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Aliases for ANP32B Gene

Aliases for ANP32B Gene

  • Acidic (Leucine-Rich) Nuclear Phosphoprotein 32 Family, Member B 2 3
  • Acidic Protein Rich In Leucines 2 3 4
  • Putative HLA-DR-Associated Protein I-2 3 4
  • Silver-Stainable Protein SSP29 3 4
  • PHAPI2 3 4
  • APRIL 3 4
  • Acidic Leucine-Rich Nuclear Phosphoprotein 32 Family Member B 3
  • SSP29 3

External Ids for ANP32B Gene

Previous GeneCards Identifiers for ANP32B Gene

  • GC09P091570
  • GC09P092489
  • GC09P094202
  • GC09P096125
  • GC09P097825
  • GC09P099785
  • GC09P100745

Summaries for ANP32B Gene

GeneCards Summary for ANP32B Gene

ANP32B (Acidic (Leucine-Rich) Nuclear Phosphoprotein 32 Family, Member B) is a Protein Coding gene. An important paralog of this gene is ANP32A.

UniProtKB/Swiss-Prot for ANP32B Gene

  • Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity (By similarity). Exhibits histone chaperone properties, stimulating core histones to assemble into a nucleosome.

Gene Wiki entry for ANP32B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANP32B Gene

Genomics for ANP32B Gene

Regulatory Elements for ANP32B Gene

Genomic Location for ANP32B Gene

Start:
97,983,207 bp from pter
End:
98,015,943 bp from pter
Size:
32,737 bases
Orientation:
Plus strand

Genomic View for ANP32B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANP32B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANP32B Gene

Proteins for ANP32B Gene

  • Protein details for ANP32B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92688-AN32B_HUMAN
    Recommended name:
    Acidic leucine-rich nuclear phosphoprotein 32 family member B
    Protein Accession:
    Q92688
    Secondary Accessions:
    • B2R9C7
    • O00655
    • P78458
    • P78459

    Protein attributes for ANP32B Gene

    Size:
    251 amino acids
    Molecular mass:
    28788 Da
    Quaternary structure:
    • Monomer. Interacts with histones H3 and H4.

    Three dimensional structures from OCA and Proteopedia for ANP32B Gene

    Alternative splice isoforms for ANP32B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANP32B Gene

Proteomics data for ANP32B Gene at MOPED

Post-translational modifications for ANP32B Gene

  • Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group (By similarity).
  • Ubiquitination at Lys86, Lys99, and Lys101
  • Modification sites at PhosphoSitePlus

Other Protein References for ANP32B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ANP32B Gene

Domains for ANP32B Gene

Gene Families for ANP32B Gene

HGNC:
  • ANP32 :ANP32 acidic nuclear phosphoproteins

Protein Domains for ANP32B Gene

Suggested Antigen Peptide Sequences for ANP32B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92688

UniProtKB/Swiss-Prot:

AN32B_HUMAN :
  • Q92688
Domain:
  • Histone binding is mediated by the concave surface of the LRR region
  • Contains 1 LRRCT domain.
Family:
  • Belongs to the ANP32 family.
Similarity:
  • Contains 4 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with ANP32B: view

Function for ANP32B Gene

Molecular function for ANP32B Gene

UniProtKB/Swiss-Prot Function: Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity (By similarity). Exhibits histone chaperone properties, stimulating core histones to assemble into a nucleosome.

Gene Ontology (GO) - Molecular Function for ANP32B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21988832
GO:0042393 histone binding IDA 20538007
GO:0070063 RNA polymerase binding IDA 9285060
genes like me logo Genes that share ontologies with ANP32B: view
genes like me logo Genes that share phenotypes with ANP32B: view

Animal Models for ANP32B Gene

MGI Knock Outs for ANP32B:

miRNA for ANP32B Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ANP32B Gene

Localization for ANP32B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANP32B Gene

Isoform 1: Nucleus. Note=Accumulates in the nuclei at the S phase. {ECO:0000250}.
Isoform 2: Cytoplasm. Note=Lacks a nuclear localization signal.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANP32B Gene COMPARTMENTS Subcellular localization image for ANP32B gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ANP32B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16791210
GO:0005730 colocalizes_with nucleolus IDA 9285060
GO:0005737 cytoplasm IDA 17178712
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with ANP32B: view

Pathways for ANP32B Gene

SuperPathways for ANP32B Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANP32B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001944 vasculature development IEA --
GO:0006334 nucleosome assembly IDA 20538007
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IMP 20015864
GO:0021591 ventricular system development IEA --
GO:0045596 negative regulation of cell differentiation IDA 22705300
genes like me logo Genes that share ontologies with ANP32B: view

No data available for Pathways by source for ANP32B Gene

Transcripts for ANP32B Gene

mRNA/cDNA for ANP32B Gene

Unigene Clusters for ANP32B Gene

Acidic (leucine-rich) nuclear phosphoprotein 32 family, member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANP32B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1: -
SP2: -
SP3:

