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Aliases for PDPN Gene

Aliases for PDPN Gene

  • Podoplanin 2 3
  • AGGRUS 3 4 6
  • GP36 3 4 6
  • Lung Type I Cell Membrane Associated Glycoprotein 2 3
  • Glycoprotein 36 3 4
  • PA2.26 Antigen 3 4
  • T1-Alpha 3 4
  • OTS8 3 6
  • T1A2 3 6
  • TI1A 3 6
  • T1A 3 4
  • Lung Type-I Cell Membrane-Associated Glycoprotein (T1A-2) 3
  • Glycoprotein, 36-KD 3
  • HT1alpha-1 3
  • HT1alpha-2 3
  • HT1A-1 3
  • PA2.26 3
  • T1A-2 3
  • GP40 3
  • Gp38 3

External Ids for PDPN Gene

Summaries for PDPN Gene

Entrez Gene Summary for PDPN Gene

  • This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined but it has been proposed as a marker of lung injury. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for PDPN Gene

PDPN (Podoplanin) is a Protein Coding gene. Diseases associated with PDPN include subglottis neoplasm and atypical neurofibroma. Among its related pathways are Cytoskeletal Signaling. GO annotations related to this gene include amino acid transmembrane transporter activity and water transmembrane transporter activity.

UniProtKB/Swiss-Prot for PDPN Gene

  • May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels.

Gene Wiki entry for PDPN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDPN Gene

Genomics for PDPN Gene

Genomic Location for PDPN Gene

Start:
13,583,465 bp from pter
End:
13,617,957 bp from pter
Size:
34,493 bases
Orientation:
Plus strand

Genomic View for PDPN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PDPN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDPN Gene

Regulatory Elements for PDPN Gene

Proteins for PDPN Gene

  • Protein details for PDPN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YL7-PDPN_HUMAN
    Recommended name:
    Podoplanin
    Protein Accession:
    Q86YL7
    Secondary Accessions:
    • A9Z1Y2
    • B2R6J8
    • E9PB68
    • F6QWX5
    • O60836
    • O95128
    • Q7L375
    • Q8NBQ8
    • Q8NBR3

    Protein attributes for PDPN Gene

    Size:
    162 amino acids
    Molecular mass:
    16698 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAM73655.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAO22143.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC11550.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC11557.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG35495.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PDPN Gene

    Alternative splice isoforms for PDPN Gene

neXtProt entry for PDPN Gene

Proteomics data for PDPN Gene at MOPED

Post-translational modifications for PDPN Gene

  • Extensively O-glycosylated. Contains sialic acid residues. O-glycosylation is necessary for platelet aggregation activity.
  • The N-terminus is blocked.
  • Glycosylation at Thr25, Thr32, Thr34, Thr35, Thr52, Thr55, Thr65, Thr66, Thr76, Thr85, Ser86, Ser88, Thr89, Ser96, Ser98, Thr100, Ser102, Thr106, Ser107, Ser109, Thr110, Thr117, Thr119, and Thr120

No data available for DME Specific Peptides for PDPN Gene

Domains for PDPN Gene

Protein Domains for PDPN Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

PDPN_HUMAN
Family:
  • Belongs to the podoplanin family.:
    • Q86YL7
genes like me logo Genes that share domains with PDPN: view

No data available for Gene Families for PDPN Gene

Function for PDPN Gene

Molecular function for PDPN Gene

UniProtKB/Swiss-Prot Function: May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels.

Gene Ontology (GO) - Molecular Function for PDPN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005372 NOT water transmembrane transporter activity ISS --
GO:0008517 NOT folic acid transporter activity ISS --
GO:0015171 NOT amino acid transmembrane transporter activity ISS --
GO:0015250 NOT water channel activity ISS --
genes like me logo Genes that share ontologies with PDPN: view
genes like me logo Genes that share phenotypes with PDPN: view

Animal Models for PDPN Gene

MGI Knock Outs for PDPN:

miRNA for PDPN Gene

miRTarBase miRNAs that target PDPN

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PDPN Gene

Localization for PDPN Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDPN Gene

Membrane; Single-pass type I membrane protein. Cell projection, filopodium membrane; Single-pass type I membrane protein. Cell projection, lamellipodium membrane; Single-pass type I membrane protein. Cell projection, microvillus membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane; Single-pass type I membrane protein. Note=Localized to actin-rich microvilli and plasma membrane projections such as filopodia, lamellipodia and ruffles. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PDPN Gene COMPARTMENTS Subcellular localization image for PDPN gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
extracellular 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PDPN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle ISS --
GO:0005886 plasma membrane ISS --
GO:0005887 integral component of plasma membrane TAS 10393083
GO:0009897 external side of plasma membrane IEA --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with PDPN: view

Pathways for PDPN Gene

SuperPathways for PDPN Gene

Superpath Contained pathways
1 Cytoskeletal Signaling
genes like me logo Genes that share pathways with PDPN: view

Pathways by source for PDPN Gene

1 Cell Signaling Technology pathway for PDPN Gene

Interacting Proteins for PDPN Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000294489%0d%0a9606.ENSP00000460823%0d%0a
Selected Interacting proteins: Q86YL7-PDPN_HUMAN ENSP00000294489 for PDPN Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for PDPN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis ISS --
GO:0001946 lymphangiogenesis ISS --
GO:0006693 prostaglandin metabolic process IEA --
GO:0006833 NOT water transport ISS --
GO:0006865 NOT amino acid transport ISS --
genes like me logo Genes that share ontologies with PDPN: view

Compounds for PDPN Gene

(8) Novoseek inferred chemical compound relationships for PDPN Gene

Compound -log(P) Hits PubMed IDs
b 723 57.5 8
paraffin 46.6 5
vegf 31.1 4
hematoxylin 30.7 1
sialic acid 8.55 2
genes like me logo Genes that share compounds with PDPN: view

Transcripts for PDPN Gene

Unigene Clusters for PDPN Gene

Podoplanin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PDPN Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1: - - - - -
SP2: - - - - -
SP3:
SP4: - - -
SP5: - -
SP6: - - - -
SP7: - - -
SP8: -

Relevant External Links for PDPN Gene

GeneLoc Exon Structure for
PDPN
ECgene alternative splicing isoforms for
PDPN

Expression for PDPN Gene

mRNA expression in normal human tissues for PDPN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for PDPN Gene

SOURCE GeneReport for Unigene cluster for PDPN Gene Hs.468675

mRNA Expression by UniProt/SwissProt for PDPN Gene

Q86YL7-PDPN_HUMAN
Tissue specificity: Highly expressed in placenta, lung, skeletal muscle and brain. Weakly expressed in brain, kidney and liver. In placenta, expressed on the apical plasma membrane of endothelium. In lung, expressed in alveolar epithelium. Up-regulated in colorectal tumors and expressed in 25% of early oral squamous cell carcinomas.
genes like me logo Genes that share expressions with PDPN: view

Orthologs for PDPN Gene

This gene was present in the common ancestor of chordates.

Orthologs for PDPN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PDPN 36
  • 99.3 (n)
  • 98.74 (a)
PDPN 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BOVAGGRUS 37
  • 46 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PDPN 36
  • 77.57 (n)
  • 66.67 (a)
PDPN 37
  • 54 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pdpn 36
  • 63.99 (n)
  • 48.15 (a)
Pdpn 16
Pdpn 37
  • 45 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PDPN 37
  • 37 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PDPN 37
  • 45 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pdpn 36
  • 64.69 (n)
  • 53.95 (a)
chicken
(Gallus gallus)
Aves PDPN 37
  • 37 (a)
OneToOne
Species with no ortholog for PDPN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PDPN Gene

ENSEMBL:
Gene Tree for PDPN (if available)
TreeFam:
Gene Tree for PDPN (if available)

Paralogs for PDPN Gene

No data available for Paralogs for PDPN Gene

Variants for PDPN Gene

Sequence variations from dbSNP and Humsavar for PDPN Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs11880 -- 13,616,236(+) TATTA(C/T)ATGCT utr-variant-3-prime
rs92406 -- 13,608,907(-) AAAAG(G/T)CAGcc intron-variant
rs173312 -- 13,592,862(+) tgatt(C/G)tttct intron-variant
rs355022 -- 13,582,195(+) CTTCA(C/T)TGTGT upstream-variant-2KB
rs355023 -- 13,582,647(+) TGTTC(A/C)TGGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PDPN Gene

Variant ID Type Subtype PubMed ID
nsv871035 CNV Gain 21882294
nsv833092 CNV Loss 17160897
nsv460483 CNV Loss 19166990
esv2744064 CNV Deletion 23290073
esv270520 CNV Insertion 20981092

Relevant External Links for PDPN Gene

HapMap Linkage Disequilibrium report
PDPN

Disorders for PDPN Gene

(38) Novoseek inferred disease relationships for PDPN Gene

Disease -log(P) Hits PubMed IDs
lymphatic metastasis 71.4 1
lymphangioma 71.3 6
metastasis 67.5 48
mesothelioma 67.1 28
congenital lymphedema 64.6 2

Relevant External Links for PDPN

Genetic Association Database (GAD)
PDPN
Human Genome Epidemiology (HuGE) Navigator
PDPN
genes like me logo Genes that share disorders with PDPN: view

No data available for UniProtKB/Swiss-Prot for PDPN Gene

Publications for PDPN Gene

  1. Cloning and characterization of gp36, a human mucin-type glycoprotein preferentially expressed in vascular endothelium. (PMID: 10393083) Zimmer G. … Herrler G. (Biochem. J. 1999) 2 3 4 23
  2. Evidence against a role of mouse, rat, and two cloned human T1alpha isoforms as a water channel or a regulator of aquaporin-type water channels. (PMID: 9651190) Ma T. … Verkman A.S. (Am. J. Respir. Cell Mol. Biol. 1998) 2 3 4 23
  3. Characterization of human PA2.26 antigen (T1alpha-2, podoplanin), a small membrane mucin induced in oral squamous cell carcinomas. (PMID: 15515019) Martin-Villar E. … Quintanilla M. (Int. J. Cancer 2005) 3 4 23
  4. Functional sialylated O-glycan to platelet aggregation on Aggrus (T1alpha/Podoplanin) molecules expressed in Chinese hamster ovary cells. (PMID: 15231832) Kaneko M. … Osawa M. (J. Biol. Chem. 2004) 3 4 23
  5. Novel interactions in platelet biology: CLEC-2/podoplanin and laminin/GPVI. (PMID: 19630798) Ozaki Y. … Inoue O. (J. Thromb. Haemost. 2009) 3 23

Products for PDPN Gene

Sources for PDPN Gene

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