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Aliases for POLD3 Gene

Aliases for POLD3 Gene

  • Polymerase (DNA-Directed), Delta 3, Accessory Subunit 2 3
  • DNA Polymerase Delta Subunit P66 2 3 4
  • Pol Delta C Subunit (P66) 2 3
  • Protein Phosphatase 1, Regulatory Subunit 128 3
  • DNA Polymerase Delta Subunit 3 3
  • Regulatory Subunit 128 2
  • Protein Phosphatase 1 2
  • PPP1R128 3
  • KIAA0039 4
  • P68 3
  • P66 3

External Ids for POLD3 Gene

Previous GeneCards Identifiers for POLD3 Gene

  • GC11P076630
  • GC11P075843
  • GC11P074008
  • GC11P074029
  • GC11P073981
  • GC11P074303
  • GC11P070599
  • GC11P074207

Summaries for POLD3 Gene

Entrez Gene Summary for POLD3 Gene

  • This gene encodes the 66-kDa subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein plays a role in regulating the activity of DNA polymerase delta through interactions with other subunits and the processivity cofactor proliferating cell nuclear antigen (PCNA). Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Mar 2012]

GeneCards Summary for POLD3 Gene

POLD3 (Polymerase (DNA-Directed), Delta 3, Accessory Subunit) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include DNA-directed DNA polymerase activity.

UniProtKB/Swiss-Prot for POLD3 Gene

  • Required for optimal DNA polymerase delta activity.

Gene Wiki entry for POLD3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLD3 Gene

Genomics for POLD3 Gene

Regulatory Elements for POLD3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for POLD3 Gene

74,493,851 bp from pter
74,669,341 bp from pter
175,491 bases
Plus strand

Genomic View for POLD3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for POLD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLD3 Gene

Proteins for POLD3 Gene

  • Protein details for POLD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DNA polymerase delta subunit 3
    Protein Accession:
    Secondary Accessions:
    • B7ZAI6
    • Q32MZ9
    • Q32N00

    Protein attributes for POLD3 Gene

    466 amino acids
    Molecular mass:
    51400 Da
    Quaternary structure:
    • Heterotetramer composed of subunits of 125 kDa, 50 kDa, 66 kDa and 12 kDa. Interacts with POLD2. Interacts with PCNA.
    • Sequence=BAA05039.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for POLD3 Gene

    Alternative splice isoforms for POLD3 Gene


neXtProt entry for POLD3 Gene

Proteomics data for POLD3 Gene at MOPED

Post-translational modifications for POLD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for POLD3 Gene

Antibody Products

No data available for DME Specific Peptides for POLD3 Gene

Domains for POLD3 Gene

Protein Domains for POLD3 Gene


Suggested Antigen Peptide Sequences for POLD3 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with POLD3: view

No data available for UniProtKB/Swiss-Prot for POLD3 Gene

Function for POLD3 Gene

Molecular function for POLD3 Gene

GENATLAS Biochemistry:
polymerase (DNA directed) delta 3,accessory subunit 66kDa,involved in DNA replication of nuclear genome,also complexing with DNA ligase 1,homolog to S pombe Cdc27
UniProtKB/Swiss-Prot Function:
Required for optimal DNA polymerase delta activity.

Gene Ontology (GO) - Molecular Function for POLD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003887 DNA-directed DNA polymerase activity NAS 10219083
GO:0005515 protein binding IPI 16000169
genes like me logo Genes that share ontologies with POLD3: view
genes like me logo Genes that share phenotypes with POLD3: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for POLD3 Gene

Localization for POLD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLD3 Gene

Subcellular locations from

Jensen Localization Image for POLD3 Gene COMPARTMENTS Subcellular localization image for POLD3 gene
Compartment Confidence
nucleus 5
mitochondrion 4
cytosol 2

Gene Ontology (GO) - Cellular Components for POLD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005739 mitochondrion IDA --
GO:0043625 delta DNA polymerase complex NAS 10219083
genes like me logo Genes that share ontologies with POLD3: view

Pathways for POLD3 Gene

genes like me logo Genes that share pathways with POLD3: view

Pathways by source for POLD3 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for POLD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0000722 telomere maintenance via recombination TAS --
GO:0000723 telomere maintenance TAS --
GO:0000731 DNA synthesis involved in DNA repair NAS 7910606
GO:0006260 DNA replication --
genes like me logo Genes that share ontologies with POLD3: view

