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Aliases for CORIN Gene

Aliases for CORIN Gene

  • Corin, Serine Peptidase 2 3
  • TMPRSS10 3 4 6
  • CRN 3 4 6
  • Heart-Specific Serine Proteinase ATC2 3 4
  • Transmembrane Protease Serine 10 3 4
  • Pro-ANP-Converting Enzyme 3 4
  • ATC2 3 6
  • PEE5 3 6
  • Atrial Natriuretic Peptide-Converting Enzyme 3
  • Corin, Serine Protease 2
  • Pro-ANP-Convertase 3
  • EC 3.4.21.- 4
  • EC 3.4.21 63
  • Corin 4
  • Lrp4 3

External Ids for CORIN Gene

Summaries for CORIN Gene

Entrez Gene Summary for CORIN Gene

  • This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]

GeneCards Summary for CORIN Gene

CORIN (Corin, Serine Peptidase) is a Protein Coding gene. Diseases associated with CORIN include preeclampsia/eclampsia 5 and preeclampsia/eclampsia 1. Among its related pathways are Myometrial Relaxation and Contraction Pathways. GO annotations related to this gene include serine-type endopeptidase activity and serine-type exopeptidase activity. An important paralog of this gene is CFI.

UniProtKB/Swiss-Prot for CORIN Gene

  • Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide

  • Isoform 2: has weaker endopeptidase activity compared to isoform 1

Gene Wiki entry for CORIN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CORIN Gene

Genomics for CORIN Gene

Genomic Location for CORIN Gene

Start:
47,593,998 bp from pter
End:
47,838,106 bp from pter
Size:
244,109 bases
Orientation:
Minus strand

Genomic View for CORIN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CORIN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CORIN Gene

Regulatory Elements for CORIN Gene

Proteins for CORIN Gene

  • Protein details for CORIN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5Q5-CORIN_HUMAN
    Recommended name:
    Atrial natriuretic peptide-converting enzyme
    Protein Accession:
    Q9Y5Q5
    Secondary Accessions:
    • B0ZBE3
    • Q2TBD2
    • Q4W5E5
    • Q4W5G6
    • Q9UHY2

    Protein attributes for CORIN Gene

    Size:
    1042 amino acids
    Molecular mass:
    116486 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Initially named CORIN due to its abundant expression in the heart.

    Alternative splice isoforms for CORIN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CORIN Gene

Proteomics data for CORIN Gene at MOPED

Selected DME Specific Peptides for CORIN Gene

Post-translational modifications for CORIN Gene

  • A disulfide bond links the activated corin protease fragment and the N-terminal propeptide. The disulfide bond also links the activated corin protease fragment with soluble fragments (100 kDa, 160 kDa and 180 kDa fragments)
  • Activated through proteolytic processing by a trypsin-like protease; cleaved into a N-terminal propeptide and an activated corin protease fragment. Different soluble forms are produced by cleavage and autocatalytic cleavage: Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment is produced by cleavage by ADAM10, while 160 kDa and 100 kDa soluble fragments are produced by autocatalytic cleavage. Cleavage by ADAM10 to produce soluble 180 kDa soluble fragment takes place after the transmembrane region and before FZ 1
  • N-glycosylated; required for processing and activation.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn80, Asn104, Asn135, Asn141, Asn231, Asn245, Asn251, Asn305, Asn320, Asn376, Asn413, Asn446, Asn451, Asn469, Asn567, Asn651, Asn697, Asn761, and Asn1022

Domains for CORIN Gene

Gene Families for CORIN Gene

HGNC:
  • TMPRSS :Serine peptidases / Transmembrane

Suggested Antigen Peptide Sequences for CORIN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y5Q5

UniProtKB/Swiss-Prot:

CORIN_HUMAN
Domain:
  • The DDNN motif is required for targeting to the cell membrane and enzyme activation.:
    • Q9Y5Q5
  • Contains 2 FZ (frizzled) domains.:
    • Q9Y5Q5
  • Contains 7 LDL-receptor class A domains.:
    • Q9Y5Q5
  • Contains 1 peptidase S1 domain.:
    • Q9Y5Q5
  • Contains 1 SRCR domain.:
    • Q9Y5Q5
Family:
  • Belongs to the peptidase S1 family.:
    • Q9Y5Q5
genes like me logo Genes that share domains with CORIN: view

Function for CORIN Gene

Molecular function for CORIN Gene

GENATLAS Biochemistry: corin,transmembrane serine protease,expressed only in the heart in the primary atrial septum and the trabecular ventricular compartment
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=1.28 mM for pyroGlu-Phe-Lys-pNA.HCl {ECO:0000269 PubMed:14559895}; KM=3.52 mM for pyroGlu-Pro-Arg-pNA.HCl {ECO:0000269 PubMed:14559895}; KM=2.95 mM for H-D-Pro-Phe-Arg-pNA.2HCl {ECO:0000269 PubMed:14559895}; KM=1.92 mM for Bz-Ile-Glu-(gamma-OR)-Gly-Arg-pNA.HCl {ECO:0000269 PubMed:14559895}; KM=16 mM for pyroGlu-Gly-Arg-pNA.HCl {ECO:0000269 PubMed:14559895};
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited in a dose-dependent manner by non-specific trypsin-like serine protease inhibitors including benzamidine
UniProtKB/Swiss-Prot Function: Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide
UniProtKB/Swiss-Prot Function: Isoform 2: has weaker endopeptidase activity compared to isoform 1

Enzyme Numbers (IUBMB) for CORIN Gene

Gene Ontology (GO) - Molecular Function for CORIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity IDA 10880574
GO:0005515 protein binding --
GO:0070008 serine-type exopeptidase activity --
genes like me logo Genes that share ontologies with CORIN: view
genes like me logo Genes that share phenotypes with CORIN: view

Animal Models for CORIN Gene

MGI Knock Outs for CORIN:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for CORIN Gene

Localization for CORIN Gene

Subcellular locations from UniProtKB/Swiss-Prot for CORIN Gene

Cell membrane; Single-pass type II membrane protein. Note=May easily detached from the endothelial cell membrane.
Isoform 2: Cell membrane; Single-pass type II membrane protein. Note=Less efficiently targeted to the cell membrane compared to isoform 1.
Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment: Secreted. Note=Soluble form produced following cleavage by ADAM10.
Atrial natriuretic peptide-converting enzyme, 160 kDa soluble fragment: Secreted. Note=Soluble form produced following autocatalytic cleavage.
Atrial natriuretic peptide-converting enzyme, 100 kDa soluble fragment: Secreted. Note=Soluble form produced following autocatalytic cleavage.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CORIN Gene COMPARTMENTS Subcellular localization image for CORIN gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CORIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IDA 21518754
GO:0009986 cell surface IEA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with CORIN: view

Pathways for CORIN Gene

genes like me logo Genes that share pathways with CORIN: view

Pathways by source for CORIN Gene

1 BioSystems pathway for CORIN Gene

Interacting Proteins for CORIN Gene

Gene Ontology (GO) - Biological Process for CORIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003050 regulation of systemic arterial blood pressure by atrial natriuretic peptide ISS --
GO:0006508 proteolysis IDA 21518754
GO:0007565 female pregnancy IMP 22437503
GO:0008217 regulation of blood pressure ISS --
GO:0016486 peptide hormone processing IDA 10880574
genes like me logo Genes that share ontologies with CORIN: view

Compounds for CORIN Gene

(1) Novoseek inferred chemical compound relationships for CORIN Gene

Compound -log(P) Hits PubMed IDs
serine 62.9 16
genes like me logo Genes that share compounds with CORIN: view

Transcripts for CORIN Gene

Unigene Clusters for CORIN Gene

Corin, serine peptidase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CORIN Gene

No ASD Table

Relevant External Links for CORIN Gene

GeneLoc Exon Structure for
CORIN
ECgene alternative splicing isoforms for
CORIN

Expression for CORIN Gene

mRNA expression in normal human tissues for CORIN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CORIN Gene

This gene is overexpressed in Heart - Atrial Appendage (19.0) and Heart - Left Ventricle (13.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CORIN Gene

SOURCE GeneReport for Unigene cluster for CORIN Gene Hs.518618

mRNA Expression by UniProt/SwissProt for CORIN Gene

Q9Y5Q5-CORIN_HUMAN
Tissue specificity: Highly expressed in heart. Expressed in heart myocytes. Also expressed in pregnant uterus. Detected in blood, in plasma as well as in serum (at protein level).
genes like me logo Genes that share expressions with CORIN: view

Orthologs for CORIN Gene

This gene was present in the common ancestor of animals.

