Aliases for PRDX4 Gene
Aliases for PRDX4 Gene
External Ids for PRDX4 Gene
- HGNC: 17169
- Entrez Gene: 10549
- Ensembl: ENSG00000123131
- OMIM: 300927
- UniProtKB: Q13162
Previous GeneCards Identifiers for PRDX4 Gene
- GC0XP022492
- GC0XP022256
- GC0XP022884
- GC0XP023047
- GC0XP023445
- GC0XP021425
Summaries for PRDX4 Gene
-
The protein encoded by this gene is an antioxidant enzyme and belongs to the peroxiredoxin family. The protein is localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. This protein has been found to play a regulatory role in the activation of the transcription factor NF-kappaB. [provided by RefSeq, Jul 2008]
GeneCards Summary for PRDX4 Gene
PRDX4 (Peroxiredoxin 4) is a Protein Coding gene. Diseases associated with PRDX4 include Hypoascorbemia. Among its related pathways are Innate Immune System and Prostaglandin 2 biosynthesis and metabolism FM. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and antioxidant activity. An important paralog of this gene is PRDX3.
UniProtKB/Swiss-Prot for PRDX4 Gene
-
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation.
Additional gene information for PRDX4 Gene
- Monarch Initiative
- Search for PRDX4 at DataMed
- Search for PRDX4 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRDX4 Gene
Genomics for PRDX4 Gene
GeneHancer (GH) Regulatory Elements for PRDX4 Gene
Promoters and enhancers for PRDX4 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH0XI023666 | Promoter/Enhancer | 1.9 | EPDnew Ensembl ENCODE | 558.8 | +3.4 | 3396 | 2.7 | SMAD1 ZNF133 ARID4B SIN3A DMAP1 ZNF2 BRCA1 ZNF48 YY1 KLF7 | PRDX4 PTCHD1 ACOT9 | |
| GH0XI023662 | Enhancer | 0.5 | ENCODE | 550.8 | -1.9 | -1861 | 0.2 | PKNOX1 ZNF146 BCL11A IKZF1 IKZF2 RUNX3 | PRDX4 GC0XP023549 | |
| GH0XI023633 | Enhancer | 0.5 | ENCODE | 8.3 | -30.3 | -30315 | 0.9 | CTCF GATA3 ZNF654 SMC3 RAD21 | PRDX4 GC0XP023549 | |
| GH0XI023627 | Enhancer | 0.2 | ENCODE | 5.6 | -36.2 | -36249 | 0.9 | PRDX4 GC0XP023549 | ||
| GH0XI023741 | Promoter/Enhancer | 2 | EPDnew Ensembl ENCODE | 0.2 | +78.5 | 78525 | 2.7 | HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 POLR2B ZNF213 ZNF143 SP3 | ACOT9 POLA1 RPL9P7 ZFX LOC105373148 PRDX4 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around PRDX4 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for PRDX4 Gene
Genomic Locations for PRDX4 Gene
- chrX:23,664,260-23,686,399
- (GRCh38/hg38)
- Size:
- 22,140 bases
- Orientation:
- Plus strand
- chrX:23,682,379-23,704,516
- (GRCh37/hg19)
Genomic View for PRDX4 Gene
Genes around PRDX4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xp22.11 by Ensembl
- Xp22.11 by Entrez Gene
- Xp22.11 by HGNC
PRDX4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PRDX4 Gene
Proteins for PRDX4 Gene
-
Protein details for PRDX4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q13162-PRDX4_HUMAN
- Recommended name:
- Peroxiredoxin-4
- Protein Accession:
- Q13162
- Q6FHT3
Protein attributes for PRDX4 Gene
- Size:
- 271 amino acids
- Molecular mass:
- 30540 Da
- Quaternary structure:
-
- Homodimer; disulfide-linked, upon oxidation (PubMed:9388242). 5 homodimers assemble to form a ring-like decamer (PubMed:21994946). Can form heterodimers with PRDX1 (PubMed:9388242).
- Miscellaneous:
-
- The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this typical 2-Cys peroxiredoxin, C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
Protein Expression for PRDX4 Gene
Selected DME Specific Peptides for PRDX4 Gene
- Q13162:
-
- HGEVCPA
- LRLVQAFQ
- VGRSVDE
- IDDKGILR
- EVCPAGWKPG
- NDLPVGR
- GRSVDET
- RGLFIID
- DFTFVCP
- HLAWINTPR
Post-translational modifications for PRDX4 Gene
- The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) and sulphonic acid (C(P)-SO3H) instead of its condensation to a disulfide bond.
Other Protein References for PRDX4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for PRDX4 (Peroxiredoxin 4)
- Novus Biologicals Antibodies for PRDX4
-
Abcam antibodies for PRDX4
-
Cloud-Clone Corp. Antibodies for PRDX4
- Invitrogen Antibodies for PRDX4
- GeneTex PRDX4 antibody for PRDX4
-
Santa Cruz Biotechnology (SCBT) Antibodies for PRDX4
Protein Products
-
OriGene Purified Proteins for PRDX4
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-
Cloud-Clone Corp. Proteins for PRDX4
- Search GeneTex for Proteins for PRDX4
-
ProSci Proteins for PRDX4
-
Abcam proteins for PRDX4
Assay Products
-
Cloud-Clone Corp. Assay Kits for PRDX4
Domains & Families for PRDX4 Gene
Gene Families for PRDX4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Enzymes
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for PRDX4 Gene
Suggested Antigen Peptide Sequences for PRDX4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q13162- Family:
-
- Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
Function for PRDX4 Gene
Molecular function for PRDX4 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- 2 R-SH + ROOH = R-S-S-R + H(2)O + ROH.
- UniProtKB/Swiss-Prot Function:
- Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation.
Enzyme Numbers (IUBMB) for PRDX4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 17644091 |
| GO:0008379 | thioredoxin peroxidase activity | TAS | 9388242 |
| GO:0016209 | antioxidant activity | IEA | -- |
| GO:0016491 | oxidoreductase activity | IEA | -- |
| GO:0042803 | protein homodimerization activity | IEA | -- |
Phenotypes for PRDX4 Gene
- MGI mutant phenotypes for PRDX4:
- inferred from 2 alleles
Animal Models for PRDX4 Gene
- MGI Knock Outs for PRDX4:
-
- Prdx4 tm1.1Jufu
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for PRDX4
-
-
ViGene Biosciences lentiviral particle packaged cDNA for PRDX4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PRDX4 gene
- Search ViGene Biosciences for PRDX4
CRISPR Products
-
OriGene CRISPR knockouts for PRDX4
- Applied Biological Materials CRISPR for PRDX4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRDX4
- GenScript: Design CRISPR guide RNA sequences for PRDX4
miRNA for PRDX4 Gene
- miRTarBase miRNAs that target PRDX4
miRNA Products
- Search ViGene Biosciences for PRDX4
Inhibitory RNA Products
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-
ViGene Biosciences ready-to-package AAV shRNAs for PRDX4 gene
Clone Products
- Sino Biological Human cDNA Clone for PRDX4
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- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PRDX4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for 127 available Peroxiredoxin 4 gene related products
- Overview of 127 available Peroxiredoxin 4 gene related products
- orf clones - Search results for 127 available Peroxiredoxin 4 gene related products
- Overview of 127 available Peroxiredoxin 4 gene related products
- Applied Biological Materials Clones for PRDX4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for PRDX4
-
ViGene Biosciences adenoviral particle packaged cDNA for PRDX4 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PRDX4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PRDX4 gene
No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRDX4 Gene
Localization for PRDX4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PRDX4 Gene
- Cytoplasm. Endoplasmic reticulum. Note=Cotranslationally translocated to and retained within the endoplasmic reticulum. A small fraction of the protein is cytoplasmic. {ECO:0000269 PubMed:18052930}.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| endoplasmic reticulum | 4 |
| cytosol | 4 |
| mitochondrion | 3 |
| plasma membrane | 1 |
| peroxisome | 1 |
- Cytosol (3)
- Endoplasmic reticulum (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IEA | -- |
