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Aliases for HEXIM1 Gene

Aliases for HEXIM1 Gene

  • Hexamethylene Bis-Acetamide Inducible 1 2 3
  • CLP1 3 4 6
  • HIS1 3 4 6
  • Hexamethylene Bis-Acetamide-Inducible Protein 1 3 4
  • Estrogen Down-Regulated Gene 1 Protein 3 4
  • Cardiac Lineage Protein 1 3 4
  • Menage A Quatre Protein 1 3 4
  • EDG1 3 4
  • MAQ1 3 4
  • Hexamethylene-Bis-Acetamide-Inducible Transcript 1 3
  • Hexamethylene Bisacetamide-Inducible Protein 3
  • Hexamthylene Bis-Acetamide Inducible 1 3
  • Menage A Quatre 1 3
  • Protein HEXIM1 3
  • HMBA-Inducible 3

External Ids for HEXIM1 Gene

Previous GeneCards Identifiers for HEXIM1 Gene

  • GC17P040583
  • GC17P043224
  • GC17P038987

Summaries for HEXIM1 Gene

Entrez Gene Summary for HEXIM1 Gene

  • Expression of this gene is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. This gene has no introns. [provided by RefSeq, Jul 2008]

GeneCards Summary for HEXIM1 Gene

HEXIM1 (Hexamethylene Bis-Acetamide Inducible 1) is a Protein Coding gene. Diseases associated with HEXIM1 include hiv-1. Among its related pathways are Nanog in Mammalian ESC Pluripotency and Human Embryonic Stem Cell Pluripotency. GO annotations related to this gene include cyclin-dependent protein serine/threonine kinase inhibitor activity and snRNA binding. An important paralog of this gene is HEXIM2.

UniProtKB/Swiss-Prot for HEXIM1 Gene

  • Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity.

Gene Wiki entry for HEXIM1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HEXIM1 Gene

Genomics for HEXIM1 Gene

Regulatory Elements for HEXIM1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HEXIM1 Gene

Start:
45,147,317 bp from pter
End:
45,152,101 bp from pter
Size:
4,785 bases
Orientation:
Plus strand

Genomic View for HEXIM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HEXIM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HEXIM1 Gene

Proteins for HEXIM1 Gene

  • Protein details for HEXIM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94992-HEXI1_HUMAN
    Recommended name:
    Protein HEXIM1
    Protein Accession:
    O94992
    Secondary Accessions:
    • B2R8Y5

    Protein attributes for HEXIM1 Gene

    Size:
    359 amino acids
    Molecular mass:
    40623 Da
    Quaternary structure:
    • Homooligomer and heterooligomer with HEXIM2; probably dimeric. Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs. Interacts with the N-CoR complex through NCOR1. Interacts with ESR1 and NR3C1. May interact with NF-kappa-B through RELA.
    Miscellaneous:
    • Inhibits Tat activity which is required for HIV-1 transcription

    Three dimensional structures from OCA and Proteopedia for HEXIM1 Gene

neXtProt entry for HEXIM1 Gene

Proteomics data for HEXIM1 Gene at MOPED

Post-translational modifications for HEXIM1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HEXIM1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for HEXIM1 (HEXIM1)

No data available for DME Specific Peptides for HEXIM1 Gene

Domains for HEXIM1 Gene

Protein Domains for HEXIM1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HEXIM1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O94992

UniProtKB/Swiss-Prot:

HEXI1_HUMAN :
  • O94992
Domain:
  • The coiled-coil domain mediates oligomerization
Family:
  • Belongs to the HEXIM family.
genes like me logo Genes that share domains with HEXIM1: view

No data available for Gene Families for HEXIM1 Gene

Function for HEXIM1 Gene

Molecular function for HEXIM1 Gene

UniProtKB/Swiss-Prot Function: Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity.
UniProtKB/Swiss-Prot Induction: Up-regulated by HMBA (hexamethylene bisacetamide) (at protein level). Down-regulated by estrogen.

Gene Ontology (GO) - Molecular Function for HEXIM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity IDA 14580347
GO:0005515 protein binding IPI 14580347
GO:0017069 snRNA binding IDA 14580347
genes like me logo Genes that share ontologies with HEXIM1: view

Phenotypes for HEXIM1 Gene

genes like me logo Genes that share phenotypes with HEXIM1: view

Animal Models for HEXIM1 Gene

MGI Knock Outs for HEXIM1:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HEXIM1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for HEXIM1 Gene

Localization for HEXIM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HEXIM1 Gene

Nucleus. Cytoplasm. Note=Binds alpha-importin and is mostly nuclear.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HEXIM1 Gene COMPARTMENTS Subcellular localization image for HEXIM1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for HEXIM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12581153
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 12581153
genes like me logo Genes that share ontologies with HEXIM1: view

Pathways for HEXIM1 Gene

genes like me logo Genes that share pathways with HEXIM1: view

Gene Ontology (GO) - Biological Process for HEXIM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 14580347
GO:0006351 transcription, DNA-templated IEA --
GO:0007507 heart development IEA --
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA 14580347
GO:0045892 negative regulation of transcription, DNA-templated IDA 14580347
genes like me logo Genes that share ontologies with HEXIM1: view

Compounds for HEXIM1 Gene

(2) Novoseek inferred chemical compound relationships for HEXIM1 Gene

Compound -log(P) Hits PubMed IDs
hmba 87.2 10
cyclohexane 74.4 5
genes like me logo Genes that share compounds with HEXIM1: view

Transcripts for HEXIM1 Gene

mRNA/cDNA for HEXIM1 Gene

(165) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HEXIM1 Gene

Hexamethylene bis-acetamide inducible 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HEXIM1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HEXIM1 Gene

No ASD Table

Relevant External Links for HEXIM1 Gene

GeneLoc Exon Structure for
HEXIM1
ECgene alternative splicing isoforms for
HEXIM1

Expression for HEXIM1 Gene

mRNA expression in normal human tissues for HEXIM1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HEXIM1 Gene

SOURCE GeneReport for Unigene cluster for HEXIM1 Gene Hs.741758

mRNA Expression by UniProt/SwissProt for HEXIM1 Gene

O94992-HEXI1_HUMAN
Tissue specificity: Ubiquitously expressed with higher expression in placenta. HEXIM1 and HEXIM2 are differentially expressed. Expressed in endocrine tissues.
genes like me logo Genes that share expressions with HEXIM1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for HEXIM1 Gene

Orthologs for HEXIM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HEXIM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HEXIM1 35
  • 100 (n)
  • 100 (a)
HEXIM1 36
  • 89 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HEXIM1 35
  • 90.94 (n)
  • 90.31 (a)
HEXIM1 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HEXIM1 35
  • 90.99 (n)
  • 90.22 (a)
HEXIM1 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hexim1 35
  • 88.01 (n)
  • 86.52 (a)
Hexim1 16
Hexim1 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HEXIM1 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hexim1 35
  • 86.89 (n)
  • 86.24 (a)
chicken
(Gallus gallus)
Aves HEXIM1 35
  • 81.36 (n)
  • 80.65 (a)
lizard
(Anolis carolinensis)
Reptilia HEXIM1 36
  • 61 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.2589 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9361 35
zebrafish
(Danio rerio)
Actinopterygii hexim1 36
  • 44 (a)
OneToOne
wufd44h02 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToMany
Species with no ortholog for HEXIM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HEXIM1 Gene

ENSEMBL:
Gene Tree for HEXIM1 (if available)
TreeFam:
Gene Tree for HEXIM1 (if available)

Paralogs for HEXIM1 Gene

Paralogs for HEXIM1 Gene

Selected SIMAP similar genes for HEXIM1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HEXIM1: view

Variants for HEXIM1 Gene

Sequence variations from dbSNP and Humsavar for HEXIM1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs901753 -- 45,151,124(-) TTACT(A/G)GGGGG utr-variant-3-prime
rs1044977 -- 45,149,847(+) CCGGA(C/T)CTCAA synonymous-codon, reference
rs1044995 -- 45,151,161(+) CTTAG(C/T)GCAAG utr-variant-3-prime
rs1801920 -- 45,150,784(+) GGAGA(A/C)TTTTC utr-variant-3-prime
rs1801921 -- 45,150,822(+) TTTAA(C/G)TATGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for HEXIM1 Gene

Variant ID Type Subtype PubMed ID
nsv527788 CNV Loss 19592680
nsv908297 CNV Loss 21882294
dgv3179n71 CNV Loss 21882294
nsv908300 CNV Loss 21882294
nsv828022 CNV Gain 20364138
nsv2062 CNV Insertion 18451855

Relevant External Links for HEXIM1 Gene

HapMap Linkage Disequilibrium report
HEXIM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HEXIM1 Gene

Disorders for HEXIM1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for HEXIM1 Gene including...

Search for HEXIM1 Gene in MalaCards »

(2) Novoseek inferred disease relationships for HEXIM1 Gene

Disease -log(P) Hits PubMed IDs
cardiac hypertrophy 48.1 3
immunodeficiency 41.3 4

Relevant External Links for HEXIM1

Genetic Association Database (GAD)
HEXIM1
genes like me logo Genes that share disorders with HEXIM1: view

No data available for UniProtKB/Swiss-Prot for HEXIM1 Gene

Publications for HEXIM1 Gene

  1. Suppression of NF-kappaB-dependent gene expression by a hexamethylene bisacetamide-inducible protein HEXIM1 in human vascular smooth muscle cells. (PMID: 12581153) Ouchida R. … Tanaka H. (Genes Cells 2003) 3 4 23
  2. Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA. (PMID: 14580347) Yik J.H.N. … Zhou Q. (Mol. Cell 2003) 3 4 23
  3. A human immunodeficiency virus type 1 Tat-like arginine-rich RNA- binding domain is essential for HEXIM1 to inhibit RNA polymerase II transcription through 7SK snRNA-mediated inactivation of P-TEFb. (PMID: 15169877) Yik J.H.N. … Zhou Q. (Mol. Cell. Biol. 2004) 3 4 23
  4. Compensatory contributions of HEXIM1 and HEXIM2 in maintaining the balance of active and inactive positive transcription elongation factor b complexes for control of transcription. (PMID: 15713661) Yik J.H.N. … Zhou Q. (J. Biol. Chem. 2005) 3 4 23
  5. HEXIM1 forms a transcriptionally abortive complex with glucocorticoid receptor without involving 7SK RNA and positive transcription elongation factor b. (PMID: 15941832) Shimizu N. … Tanaka H. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 4 23

Products for HEXIM1 Gene

Sources for HEXIM1 Gene

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