Orthologs for CORIN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CORIN 35
  • 99.46 (n)
  • 98.85 (a)
CORIN 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CORIN 35
  • 88.14 (n)
  • 87.31 (a)
CORIN 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CORIN 35
  • 83.11 (n)
  • 82.26 (a)
CORIN 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Corin 35
  • 83.74 (n)
  • 83.68 (a)
Corin 16
Corin 36
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CORIN 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 75 (a)
OneToMany
-- 36
  • 21 (a)
OneToMany
-- 36
  • 52 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Corin 35
  • 83.27 (n)
  • 83.2 (a)
chicken
(Gallus gallus)
Aves CORIN 35
  • 75.48 (n)
  • 77.56 (a)
CORIN 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CORIN 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia corin 35
  • 70.16 (n)
  • 71.32 (a)
zebrafish
(Danio rerio)
Actinopterygii CORIN (1 of 2) 36
  • 55 (a)
OneToMany
CORIN (2 of 2) 36
  • 67 (a)
OneToMany
si:ch1073-76a20.1 35
  • 60.87 (n)
  • 58.48 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1632 36
  • 14 (a)
ManyToMany
Corin 36
  • 12 (a)
ManyToMany
ndl 36
  • 6 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3795 36
  • 23 (a)
OneToOne
Species with no ortholog for CORIN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CORIN Gene

ENSEMBL:
Gene Tree for CORIN (if available)
TreeFam:
Gene Tree for CORIN (if available)

Paralogs for CORIN Gene

Paralogs for CORIN Gene

genes like me logo Genes that share paralogs with CORIN: view

Variants for CORIN Gene

Sequence variations from dbSNP and Humsavar for CORIN Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs937680 -- 47,734,717(-) AGTGC(G/T)GCTTT intron-variant
rs1317157 -- 47,639,080(+) AAATT(C/G)CCTCC intron-variant
rs1317158 -- 47,639,144(+) GTTCC(A/G)GACCC intron-variant
rs1317159 -- 47,639,198(+) TGAAC(A/G)GATGA intron-variant
rs1317606 -- 47,649,428(+) GACAG(A/G)ACTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CORIN Gene

Variant ID Type Subtype PubMed ID
nsv829923 CNV Gain 17160897
esv2660213 CNV Deletion 23128226
nsv822557 CNV Loss 20364138
esv2727531 CNV Deletion 23290073
nsv829924 CNV Gain 17160897
esv27666 CNV Loss 19812545
nsv879007 CNV Loss 21882294
nsv4328 CNV Loss 18451855

Relevant External Links for CORIN Gene

HapMap Linkage Disequilibrium report
CORIN
Human Gene Mutation Database (HGMD)
CORIN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CORIN Gene

Disorders for CORIN Gene

(1) OMIM Diseases for CORIN Gene (605236)

UniProtKB/Swiss-Prot

CORIN_HUMAN
  • Pre-eclampsia/eclampsia 5 (PEE5) [MIM:614595]: A hypertensive disorder of pregnancy characterized by new hypertension (blood pressure 140/90 or greater) presenting after 20 weeks gestation with clinically relevant proteinuria. It impacts 2 individuals, the mother and her child, both of whom can be severely affected. Preeclampsia is one of the causes of maternal mortality and morbidity worldwide. {ECO:0000269 PubMed:22437503}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for CORIN Gene

(7) Novoseek inferred disease relationships for CORIN Gene

Disease -log(P) Hits PubMed IDs
total anomalous pulmonary venous connection 59.5 1
cardiac hypertrophy 54.6 4
heart failure 39.2 2
heart failure congestive 29.5 1
congenital heart disease 21.6 1

Relevant External Links for CORIN

Genetic Association Database (GAD)
CORIN
Human Genome Epidemiology (HuGE) Navigator
CORIN
genes like me logo Genes that share disorders with CORIN: view

Publications for CORIN Gene

  1. Corin, a mosaic transmembrane serine protease encoded by a novel cDNA from human heart. (PMID: 10329693) Yan W. … Wu Q. (J. Biol. Chem. 1999) 2 3 4 23
  2. Corin, a transmembrane cardiac serine protease, acts as a pro-atrial natriuretic peptide-converting enzyme. (PMID: 10880574) Yan W. … Wu Q. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4 23
  3. Localization of the mosaic transmembrane serine protease corin to heart myocytes. (PMID: 11082206) Hooper J.D. … Antalis T.M. (Eur. J. Biochem. 2000) 3 4 23
  4. Functional analysis of the transmembrane domain and activation cleavage of human corin: design and characterization of a soluble corin. (PMID: 14559895) Knappe S. … Wu Q. (J. Biol. Chem. 2003) 3 4 23
  5. Corin gene minor allele defined by 2 missense mutations is common in blacks and associated with high blood pressure and hypertension. (PMID: 16216958) Dries D.L. … Drazner M.H. (Circulation 2005) 3 23 48

Products for CORIN Gene

Sources for CORIN Gene

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