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Aliases for PRDX4 Gene

Aliases for PRDX4 Gene

  • Peroxiredoxin 4 2 3 5
  • Thioredoxin-Dependent Peroxide Reductase A0372 3 4
  • Thioredoxin Peroxidase AO372 3 4
  • Antioxidant Enzyme AOE372 3 4
  • Peroxiredoxin IV 3 4
  • EC 1.11.1.15 4 56
  • AOE37-2 3 4
  • Prx-IV 3 4
  • Epididymis Secretory Sperm Binding Protein Li 97n 3
  • Thioredoxin Peroxidase (Antioxidant Enzyme) 3
  • Peroxiredoxin-4 3
  • HEL-S-97n 3
  • AOE372 3
  • PRX-4 3

External Ids for PRDX4 Gene

Previous GeneCards Identifiers for PRDX4 Gene

  • GC0XP022492
  • GC0XP022256
  • GC0XP022884
  • GC0XP023047
  • GC0XP023445
  • GC0XP021425

Summaries for PRDX4 Gene

Entrez Gene Summary for PRDX4 Gene

  • The protein encoded by this gene is an antioxidant enzyme and belongs to the peroxiredoxin family. The protein is localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. This protein has been found to play a regulatory role in the activation of the transcription factor NF-kappaB. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRDX4 Gene

PRDX4 (Peroxiredoxin 4) is a Protein Coding gene. Diseases associated with PRDX4 include Hypoascorbemia. Among its related pathways are Innate Immune System and Prostaglandin 2 biosynthesis and metabolism FM. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and antioxidant activity. An important paralog of this gene is PRDX3.

UniProtKB/Swiss-Prot for PRDX4 Gene

  • Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation.

Gene Wiki entry for PRDX4 Gene

Additional gene information for PRDX4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRDX4 Gene

Genomics for PRDX4 Gene

GeneHancer (GH) Regulatory Elements for PRDX4 Gene

Promoters and enhancers for PRDX4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI023666 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 558.8 +3.4 3396 2.7 SMAD1 ZNF133 ARID4B SIN3A DMAP1 ZNF2 BRCA1 ZNF48 YY1 KLF7 PRDX4 PTCHD1 ACOT9
GH0XI023662 Enhancer 0.5 ENCODE 550.8 -1.9 -1861 0.2 PKNOX1 ZNF146 BCL11A IKZF1 IKZF2 RUNX3 PRDX4 GC0XP023549
GH0XI023633 Enhancer 0.5 ENCODE 8.3 -30.3 -30315 0.9 CTCF GATA3 ZNF654 SMC3 RAD21 PRDX4 GC0XP023549
GH0XI023627 Enhancer 0.2 ENCODE 5.6 -36.2 -36249 0.9 PRDX4 GC0XP023549
GH0XI023741 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 0.2 +78.5 78525 2.7 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 POLR2B ZNF213 ZNF143 SP3 ACOT9 POLA1 RPL9P7 ZFX LOC105373148 PRDX4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PRDX4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRDX4 gene promoter:

Genomic Locations for PRDX4 Gene

Genomic Locations for PRDX4 Gene
chrX:23,664,260-23,686,399
(GRCh38/hg38)
Size:
22,140 bases
Orientation:
Plus strand
chrX:23,682,379-23,704,516
(GRCh37/hg19)

Genomic View for PRDX4 Gene

Genes around PRDX4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRDX4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRDX4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRDX4 Gene

Proteins for PRDX4 Gene

  • Protein details for PRDX4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13162-PRDX4_HUMAN
    Recommended name:
    Peroxiredoxin-4
    Protein Accession:
    Q13162
    Secondary Accessions:
    • Q6FHT3

    Protein attributes for PRDX4 Gene

    Size:
    271 amino acids
    Molecular mass:
    30540 Da
    Quaternary structure:
    • Homodimer; disulfide-linked, upon oxidation (PubMed:9388242). 5 homodimers assemble to form a ring-like decamer (PubMed:21994946). Can form heterodimers with PRDX1 (PubMed:9388242).
    Miscellaneous:
    • The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this typical 2-Cys peroxiredoxin, C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.

    Three dimensional structures from OCA and Proteopedia for PRDX4 Gene

neXtProt entry for PRDX4 Gene

Selected DME Specific Peptides for PRDX4 Gene

Q13162:
  • HGEVCPA
  • LRLVQAFQ
  • VGRSVDE
  • IDDKGILR
  • EVCPAGWKPG
  • NDLPVGR
  • GRSVDET
  • RGLFIID
  • DFTFVCP
  • HLAWINTPR

Post-translational modifications for PRDX4 Gene

  • The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) and sulphonic acid (C(P)-SO3H) instead of its condensation to a disulfide bond.

Other Protein References for PRDX4 Gene

Antibody Products

  • R&D Systems Antibodies for PRDX4 (Peroxiredoxin 4)

Domains & Families for PRDX4 Gene

Gene Families for PRDX4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for PRDX4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13162

UniProtKB/Swiss-Prot:

PRDX4_HUMAN :
  • Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
Family:
  • Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
genes like me logo Genes that share domains with PRDX4: view

Function for PRDX4 Gene

Molecular function for PRDX4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
2 R-SH + ROOH = R-S-S-R + H(2)O + ROH.
UniProtKB/Swiss-Prot Function:
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation.

Enzyme Numbers (IUBMB) for PRDX4 Gene

Gene Ontology (GO) - Molecular Function for PRDX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17644091
GO:0008379 thioredoxin peroxidase activity TAS 9388242
GO:0016209 antioxidant activity IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0042803 protein homodimerization activity IEA --
genes like me logo Genes that share ontologies with PRDX4: view
genes like me logo Genes that share phenotypes with PRDX4: view

Animal Models for PRDX4 Gene

MGI Knock Outs for PRDX4:

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRDX4 Gene

Localization for PRDX4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRDX4 Gene

Cytoplasm. Endoplasmic reticulum. Note=Cotranslationally translocated to and retained within the endoplasmic reticulum. A small fraction of the protein is cytoplasmic. {ECO:0000269 PubMed:18052930}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRDX4 gene
Compartment Confidence
extracellular 5
nucleus 5
endoplasmic reticulum 4
cytosol 4
mitochondrion 3
plasma membrane 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Endoplasmic reticulum (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PRDX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
GO:0005623 cell IEA --
GO:0005634 nucleus IDA,HDA 21630459
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PRDX4: view

Pathways & Interactions for PRDX4 Gene

genes like me logo Genes that share pathways with PRDX4: view

Pathways by source for PRDX4 Gene

1 BioSystems pathway for PRDX4 Gene
3 Reactome pathways for PRDX4 Gene
1 GeneGo (Thomson Reuters) pathway for PRDX4 Gene

Gene Ontology (GO) - Biological Process for PRDX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007252 I-kappaB phosphorylation TAS 9388242
GO:0007283 spermatogenesis IEA --
GO:0008584 male gonad development IEA --
GO:0019471 4-hydroxyproline metabolic process IEA --
GO:0022417 protein maturation by protein folding IEA --
genes like me logo Genes that share ontologies with PRDX4: view

No data available for SIGNOR curated interactions for PRDX4 Gene

Drugs & Compounds for PRDX4 Gene

(8) Drugs for PRDX4 Gene - From: PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Docetaxel Approved May 1996, Investigational Pharma Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes 2040
Water Approved Pharma 0

(9) Additional Compounds for PRDX4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PRDX4: view

Transcripts for PRDX4 Gene

Unigene Clusters for PRDX4 Gene

Peroxiredoxin 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRDX4 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8
SP1: - -
SP2: - - -
SP3: -
SP4: - - - - - - -
SP5: -

Relevant External Links for PRDX4 Gene

GeneLoc Exon Structure for
PRDX4
ECgene alternative splicing isoforms for
PRDX4

Expression for PRDX4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRDX4 Gene

mRNA differential expression in normal tissues according to GTEx for PRDX4 Gene

This gene is overexpressed in Pancreas (x7.1) and Liver (x4.8).

