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Aliases for CENPA Gene

Aliases for CENPA Gene

  • Centromere Protein A 2 3 4 5
  • Centromere-Specific Histone 2 3
  • Centromere Protein A, 17kDa 2 3
  • Centromere Autoantigen A 3 4
  • CENP-A 3 4
  • Histone H3-Like Centromeric Protein A 2
  • Centromere Protein A (17kD) 2
  • CenH3 3

External Ids for CENPA Gene

Previous GeneCards Identifiers for CENPA Gene

  • GC02P026908
  • GC02P027080
  • GC02P026962
  • GC02P026963
  • GC02P026898
  • GC02P026920
  • GC02P026988

Summaries for CENPA Gene

Entrez Gene Summary for CENPA Gene

  • Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. This gene encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. Centromere protein A is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. The protein is a replication-independent histone that is a member of the histone H3 family. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2015]

GeneCards Summary for CENPA Gene

CENPA (Centromere Protein A) is a Protein Coding gene. Diseases associated with CENPA include systemic scleroderma and gastric antral vascular ectasia. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include protein heterodimerization activity and chromatin binding.

UniProtKB/Swiss-Prot for CENPA Gene

  • Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro).

Gene Wiki entry for CENPA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CENPA Gene

Genomics for CENPA Gene

Regulatory Elements for CENPA Gene

Promoters for CENPA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CENPA on UCSC Golden Path with GeneCards custom track

Genomic Location for CENPA Gene

Chromosome:
2
Start:
26,764,289 bp from pter
End:
26,801,067 bp from pter
Size:
36,779 bases
Orientation:
Plus strand

Genomic View for CENPA Gene

Genes around CENPA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CENPA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CENPA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CENPA Gene

Proteins for CENPA Gene

  • Protein details for CENPA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49450-CENPA_HUMAN
    Recommended name:
    Histone H3-like centromeric protein A
    Protein Accession:
    P49450
    Secondary Accessions:
    • D6W544
    • Q53T74
    • Q9BVW2

    Protein attributes for CENPA Gene

    Size:
    140 amino acids
    Molecular mass:
    15991 Da
    Quaternary structure:
    • Forms a nucleosome-like histone octamer containing two molecules each of H2A, H2B, CENPA and H4 assembled in one CENPA-H4 heterotetramer and two H2A-H2B heterodimers. Nucleosomes containing CENPA also contain histone H2A variants such as macroH2A H2AFY and H2A.Z/H2AFZ. The CENPA-H4 heterotetramer is more compact and structurally more rigid than corresponding H3-H4 heterotetramers. Heterotrimer composed of HJURP, CENPA and histone H4, where HJURP interacts with the dimer formed by CENPA and histone H4 and prevents tetramerization of CENPA and H4. Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. Interacts (via CATD domain) with HJURP; the interaction is direct and is required for its localization to centromeres. Interacts with CENPC, CENPN and CENPT; interaction is direct. Interacts directly with herpes virus HSV-1 ICP0 protein. Part of a centromere complex consisting of CENPA, CENPT and CENPW.
    Miscellaneous:
    • Antibodies against CENPA are present in sera from patients with autoimmune diseases that developed autoantibodies against centrosomal proteins.

    Three dimensional structures from OCA and Proteopedia for CENPA Gene

    Alternative splice isoforms for CENPA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CENPA Gene

Proteomics data for CENPA Gene at MOPED

Post-translational modifications for CENPA Gene

  • Phosphorylation of Ser-7 by AURKA and AURKB during prophase is required for localization of AURKA and AURKB at inner centromere and is essential for kinetochore function. Initial phosphorylation during prophase is mediated by AURKA and is maintained by AURKB.
  • Poly-ADP-ribosylated by PARP1.
  • Ubiquitinated (Probable). Interaction with herpes virus HSV-1 ICP0 protein, leads to its degradation by the proteasome pathway.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CENPA Gene

Antibody Products

No data available for DME Specific Peptides for CENPA Gene

Domains & Families for CENPA Gene

Protein Domains for CENPA Gene

Suggested Antigen Peptide Sequences for CENPA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P49450

UniProtKB/Swiss-Prot:

CENPA_HUMAN :
  • The CATD (CENPA targeting domain) region is responsible for the more compact structure of nucleosomes containing CENPA and is necessary and sufficient to mediate the localization into centromeres.
  • Belongs to the histone H3 family.
Domain:
  • The CATD (CENPA targeting domain) region is responsible for the more compact structure of nucleosomes containing CENPA and is necessary and sufficient to mediate the localization into centromeres.
Family:
  • Belongs to the histone H3 family.
genes like me logo Genes that share domains with CENPA: view

No data available for Gene Families for CENPA Gene

Function for CENPA Gene

Molecular function for CENPA Gene

GENATLAS Biochemistry:
centromeric protein A,histone H3 related,likely replaying H3 to form a centromere unique nucleosomal structure
UniProtKB/Swiss-Prot Function:
Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro).

Gene Ontology (GO) - Molecular Function for CENPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding TAS 7962047
genes like me logo Genes that share ontologies with CENPA: view
genes like me logo Genes that share phenotypes with CENPA: view

Animal Models for CENPA Gene

MGI Knock Outs for CENPA:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CENPA Gene

Localization for CENPA Gene

Subcellular locations from UniProtKB/Swiss-Prot for CENPA Gene

Nucleus. Chromosome, centromere, kinetochore. Note=Localizes exclusively in the kinetochore domain of centromeres. Occupies a compact domain at the inner kinetochore plate stretching across 2 thirds of the length of the constriction but encompassing only one third of the constriction width and height.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CENPA Gene COMPARTMENTS Subcellular localization image for CENPA gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CENPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000778 condensed nuclear chromosome kinetochore IDA 18195732
GO:0000939 condensed chromosome inner kinetochore IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CENPA: view

Pathways & Interactions for CENPA Gene

genes like me logo Genes that share pathways with CENPA: view

Pathways by source for CENPA Gene

Gene Ontology (GO) - Biological Process for CENPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0007062 sister chromatid cohesion TAS --
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with CENPA: view

No data available for SIGNOR curated interactions for CENPA Gene

Drugs & Compounds for CENPA Gene

(1) Drugs for CENPA Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for CENPA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CENPA: view

Transcripts for CENPA Gene

Unigene Clusters for CENPA Gene

Centromere protein A:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CENPA Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11
SP1:
SP2:
SP3: -
SP4: -
SP5: -
SP6: - - - - - - - - - - -
SP7: - - -

Relevant External Links for CENPA Gene

GeneLoc Exon Structure for
CENPA
ECgene alternative splicing isoforms for
CENPA

Expression for CENPA Gene

mRNA expression in normal human tissues for CENPA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CENPA Gene

This gene is overexpressed in Plasma (45.1) and NK cells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CENPA Gene



SOURCE GeneReport for Unigene cluster for CENPA Gene Hs.1594

genes like me logo Genes that share expression patterns with CENPA: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CENPA Gene

Orthologs for CENPA Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CENPA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CENPA 35
  • 97.34 (n)
  • 98.55 (a)
CENPA 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 50 (a)
OneToMany
-- 36
  • 80 (a)
OneToMany
-- 36
  • 68 (a)
OneToMany
-- 36
  • 74 (a)
OneToMany
CENPA 35
  • 82.13 (n)
  • 78.99 (a)
dog
(Canis familiaris)
Mammalia CENPA 35
  • 84.2 (n)
  • 79.26 (a)
CENPA 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cenpa 16
Cenpa 35
  • 72.09 (n)
  • 77.52 (a)
Cenpa 36
  • 63 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CENPA 36
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CENPA 36
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cenpa 35
  • 81.52 (n)
  • 81.19 (a)
chicken
(Gallus gallus)
Aves CENPA 36
  • 54 (a)
OneToOne
CENPA 35
  • 61.29 (n)
  • 62.9 (a)
lizard
(Anolis carolinensis)
Reptilia CENPA 36
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cenpa 35
  • 62.37 (n)
  • 67.74 (a)
zebrafish
(Danio rerio)
Actinopterygii seph 36
  • 52 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea cpar-1 36
  • 20 (a)
OneToMany
F20D6.9 36
  • 33 (a)
OneToMany
hcp-3 36
  • 19 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CSE4 36
  • 25 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3908 36
  • 32 (a)
OneToOne
Species with no ortholog for CENPA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CENPA Gene

ENSEMBL:
Gene Tree for CENPA (if available)
TreeFam:
Gene Tree for CENPA (if available)

Paralogs for CENPA Gene

genes like me logo Genes that share paralogs with CENPA: view

No data available for Paralogs for CENPA Gene

Variants for CENPA Gene

Sequence variations from dbSNP and Humsavar for CENPA Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs2289017 -- 26,793,035(+) GTGAA(C/T)AGTTT intron-variant
rs2289018 -- 26,793,101(+) AGCCC(A/C/G)TGGCC intron-variant
rs2196151 -- 26,789,626(+) ACTCC(C/T)CTCCA intron-variant
rs2217742 -- 26,789,296(+) AGTGG(A/G)CCTCT intron-variant
rs2117274 -- 26,791,310(+) ATTTC(C/T)AAATA intron-variant

Variation tolerance for CENPA Gene

Residual Variation Intolerance Score: 69.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.27; 6.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CENPA Gene

HapMap Linkage Disequilibrium report
CENPA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CENPA Gene

Disorders for CENPA Gene

MalaCards: The human disease database

(5) MalaCards diseases for CENPA Gene - From: DISEASES

Disorder Aliases PubMed IDs
systemic scleroderma
  • diffuse scleroderma
gastric antral vascular ectasia
  • watermelon stomach
limited scleroderma
  • limited cutaneous systemic sclerosis
collagen disease
  • collagen disorder
dyskinesia of esophagus
  • dyskinesia of oesophagus
- elite association - COSMIC cancer census association via MalaCards
Search CENPA in MalaCards View complete list of genes associated with diseases

Relevant External Links for CENPA

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CENPA
genes like me logo Genes that share disorders with CENPA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CENPA Gene

Publications for CENPA Gene

  1. HJURP is a cell-cycle-dependent maintenance and deposition factor of CENP-A at centromeres. (PMID: 19410545) Dunleavy E.M. … Almouzni-Pettinotti G. (Cell 2009) 3 4 23 67
  2. HJURP binds CENP-A via a highly conserved N-terminal domain and mediates its deposition at centromeres. (PMID: 20080577) Shuaib M. … Hamiche A. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 23
  3. CENP-A reduction induces a p53-dependent cellular senescence response to protect cells from executing defective mitoses. (PMID: 20160010) Maehara K. … Saitoh S. (Mol. Cell. Biol. 2010) 3 23
  4. Building centromeres: home sweet home or a nomadic existence? (PMID: 20206496) Buscaino A. … Pidoux A. (Curr. Opin. Genet. Dev. 2010) 3 23
  5. Double-strand DNA breaks recruit the centromeric histone CENP-A. (PMID: 19717431) Zeitlin S.G. … Cleveland D.W. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 23

Products for CENPA Gene

Sources for CENPA Gene

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