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Aliases for IGF2BP2 Gene

Aliases for IGF2BP2 Gene

  • Insulin Like Growth Factor 2 MRNA Binding Protein 2 2 3 5
  • IGF-II MRNA-Binding Protein 2 3 4
  • IGF2 MRNA-Binding Protein 2 3 4
  • VICKZ Family Member 2 3 4
  • VICKZ2 3 4
  • IMP-2 3 4
  • IMP2 3 4
  • Insulin-Like Growth Factor 2 MRNA Binding Protein 2 2
  • Insulin-Like Growth Factor 2 MRNA-Binding Protein 2 3
  • Hepatocellular Carcinoma Autoantigen P62 4
  • IGF II MRNA Binding Protein 2 2

External Ids for IGF2BP2 Gene

Previous GeneCards Identifiers for IGF2BP2 Gene

  • GC03M186845
  • GC03M185361
  • GC03M182771

Summaries for IGF2BP2 Gene

Entrez Gene Summary for IGF2BP2 Gene

  • This gene encodes a protein that binds the 5' UTR of insulin-like growth factor 2 (IGF2) mRNA and regulates its translation. It plays an important role in metabolism and variation in this gene is associated with susceptibility to diabetes. Alternative splicing and promoter usage results in multiple transcript variants. Related pseudogenes are found on several chromosomes. [provided by RefSeq, Sep 2016]

GeneCards Summary for IGF2BP2 Gene

IGF2BP2 (Insulin Like Growth Factor 2 MRNA Binding Protein 2) is a Protein Coding gene. Diseases associated with IGF2BP2 include Diabetes Mellitus, Noninsulin-Dependent and Hepatocellular Carcinoma. Among its related pathways are Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA and MAPK-Erk Pathway. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is IGF2BP1.

UniProtKB/Swiss-Prot for IGF2BP2 Gene

  • RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript caging into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Binds to the 5-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts.

Gene Wiki entry for IGF2BP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGF2BP2 Gene

Genomics for IGF2BP2 Gene

Regulatory Elements for IGF2BP2 Gene

Enhancers for IGF2BP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F185795 1.2 Ensembl ENCODE 18.7 +27.7 27721 4.1 PKNOX1 ARNT ARID4B FOS MAFF SMARCA4 GLIS1 ETV4 RCOR2 STAT3 IGF2BP2 IGF2BP2-AS1 MIR548AQ
GH03F185687 1 Ensembl ENCODE 11.7 +136.4 136404 3.1 TBP CREB3L1 JUN ZIC2 ZFHX2 RCOR1 NFE2 FOSL2 FOS CREM IGF2BP2-AS1 IGF2BP2 PIR53085
GH03F185773 1 Ensembl ENCODE 11.5 +51.0 51024 0.7 LEF1 NFIA ZBTB8A FEZF1 REST ZIC2 GATA2 ZNF341 BCL6 ZNF600 IGF2BP2-AS1 IGF2BP2 MIR548AQ
GH03F185769 0.8 ENCODE 11.5 +56.4 56369 0.2 CTCF USF1 MAX RAD21 RFX5 CHAMP1 ZNF143 SMC3 ZNF652 ZNF654 IGF2BP2-AS1 IGF2BP2 MIR548AQ
GH03F185807 1.2 Ensembl ENCODE 6.8 +17.2 17234 1.2 PKNOX1 SIN3A FEZF1 GLIS2 CBX5 FOS SP3 TSHZ1 ZNF518A MAFF SNORA4 TBCCD1 RFC4 SNORA81 ENSG00000200418 SNORA63 IGF2BP2 MIR548AQ
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IGF2BP2 on UCSC Golden Path with GeneCards custom track

Promoters for IGF2BP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001381646 1656 6401 HDGF CREB3L1 ZFP64 ARID4B SIN3A DMAP1 FOS ZNF263 SP3 SP5

Genomic Location for IGF2BP2 Gene

Chromosome:
3
Start:
185,643,131 bp from pter
End:
185,825,056 bp from pter
Size:
181,926 bases
Orientation:
Minus strand

Genomic View for IGF2BP2 Gene

Genes around IGF2BP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGF2BP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGF2BP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGF2BP2 Gene

Proteins for IGF2BP2 Gene

  • Protein details for IGF2BP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6M1-IF2B2_HUMAN
    Recommended name:
    Insulin-like growth factor 2 mRNA-binding protein 2
    Protein Accession:
    Q9Y6M1
    Secondary Accessions:
    • A0A4Z0
    • B3FTN2
    • B3FTN3
    • B3FTN4

    Protein attributes for IGF2BP2 Gene

    Size:
    599 amino acids
    Molecular mass:
    66121 Da
    Quaternary structure:
    • Can form homooligomers and heterooligomers with IGF2BP1 and IGF2BP3 in an RNA-dependent manner. Interacts with HNRPD and IGF2BP1. Interacts with ELAVL1, DHX9 and HNRNPU.
    Miscellaneous:
    • Autoantibodies against IGF2BP2 are detected in sera from some patients with hepatocellular carcinoma.
    SequenceCaution:
    • Sequence=AAH21290.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IGF2BP2 Gene

    Alternative splice isoforms for IGF2BP2 Gene

neXtProt entry for IGF2BP2 Gene

Post-translational modifications for IGF2BP2 Gene

  • Ubiquitination at Lys 278 and Lys 419
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for IGF2BP2 (IGF2BP2)
  • Abcam antibodies for IGF2BP2
  • Cloud-Clone Corp. Antibodies for IGF2BP2

No data available for DME Specific Peptides for IGF2BP2 Gene

Domains & Families for IGF2BP2 Gene

Gene Families for IGF2BP2 Gene

Suggested Antigen Peptide Sequences for IGF2BP2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y6M1

UniProtKB/Swiss-Prot:

IF2B2_HUMAN :
  • Domain KH3 and KH4 are the major RNA-binding modules, although KH1 and KH2 may also contribute. The contribution to RNA-binding of individual KH domains may be target-specific. KH1 and KH2, and possibly KH3 and KH4, promote the formation of higher ordered protein-RNA complexes, which may be essential for IGF2BP1 cytoplasmic retention. KH domains are required for RNA-dependent homo- and heterooligomerization and for localization to stress granules.
  • Belongs to the RRM IMP/VICKZ family.
Domain:
  • Domain KH3 and KH4 are the major RNA-binding modules, although KH1 and KH2 may also contribute. The contribution to RNA-binding of individual KH domains may be target-specific. KH1 and KH2, and possibly KH3 and KH4, promote the formation of higher ordered protein-RNA complexes, which may be essential for IGF2BP1 cytoplasmic retention. KH domains are required for RNA-dependent homo- and heterooligomerization and for localization to stress granules.
  • Contains 4 KH domains.
  • Contains 2 RRM (RNA recognition motif) domains.
Family:
  • Belongs to the RRM IMP/VICKZ family.
genes like me logo Genes that share domains with IGF2BP2: view

Function for IGF2BP2 Gene

Molecular function for IGF2BP2 Gene

UniProtKB/Swiss-Prot Function:
RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript caging into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Binds to the 5-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts.

Gene Ontology (GO) - Molecular Function for IGF2BP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
GO:0003729 mRNA binding IEA --
GO:0003730 mRNA 3-UTR binding IDA 20080952
genes like me logo Genes that share ontologies with IGF2BP2: view
genes like me logo Genes that share phenotypes with IGF2BP2: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IGF2BP2 Gene

Localization for IGF2BP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGF2BP2 Gene

Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Localizes at the connecting piece and the tail of the spermatozoa. In response to cellular stress, such as oxidative stress, recruited to stress granules.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IGF2BP2 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
plasma membrane 1

Gene Ontology (GO) - Cellular Components for IGF2BP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15618018
GO:0005737 cytoplasm IDA 15618018
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IDA 15618018
genes like me logo Genes that share ontologies with IGF2BP2: view

Pathways & Interactions for IGF2BP2 Gene

genes like me logo Genes that share pathways with IGF2BP2: view

Pathways by source for IGF2BP2 Gene

2 Sino Biological pathways for IGF2BP2 Gene
1 Cell Signaling Technology pathway for IGF2BP2 Gene

Gene Ontology (GO) - Biological Process for IGF2BP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation IEA --
GO:0006810 transport IEA --
GO:0009653 anatomical structure morphogenesis TAS 9891060
GO:0010467 gene expression TAS --
GO:0017148 negative regulation of translation ISS 9891060
genes like me logo Genes that share ontologies with IGF2BP2: view

No data available for SIGNOR curated interactions for IGF2BP2 Gene

Drugs & Compounds for IGF2BP2 Gene

(1) Drugs for IGF2BP2 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Repaglinide Approved, Investigational Pharma Kir6 (KATP) channel blocker 51
genes like me logo Genes that share compounds with IGF2BP2: view

Transcripts for IGF2BP2 Gene

Unigene Clusters for IGF2BP2 Gene

Insulin-like growth factor 2 mRNA binding protein 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGF2BP2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^
SP1: - - - - -
SP2: - - - - - -
SP3: -
SP4: - - - -
SP5: - - -
SP6: - -
SP7: - - - - - - -
SP8: - - -
SP9:

ExUns: 18a · 18b ^ 19a · 19b ^ 20a · 20b
SP1: -
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for IGF2BP2 Gene

GeneLoc Exon Structure for
IGF2BP2
ECgene alternative splicing isoforms for
IGF2BP2

Expression for IGF2BP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IGF2BP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IGF2BP2 Gene

This gene is overexpressed in Liver (23.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IGF2BP2 Gene



Protein tissue co-expression partners for IGF2BP2 Gene

NURSA nuclear receptor signaling pathways regulating expression of IGF2BP2 Gene:

IGF2BP2

SOURCE GeneReport for Unigene cluster for IGF2BP2 Gene:

Hs.35354

mRNA Expression by UniProt/SwissProt for IGF2BP2 Gene:

Q9Y6M1-IF2B2_HUMAN
Tissue specificity: Expressed in oocytes, granulosa cells of small and growing follicles, Leydig cells, spermatogonia and semen (at protein level). Expressed in testicular cancer (at protein level). Expressed weakly in heart, placenta, skeletal muscle, bone marrow, colon, kidney, salivary glands, testis and pancreas. Detected in fetal liver, fetal ovary, gonocytes and interstitial cells of the testis.
genes like me logo Genes that share expression patterns with IGF2BP2: view

Primer Products

No data available for mRNA differential expression in normal tissues for IGF2BP2 Gene

Orthologs for IGF2BP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for IGF2BP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IGF2BP2 34 35
  • 99.89 (n)
cow
(Bos Taurus)
Mammalia IGF2BP2 34 35
  • 95.05 (n)
dog
(Canis familiaris)
Mammalia IGF2BP2 34 35
  • 95.04 (n)
mouse
(Mus musculus)
Mammalia Igf2bp2 34 16 35
  • 90.99 (n)
rat
(Rattus norvegicus)
Mammalia Igf2bp2 34
  • 90.48 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia IGF2BP2 35
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IGF2BP2 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves IGF2BP2 34 35
  • 79.91 (n)
lizard
(Anolis carolinensis)
Reptilia IGF2BP2 35
  • 66 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii igf2bp2a 34 35
  • 72.8 (n)
fruit fly
(Drosophila melanogaster)
Insecta Imp 35
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea zbp-1 35
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 40 (a)
OneToMany
Species where no ortholog for IGF2BP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for IGF2BP2 Gene

ENSEMBL:
Gene Tree for IGF2BP2 (if available)
TreeFam:
Gene Tree for IGF2BP2 (if available)

Paralogs for IGF2BP2 Gene

Paralogs for IGF2BP2 Gene

(6) SIMAP similar genes for IGF2BP2 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for IGF2BP2 Gene

genes like me logo Genes that share paralogs with IGF2BP2: view

Variants for IGF2BP2 Gene

Sequence variations from dbSNP and Humsavar for IGF2BP2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs4402960 other 185,793,899(+) AGATT(G/T)AAGAT intron-variant
rs10428126 -- 185,802,554(+) AATAA(C/T)TTGTT intron-variant
rs10440055 -- 185,738,171(+) TTGCT(A/G)TCTAT intron-variant
rs1047162 -- 185,816,416(+) GTACA(G/T)ATCAC intron-variant
rs10513800 -- 185,762,600(+) AGAGA(A/C)AGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IGF2BP2 Gene

Variant ID Type Subtype PubMed ID
nsv965242 CNV duplication 23825009
nsv963389 CNV duplication 23825009
nsv963388 CNV duplication 23825009
nsv1152905 CNV deletion 26484159
nsv1136788 CNV deletion 24896259
nsv1130802 CNV deletion 24896259
esv990977 CNV deletion 20482838
esv3598974 CNV gain 21293372
esv3563023 CNV deletion 23714750
esv2726327 CNV deletion 23290073
esv2726326 CNV deletion 23290073
esv2670919 CNV deletion 23128226
dgv962e214 CNV loss 21293372

Variation tolerance for IGF2BP2 Gene

Residual Variation Intolerance Score: 13.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.86; 17.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IGF2BP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGF2BP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGF2BP2 Gene

Disorders for IGF2BP2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for IGF2BP2 Gene - From: OMIM, ClinVar, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
diabetes mellitus, noninsulin-dependent
  • diabetes mellitus, noninsulin-dependent, 2
hepatocellular carcinoma
  • hepatocellular carcinoma, somatic
testicular cancer
  • childhood neoplasm of the testis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for IGF2BP2

Genetic Association Database (GAD)
IGF2BP2
Human Genome Epidemiology (HuGE) Navigator
IGF2BP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IGF2BP2
genes like me logo Genes that share disorders with IGF2BP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IGF2BP2 Gene

Publications for IGF2BP2 Gene

  1. IGF2BP2 variations influence repaglinide response and risk of type 2 diabetes in Chinese population. (PMID: 20523342) Huang Q. … Liu Z.Q. (Acta Pharmacol. Sin. 2010) 3 22 46 64
  2. Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population. (PMID: 17928989) Horikoshi M. … Kadowaki T. (Diabetologia 2007) 3 22 46 64
  3. A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development. (PMID: 9891060) Nielsen J. … Nielsen F.C. (Mol. Cell. Biol. 1999) 2 3 4 64
  4. A novel cytoplasmic protein with RNA-binding motifs is an autoantigen in human hepatocellular carcinoma. (PMID: 10190901) Zhang J.-Y. … Tan E.M. (J. Exp. Med. 1999) 2 3 4 64
  5. Subcellular localization and RNP formation of IGF2BPs (IGF2 mRNA- binding proteins) is modulated by distinct RNA-binding domains. (PMID: 23640942) Wachter K. … Huttelmaier S. (Biol. Chem. 2013) 3 4 64

Products for IGF2BP2 Gene

Sources for IGF2BP2 Gene

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