Protein differential expression in normal tissues from HIPED for PRDX4 Gene

This gene is overexpressed in Fetal testis (7.7) and Testis (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PRDX4 Gene



Protein tissue co-expression partners for PRDX4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PRDX4 Gene:

PRDX4

SOURCE GeneReport for Unigene cluster for PRDX4 Gene:

Hs.83383

Evidence on tissue expression from TISSUES for PRDX4 Gene

  • Liver(4.5)
  • Nervous system(4.5)
  • Kidney(4.4)
  • Pancreas(3)
  • Lung(2.3)
  • Intestine(2.1)
  • Heart(2)
  • Skin(2)
genes like me logo Genes that share expression patterns with PRDX4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRDX4 Gene

Orthologs for PRDX4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PRDX4 Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia PRDX4 34
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PRDX4 33 34
  • 90.79 (n)
rat
(Rattus norvegicus)
Mammalia Prdx4 33
  • 90.34 (n)
dog
(Canis familiaris)
Mammalia PRDX4 33 34
  • 89.18 (n)
mouse
(Mus musculus)
Mammalia Prdx4 33 16 34
  • 89.08 (n)
oppossum
(Monodelphis domestica)
Mammalia PRDX4 34
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves PRDX4 33 34
  • 81.6 (n)
lizard
(Anolis carolinensis)
Reptilia PRDX4 34
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prdx4 33
  • 81.13 (n)
Str.7399 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.14602 33
zebrafish
(Danio rerio)
Actinopterygii prdx4 33 34
  • 74.81 (n)
wufb59c09 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12199 33
fruit fly
(Drosophila melanogaster)
Insecta Jafrac1 35
  • 68 (a)
Jafrac2 35 33 34
  • 64.36 (n)
Prx5037 35
  • 60 (a)
CG6888 35
  • 56 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta TPX3 33
  • 65.9 (n)
worm
(Caenorhabditis elegans)
Secernentea R07E5.2 35
  • 57 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TSA1 34
  • 55 (a)
ManyToMany
TSA2 34
  • 53 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 76 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10388 33
Species where no ortholog for PRDX4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRDX4 Gene

ENSEMBL:
Gene Tree for PRDX4 (if available)
TreeFam:
Gene Tree for PRDX4 (if available)

Paralogs for PRDX4 Gene

Paralogs for PRDX4 Gene

(3) SIMAP similar genes for PRDX4 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for PRDX4 Gene

genes like me logo Genes that share paralogs with PRDX4: view

Variants for PRDX4 Gene

Sequence variations from dbSNP and Humsavar for PRDX4 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000057586 -- 23,669,993(+) T/C intron_variant
rs1000229469 -- 23,669,324(+) C/T intron_variant
rs1000450838 -- 23,677,777(+) C/T intron_variant
rs1000802169 -- 23,678,074(+) C/T intron_variant
rs1000887249 -- 23,684,460(+) A/G/T 3_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PRDX4 Gene

Variant ID Type Subtype PubMed ID
nsv526897 CNV gain 19592680

Variation tolerance for PRDX4 Gene

Residual Variation Intolerance Score: 37.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.76; 33.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRDX4 Gene

Human Gene Mutation Database (HGMD)
PRDX4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRDX4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRDX4 Gene

Disorders for PRDX4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PRDX4 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
hypoascorbemia
  • scurvy
- elite association - COSMIC cancer census association via MalaCards
Search PRDX4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PRDX4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PRDX4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRDX4 Gene

Publications for PRDX4 Gene

  1. Regulatory role for a novel human thioredoxin peroxidase in NF-kappaB activation. (PMID: 9388242) Jin DY … Jeang KT (The Journal of biological chemistry 1997) 2 3 4 22 58
  2. Peroxiredoxin IV is an endoplasmic reticulum-localized enzyme forming oligomeric complexes in human cells. (PMID: 18052930) Tavender TJ … Bulleid NJ (The Biochemical journal 2008) 3 4 22 58
  3. Structural insights into the peroxidase activity and inactivation of human peroxiredoxin 4. (PMID: 21916849) Wang X … Wang CC (The Biochemical journal 2012) 3 4 58
  4. Crystal structure of reduced and of oxidized peroxiredoxin IV enzyme reveals a stable oxidized decamer and a non-disulfide-bonded intermediate in the catalytic cycle. (PMID: 21994946) Cao Z … Bulleid NJ (The Journal of biological chemistry 2011) 3 4 58
  5. SNPs in genes coding for ROS metabolism and signalling in association with docetaxel clearance. (PMID: 20157331) Edvardsen H … Kristensen VN (The pharmacogenomics journal 2010) 3 44 58

Products for PRDX4 Gene

Sources for PRDX4 Gene

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