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Aliases for BATF Gene

Aliases for BATF Gene

  • Basic Leucine Zipper ATF-Like Transcription Factor 2 3 5
  • Basic Leucine Zipper Transcription Factor, ATF-Like 2 3
  • B-Cell-Activating Transcription Factor 3 4
  • Activating Transcription Factor B 2 3
  • SF-HT-Activated Gene 2 Protein 3 4
  • B-ATF 3 4
  • SFA-2 3 4
  • Basic Leucine Zipper Transcriptional Factor ATF-Like 3
  • SF-HT-Activated Gene 2 2
  • BATF1 3
  • SFA2 3

External Ids for BATF Gene

Previous GeneCards Identifiers for BATF Gene

  • GC14P073494
  • GC14P069805
  • GC14P073978
  • GC14P075058
  • GC14P075988
  • GC14P056156

Summaries for BATF Gene

Entrez Gene Summary for BATF Gene

  • The protein encoded by this gene is a nuclear basic leucine zipper protein that belongs to the AP-1/ATF superfamily of transcription factors. The leucine zipper of this protein mediates dimerization with members of the Jun family of proteins. This protein is thought to be a negative regulator of AP-1/ATF transcriptional events. [provided by RefSeq, Jul 2008]

GeneCards Summary for BATF Gene

BATF (Basic Leucine Zipper ATF-Like Transcription Factor) is a Protein Coding gene. Among its related pathways are Cytokine Signaling in Immune system and MAP Kinase Signaling. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is BATF3.

UniProtKB/Swiss-Prot for BATF Gene

  • AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5-TGA[CG]TCA-3. The BATF-JUNB heterodimer also forms a complex with IRF4 (or IRF8) in immune cells, leading to recognition of AICE sequence (5-TGAnTCA/GAAA-3), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 (or IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells) by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and RORC target genes such as IL17 (IL17A or IL17B). Also involved in differentiation of follicular T-helper cells (TfH) by directing expression of BCL6 and MAF. In B-cells, involved in class-switch recombination (CSR) by controlling the expression of both AICDA and of germline transcripts of the intervening heavy-chain region and constant heavy-chain region (I(H)-C(H)). Following infection, can participate in CD8(+) dendritic cell differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation. Regulates effector CD8(+) T-cell differentiation by regulating expression of SIRT1. