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Aliases for POLD3 Gene

Aliases for POLD3 Gene

  • Polymerase (DNA) Delta 3, Accessory Subunit 2 3
  • Polymerase (DNA-Directed), Delta 3, Accessory Subunit 2 3 5
  • DNA Polymerase Delta Subunit P66 2 3 4
  • Pol Delta C Subunit (P66) 2 3
  • Protein Phosphatase 1, Regulatory Subunit 128 3
  • Regulatory Subunit 128 2
  • Protein Phosphatase 1 2
  • PPP1R128 3
  • KIAA0039 4
  • P68 3
  • P66 3

External Ids for POLD3 Gene

Previous GeneCards Identifiers for POLD3 Gene

  • GC11P076630
  • GC11P075843
  • GC11P074008
  • GC11P074029
  • GC11P073981
  • GC11P074303
  • GC11P070599
  • GC11P074207

Summaries for POLD3 Gene

Entrez Gene Summary for POLD3 Gene

  • This gene encodes the 66-kDa subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein plays a role in regulating the activity of DNA polymerase delta through interactions with other subunits and the processivity cofactor proliferating cell nuclear antigen (PCNA). Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Mar 2012]

GeneCards Summary for POLD3 Gene

POLD3 (Polymerase (DNA) Delta 3, Accessory Subunit) is a Protein Coding gene. Diseases associated with POLD3 include Mental Retardation, Autosomal Dominant 18. Among its related pathways are HTLV-I infection and Transcription-Coupled Nucleotide Excision Repair (TC-NER). GO annotations related to this gene include DNA-directed DNA polymerase activity.

UniProtKB/Swiss-Prot for POLD3 Gene

  • Required for optimal DNA polymerase delta activity.

Gene Wiki entry for POLD3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLD3 Gene

Genomics for POLD3 Gene

Regulatory Elements for POLD3 Gene

Enhancers for POLD3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around POLD3 on UCSC Golden Path with GeneCards custom track

Promoters for POLD3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around POLD3 on UCSC Golden Path with GeneCards custom track

Genomic Location for POLD3 Gene

74,493,851 bp from pter
74,669,341 bp from pter
175,491 bases
Plus strand

Genomic View for POLD3 Gene

Genes around POLD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLD3 Gene

Proteins for POLD3 Gene

  • Protein details for POLD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DNA polymerase delta subunit 3
    Protein Accession:
    Secondary Accessions:
    • B7ZAI6
    • Q32MZ9
    • Q32N00

    Protein attributes for POLD3 Gene

    466 amino acids
    Molecular mass:
    51400 Da
    Quaternary structure:
    • Heterotetramer composed of subunits of 125 kDa, 50 kDa, 66 kDa and 12 kDa. Interacts with POLD2. Interacts with PCNA.
    • Sequence=BAA05039.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for POLD3 Gene

    Alternative splice isoforms for POLD3 Gene


neXtProt entry for POLD3 Gene

Proteomics data for POLD3 Gene at MOPED

Post-translational modifications for POLD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for POLD3 Gene

Domains & Families for POLD3 Gene

Protein Domains for POLD3 Gene


Suggested Antigen Peptide Sequences for POLD3 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with POLD3: view

No data available for UniProtKB/Swiss-Prot for POLD3 Gene

Function for POLD3 Gene

Molecular function for POLD3 Gene

GENATLAS Biochemistry:
polymerase (DNA directed) delta 3,accessory subunit 66kDa,involved in DNA replication of nuclear genome,also complexing with DNA ligase 1,homolog to S pombe Cdc27
UniProtKB/Swiss-Prot Function:
Required for optimal DNA polymerase delta activity.
genes like me logo Genes that share phenotypes with POLD3: view

Animal Models for POLD3 Gene

MGI Knock Outs for POLD3:

Animal Model Products

miRNA for POLD3 Gene

miRTarBase miRNAs that target POLD3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for POLD3 Gene

Localization for POLD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLD3 Gene

Subcellular locations from

Jensen Localization Image for POLD3 Gene COMPARTMENTS Subcellular localization image for POLD3 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for POLD3 Gene

Pathways & Interactions for POLD3 Gene

SuperPathways for POLD3 Gene

Superpath Contained pathways
1 Telomere C-strand (Lagging Strand) Synthesis
2 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
3 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
4 Mismatch repair
5 DNA Double-Strand Break Repair
genes like me logo Genes that share pathways with POLD3: view

Pathways by source for POLD3 Gene

SIGNOR curated interactions for POLD3 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for POLD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000722 telomere maintenance via recombination TAS --
GO:0000731 DNA synthesis involved in DNA repair NAS 7910606
GO:0006260 DNA replication IEA --
GO:0006271 DNA strand elongation involved in DNA replication TAS --
GO:0006283 transcription-coupled nucleotide-excision repair TAS --
genes like me logo Genes that share ontologies with POLD3: view

Drugs & Compounds for POLD3 Gene

(3) Drugs for POLD3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
dctp Experimental Pharma 0
Deoxyadenosine triphosphate Experimental Pharma 0
dgtp Experimental Pharma 0