| GO:0005623 | cell | IEA | -- |
| GO:0005634 | nucleus | IDA,HDA | 21630459 |
| GO:0005737 | cytoplasm | IEA | -- |
Pathways & Interactions for PRDX4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Innate Immune System |
.61
|
|
| 2 | Prostaglandin 2 biosynthesis and metabolism FM | ||
| 3 | Folate Metabolism | ||
Pathways by source for PRDX4 Gene
1 BioSystems pathway for PRDX4 Gene
3 Reactome pathways for PRDX4 Gene
1 GeneGo (Thomson Reuters) pathway for PRDX4 Gene
Interacting Proteins for PRDX4 Gene
Selected Interacting proteins:
ENSP00000368646
Q13162-PRDX4_HUMAN
for PRDX4 Gene via
STRING
IID
UniProtKB
MINT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007252 | I-kappaB phosphorylation | TAS | 9388242 |
| GO:0007283 | spermatogenesis | IEA | -- |
| GO:0008584 | male gonad development | IEA | -- |
| GO:0019471 | 4-hydroxyproline metabolic process | IEA | -- |
| GO:0022417 | protein maturation by protein folding | IEA | -- |
No data available for SIGNOR curated interactions for PRDX4 Gene
Drugs & Compounds for PRDX4 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for PRDX4 Gene
mRNA/cDNA for PRDX4 Gene
- (4) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (356) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for PRDX4
- Applied Biological Materials CRISPR for PRDX4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRDX4
- GenScript: Design CRISPR guide RNA sequences for PRDX4
miRNA Products
- Search ViGene Biosciences for PRDX4
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PRDX4
- Browse OriGene Inhibitory RNA Products For PRDX4
-
ViGene Biosciences ready-to-package AAV shRNAs for PRDX4 gene
Clone Products
- Sino Biological Human cDNA Clone for PRDX4
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for PRDX4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PRDX4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for 127 available Peroxiredoxin 4 gene related products
- Overview of 127 available Peroxiredoxin 4 gene related products
- orf clones - Search results for 127 available Peroxiredoxin 4 gene related products
- Overview of 127 available Peroxiredoxin 4 gene related products
- Applied Biological Materials Clones for PRDX4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | ||||||||||||||||||||||
| SP5: | - |
Expression for PRDX4 Gene
mRNA differential expression in normal tissues according to GTEx for PRDX4 Gene
This gene is overexpressed in Pancreas (x7.1) and Liver (x4.8).
This gene is overexpressed in Fetal testis (7.7) and Testis (6.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PRDX4 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of PRDX4 Gene:
PRDX4SOURCE GeneReport for Unigene cluster for PRDX4 Gene:
Hs.83383Evidence on tissue expression from TISSUES for PRDX4 Gene
- Liver(4.5)
- Nervous system(4.5)
- Kidney(4.4)
- Pancreas(3)
- Lung(2.3)
- Intestine(2.1)
- Heart(2)
- Skin(2)
Primer Products
-
OriGene qPCR primer pairs for PRDX4
-
OriGene qPCR primer pairs and template standards for PRDX4
- genomics-online: primer clones - Search results for 127 available Peroxiredoxin 4 gene related products
- Overview of 127 available Peroxiredoxin 4 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRDX4 Gene
Orthologs for PRDX4 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| platypus (Ornithorhynchus anatinus) |
Mammalia | PRDX4 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | PRDX4 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Prdx4 33 |
|
||
| dog (Canis familiaris) |
Mammalia | PRDX4 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Prdx4 33 16 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PRDX4 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PRDX4 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | PRDX4 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | prdx4 33 |
|
||
| Str.7399 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.14602 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | prdx4 33 34 |
|
||
| wufb59c09 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.12199 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Jafrac1 35 |
|
|
|
| Jafrac2 35 33 34 |
|
||||
| Prx5037 35 |
|
|
|||
| CG6888 35 |
|
|
|||
| African malaria mosquito (Anopheles gambiae) |
Insecta | TPX3 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | R07E5.2 35 |
|
|
|
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | TSA1 34 |
|
