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Aliases for POSTN Gene

Aliases for POSTN Gene

  • Periostin 2
  • Periostin, Osteoblast Specific Factor 2 3 5
  • OSF-2 3 4
  • OSF2 3 4
  • PN 3 4
  • Osteoblast Specific Factor 2 (Fasciclin I-Like) 3
  • Periodontal Ligament-Specific Periostin 3
  • Osteoblast Specific Factor 2 2
  • Osteoblast-Specific Factor 2 4

External Ids for POSTN Gene

Previous GeneCards Identifiers for POSTN Gene

  • GC13M035934
  • GC13M037034
  • GC13M038136
  • GC13M018936

Summaries for POSTN Gene

Entrez Gene Summary for POSTN Gene

  • This gene encodes a secreted extracellular matrix protein that functions in tissue development and regeneration, including wound healing, and ventricular remodeling following myocardial infarction. The encoded protein binds to integrins to support adhesion and migration of epithelial cells. This protein plays a role in cancer stem cell maintenance and metastasis. Mice lacking this gene exhibit cardiac valve disease, and skeletal and dental defects. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]

GeneCards Summary for POSTN Gene

POSTN (Periostin) is a Protein Coding gene. Diseases associated with POSTN include Poikiloderma With Neutropenia and Juxtacortical Osteosarcoma. GO annotations related to this gene include heparin binding and cell adhesion molecule binding. An important paralog of this gene is TGFBI.

UniProtKB/Swiss-Prot for POSTN Gene

  • Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (By similarity). Induces cell attachment and spreading and plays a role in cell adhesion. May play a role in extracellular matrix mineralization.

Gene Wiki entry for POSTN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POSTN Gene

Genomics for POSTN Gene

Regulatory Elements for POSTN Gene

Enhancers for POSTN Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around POSTN on UCSC Golden Path with GeneCards custom track

Promoters for POSTN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around POSTN on UCSC Golden Path with GeneCards custom track

Genomic Location for POSTN Gene

37,562,582 bp from pter
37,598,844 bp from pter
36,263 bases
Minus strand

Genomic View for POSTN Gene

Genes around POSTN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POSTN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POSTN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POSTN Gene

Proteins for POSTN Gene

  • Protein details for POSTN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B1ALD8
    • C0IMJ1
    • C0IMJ2
    • C0IMJ4
    • D2KRH7
    • F5H628
    • Q15064
    • Q29XZ0
    • Q3KPJ5
    • Q5VSY5
    • Q8IZF9

    Protein attributes for POSTN Gene

    836 amino acids
    Molecular mass:
    93314 Da
    Quaternary structure:
    • Interacts with BMP1 and fibronectin.

    Alternative splice isoforms for POSTN Gene

neXtProt entry for POSTN Gene

Proteomics data for POSTN Gene at MOPED

Post-translational modifications for POSTN Gene

  • Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
  • Glycosylation at Asn 599
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for POSTN (Periostin/OSF-2)

No data available for DME Specific Peptides for POSTN Gene

Domains & Families for POSTN Gene

Gene Families for POSTN Gene

Protein Domains for POSTN Gene

Suggested Antigen Peptide Sequences for POSTN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 EMI domain.
  • Contains 1 EMI domain.
  • Contains 4 FAS1 domains.
genes like me logo Genes that share domains with POSTN: view

Function for POSTN Gene

Molecular function for POSTN Gene

UniProtKB/Swiss-Prot Function:
Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (By similarity). Induces cell attachment and spreading and plays a role in cell adhesion. May play a role in extracellular matrix mineralization.
genes like me logo Genes that share phenotypes with POSTN: view

Animal Models for POSTN Gene

MGI Knock Outs for POSTN:

Animal Model Products

  • Taconic Biosciences Mouse Models for POSTN

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for POSTN Gene

Localization for POSTN Gene

Subcellular locations from UniProtKB/Swiss-Prot for POSTN Gene

Golgi apparatus. Secreted, extracellular space, extracellular matrix. Note=Colocalizes with BMP1 in the Golgi. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for POSTN Gene COMPARTMENTS Subcellular localization image for POSTN gene
Compartment Confidence
extracellular 5
golgi apparatus 4
endoplasmic reticulum 3
cytoskeleton 2
plasma membrane 2
cytosol 1
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for POSTN Gene

Pathways & Interactions for POSTN Gene

SuperPathways for POSTN Gene

No Data Available

Interacting Proteins for POSTN Gene

Gene Ontology (GO) - Biological Process for POSTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development TAS 8363580
GO:0001953 negative regulation of cell-matrix adhesion IEA --
GO:0003073 regulation of systemic arterial blood pressure IEA --
GO:0008593 regulation of Notch signaling pathway IEA --
GO:0009612 response to mechanical stimulus IEA --
genes like me logo Genes that share ontologies with POSTN: view

No data available for Pathways by source and SIGNOR curated interactions for POSTN Gene

Drugs & Compounds for POSTN Gene

(2) Drugs for POSTN Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(1) Additional Compounds for POSTN Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with POSTN: view

Transcripts for POSTN Gene

Unigene Clusters for POSTN Gene

Periostin, osteoblast specific factor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for POSTN Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b · 18c ^ 19a · 19b · 19c ^ 20a · 20b ^
SP1: - - -
SP2: - - - - - -
SP3: - - - -
SP4: - - - - - -
SP5: - - - - - - - -
SP6: -
SP7: -
SP8: -

ExUns: 21a · 21b ^ 22 ^ 23a · 23b · 23c · 23d
SP1: -
SP2: -
SP4: - -
SP5: - -
SP6: - -

Relevant External Links for POSTN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for POSTN Gene

mRNA expression in normal human tissues for POSTN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for POSTN Gene

This gene is overexpressed in Artery - Coronary (x4.6), Artery - Aorta (x4.4), and Heart - Atrial Appendage (x4.2).

Protein differential expression in normal tissues from HIPED for POSTN Gene

This gene is overexpressed in Breast (37.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for POSTN Gene

SOURCE GeneReport for Unigene cluster for POSTN Gene Hs.136348

mRNA Expression by UniProt/SwissProt for POSTN Gene

Tissue specificity: Widely expressed with highest levels in aorta, stomach, lower gastrointestinal tract, placenta, uterus, thyroid tissue and breast. Up-regulated in epithelial ovarian tumors. Not expressed in normal ovaries. Also highly expressed at the tumor periphery of lung carcinoma tissue but not within the tumor. Overexpressed in breast cancers.
genes like me logo Genes that share expression patterns with POSTN: view

Protein tissue co-expression partners for POSTN Gene

- Elite partner

Primer Products

Orthologs for POSTN Gene

This gene was present in the common ancestor of animals.

Orthologs for POSTN Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia POSTN 35
  • 91.36 (n)
  • 94.99 (a)
  • 95 (a)
(Canis familiaris)
Mammalia POSTN 35
  • 92.88 (n)
  • 96 (a)
  • 96 (a)
(Mus musculus)
Mammalia Postn 35
  • 85.17 (n)
  • 89.74 (a)
Postn 16
Postn 36
  • 90 (a)
(Pan troglodytes)
Mammalia POSTN 35
  • 99.6 (n)
  • 99.64 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Postn 35
  • 85.02 (n)
  • 90.47 (a)
(Monodelphis domestica)
Mammalia POSTN 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia POSTN 36
  • 86 (a)
(Gallus gallus)
Aves POSTN 35
  • 74.71 (n)
  • 77.72 (a)
OSF-2 36
  • 74 (a)
(Anolis carolinensis)
Reptilia POSTN 36
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia postn 35
  • 69.74 (n)
  • 69.78 (a)
(Danio rerio)
Actinopterygii postnb 35
  • 60.67 (n)
  • 59.79 (a)
postna 36
  • 42 (a)
postnb 36
  • 57 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG43333 36
  • 7 (a)
Fas1 36
  • 19 (a)
mfas 36
  • 16 (a)
(Caenorhabditis elegans)
Secernentea F26E4.7 36
  • 19 (a)
Species with no ortholog for POSTN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POSTN Gene

Gene Tree for POSTN (if available)
Gene Tree for POSTN (if available)

Paralogs for POSTN Gene

Paralogs for POSTN Gene

(1) SIMAP similar genes for POSTN Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with POSTN: view

Variants for POSTN Gene

Sequence variations from dbSNP and Humsavar for POSTN Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs9594223 - 37,584,808(+) TTACT(A/G)TTATA reference, missense
rs9547952 - 37,564,552(+) CCTCA(C/T)GGGTG reference, missense
rs6750 -- 37,562,695(-) AAATT(C/G)AGTAA utr-variant-3-prime
rs12848 -- 37,562,942(-) AAATG(C/G)ACGCA utr-variant-3-prime
rs1006416 -- 37,590,308(-) ACTGA(C/T)TTATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for POSTN Gene

Variant ID Type Subtype PubMed ID
esv34109 CNV Loss 18971310
nsv832583 CNV Loss 17160897
nsv818956 CNV Gain 17921354

Variation tolerance for POSTN Gene

Residual Variation Intolerance Score: 12% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.17; 75.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POSTN Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POSTN Gene

Disorders for POSTN Gene

MalaCards: The human disease database

(7) MalaCards diseases for POSTN Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
poikiloderma with neutropenia
  • clericuzio type poikiloderma with neutropenia
juxtacortical osteosarcoma
  • parosteal osteogenic sarcoma
hypertensive nephropathy
  • nephropathy hypertensive
peripheral osteosarcoma
  • surface osteosarcoma
esophagitis, eosinophilic, 1
  • eosinophilic esophagitis
- elite association - COSMIC cancer census association via MalaCards
Search POSTN in MalaCards View complete list of genes associated with diseases

Relevant External Links for POSTN

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with POSTN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for POSTN Gene

Publications for POSTN Gene

  1. Periostin secreted by epithelial ovarian carcinoma is a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins and promotes cell motility. (PMID: 12235007) Gillan L. … Chang D.D. (Cancer Res. 2002) 2 3 4 23 67
  2. Osteoblast-specific factor 2: cloning of a putative bone adhesion protein with homology with the insect protein fasciclin I. (PMID: 8363580) Takeshita S. … Amann E. (Biochem. J. 1993) 2 3 23
  3. The expression analysis of periostin in human breast cancer. (PMID: 19524268) Zhang Y. … Tang W. (J. Surg. Res. 2010) 3 23
  4. Periostin mediates vascular smooth muscle cell migration through the integrins alphavbeta3 and alphavbeta5 and focal adhesion kinase (FAK) pathway. (PMID: 19695571) Li G. … Granger D.N. (Atherosclerosis 2010) 3 23
  5. Incorporation of tenascin-C into the extracellular matrix by periostin underlies an extracellular meshwork architecture. (PMID: 19887451) Kii I. … Kudo A. (J. Biol. Chem. 2010) 3 23

Products for POSTN Gene

Sources for POSTN Gene