(1) Additional Compounds for POLD3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Thymidine 5'-triphosphate
  • 2'-Deoxythymidine 5'-triphosphate
  • 2'-Deoxythymidine triphosphate
  • 5'-TTP
  • 5-Methyl-dUTP
  • Deoxy-TTP
genes like me logo Genes that share compounds with POLD3: view

Transcripts for POLD3 Gene

Unigene Clusters for POLD3 Gene

Polymerase (DNA-directed), delta 3, accessory subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for POLD3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c
SP1: - - - -
SP2: - -
SP3: - - - - -
SP4: - -
SP5: - -

Relevant External Links for POLD3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for POLD3 Gene

mRNA expression in normal human tissues for POLD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for POLD3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (24.2), Monocytes (10.5), and Testis (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for POLD3 Gene

SOURCE GeneReport for Unigene cluster for POLD3 Gene Hs.82502

genes like me logo Genes that share expression patterns with POLD3: view

Protein tissue co-expression partners for POLD3 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for POLD3 Gene

Orthologs for POLD3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for POLD3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia POLD3 35
  • 89.08 (n)
  • 87.72 (a)
POLD3 36
  • 83 (a)
(Canis familiaris)
Mammalia POLD3 35
  • 91.52 (n)
  • 91.38 (a)
POLD3 36
  • 77 (a)
(Mus musculus)
Mammalia Pold3 35
  • 86.55 (n)
  • 85.25 (a)
Pold3 16
Pold3 36
  • 85 (a)
(Pan troglodytes)
Mammalia POLD3 35
  • 99 (n)
  • 98.71 (a)
POLD3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Pold3 35
  • 87.2 (n)
  • 85.9 (a)
(Monodelphis domestica)
Mammalia POLD3 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia POLD3 36
  • 68 (a)
(Gallus gallus)
Aves POLD3 35
  • 66.81 (n)
  • 61.49 (a)
POLD3 36
  • 62 (a)
(Anolis carolinensis)
Reptilia POLD3 36
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pold3 35
  • 67.49 (n)
  • 67.82 (a)
Str.4281 35
African clawed frog
(Xenopus laevis)
Amphibia POLD3 35
(Danio rerio)
Actinopterygii Dr.29127 35
pold3 35
  • 56.54 (n)
  • 52.9 (a)
pold3 36
  • 47 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2047 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2854 36
  • 30 (a)
Species with no ortholog for POLD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for POLD3 Gene

Gene Tree for POLD3 (if available)
Gene Tree for POLD3 (if available)

Paralogs for POLD3 Gene

No data available for Paralogs for POLD3 Gene

Variants for POLD3 Gene

Sequence variations from dbSNP and Humsavar for POLD3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_064745 -
VAR_064746 -
rs593374 -- 74,606,736(-) AACAC(A/T)ATTTG intron-variant
rs602275 -- 74,630,026(-) ACAAT(G/T)GATTA intron-variant
rs608303 -- 74,617,407(+) ttttt(G/T)gtttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for POLD3 Gene

Variant ID Type Subtype PubMed ID
dgv397e1 CNV Complex 17122850
esv34979 CNV Gain 17911159
nsv825994 CNV Gain 20364138
nsv832209 CNV Gain 17160897
dgv1222n71 CNV Loss 21882294
nsv509431 CNV Insertion 20534489

Variation tolerance for POLD3 Gene

Residual Variation Intolerance Score: 80.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.02; 50.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POLD3 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLD3 Gene

Disorders for POLD3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for POLD3 Gene - From: OMIM

Disorder Aliases PubMed IDs
mental retardation, autosomal dominant 18
  • mrd18
- elite association - COSMIC cancer census association via MalaCards
Search POLD3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for POLD3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with POLD3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for POLD3 Gene

Publications for POLD3 Gene

  1. Isolation and identification of the third subunit of mammalian DNA polymerase delta by PCNA-affinity chromatography of mouse FM3A cell extracts. (PMID: 10219083) Hughes P. … Baldacci G. (Nucleic Acids Res. 1999) 2 3 4 67
  2. Three DNA polymerases, recruited by different mechanisms, carry out NER repair synthesis in human cells. (PMID: 20227374) Ogi T. … Lehmann A.R. (Mol. Cell 2010) 3 23
  3. Functional roles of p12, the fourth subunit of human DNA polymerase delta. (PMID: 16510448) Li H. … Lee M.Y. (J. Biol. Chem. 2006) 3 23
  4. An in vivo analysis of the localisation and interactions of human p66 DNA polymerase delta subunit. (PMID: 16000169) Pohler J.R. … Warbrick E. (BMC Mol. Biol. 2005) 3 23
  5. Structural and thermodynamic analysis of human PCNA with peptides derived from DNA polymerase-delta p66 subunit and flap endonuclease- 1. (PMID: 15576034) Bruning J.B. … Shamoo Y. (Structure 2004) 3 23

Products for POLD3 Gene

Sources for POLD3 Gene