Aliases for CEL Gene
- Carboxyl Ester Lipase 2 3 4 5
- Bile Salt-Stimulated Lipase 2 4
- Cholesterol Esterase 3 4
- Sterol Esterase 3 4
- Bucelipase 3 4
- BSSL 3 4
- BAL 3 4
- Carboxyl Ester Lipase (Bile Salt-Stimulated Lipase) 3
- Bile Salt-Dependent Lipase, Oncofetal Isoform 3
- Fetoacinar Pancreatic Protein 3
- Lysophospholipase, Pancreatic 3
- Pancreatic Lysophospholipase 4
External Ids for CEL Gene
Previous GeneCards Identifiers for CEL Gene
The protein encoded by this gene is a glycoprotein secreted from the pancreas into the digestive tract and from the lactating mammary gland into human milk. The physiological role of this protein is in cholesterol and lipid-soluble vitamin ester hydrolysis and absorption. This encoded protein promotes large chylomicron production in the intestine. Also its presence in plasma suggests its interactions with cholesterol and oxidized lipoproteins to modulate the progression of atherosclerosis. In pancreatic tumoral cells, this encoded protein is thought to be sequestrated within the Golgi compartment and is probably not secreted. This gene contains a variable number of tandem repeat (VNTR) polymorphism in the coding region that may influence the function of the encoded protein. [provided by RefSeq, Jul 2008]
GeneCards Summary for CEL Gene
CEL (Carboxyl Ester Lipase) is a Protein Coding gene. Diseases associated with CEL include Maturity-Onset Diabetes Of The Young, Type Viii and Maturity-Onset Diabetes Of The Young. Among its related pathways are Pancreatic secretion and cholesterol biosynthesis II (via 24,25-dihydrolanosterol). GO annotations related to this gene include hydrolase activity and carboxylic ester hydrolase activity. An important paralog of this gene is CES2.
UniProtKB/Swiss-Prot for CEL Gene
Catalyzes fat and vitamin absorption. Acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides.
Lipases are esterase enzymes that catalyze the hydrolysis of ester bonds within hydrophobic lipids. The diverse class of lipase enzymes includes diacylglycerol lipase (DAGL) and lipoprotein lipase (LPL) and endothelial lipase (LIPG).