Relevant External Links for ANP32B Gene

GeneLoc Exon Structure for
ANP32B
ECgene alternative splicing isoforms for
ANP32B

Expression for ANP32B Gene

mRNA expression in normal human tissues for ANP32B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ANP32B Gene

SOURCE GeneReport for Unigene cluster for ANP32B Gene Hs.730654

mRNA Expression by UniProt/SwissProt for ANP32B Gene

Q92688-AN32B_HUMAN
Tissue specificity: Expressed in heart, lung, pancreas, prostate and in spleen, thymus and placenta.
genes like me logo Genes that share expressions with ANP32B: view

No data available for mRNA differential expression in normal tissues for ANP32B Gene

Orthologs for ANP32B Gene

This gene was present in the common ancestor of animals.

Orthologs for ANP32B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANP32B 35
  • 99.87 (n)
  • 99.6 (a)
ANP32B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ANP32B 35
  • 94.17 (n)
  • 98.12 (a)
ANP32B 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANP32B 35
  • 84.27 (n)
  • 80 (a)
ANP32B 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Anp32b 16
Anp32b 36
  • 80 (a)
OneToMany
Gm5263 36
  • 79 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia ANP32B 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANP32B 36
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANP32B 36
  • 60 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia ANP32B 36
  • 75 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6758 35
tropical clawed frog
(Silurana tropicalis)
Amphibia anp32b 35
  • 78.54 (n)
  • 90 (a)
Str.20236 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5197 35
zebrafish
(Danio rerio)
Actinopterygii anp32b 35
  • 77.92 (n)
  • 89.37 (a)
anp32b 36
  • 77 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Mapmodulin 36
  • 31 (a)
OneToMany
Mapmodulin 37
  • 54 (a)
worm
(Caenorhabditis elegans)
Secernentea F33H2.3 36
  • 35 (a)
ManyToMany
T19H12.2 36
  • 32 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12721 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11188 36
  • 43 (a)
OneToMany
Species with no ortholog for ANP32B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANP32B Gene

ENSEMBL:
Gene Tree for ANP32B (if available)
TreeFam:
Gene Tree for ANP32B (if available)

Paralogs for ANP32B Gene

Paralogs for ANP32B Gene

Selected SIMAP similar genes for ANP32B Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ANP32B Gene

genes like me logo Genes that share paralogs with ANP32B: view

Variants for ANP32B Gene

Sequence variations from dbSNP and Humsavar for ANP32B Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs872251 -- 97,995,061(+) TCAAT(A/G)AGTAG intron-variant
rs957955 -- 97,985,329(-) GGCCC(C/G)CCCCG intron-variant
rs3215934 -- 97,994,609(+) TATCC(-/T)TTTTT intron-variant
rs3739672 -- 97,983,620(-) AGGGG(C/T)CTCTG intron-variant
rs3739673 -- 97,983,483(-) GGCTT(A/G)CGCAG utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ANP32B Gene

Variant ID Type Subtype PubMed ID
nsv893612 CNV Loss 21882294
esv2540773 CNV Deletion 19546169
esv4458 CNV Deletion 18987735
esv2738816 CNV Deletion 23290073
nsv416479 CNV Loss 16902084
esv1007178 CNV Deletion 20482838
esv1721459 CNV Deletion 17803354
esv7209 CNV Loss 19470904

Relevant External Links for ANP32B Gene

HapMap Linkage Disequilibrium report
ANP32B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANP32B Gene

Disorders for ANP32B Gene

Relevant External Links for ANP32B

Genetic Association Database (GAD)
ANP32B
genes like me logo Genes that share disorders with ANP32B: view

No data available for UniProtKB/Swiss-Prot for ANP32B Gene

Publications for ANP32B Gene

  1. Expression analysis and chromosomal mapping of a novel human gene, APRIL, encoding an acidic protein rich in leucines. (PMID: 9473664) Mencinger M. … Aman P. (Biochim. Biophys. Acta 1998) 2 3 4 23
  2. Cloning and characterization of a new silver-stainable protein SSP29, a member of the LRR family. (PMID: 9285060) Zhu L. … Valdez B.C. (Biochem. Mol. Biol. Int. 1997) 2 3 23
  3. Analysis of nucleocytoplasmic trafficking of the HuR ligand APRIL and its influence on CD83 expression. (PMID: 17178712) Fries B. … Chemnitz J. (J. Biol. Chem. 2007) 3 23
  4. Phosphorylation of the HuR ligand APRIL by casein kinase 2 regulates CD83 expression. (PMID: 19130553) Chemnitz J. … Hauber J. (Eur. J. Immunol. 2009) 3 23
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4

Products for ANP32B Gene

Sources for ANP32B Gene

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