Drugs for POLD3 Gene

(4) HMDB Compounds for POLD3 Gene

Compound Synonyms Cas Number PubMed IDs
  • 2'-Deoxycytidine-5'-triphosphate
Deoxyadenosine triphosphate
  • 2'-Deoxy-5'-ATP
  • Deoxyguanosine 5'-triphosphate
Thymidine 5'-triphosphate
  • 2'-Deoxythymidine 5'-triphosphate
genes like me logo Genes that share compounds with POLD3: view

Transcripts for POLD3 Gene

Unigene Clusters for POLD3 Gene

Polymerase (DNA-directed), delta 3, accessory subunit:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for POLD3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for POLD3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c
SP1: - - - -
SP2: - -
SP3: - - - - -
SP4: - -
SP5: - -

Relevant External Links for POLD3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for POLD3 Gene

mRNA expression in normal human tissues for POLD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for POLD3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (24.2), Monocytes (10.5), and Testis (8.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for POLD3 Gene

SOURCE GeneReport for Unigene cluster for POLD3 Gene Hs.82502

genes like me logo Genes that share expressions with POLD3: view

Expression partners for POLD3 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for POLD3 Gene

Orthologs for POLD3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for POLD3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia POLD3 35
  • 89.08 (n)
  • 87.72 (a)
POLD3 36
  • 83 (a)
(Canis familiaris)
Mammalia POLD3 35
  • 91.52 (n)
  • 91.38 (a)
POLD3 36
  • 77 (a)
(Mus musculus)
Mammalia Pold3 35
  • 86.55 (n)
  • 85.25 (a)
Pold3 16
Pold3 36
  • 85 (a)
(Pan troglodytes)
Mammalia POLD3 35
  • 99 (n)
  • 98.71 (a)
POLD3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Pold3 35
  • 87.2 (n)
  • 85.9 (a)
(Monodelphis domestica)
Mammalia POLD3 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia POLD3 36
  • 68 (a)
(Gallus gallus)
Aves POLD3 35
  • 66.81 (n)
  • 61.49 (a)
POLD3 36
  • 62 (a)
(Anolis carolinensis)
Reptilia POLD3 36
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pold3 35
  • 67.49 (n)
  • 67.82 (a)
Str.4281 35
African clawed frog
(Xenopus laevis)
Amphibia POLD3 35
(Danio rerio)
Actinopterygii Dr.29127 35
pold3 35
  • 56.54 (n)
  • 52.9 (a)
pold3 36
  • 47 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2047 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2854 36
  • 30 (a)
Species with no ortholog for POLD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for POLD3 Gene

Gene Tree for POLD3 (if available)
Gene Tree for POLD3 (if available)

Paralogs for POLD3 Gene

No data available for Paralogs for POLD3 Gene

Variants for POLD3 Gene

Sequence variations from dbSNP and Humsavar for POLD3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs10857 -- 74,642,326(-) TTTTC(A/C)TTTTA utr-variant-3-prime, nc-transcript-variant, intron-variant
rs593374 -- 74,606,736(-) AACAC(A/T)ATTTG intron-variant
rs602275 -- 74,630,026(-) ACAAT(G/T)GATTA intron-variant
rs608303 -- 74,617,407(+) ttttt(G/T)gtttt intron-variant
rs648043 -- 74,636,608(-) GTTTT(G/T)GGATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for POLD3 Gene

Variant ID Type Subtype PubMed ID
dgv397e1 CNV Complex 17122850
esv34979 CNV Gain 17911159
nsv825994 CNV Gain 20364138
nsv832209 CNV Gain 17160897
dgv1222n71 CNV Loss 21882294
nsv509431 CNV Insertion 20534489

Relevant External Links for POLD3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLD3 Gene

Disorders for POLD3 Gene

(1) Novoseek inferred disease relationships for POLD3 Gene

Disease -log(P) Hits PubMed IDs
cancer lung 18.8 1

Relevant External Links for POLD3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with POLD3: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for POLD3 Gene

Publications for POLD3 Gene

  1. Functional roles of p12, the fourth subunit of human DNA polymerase delta. (PMID: 16510448) Li H. … Lee M.Y. (J. Biol. Chem. 2006) 3 4 23
  2. Isolation and identification of the third subunit of mammalian DNA polymerase delta by PCNA-affinity chromatography of mouse FM3A cell extracts. (PMID: 10219083) Hughes P. … Baldacci G. (Nucleic Acids Res. 1999) 2 3 4
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  4. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PMID: 7584026) Nomura N. … Tabata S. (DNA Res. 1994) 3 4
  5. Structural and thermodynamic analysis of human PCNA with peptides derived from DNA polymerase-delta p66 subunit and flap endonuclease- 1. (PMID: 15576034) Bruning J.B. … Shamoo Y. (Structure 2004) 3 23

Products for POLD3 Gene

Sources for POLD3 Gene

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