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Aliases for PAIP1 Gene

Aliases for PAIP1 Gene

  • Poly(A) Binding Protein Interacting Protein 1 2 3
  • Poly(A)-Binding Protein-Interacting Protein 1 3 4
  • PABP-Interacting Protein 1 3 4
  • PAIP-1 3 4
  • Polyadenylate Binding Protein-Interacting Protein 1 3
  • Polyadenylate-Binding Protein-Interacting Protein 1 3
  • PABC1-Interacting Protein 1 3

External Ids for PAIP1 Gene

Previous GeneCards Identifiers for PAIP1 Gene

  • GC05M043835
  • GC05M044703
  • GC05M043571
  • GC05M043562
  • GC05M043477

Summaries for PAIP1 Gene

Entrez Gene Summary for PAIP1 Gene

  • The protein encoded by this gene interacts with poly(A)-binding protein and with the cap-binding complex eIF4A. It is involved in translational initiation and protein biosynthesis. Overexpression of this gene in COS7 cells stimulates translation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for PAIP1 Gene

PAIP1 (Poly(A) Binding Protein Interacting Protein 1) is a Protein Coding gene. Among its related pathways are TGF-Beta Pathway and Gene Expression. GO annotations related to this gene include RNA binding and translation activator activity.

UniProtKB/Swiss-Prot for PAIP1 Gene

  • Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.

Gene Wiki entry for PAIP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAIP1 Gene

Genomics for PAIP1 Gene

Regulatory Elements for PAIP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PAIP1 Gene

Start:
43,526,267 bp from pter
End:
43,557,758 bp from pter
Size:
31,492 bases
Orientation:
Minus strand

Genomic View for PAIP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PAIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAIP1 Gene

Proteins for PAIP1 Gene

  • Protein details for PAIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H074-PAIP1_HUMAN
    Recommended name:
    Polyadenylate-binding protein-interacting protein 1
    Protein Accession:
    Q9H074
    Secondary Accessions:
    • A6NKV8
    • O60455
    • Q96B61
    • Q9BS63

    Protein attributes for PAIP1 Gene

    Size:
    479 amino acids
    Molecular mass:
    53525 Da
    Quaternary structure:
    • Interacts with the RRM1-RRM2 and C-terminus regions of PABPC1 in a 1:1 stoichiometry. Interacts with EIF4A.

    Three dimensional structures from OCA and Proteopedia for PAIP1 Gene

    Alternative splice isoforms for PAIP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PAIP1 Gene

Proteomics data for PAIP1 Gene at MOPED

Post-translational modifications for PAIP1 Gene

  • Ubiquitination at Lys368
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for PAIP1 Gene

Domains for PAIP1 Gene

Protein Domains for PAIP1 Gene

Suggested Antigen Peptide Sequences for PAIP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H074

UniProtKB/Swiss-Prot:

PAIP1_HUMAN :
  • Q9H074
Domain:
  • Only the PABPC1-interacting motif-1 (PAM1) stimulates translation initiation
  • Contains 1 MIF4G domain.
genes like me logo Genes that share domains with PAIP1: view

No data available for Gene Families for PAIP1 Gene

Function for PAIP1 Gene

Molecular function for PAIP1 Gene

UniProtKB/Swiss-Prot Function:
Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.

Gene Ontology (GO) - Molecular Function for PAIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0005488 binding --
GO:0005515 protein binding IPI 10970864
GO:0008494 translation activator activity IDA 9548260
genes like me logo Genes that share ontologies with PAIP1: view

Animal Model Products

miRNA for PAIP1 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PAIP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for PAIP1 Gene

Localization for PAIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PAIP1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PAIP1 Gene COMPARTMENTS Subcellular localization image for PAIP1 gene
Compartment Confidence
cytosol 4
nucleus 2

Gene Ontology (GO) - Cellular Components for PAIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 9548260
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PAIP1: view

Pathways for PAIP1 Gene

genes like me logo Genes that share pathways with PAIP1: view

Pathways by source for PAIP1 Gene

1 Qiagen pathway for PAIP1 Gene
1 BioSystems pathway for PAIP1 Gene
1 KEGG pathway for PAIP1 Gene

Gene Ontology (GO) - Biological Process for PAIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS --
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS --
GO:0006413 translational initiation TAS 9548260
GO:0010467 gene expression TAS --
GO:0016070 RNA metabolic process --
genes like me logo Genes that share ontologies with PAIP1: view

Compounds for PAIP1 Gene

(2) Novoseek inferred chemical compound relationships for PAIP1 Gene

Compound -log(P) Hits PubMed IDs
pabc 94.9 2
adenylate 60.8 2
genes like me logo Genes that share compounds with PAIP1: view

Transcripts for PAIP1 Gene

Unigene Clusters for PAIP1 Gene

Poly(A) binding protein interacting protein 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PAIP1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PAIP1 Gene

No ASD Table

Relevant External Links for PAIP1 Gene

GeneLoc Exon Structure for
PAIP1
ECgene alternative splicing isoforms for
PAIP1

Expression for PAIP1 Gene

mRNA expression in normal human tissues for PAIP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for PAIP1 Gene

This gene is overexpressed in Skin (6.6) and Heart (6.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PAIP1 Gene

SOURCE GeneReport for Unigene cluster for PAIP1 Gene Hs.482038

genes like me logo Genes that share expressions with PAIP1: view

Expression partners for PAIP1 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PAIP1 Gene

Orthologs for PAIP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PAIP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PAIP1 35
  • 93.79 (n)
  • 96.94 (a)
-- 36
  • 85 (a)
OneToMany
PAIP1 36
  • 95 (a)
OneToMany
dog
(Canis familiaris)
Mammalia PAIP1 35
  • 93.91 (n)
  • 96.85 (a)
PAIP1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Paip1 35
  • 92.86 (n)
  • 97.96 (a)
Paip1 16
Paip1 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PAIP1 35
  • 99.32 (n)
  • 99.74 (a)
PAIP1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Paip1 35
  • 92.46 (n)
  • 98.37 (a)
oppossum
(Monodelphis domestica)
Mammalia PAIP1 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PAIP1 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves PAIP1 35
  • 76.31 (n)
  • 80 (a)
PAIP1 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PAIP1 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia paip1 35
  • 65.21 (n)
  • 64.8 (a)
Str.1486 35
African clawed frog
(Xenopus laevis)
Amphibia paip1-pending-prov 35
zebrafish
(Danio rerio)
Actinopterygii paip1 35
  • 61.44 (n)
  • 61.03 (a)
wufb53g01 35
paip1 36
  • 59 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5680 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011627 35
  • 41.63 (n)
  • 29.54 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8963 35
  • 42.37 (n)
  • 30 (a)
CG8963 36
  • 19 (a)
OneToOne
Species with no ortholog for PAIP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PAIP1 Gene

ENSEMBL:
Gene Tree for PAIP1 (if available)
TreeFam:
Gene Tree for PAIP1 (if available)

Paralogs for PAIP1 Gene

Pseudogenes.org Pseudogenes for PAIP1 Gene

genes like me logo Genes that share paralogs with PAIP1: view

No data available for Paralogs for PAIP1 Gene

Variants for PAIP1 Gene

Sequence variations from dbSNP and Humsavar for PAIP1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs1053493 -- 43,527,032(-) CTTCG(C/T)CTGGA utr-variant-3-prime
rs4318791 -- 43,527,571(+) ACTGA(C/G)TTATA intron-variant
rs4349723 -- 43,527,781(+) AAGAT(C/T)GATAT intron-variant
rs4367306 -- 43,540,522(+) GCAAT(A/G)TATGT intron-variant
rs4386738 -- 43,550,931(+) TACAA(A/C)TATCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PAIP1 Gene

Variant ID Type Subtype PubMed ID
dgv6043n71 CNV Gain 21882294
nsv830275 CNV Gain 17160897
nsv823062 CNV Gain 20364138
esv2550683 CNV Insertion 19546169
nsv512851 CNV Insertion 21212237
esv270544 CNV Insertion 20981092
esv273191 CNV Insertion 20981092
esv2660584 CNV Deletion 23128226
esv27940 CNV Loss 19812545

Relevant External Links for PAIP1 Gene

HapMap Linkage Disequilibrium report
PAIP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PAIP1 Gene

Disorders for PAIP1 Gene

Relevant External Links for PAIP1

Genetic Association Database (GAD)
PAIP1

No disorders were found for PAIP1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for PAIP1 Gene

Publications for PAIP1 Gene

  1. A mechanism for translationally coupled mRNA turnover: interaction between the poly(A) tail and a c-fos RNA coding determinant via a protein complex. (PMID: 11051545) Grosset C. … Shyu A.-B. (Cell 2000) 3 4 23
  2. Translational repression by a novel partner of human poly(A) binding protein, Paip2. (PMID: 11172725) Khaleghpour K. … Sonenberg N. (Mol. Cell 2001) 3 4 23
  3. Paip1 interacts with poly(A) binding protein through two independent binding motifs. (PMID: 11997512) Roy G. … Sonenberg N. (Mol. Cell. Biol. 2002) 3 4 23
  4. Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation. (PMID: 9548260) Craig A.W.B. … Sonenberg N. (Nature 1998) 2 3 4
  5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4

Products for PAIP1 Gene

Sources for PAIP1 Gene

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