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Aliases for GLRX3 Gene

Aliases for GLRX3 Gene

  • Glutaredoxin 3 2 3 5
  • PKC-Interacting Cousin Of Thioredoxin 3 4
  • PKC-Theta-Interacting Protein 3 4
  • Thioredoxin-Like Protein 2 3 4
  • PKCq-Interacting Protein 3 4
  • Glutaredoxin 4 2 3
  • TXNL2 3 4
  • PICOT 3 4
  • Testicular Tissue Protein Li 75 3
  • Thioredoxin-Like 2 2
  • Glutaredoxin-3 3
  • GLRX4 3
  • TXNL3 3
  • GRX3 3
  • GRX4 3

External Ids for GLRX3 Gene

Previous HGNC Symbols for GLRX3 Gene

  • TXNL2

Previous GeneCards Identifiers for GLRX3 Gene

  • GC10P131826
  • GC10P131934
  • GC10P125514

Summaries for GLRX3 Gene

Entrez Gene Summary for GLRX3 Gene

  • This gene encodes a member of the glutaredoxin family. Glutaredoxins are oxidoreductase enzymes that reduce a variety of substrates using glutathione as a cofactor. The encoded protein binds to and modulates the function of protein kinase C theta. The encoded protein may also inhibit apoptosis and play a role in cellular growth, and the expression of this gene may be a marker for cancer. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 9. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for GLRX3 Gene

GLRX3 (Glutaredoxin 3) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and protein kinase C binding.

UniProtKB/Swiss-Prot for GLRX3 Gene

  • Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (PubMed:26613676, PubMed:27519415). Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). Required for hemoglobin maturation (PubMed:23615448). Does not posses any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity.

Gene Wiki entry for GLRX3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLRX3 Gene

Genomics for GLRX3 Gene

Regulatory Elements for GLRX3 Gene

Enhancers for GLRX3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G130108 1.1 ENCODE 10.8 -25.7 -25733 3.5 HDGF PKNOX1 FOXA2 CREB3L1 WRNIP1 SIN3A ARID4B DMAP1 ZNF2 YY1 LINC00959 GLRX3 CTAGE7P
GH10G130105 0.7 ENCODE 13 -30.4 -30444 0.2 HIC1 ZNF366 PATZ1 FOSL2 PRDM10 KLF8 ZBTB10 SCRT1 NRF1 ZEB2 PPIAP32 GLRX3 CTAGE7P ENSG00000277218
GH10G130636 0.8 Ensembl 10.5 +500.0 500026 0.8 PKNOX1 DDX20 ZBTB40 ZNF316 KDM5B NFE2 NFE2L2 CEBPZ PHF8 ZBTB11 GLRX3 LOC105378562 PIR57116
GH10G130189 1.2 Ensembl ENCODE 6.4 +54.1 54076 1.7 HDGF ARNT SIN3A ZNF2 ZNF48 GLIS2 ZNF766 ZNF143 ZNF207 PAF1 GLRX3 PIR61521
GH10G130135 1.1 ENCODE 6.2 +1.1 1124 3.7 PKNOX1 FOXA2 ARID4B SIN3A ZNF2 ZBTB7B YY1 ZNF143 FOS KLF13 GLRX3 PPIAP32 PIR61521
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GLRX3 on UCSC Golden Path with GeneCards custom track

Promoters for GLRX3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000035292 325 1401 ARID4B SIN3A ZNF2 ZNF48 ZBTB7B YY1 ETS1 GLIS2 ELK1 ZNF143

Genomic Location for GLRX3 Gene

Chromosome:
10
Start:
130,136,375 bp from pter
End:
130,184,521 bp from pter
Size:
48,147 bases
Orientation:
Plus strand

Genomic View for GLRX3 Gene

Genes around GLRX3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLRX3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLRX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLRX3 Gene

Proteins for GLRX3 Gene

  • Protein details for GLRX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O76003-GLRX3_HUMAN
    Recommended name:
    Glutaredoxin-3
    Protein Accession:
    O76003
    Secondary Accessions:
    • B3KMP7
    • B3KMQ5
    • D3DRG2
    • Q5JV01
    • Q96CE0
    • Q9P1B0
    • Q9P1B1

    Protein attributes for GLRX3 Gene

    Size:
    335 amino acids
    Molecular mass:
    37432 Da
    Quaternary structure:
    • Homodimer; the homodimer is independent of 2Fe-2S clusters (PubMed:27519415). Heterotrimer; forms a heterotrimeric complex composed by two BOLA2 molecules and one GLRX3 molecule; linked by [2Fe-2S] clusters (PubMed:22309771, PubMed:26613676, PubMed:27519415). Interacts (via N-terminus) with PRKCQ/PKC-theta (PubMed:10636891). Interacts (via C-terminus) with CSRP3 (By similarity). Interacts with CSRP2 (By similarity).
    Miscellaneous:
    • Silencing of Grx3 in HeLa cells decreases the activities of several cytosolic Fe/S proteins, such as ACO1, a major component of post-transcriptional iron regulation. As a consequence, Grx3-depleted cells show decreased levels of ferritin and increased levels of transferrin receptor, features characteristic of cellular iron starvation (PubMed:23615448).

