and olfactory cortex. The C-terminal region this similar protein was found to be necessary and sufficient for association with the guanylate kinase domain of calcium/calmodulin-dependent serine protein kinase. [provided by RefSeq, Jul 2008]
GeneCards Summary for TBR1 Gene
TBR1 (T-Box, Brain, 1) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter sequence-specific DNA binding. An important paralog of this gene is MGA.
UniProtKB/Swiss-Prot for TBR1 Gene
Probable transcriptional regulator involved in developmental processes. Required for normal brain development