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Aliases for SLC34A2 Gene

Aliases for SLC34A2 Gene

  • Solute Carrier Family 34 Member 2 2 3 4
  • Solute Carrier Family 34 (Type II Sodium/Phosphate Cotransporter), Member 2 2 3 5
  • Solute Carrier Family 34 (Sodium Phosphate), Member 2 2 3
  • Sodium/Phosphate Cotransporter 2B 3 4
  • Type II Sodium-Dependent Phosphate Transporter 3b 3
  • Na(+)-Dependent Phosphate Cotransporter 2B 4
  • Sodium-Phosphate Transport Protein 2B 4
  • Na(+)/Pi Cotransporter 2B 4
  • NAPI-IIb 3
  • NAPI-3B 3
  • NaPi-2b 4
  • NPTIIb 3
  • NaPi3b 4

External Ids for SLC34A2 Gene

Previous GeneCards Identifiers for SLC34A2 Gene

  • GC04P025772
  • GC04P025345
  • GC04P025408
  • GC04P025333
  • GC04P025266
  • GC04P024995

Summaries for SLC34A2 Gene

Entrez Gene Summary for SLC34A2 Gene

  • The protein encoded by this gene is a pH-sensitive sodium-dependent phosphate transporter. Phosphate uptake is increased at lower pH. Defects in this gene are a cause of pulmonary alveolar microlithiasis. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, May 2010]

GeneCards Summary for SLC34A2 Gene

SLC34A2 (Solute Carrier Family 34 Member 2) is a Protein Coding gene. Diseases associated with SLC34A2 include pulmonary alveolar microlithiasis and testicular microlithiasis. Among its related pathways are Transport to the Golgi and subsequent modification and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include protein domain specific binding and phosphate ion binding. An important paralog of this gene is SLC34A1.

UniProtKB/Swiss-Prot for SLC34A2 Gene

  • May be involved in actively transporting phosphate into cells via Na(+) cotransport. It may be the main phosphate transport protein in the intestinal brush border membrane. May have a role in the synthesis of surfactant in lungs alveoli.

Gene Wiki entry for SLC34A2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC34A2 Gene

Genomics for SLC34A2 Gene

Regulatory Elements for SLC34A2 Gene

Genomic Location for SLC34A2 Gene

Chromosome:
4
Start:
25,655,301 bp from pter
End:
25,678,748 bp from pter
Size:
23,448 bases
Orientation:
Plus strand

Genomic View for SLC34A2 Gene

Genes around SLC34A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC34A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC34A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC34A2 Gene

Proteins for SLC34A2 Gene

  • Protein details for SLC34A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95436-NPT2B_HUMAN
    Recommended name:
    Sodium-dependent phosphate transport protein 2B
    Protein Accession:
    O95436
    Secondary Accessions:
    • A5PL17
    • Q8N2K2
    • Q8WYA9
    • Q9P0V7

    Protein attributes for SLC34A2 Gene

    Size:
    690 amino acids
    Molecular mass:
    75759 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC11354.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC34A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC34A2 Gene

Proteomics data for SLC34A2 Gene at MOPED

Post-translational modifications for SLC34A2 Gene

  • Glycosylation at Asn 295, Asn 308, Asn 313, Asn 321, and Asn 340
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC34A2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SLC34A2 (SLC34A2)

No data available for DME Specific Peptides for SLC34A2 Gene

Domains & Families for SLC34A2 Gene

Gene Families for SLC34A2 Gene

Protein Domains for SLC34A2 Gene

Suggested Antigen Peptide Sequences for SLC34A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95436

UniProtKB/Swiss-Prot:

NPT2B_HUMAN :
  • Belongs to the SLC34A transporter family.
Family:
  • Belongs to the SLC34A transporter family.
genes like me logo Genes that share domains with SLC34A2: view

Function for SLC34A2 Gene

Molecular function for SLC34A2 Gene

GENATLAS Biochemistry:
solute carrier family 34 (sodium/phosphate cotransport) member A2, (brain)
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 6.6. {ECO:0000269 PubMed:10329428};
UniProtKB/Swiss-Prot Function:
May be involved in actively transporting phosphate into cells via Na(+) cotransport. It may be the main phosphate transport protein in the intestinal brush border membrane. May have a role in the synthesis of surfactant in lungs alveoli.
UniProtKB/Swiss-Prot Induction:
Down-regulated by EGF.

Gene Ontology (GO) - Molecular Function for SLC34A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015321 sodium-dependent phosphate transmembrane transporter activity IEA,TAS --
genes like me logo Genes that share ontologies with SLC34A2: view
genes like me logo Genes that share phenotypes with SLC34A2: view

Human Phenotype Ontology for SLC34A2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for SLC34A2 Gene

MGI Knock Outs for SLC34A2:

Animal Model Products

CRISPR Products

miRNA for SLC34A2 Gene

miRTarBase miRNAs that target SLC34A2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SLC34A2 Gene

Localization for SLC34A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC34A2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC34A2 Gene COMPARTMENTS Subcellular localization image for SLC34A2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SLC34A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane NAS 10329428
GO:0016324 apical plasma membrane IDA 15970207
genes like me logo Genes that share ontologies with SLC34A2: view

Pathways & Interactions for SLC34A2 Gene

genes like me logo Genes that share pathways with SLC34A2: view

Interacting Proteins for SLC34A2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000371483%0d%0a9606.ENSP00000239690%0d%0a
Selected Interacting proteins: ENSP00000371483 for SLC34A2 Gene via STRING

Symbol External ID(s) Details
NUDCD1

SIGNOR curated interactions for SLC34A2 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for SLC34A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035435 phosphate ion transmembrane transport IDA 10329428
GO:0035725 sodium ion transmembrane transport IDA 10329428
GO:0055085 transmembrane transport IBA,TAS --
genes like me logo Genes that share ontologies with SLC34A2: view

Drugs & Compounds for SLC34A2 Gene

(1) Drugs for SLC34A2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(2) Additional Compounds for SLC34A2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
genes like me logo Genes that share compounds with SLC34A2: view

Transcripts for SLC34A2 Gene

Unigene Clusters for SLC34A2 Gene

Solute carrier family 34 (sodium phosphate), member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC34A2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: -
SP2:
SP3: -
SP4:

Relevant External Links for SLC34A2 Gene

GeneLoc Exon Structure for
SLC34A2
ECgene alternative splicing isoforms for
SLC34A2

Expression for SLC34A2 Gene

mRNA expression in normal human tissues for SLC34A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC34A2 Gene

This gene is overexpressed in Lung (x31.0) and Minor Salivary Gland (x10.9).

Protein differential expression in normal tissues from HIPED for SLC34A2 Gene

This gene is overexpressed in Lung (33.8) and Milk (19.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC34A2 Gene



SOURCE GeneReport for Unigene cluster for SLC34A2 Gene Hs.479372

mRNA Expression by UniProt/SwissProt for SLC34A2 Gene

O95436-NPT2B_HUMAN
Tissue specificity: Highly expressed in lung. Also detected in pancreas, kidney, small intestine, ovary, testis, prostate and mammary gland. In lung, it is found in alveolar type II cells but not in bronchiolar epithelium.
genes like me logo Genes that share expression patterns with SLC34A2: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for SLC34A2 Gene

Orthologs for SLC34A2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC34A2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC34A2 35
  • 80.9 (n)
  • 76.82 (a)
SLC34A2 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC34A2 35
  • 80.97 (n)
  • 79.44 (a)
SLC34A2 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc34a2 35
  • 80.72 (n)
  • 80.33 (a)
Slc34a2 16
Slc34a2 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC34A2 35
  • 99.28 (n)
  • 99.28 (a)
SLC34A2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc34a2 35
  • 81.11 (n)
  • 80.62 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 51 (a)
OneToMany
-- 36
  • 53 (a)
OneToMany
-- 36
  • 74 (a)
OneToMany
-- 36
  • 69 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SLC34A2 36
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC34A2 35
  • 65.54 (n)
  • 65.08 (a)
SLC34A2 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC34A2 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc34a2 35
  • 61.22 (n)
  • 62.9 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5596 35
zebrafish
(Danio rerio)
Actinopterygii slc34a2b 35
  • 64.25 (n)
  • 63.15 (a)
slc34a2a 36
  • 61 (a)
OneToMany
slc34a2b 36
  • 52 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ZK563.2 37
  • 40 (a)
ZK563.2 36
  • 32 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1462 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
-- 36
  • 50 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
Species with no ortholog for SLC34A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC34A2 Gene

ENSEMBL:
Gene Tree for SLC34A2 (if available)
TreeFam:
Gene Tree for SLC34A2 (if available)

Paralogs for SLC34A2 Gene

Paralogs for SLC34A2 Gene

(4) SIMAP similar genes for SLC34A2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLC34A2: view

Variants for SLC34A2 Gene

Sequence variations from dbSNP and Humsavar for SLC34A2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
VAR_030677 Pulmonary alveolar microlithiasis (PALM)
rs6448389 - 25,676,577(+) GTGTG(A/G)CTGCC reference, missense
rs35426730 - 25,662,726(+) ACCTG(C/T)AACCA reference, missense
rs1132584 -- 25,678,628(+) cgccc(A/C)cctca utr-variant-3-prime
rs1132601 -- 25,678,671(+) ccacc(A/C)ccagg utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SLC34A2 Gene

Variant ID Type Subtype PubMed ID
nsv878761 CNV Gain 21882294
nsv878765 CNV Gain 21882294
nsv526729 CNV Loss 19592680
nsv507156 CNV Insertion 20534489

Variation tolerance for SLC34A2 Gene

Residual Variation Intolerance Score: 16.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.63; 56.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC34A2 Gene

HapMap Linkage Disequilibrium report
SLC34A2
Human Gene Mutation Database (HGMD)
SLC34A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC34A2 Gene

Disorders for SLC34A2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SLC34A2 Gene - From: OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
pulmonary alveolar microlithiasis
  • pam
testicular microlithiasis
hypophosphatemic rickets with hypercalciuria
  • hereditary hypophosphatemic rickets with hypercalciuria
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

NPT2B_HUMAN
  • Note=A chromosomal aberration involving SLC34A2 is found in a glioblastoma multiforme cell line U-118MG. Results in the formation of a SLC34A2-ROS1 chimeric protein that retains a constitutive kinase activity. {ECO:0000269 PubMed:12661006}.
  • Pulmonary alveolar microlithiasis (PALM) [MIM:265100]: Rare disease characterized by the deposition of calcium phosphate microliths throughout the lungs. Most patients are asymptomatic for several years or even for decades and generally, the diagnosis is incidental to clinical investigations unrelated to the disease. Cases with early-onset or rapid progression are rare. A sandstorm-appearing chest roentgenogram is a typical diagnostic finding. The onset of this potentially lethal disease varies from the neonatal period to old age and the disease follows a long-term, progressive course, resulting in a slow deterioration of lung functions. Pulmonary alveolar microlithiasis is a recessive monogenic disease with full penetrance. {ECO:0000269 PubMed:16960801}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for SLC34A2

Human Genome Epidemiology (HuGE) Navigator
SLC34A2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC34A2
genes like me logo Genes that share disorders with SLC34A2: view

No data available for Genatlas for SLC34A2 Gene

Publications for SLC34A2 Gene

  1. Molecular cloning, functional characterization, tissue distribution, and chromosomal localization of a human, small intestinal sodium- phosphate (Na+-Pi) transporter (SLC34A2). (PMID: 10610722) Xu H. … Ghishan F.K. (Genomics 1999) 2 3 4 23 67
  2. [A novel mutation of the SLC34A2 gene in a Chinese pedigree with pulmonary alveolar microlithiasis]. (PMID: 20017296) Zhong Y.Q. … Nie H.P. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2009) 3 23
  3. Regulation of intestinal NaPi-IIb cotransporter gene expression by estrogen. (PMID: 12893629) Xu H. … Ghishan F.K. (Am. J. Physiol. Gastrointest. Liver Physiol. 2003) 3 23
  4. Regulation of the human sodium-phosphate cotransporter NaPi-IIb gene promoter by epidermal growth factor. (PMID: 11171583) Xu H. … Ghishan F.K. (Am. J. Physiol. 2001) 3 23
  5. Cloning and functional characterization of a sodium-dependent phosphate transporter expressed in human lung and small intestine. (PMID: 10329428) Feild J.A. … Edwards R.M. (Biochem. Biophys. Res. Commun. 1999) 2 3

Products for SLC34A2 Gene

Sources for SLC34A2 Gene

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