    Three dimensional structures from OCA and Proteopedia for GLRX3 Gene

neXtProt entry for GLRX3 Gene

Post-translational modifications for GLRX3 Gene

  • Ubiquitination at Lys240
  • Modification sites at PhosphoSitePlus

Other Protein References for GLRX3 Gene

Antibody Products

  • R&D Systems Antibodies for GLRX3 (Glutaredoxin 3/GLRX3)

No data available for DME Specific Peptides for GLRX3 Gene

Domains & Families for GLRX3 Gene

Suggested Antigen Peptide Sequences for GLRX3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O76003

UniProtKB/Swiss-Prot:

GLRX3_HUMAN :
  • The thioredoxin domain lacks the two redox-active cysteines. This strongly suggests that it lacks thioredoxin activity.
Domain:
  • The thioredoxin domain lacks the two redox-active cysteines. This strongly suggests that it lacks thioredoxin activity.
genes like me logo Genes that share domains with GLRX3: view

No data available for Gene Families for GLRX3 Gene

Function for GLRX3 Gene

Molecular function for GLRX3 Gene

UniProtKB/Swiss-Prot Function:
Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (PubMed:26613676, PubMed:27519415). Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). Required for hemoglobin maturation (PubMed:23615448). Does not posses any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity.

Gene Ontology (GO) - Molecular Function for GLRX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0005080 protein kinase C binding IEA --
GO:0005515 protein binding IPI 10636891
GO:0009055 electron carrier activity IEA --
GO:0015035 protein disulfide oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with GLRX3: view
genes like me logo Genes that share phenotypes with GLRX3: view

Animal Model Products

CRISPR Products

miRNA for GLRX3 Gene

miRTarBase miRNAs that target GLRX3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GLRX3 Gene

Localization for GLRX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLRX3 Gene

Cytoplasm, cytosol. Cytoplasm, cell cortex. Cytoplasm, myofibril, sarcomere, Z line. Note=Under the plasma membrane (By similarity). After PMA stimulation, GLRX3 and PRKCQ/PKC-theta translocate to a more extended submembrane area (By similarity). In the Z line, found associated with CSRP3 (By similarity). {ECO:0000250 UniProtKB:Q9CQM9}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GLRX3 gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 4
plasma membrane 2
mitochondrion 2
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for GLRX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IEA --
GO:0005938 cell cortex IEA --
GO:0030018 Z disc IEA --
genes like me logo Genes that share ontologies with GLRX3: view

Pathways & Interactions for GLRX3 Gene

SuperPathways for GLRX3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GLRX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002026 regulation of the force of heart contraction ISS 18258855
GO:0010614 negative regulation of cardiac muscle hypertrophy ISS --
GO:0044571 [2Fe-2S] cluster assembly IDA 27519415
GO:0045454 cell redox homeostasis IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with GLRX3: view

No data available for Pathways by source and SIGNOR curated interactions for GLRX3 Gene

Drugs & Compounds for GLRX3 Gene

(1) Drugs for GLRX3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for GLRX3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GLRX3: view

Transcripts for GLRX3 Gene

Unigene Clusters for GLRX3 Gene

Glutaredoxin 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GLRX3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - -
SP2:
SP3: - - -
SP4: -
SP5:

Relevant External Links for GLRX3 Gene

GeneLoc Exon Structure for
GLRX3
ECgene alternative splicing isoforms for
GLRX3

Expression for GLRX3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GLRX3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GLRX3 Gene



Protein tissue co-expression partners for GLRX3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GLRX3 Gene:

GLRX3

SOURCE GeneReport for Unigene cluster for GLRX3 Gene:

Hs.42644

mRNA Expression by UniProt/SwissProt for GLRX3 Gene:

O76003-GLRX3_HUMAN
Tissue specificity: Expressed in heart, spleen, testis and, to a lower extent, in thymus and peripheral blood leukocytes. Weakly expressed in lung, placenta, colon and small intestine.

Evidence on tissue expression from TISSUES for GLRX3 Gene

  • Liver(4.3)
  • Skin(4.3)
  • Spleen(4.3)
  • Bone marrow(4.2)
  • Nervous system(4)
  • Heart(2.2)
genes like me logo Genes that share expression patterns with GLRX3: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for GLRX3 Gene

Orthologs for GLRX3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GLRX3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GLRX3 34 35
  • 99.5 (n)
rat
(Rattus norvegicus)
Mammalia Glrx3 34
  • 90.99 (n)
dog
(Canis familiaris)
Mammalia GLRX3 34 35
  • 90.78 (n)
mouse
(Mus musculus)
Mammalia Glrx3 34 16 35
  • 90.46 (n)
cow
(Bos Taurus)
Mammalia GLRX3 34 35
  • 90.15 (n)
oppossum
(Monodelphis domestica)
Mammalia GLRX3 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves GLRX3 34 35
  • 79.04 (n)
lizard
(Anolis carolinensis)
Reptilia GLRX3 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia glrx3 34
  • 72.87 (n)
Str.7370 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.9203 34
zebrafish
(Danio rerio)
Actinopterygii glrx3 34 35
  • 68.99 (n)
wufb38e09 34
fruit fly
(Drosophila melanogaster)
Insecta CG6523 35
  • 45 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea glrx-3 34 35
  • 57.27 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GRX4 34 35 37
  • 52.33 (n)
GRX3 35
  • 33 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C17842g 34
  • 52.24 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR111W 34
  • 51.74 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G04950 34
  • 58.5 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6485 34
rice
(Oryza sativa)
Liliopsida Os10g0500700 34
  • 54.55 (n)
Os.11576 34
barley
(Hordeum vulgare)
Liliopsida Hv.4967 34
wheat
(Triticum aestivum)
Liliopsida Ta.20390 34
corn
(Zea mays)
Liliopsida Zm.7955 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9660 35
  • 56 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes grx4 34
  • 52.45 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU09803 34
  • 51.83 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13908 34
Species where no ortholog for GLRX3 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for GLRX3 Gene

ENSEMBL:
Gene Tree for GLRX3 (if available)
TreeFam:
Gene Tree for GLRX3 (if available)

Paralogs for GLRX3 Gene

Pseudogenes.org Pseudogenes for GLRX3 Gene

genes like me logo Genes that share paralogs with GLRX3: view

No data available for Paralogs for GLRX3 Gene

Variants for GLRX3 Gene

Sequence variations from dbSNP and Humsavar for GLRX3 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000010287 -- 130,134,554(+) AAAAC(C/T)GAATA nc-transcript-variant, upstream-variant-2KB
rs1000017786 -- 130,137,073(+) AGCTA(G/T)GCCTG intron-variant, upstream-variant-2KB
rs1000107260 -- 130,171,703(+) GCTCA(C/T)GTCTA intron-variant
rs1000163844 -- 130,155,141(+) GGGCC(A/G)TTTGA intron-variant
rs1000164874 -- 130,163,438(+) AAACA(C/T)ATTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GLRX3 Gene

Variant ID Type Subtype PubMed ID
nsv1048253 CNV gain 25217958
nsv825630 CNV gain 20364138
nsv832024 CNV loss 17160897

Variation tolerance for GLRX3 Gene

Residual Variation Intolerance Score: 36.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.33; 88.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GLRX3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GLRX3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLRX3 Gene

Disorders for GLRX3 Gene

Relevant External Links for GLRX3

Genetic Association Database (GAD)
GLRX3
Human Genome Epidemiology (HuGE) Navigator
GLRX3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GLRX3

No disorders were found for GLRX3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GLRX3 Gene

Publications for GLRX3 Gene

  1. Characterization of 16 novel human genes showing high similarity to yeast sequences. (PMID: 11124703) Stanchi F. … Valle G. (Yeast 2001) 2 3 4 64
  2. Inhibition of the c-Jun N-terminal kinase/AP-1 and NF-kappaB pathways by PICOT, a novel protein kinase C-interacting protein with a thioredoxin homology domain. (PMID: 10636891) Witte S. … Altman A. (J. Biol. Chem. 2000) 2 3 4 64
  3. A glutaredoxin-BolA complex serves as an iron-sulfur cluster chaperone for the cytosolic cluster assembly machinery. (PMID: 27519415) Frey A.G. … Philpott C.C. (J. Biol. Chem. 2017) 3 4 64
  4. Elucidating the Molecular Function of Human BOLA2 in GRX3-Dependent Anamorsin Maturation Pathway. (PMID: 26613676) Banci L. … Muzzioli R. (J. Am. Chem. Soc. 2015) 3 4 64
  5. Crucial function of vertebrate glutaredoxin 3 (PICOT) in iron homeostasis and hemoglobin maturation. (PMID: 23615448) Haunhorst P. … Lillig C.H. (Mol. Biol. Cell 2013) 3 4 64

Products for GLRX3 Gene

Sources for GLRX3 Gene

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