Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GNB5 Gene

Aliases for GNB5 Gene

  • G Protein Subunit Beta 5 2 3
  • Guanine Nucleotide Binding Protein (G Protein), Beta 5 2 3 5
  • Transducin Beta Chain 5 3 4
  • Gbeta5 3 4
  • Guanine Nucleotide-Binding Protein, Beta Subunit 5L 3
  • G Protein, Beta Subunit 5L 3
  • G Protein, Beta-5 Subunit 3
  • GB5 3

External Ids for GNB5 Gene

Previous GeneCards Identifiers for GNB5 Gene

  • GC15M047972
  • GC15M045460
  • GC15M049992
  • GC15M050129
  • GC15M050201
  • GC15M052413
  • GC15M029244
  • GC15M052416
  • GC15M052686

Summaries for GNB5 Gene

Entrez Gene Summary for GNB5 Gene

  • Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Alternatively spliced transcript variants encoding different isoforms exist. [provided by RefSeq, Jul 2008]

GeneCards Summary for GNB5 Gene

GNB5 (G Protein Subunit Beta 5) is a Protein Coding gene. Diseases associated with GNB5 include bradyopsia and miller fisher syndrome. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Chemokine Signaling. GO annotations related to this gene include GTPase activity and chaperone binding. An important paralog of this gene is GNB4.

UniProtKB/Swiss-Prot for GNB5 Gene

  • Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Tocris Summary for GNB5 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.

Gene Wiki entry for GNB5 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNB5 Gene

Genomics for GNB5 Gene

Regulatory Elements for GNB5 Gene

Enhancers for GNB5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GNB5 on UCSC Golden Path with GeneCards custom track

Genomic Location for GNB5 Gene

Chromosome:
15
Start:
52,115,105 bp from pter
End:
52,191,369 bp from pter
Size:
76,265 bases
Orientation:
Minus strand

Genomic View for GNB5 Gene

Genes around GNB5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GNB5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GNB5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNB5 Gene

Proteins for GNB5 Gene

  • Protein details for GNB5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14775-GBB5_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein subunit beta-5
    Protein Accession:
    O14775
    Secondary Accessions:
    • B2RBR5
    • Q9HAU9
    • Q9UFT3

    Protein attributes for GNB5 Gene

    Size:
    395 amino acids
    Molecular mass:
    43566 Da
    Quaternary structure:
    • Heterotrimeric G proteins are composed of 3 subunits; alpha, beta and gamma. Interacts with RGS9. Component of a complex composed of RGS9 (isoform RGS9-1), GNB5 and RGS9BP (By similarity). Interacts with RGS6 and RGS7 (PubMed:10521509, PubMed:10339615).

    Alternative splice isoforms for GNB5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GNB5 Gene

Proteomics data for GNB5 Gene at MOPED

Post-translational modifications for GNB5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GNB5 Gene

No data available for DME Specific Peptides for GNB5 Gene

Domains & Families for GNB5 Gene

Gene Families for GNB5 Gene

Graphical View of Domain Structure for InterPro Entry

O14775

UniProtKB/Swiss-Prot:

GBB5_HUMAN :
  • Belongs to the WD repeat G protein beta family.
  • Contains 7 WD repeats.
Family:
  • Belongs to the WD repeat G protein beta family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with GNB5: view

Function for GNB5 Gene

Molecular function for GNB5 Gene

GENATLAS Biochemistry:
guanine nucleotide binding protein 5,involved in signal transduction
UniProtKB/Swiss-Prot Function:
Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Gene Ontology (GO) - Molecular Function for GNB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IDA 10521509
genes like me logo Genes that share ontologies with GNB5: view
genes like me logo Genes that share phenotypes with GNB5: view

Animal Models for GNB5 Gene

MGI Knock Outs for GNB5:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GNB5 Gene

Localization for GNB5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNB5 Gene

Membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GNB5 Gene COMPARTMENTS Subcellular localization image for GNB5 gene
Compartment Confidence
cytosol 5
nucleus 3
plasma membrane 3
cytoskeleton 2

No data available for Gene Ontology (GO) - Cellular Components for GNB5 Gene

Pathways & Interactions for GNB5 Gene

SuperPathways for GNB5 Gene

Superpath Contained pathways
1 Circadian entrainment
2 Development Angiotensin activation of ERK
3 fMLP Pathway
4 Presynaptic function of Kainate receptors
5 Development Dopamine D2 receptor transactivation of EGFR
genes like me logo Genes that share pathways with GNB5: view

Gene Ontology (GO) - Biological Process for GNB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007603 phototransduction, visible light TAS --
genes like me logo Genes that share ontologies with GNB5: view

No data available for SIGNOR curated interactions for GNB5 Gene

Drugs & Compounds for GNB5 Gene

(3) Drugs for GNB5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(5) Additional Compounds for GNB5 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[D-Trp7,9,10]-Substance P
89430-38-6
mastoparan
72093-21-1
Mastoparan X
72093-22-2
NF 023
104869-31-0
SCH 202676 hydrobromide
265980-25-4

(5) Tocris Compounds for GNB5 Gene

Compound Action Cas Number
[D-Trp7,9,10]-Substance P Inhibits M1 ACh receptor activation of Gq/11 89430-38-6
Mastoparan Activates Gi and Go 72093-21-1
Mastoparan X G protein activator peptide 72093-22-2
NF 023 Selective, competitive P2X1 antagonist 104869-31-0
SCH 202676 hydrobromide Inhibitor of ligand binding to G-protein-coupled receptors 265980-25-4
genes like me logo Genes that share compounds with GNB5: view

Transcripts for GNB5 Gene

Unigene Clusters for GNB5 Gene

Guanine nucleotide binding protein (G protein), beta 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GNB5 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ·
SP1: - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - -
SP4: - - - - - - -
SP5: - - - - - -
SP6: - - - - - - - - - -
SP7: - -
SP8: -
SP9:
SP10:

ExUns: 13c · 13d ^ 14a · 14b · 14c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for GNB5 Gene

GeneLoc Exon Structure for
GNB5
ECgene alternative splicing isoforms for
GNB5

Expression for GNB5 Gene

mRNA expression in normal human tissues for GNB5 Gene

Protein differential expression in normal tissues from HIPED for GNB5 Gene

This gene is overexpressed in Frontal cortex (25.2), Retina (14.9), Peripheral blood mononuclear cells (11.7), and Fetal Brain (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GNB5 Gene



SOURCE GeneReport for Unigene cluster for GNB5 Gene Hs.155090

mRNA Expression by UniProt/SwissProt for GNB5 Gene

O14775-GBB5_HUMAN
Tissue specificity: Expressed in multiple tissues.
genes like me logo Genes that share expression patterns with GNB5: view

Protein tissue co-expression partners for GNB5 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for GNB5 Gene

Orthologs for GNB5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GNB5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GNB5 35
  • 93.67 (n)
  • 99.15 (a)
GNB5 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GNB5 35
  • 93.13 (n)
  • 99.48 (a)
GNB5 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gnb5 35
  • 90.21 (n)
  • 99.24 (a)
Gnb5 16
Gnb5 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GNB5 35
  • 99.26 (n)
  • 99.68 (a)
GNB5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gnb5 35
  • 91.41 (n)
  • 99.43 (a)
oppossum
(Monodelphis domestica)
Mammalia GNB5 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GNB5 36
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves GNB5 35
  • 83.21 (n)
  • 94.94 (a)
lizard
(Anolis carolinensis)
Reptilia GNB5 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gnb5 35
  • 81.3 (n)
  • 96.88 (a)
Str.8147 35
zebrafish
(Danio rerio)
Actinopterygii gnb5b 35
  • 74.94 (n)
  • 84.81 (a)
zgc73196 35
gnb3a 36
  • 49 (a)
OneToMany
gnb3b 36
  • 48 (a)
OneToMany
gnb5a 36
  • 90 (a)
OneToMany
gnb5b 36
  • 85 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11240 35
fruit fly
(Drosophila melanogaster)
Insecta Gbgr5 37
  • 68 (a)
Gbeta5 35
  • 65.4 (n)
  • 69.01 (a)
Gbeta5 36
  • 66 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012525 35
  • 63.75 (n)
  • 70.37 (a)
worm
(Caenorhabditis elegans)
Secernentea gpb-2 37
  • 64 (a)
gpb-2 35
  • 58.7 (n)
  • 65.31 (a)
gpb-2 36
  • 64 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR097W 35
  • 46.31 (n)
  • 39.73 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D06787g 35
  • 48.4 (n)
  • 41.1 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STE4 35
  • 45.97 (n)
  • 40.73 (a)
STE4 36
  • 32 (a)
OneToMany
STE4 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10984 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2578 36
  • 56 (a)
OneToOne
Species with no ortholog for GNB5:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GNB5 Gene

ENSEMBL:
Gene Tree for GNB5 (if available)
TreeFam:
Gene Tree for GNB5 (if available)

Paralogs for GNB5 Gene

Paralogs for GNB5 Gene

genes like me logo Genes that share paralogs with GNB5: view

Variants for GNB5 Gene

Sequence variations from dbSNP and Humsavar for GNB5 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs34637551 - 52,135,746(+) CGCTC(A/G)CTGTC reference, missense
rs12396 -- 52,121,119(+) GCTCT(C/G)GAAGA utr-variant-3-prime
rs5812581 -- 52,122,977(+) AATGC(-/A)AAAGG intron-variant
rs5812582 -- 52,123,049(+) CTTAC(-/TA)GGGCC intron-variant
rs6493536 -- 52,124,394(+) GATAG(C/G/T)CTTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GNB5 Gene

Variant ID Type Subtype PubMed ID
nsv471244 CNV Gain 18288195
nsv833005 CNV Gain 17160897
esv2667228 CNV Deletion 23128226
esv2571437 CNV Deletion 19546169

Variation tolerance for GNB5 Gene

Residual Variation Intolerance Score: 26.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.14; 38.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GNB5 Gene

HapMap Linkage Disequilibrium report
GNB5
Human Gene Mutation Database (HGMD)
GNB5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNB5 Gene

Disorders for GNB5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GNB5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
bradyopsia
  • prolonged electroretinal response suppression
miller fisher syndrome
  • fisher's syndrome
- elite association - COSMIC cancer census association via MalaCards
Search GNB5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GNB5

Genetic Association Database (GAD)
GNB5
Human Genome Epidemiology (HuGE) Navigator
GNB5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GNB5
genes like me logo Genes that share disorders with GNB5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GNB5 Gene

Publications for GNB5 Gene

  1. Cloning and tissue distribution of the human G protein beta 5 cDNA. (PMID: 9606987) Jones P.G. … Cockett M.I. (Biochim. Biophys. Acta 1998) 2 3 4 23 67
  2. Role of molecular chaperones in G protein beta5/regulator of G protein signaling dimer assembly and G protein betagamma dimer specificity. (PMID: 19376773) Howlett A.C. … Willardson B.M. (J. Biol. Chem. 2009) 3 23
  3. Hepatitis B virus X protein interacts with beta5 subunit of heterotrimeric guanine nucleotide binding protein. (PMID: 16135253) Lwa S.H. … Chen W.N. (Virol. J. 2005) 3 23
  4. The GI^5 protein regulates sensitivity to TRAIL-induced cell death in colon carcinoma. (PMID: 25043307) Fuchs D. … Roth W. (Oncogene 2015) 3
  5. A Non-Canonical Function of GI^ as a Subunit of E3 Ligase in Targeting GRK2A Ubiquitylation. (PMID: 25982117) Zha Z. … Xiong Y. (Mol. Cell 2015) 3

Products for GNB5 Gene

Sources for GNB5 Gene

Content