Aliases for SMC2 Gene
External Ids for SMC2 Gene
Previous HGNC Symbols for SMC2 Gene
Previous GeneCards Identifiers for SMC2 Gene
Members of the structural maintenance of chromosomes, or SMC, family (e.g., SMC1A; MIM 300040) are critical for mitotic chromosome condensation in frogs and for DNA repair in mammals.[supplied by OMIM, Nov 2010]
GeneCards Summary for SMC2 Gene
SMC2 (Structural Maintenance Of Chromosomes 2) is a Protein Coding gene. Diseases associated with SMC2 include Smith-Mccort Dysplasia 2. Among its related pathways are RB in Cancer and ATM Pathway. GO annotations related to this gene include protein heterodimerization activity.
UniProtKB/Swiss-Prot for SMC2 Gene
Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.