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Aliases for CETP Gene

Aliases for CETP Gene

  • Cholesteryl Ester Transfer Protein, Plasma 2 3
  • BPI Fold Containing Family F 2 3
  • Lipid Transfer Protein I 3 4
  • HDLCQ10 3
  • BPIFF 3

External Ids for CETP Gene

Previous GeneCards Identifiers for CETP Gene

  • GC16M047282
  • GC16P057046
  • GC16P056730
  • GC16P056771
  • GC16P055553
  • GC16P042865

Summaries for CETP Gene

Entrez Gene Summary for CETP Gene

  • The protein encoded by this gene is found in plasma, where it is involved in the transfer of cholesteryl ester from high density lipoprotein (HDL) to other lipoproteins. Defects in this gene are a cause of hyperalphalipoproteinemia 1 (HALP1). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]

GeneCards Summary for CETP Gene

CETP (Cholesteryl Ester Transfer Protein, Plasma) is a Protein Coding gene. Diseases associated with CETP include hyperalphalipoproteinemia and cetp-related hyperalphalipoproteinemia. Among its related pathways are Metabolism and Cholesterol and Sphingolipids transport / Transport from Golgi and ER to the apical membrane (normal and CF). GO annotations related to this gene include lipid binding and lipid transporter activity.

UniProtKB/Swiss-Prot for CETP Gene

  • Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL (PubMed:3600759, PubMed:24293641). Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination (PubMed:17237796).

Tocris Summary for CETP Gene

  • When glucose supplies are low, the body is able to draw upon lipids as an alternative energy source. Lipids are generally stored as triglycerides and the first step in lipid metabolism is the conversion to glycerol and fatty acids which then enter the Krebs cycle.

Gene Wiki entry for CETP Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CETP Gene

Genomics for CETP Gene

Regulatory Elements for CETP Gene

Genomic Location for CETP Gene

Chromosome:
16
Start:
56,961,850 bp from pter
End:
56,983,845 bp from pter
Size:
21,996 bases
Orientation:
Plus strand

Genomic View for CETP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CETP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CETP Gene

Proteins for CETP Gene

  • Protein details for CETP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11597-CETP_HUMAN
    Recommended name:
    Cholesteryl ester transfer protein
    Protein Accession:
    P11597
    Secondary Accessions:
    • Q13987
    • Q13988
    • Q53YZ1

    Protein attributes for CETP Gene

    Size:
    493 amino acids
    Molecular mass:
    54756 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CETP Gene

    Alternative splice isoforms for CETP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CETP Gene

Proteomics data for CETP Gene at MOPED

Post-translational modifications for CETP Gene

  • Glycosylation at Asn 105, Asn 257, Asn 358, and Asn 413
  • Modification sites at PhosphoSitePlus

Other Protein References for CETP Gene

Antibody Products

No data available for DME Specific Peptides for CETP Gene

Domains & Families for CETP Gene

Gene Families for CETP Gene

Graphical View of Domain Structure for InterPro Entry

P11597

UniProtKB/Swiss-Prot:

CETP_HUMAN :
  • Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
Family:
  • Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
genes like me logo Genes that share domains with CETP: view

Function for CETP Gene

Molecular function for CETP Gene

GENATLAS Biochemistry:
cholesteryl ester transfer protein,plasma,with low homology to LBP expressed in and throughout differentiation of preadypocyte
UniProtKB/Swiss-Prot Function:
Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL (PubMed:3600759, PubMed:24293641). Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination (PubMed:17237796).

Gene Ontology (GO) - Molecular Function for CETP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005319 lipid transporter activity IDA 2833496
GO:0005548 phospholipid transporter activity IDA 2833496
GO:0008289 lipid binding IDA 3818596
GO:0015485 cholesterol binding IDA 2833496
GO:0017127 cholesterol transporter activity IDA 2833496
genes like me logo Genes that share ontologies with CETP: view

Phenotypes for CETP Gene

GenomeRNAi human phenotypes for CETP:
genes like me logo Genes that share phenotypes with CETP: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CETP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CETP Gene

Localization for CETP Gene

Subcellular locations from UniProtKB/Swiss-Prot for CETP Gene

Secreted, extracellular space. Note=Secreted in plasma. {ECO:0000250 UniProtKB:P47896}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CETP Gene COMPARTMENTS Subcellular localization image for CETP gene
Compartment Confidence
extracellular 5
nucleus 1

Gene Ontology (GO) - Cellular Components for CETP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 3104518
GO:0031982 vesicle IDA 2833496
GO:0034364 high-density lipoprotein particle IDA 3104518
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with CETP: view

Pathways & Interactions for CETP Gene

genes like me logo Genes that share pathways with CETP: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Lipoprotein Signaling & Cholesterol Metabolism in human,mouse,rat

Gene Ontology (GO) - Biological Process for CETP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006641 triglyceride metabolic process IDA 2833496
GO:0006869 lipid transport IDA 3818596
GO:0006898 receptor-mediated endocytosis TAS --
GO:0008203 cholesterol metabolic process IMP 2586614
GO:0010745 negative regulation of macrophage derived foam cell differentiation IC 16670775
genes like me logo Genes that share ontologies with CETP: view

No data available for SIGNOR curated interactions for CETP Gene

Drugs & Compounds for CETP Gene

(52) Drugs for CETP Gene - From: NovoSeek, PharmGKB, ApexBio, DGIdb, Tocris, and ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Atorvastatin Approved Pharma Competitive, Inhibitor 690
Fluvastatin Approved Pharma Competitive, Inhibitor 58
Lovastatin Approved, Investigational Pharma Competitive, Inhibitor HMG-CoA reductase inhibitor 56
Pravastatin Approved Pharma 142
Simvastatin Approved Pharma Competitive, Inhibitor HMG-CoA reductase inhibitor 482

(37) Additional Compounds for CETP Gene - From: NovoSeek, HMDB, and Tocris