Aliases for GLRX3 Gene
External Ids for GLRX3 Gene
Previous HGNC Symbols for GLRX3 Gene
Previous GeneCards Identifiers for GLRX3 Gene
This gene encodes a member of the glutaredoxin family. Glutaredoxins are oxidoreductase enzymes that reduce a variety of substrates using glutathione as a cofactor. The encoded protein binds to and modulates the function of protein kinase C theta. The encoded protein may also inhibit apoptosis and play a role in cellular growth, and the expression of this gene may be a marker for cancer. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 9. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]
GeneCards Summary for GLRX3 Gene
GLRX3 (Glutaredoxin 3) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and protein kinase C binding.
UniProtKB/Swiss-Prot for GLRX3 Gene
Critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). Crucial regulator of cellular iron homeostasis and hemoglobin maturation. May play a role in regulating the function of the thioredoxin system. Does not posses any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity.