Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CAMKK2 Gene

Aliases for CAMKK2 Gene

  • Calcium/Calmodulin-Dependent Protein Kinase Kinase 2, Beta 2 3
  • CAMKKB 3 4 6
  • CaM-Kinase Kinase Beta 3 4
  • CaM-Kinase Kinase 2 3 4
  • CaM-KK Beta 3 4
  • CaM-KK 2 3 4
  • KIAA0787 4 6
  • Calcium/Calmodulin-Dependent Protein Kinase Kinase Beta 4
  • Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 3
  • Calcium/Calmodulin-Dependent Protein Kinase Beta 3
  • CAMKK Beta Protein 3
  • EC 2.7.11.17 4
  • CaMKK Beta 4
  • EC 2.7.11 63
  • CaMKK 2 4
  • CAMKK 3

External Ids for CAMKK2 Gene

Previous GeneCards Identifiers for CAMKK2 Gene

  • GC12M120537
  • GC12M121458
  • GC12M120087
  • GC12M120138
  • GC12M120159
  • GC12M121675
  • GC12M118685

Summaries for CAMKK2 Gene

Entrez Gene Summary for CAMKK2 Gene

  • The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse formation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo autophosphorylation and to phosphorylate downstream kinases. [provided by RefSeq, Jul 2012]

GeneCards Summary for CAMKK2 Gene

CAMKK2 (Calcium/Calmodulin-Dependent Protein Kinase Kinase 2, Beta) is a Protein Coding gene. Among its related pathways are CREB Pathway and Glucose / Energy Metabolism. GO annotations related to this gene include calcium ion binding and protein tyrosine kinase activity. An important paralog of this gene is STK11.

UniProtKB/Swiss-Prot for CAMKK2 Gene

  • Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.

Tocris Summary for CAMKK2 Gene

  • Calmodulin-dependent kinases (CaMK) are a family of serine/threonine kinases that mediate many of the second messenger effects of Ca2+. At basal Ca2+ levels, CaMKs are maintained in a dormant state through autoinhibition. Increases in Ca2+ levels allows calmodulin to relieve this autoinhibition and activate the kinase activity. There are two main classes of CaMKs; mulitfunctional CaMKs (CaMKK, CaMKI, CaMKII and CaMKIV) which have multiple downstream targets and substrate-specific CaMKs (CaMKIII) which have only one known downstream target. All CaMKs, with the exception of CaMKII, exist as monomers and most are expressed ubiquitously. Some subtypes display specific distributions, for example, CaMKIVbeta is expressed exclusively in cerebellar granule cells. CaMKs have numerous cellular functions and they influence processes as diverse as gene transcription, cell survival, apoptosis, cytoskeletal re-organization and learning and memory.

Gene Wiki entry for CAMKK2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAMKK2 Gene

Genomics for CAMKK2 Gene

Regulatory Elements for CAMKK2 Gene

Transcription factor binding sites by QIAGEN in the CAMKK2 gene promoter:

Genomic Location for CAMKK2 Gene

Start:
121,237,691 bp from pter
End:
121,298,308 bp from pter
Size:
60,618 bases
Orientation:
Minus strand

Genomic View for CAMKK2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CAMKK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAMKK2 Gene

Proteins for CAMKK2 Gene

  • Protein details for CAMKK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RR4-KKCC2_HUMAN
    Recommended name:
    Calcium/calmodulin-dependent protein kinase kinase 2
    Protein Accession:
    Q96RR4
    Secondary Accessions:
    • A8K7Q7
    • O94883
    • Q8IUG2
    • Q8IUG3
    • Q8N3I4
    • Q8WY03
    • Q8WY04
    • Q8WY05
    • Q8WY06
    • Q96RP1
    • Q96RP2
    • Q96RR3
    • Q9BWE9
    • Q9UER3
    • Q9UES2
    • Q9Y5N2

    Protein attributes for CAMKK2 Gene

    Size:
    588 amino acids
    Molecular mass:
    64746 Da
    Quaternary structure:
    • Interacts with calmodulin.
    SequenceCaution:
    • Sequence=AAC72943.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA34507.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD38990.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CAMKK2 Gene

    Alternative splice isoforms for CAMKK2 Gene

neXtProt entry for CAMKK2 Gene

Proteomics data for CAMKK2 Gene at MOPED

Selected DME Specific Peptides for CAMKK2 Gene

Post-translational modifications for CAMKK2 Gene

  • Autophosphorylated and phosphorylated by PKA. Each isoform may show a different pattern of phosphorylation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CAMKK2 (CAMKK2)

Domains for CAMKK2 Gene

Suggested Antigen Peptide Sequences for CAMKK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96RR4

UniProtKB/Swiss-Prot:

KKCC2_HUMAN :
  • Q96RR4
Domain:
  • The autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric autoinhibition
  • The RP domain (arginine/proline-rich) is involved in the recognition of CAMKI and CAMK4 as substrates.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
genes like me logo Genes that share domains with CAMKK2: view

Function for CAMKK2 Gene

Molecular function for CAMKK2 Gene

GENATLAS Biochemistry: calcium/calmodulin-dependent protein kinase,kinase 2,beta,expressed as a flag-tagged protein in human non small cell lung cancer
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by Ca(2+)/calmodulin. Binding of calmodulin may relieve intrasteric autoinhibition. Autophosphorylation does not alter activity or regulation by Ca(2+)/calmodulin. In part, activity is independent on Ca(2+)/calmodulin (By similarity).
UniProtKB/Swiss-Prot Function: Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.
UniProtKB/Swiss-Prot Induction: Isoform 1 is up-regulated by PKA pathway.

Enzyme Numbers (IUBMB) for CAMKK2 Gene

Gene Ontology (GO) - Molecular Function for CAMKK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity --
GO:0004683 calmodulin-dependent protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity TAS 11395482
GO:0005509 calcium ion binding IDA 11395482
genes like me logo Genes that share ontologies with CAMKK2: view
genes like me logo Genes that share phenotypes with CAMKK2: view

Animal Models for CAMKK2 Gene

MGI Knock Outs for CAMKK2:

Animal Model Products

CRISPR Products

miRNA for CAMKK2 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CAMKK2

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for CAMKK2 Gene

Localization for CAMKK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAMKK2 Gene

Nucleus. Cytoplasm. Cell projection. Note=Predominantly nuclear in unstimulated cells (By similarity). Found in the cytoplasm and neurites after forskolin induction. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CAMKK2 Gene COMPARTMENTS Subcellular localization image for CAMKK2 gene
Compartment Confidence
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for CAMKK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular TAS 11395482
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with CAMKK2: view

Pathways for CAMKK2 Gene

genes like me logo Genes that share pathways with CAMKK2: view

Gene Ontology (GO) - Biological Process for CAMKK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS 11395482
GO:0006468 protein phosphorylation IDA 11395482
GO:0018108 peptidyl-tyrosine phosphorylation TAS 11395482
GO:0019722 calcium-mediated signaling TAS 11395482
GO:0045859 regulation of protein kinase activity TAS 11395482
genes like me logo Genes that share ontologies with CAMKK2: view

Compounds for CAMKK2 Gene

(5) Tocris Compounds for CAMKK2 Gene

Compound Action Cas Number
A 484954 CaM kinase III (eEF-2 kinase) inhibitor [142557-61-7]
Arcyriaflavin A Potent cdk4/cyclin D1 and CaM Kinase II inhibitor. Antiviral agent (anti-HCMV) [118458-54-1]
KN 93 CaM kinase II inhibitor; also K+ channel blocker (KV) [139298-40-1]
KN 93 phosphate CaM kinase II inhibitor; water soluble version of KN 93 (Cat. No. 1278). [1188890-41-6]
STO-609 acetate Selective CaM kinase kinase inhibitor [1173022-21-3]

(3) HMDB Compounds for CAMKK2 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Calcium
  • Ca
7440-70-2

(6) Novoseek inferred chemical compound relationships for CAMKK2 Gene

Compound -log(P) Hits PubMed IDs
calcium 53.9 25
atp 33.6 4
nmda 30.1 4
serine 24.1 1
forskolin 23.5 3
genes like me logo Genes that share compounds with CAMKK2: view

Transcripts for CAMKK2 Gene

Unigene Clusters for CAMKK2 Gene

Calcium/calmodulin-dependent protein kinase kinase 2, beta:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CAMKK2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAMKK2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c · 13d ^
SP1:
SP2:
SP3:
SP4:
SP5: - - - - - - - - -
SP6: - -
SP7: - - -
SP8: - -
SP9: -
SP10:
SP11: - - - -
SP12: -
SP13: -
SP14: - - - - - -
SP15: - - - - -
SP16: - - - -

ExUns: 14 ^ 15 ^ 16a · 16b · 16c ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25
SP1: - - -
SP2:
SP3: - - -
SP4: - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: - -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for CAMKK2 Gene

GeneLoc Exon Structure for
CAMKK2
ECgene alternative splicing isoforms for
CAMKK2

Expression for CAMKK2 Gene

mRNA expression in normal human tissues for CAMKK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CAMKK2 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (7.3) and Brain - Cerebellum (7.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CAMKK2 Gene

SOURCE GeneReport for Unigene cluster for CAMKK2 Gene Hs.297343

mRNA Expression by UniProt/SwissProt for CAMKK2 Gene

Q96RR4-KKCC2_HUMAN
Tissue specificity: Ubiquitously expressed with higher levels in the brain. Intermediate levels are detected in spleen, prostate, thyroid and leukocytes. The lowest level is in lung.
genes like me logo Genes that share expressions with CAMKK2: view

In Situ Assay Products

Orthologs for CAMKK2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CAMKK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CAMKK2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CAMKK2 35
  • 89.83 (n)
  • 92.06 (a)
CAMKK2 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAMKK2 35
  • 90.88 (n)
  • 94.34 (a)
CAMKK2 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Camkk2 35
  • 87.09 (n)
  • 91.67 (a)
Camkk2 16
Camkk2 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CAMKK2 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAMKK2 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Camkk2 35
  • 87.91 (n)
  • 92.36 (a)
chicken
(Gallus gallus)
Aves CAMKK2 35
  • 79.1 (n)
  • 83.95 (a)
CAMKK2 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 74 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia camkk2 35
  • 71.3 (n)
  • 77.02 (a)
zebrafish
(Danio rerio)
Actinopterygii CAMKK2 36
  • 69 (a)
OneToOne
zgc:194737 35
  • 66.75 (n)
  • 69.63 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002250 35
  • 60.11 (n)
  • 56.38 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17698 36
  • 33 (a)
OneToMany
CG17698 37
  • 54 (a)
worm
(Caenorhabditis elegans)
Secernentea ckk-1 35
  • 57.56 (n)
  • 56.01 (a)
ckk-1 36
  • 42 (a)
OneToMany
ckk-1 37
  • 56 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SAK1 36
  • 13 (a)
ManyToMany
TOS3 36
  • 22 (a)
ManyToMany
TOS3 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
OneToMany
Species with no ortholog for CAMKK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAMKK2 Gene

ENSEMBL:
Gene Tree for CAMKK2 (if available)
TreeFam:
Gene Tree for CAMKK2 (if available)

Paralogs for CAMKK2 Gene

Paralogs for CAMKK2 Gene

genes like me logo Genes that share paralogs with CAMKK2: view

Variants for CAMKK2 Gene

Sequence variations from dbSNP and Humsavar for CAMKK2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs11308 -- 121,237,881(-) TGCCC(A/G)ATGCT utr-variant-3-prime
rs891779 -- 121,274,128(+) TGCGG(A/G)GAGCT reference, synonymous-codon
rs891780 -- 121,274,461(+) CCCCT(A/G)CCCCC reference, synonymous-codon
rs1053324 -- 121,239,932(-) GAGCT(A/C)TGGTA utr-variant-3-prime
rs1063835 -- 121,244,056(-) CAGAC(C/G)TTCTT intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CAMKK2 Gene

Variant ID Type Subtype PubMed ID
nsv521928 CNV Gain 19592680
nsv899564 CNV Loss 21882294
nsv899565 CNV Gain+Loss 21882294
nsv455731 CNV Loss 19166990
nsv513372 CNV Insertion 21212237
esv1008629 CNV Insertion 20482838
esv2746484 CNV Deletion 23290073
esv2660506 CNV Deletion 23128226
esv2746485 CNV Deletion 23290073

Relevant External Links for CAMKK2 Gene

HapMap Linkage Disequilibrium report
CAMKK2
Human Gene Mutation Database (HGMD)
CAMKK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAMKK2 Gene

Disorders for CAMKK2 Gene

Relevant External Links for CAMKK2

Genetic Association Database (GAD)
CAMKK2
Human Genome Epidemiology (HuGE) Navigator
CAMKK2
genes like me logo Genes that share disorders with CAMKK2: view

No data available for UniProtKB/Swiss-Prot for CAMKK2 Gene

Publications for CAMKK2 Gene

  1. Cloning, expression and chromosomal localization of human Ca2+/calmodulin-dependent protein kinase kinase. (PMID: 9662074) Hsu L.-S. … Chen J.-Y. (J. Biomed. Sci. 1998) 2 3 4 23
  2. Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta. (PMID: 9822657) Anderson K.A. … Means A.R. (J. Biol. Chem. 1998) 3 4 23
  3. Identification and characterization of novel components of a Ca2+/calmodulin-dependent protein kinase cascade in HeLa cells. (PMID: 12935886) Ishikawa Y. … Kobayashi R. (FEBS Lett. 2003) 3 4 23
  4. Association of polymorphisms in P2RX7 and CaMKKb with anxiety disorders. (PMID: 17197037) Erhardt A. … Holsboer F. (J Affect Disord 2007) 3 23 48
  5. Human Ca2+/calmodulin-dependent protein kinase kinase beta gene encodes multiple isoforms that display distinct kinase activity. (PMID: 11395482) Hsu L.-S. … Chen J.-Y. (J. Biol. Chem. 2001) 3 4 23

Products for CAMKK2 Gene

Sources for CAMKK2 Gene

Back to Top

Content