ManyToMany | |
| TSA2 34 |
|
ManyToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne | |
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.10388 33 |
|
- Species where no ortholog for PRDX4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for PRDX4 Gene
(3) SIMAP similar genes for PRDX4 Gene using alignment to 4 proteins:
Pseudogenes.org Pseudogenes for PRDX4 Gene
Variants for PRDX4 Gene
| SNP ID | Clin | Chr 0X pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000057586 | -- | 23,669,993(+) | T/C | intron_variant | |
| rs1000229469 | -- | 23,669,324(+) | C/T | intron_variant | |
| rs1000450838 | -- | 23,677,777(+) | C/T | intron_variant | |
| rs1000802169 | -- | 23,678,074(+) | C/T | intron_variant | |
| rs1000887249 | -- | 23,684,460(+) | A/G/T | 3_prime_UTR_variant, intron_variant |
Residual Variation Intolerance Score:
37.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.76;
33.30% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PRDX4 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRDX4 Gene
Disorders for PRDX4 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hypoascorbemia |
|
|
Search PRDX4 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PRDX4
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for PRDX4 Gene
Publications for PRDX4 Gene
- Regulatory role for a novel human thioredoxin peroxidase in NF-kappaB activation. (PMID: 9388242) Jin DY … Jeang KT (The Journal of biological chemistry 1997) 2 3 4 22 58
- Peroxiredoxin IV is an endoplasmic reticulum-localized enzyme forming oligomeric complexes in human cells. (PMID: 18052930) Tavender TJ … Bulleid NJ (The Biochemical journal 2008) 3 4 22 58
- Structural insights into the peroxidase activity and inactivation of human peroxiredoxin 4. (PMID: 21916849) Wang X … Wang CC (The Biochemical journal 2012) 3 4 58
- Crystal structure of reduced and of oxidized peroxiredoxin IV enzyme reveals a stable oxidized decamer and a non-disulfide-bonded intermediate in the catalytic cycle. (PMID: 21994946) Cao Z … Bulleid NJ (The Journal of biological chemistry 2011) 3 4 58
- SNPs in genes coding for ROS metabolism and signalling in association with docetaxel clearance. (PMID: 20157331) Edvardsen H … Kristensen VN (The pharmacogenomics journal 2010) 3 44 58
Products for PRDX4 Gene
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for PRDX4
- VectorBuilder custom plasmid, inducible vectors for PRDX4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PRDX4
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available Peroxiredoxin 4 related products ranked by validation data
- antibodies-online: Search results for 23 available Peroxiredoxin 4 Elisa Kits ranked by validation data
- Compare Top Peroxiredoxin 4 Elisa Kits
- Quality Products:
- antibodies-online: Search results for 25 available Peroxiredoxin 4 Proteins ranked by validation data
- Compare Top Peroxiredoxin 4 Proteins
- GeneTex PRDX4 antibody for PRDX4
- Search GeneTex for Proteins for PRDX4
- ViGene Biosciences adenoviral particle packaged cDNA for PRDX4 gene
- ViGene Biosciences lentiviral particle packaged cDNA for PRDX4 gene
- ViGene Biosciences ready-to-package AAV shRNAs for PRDX4 gene
- Search ViGene Biosciences for PRDX4
- Santa Cruz Biotechnology (SCBT) Antibodies for PRDX4
- Search Santa Cruz Biotechnology (SCBT) for PRDX4 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PRDX4
- Search for PRDX4 Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for PRDX4
- Horizon Cell Lines for PRDX4
- genomics-online: cdna clones - Search results for 127 available Peroxiredoxin 4 gene related products
- Overview of 127 available Peroxiredoxin 4 gene related products
- orf clones - Search results for 127 available Peroxiredoxin 4 gene related products
- Overview of 127 available Peroxiredoxin 4 gene related products
- genomics-online: gRNA clones - Search results for 127 available Peroxiredoxin 4 gene related products
- Overview of 127 available Peroxiredoxin 4 gene related products
- genomics-online: primer clones - Search results for 127 available Peroxiredoxin 4 gene related products
- Overview of 127 available Peroxiredoxin 4 gene related products
- genomics-online: shRNA clones - Search results for 127 available Peroxiredoxin 4 gene related products
- Overview of 127 available Peroxiredoxin 4 gene related products
Sources for PRDX4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew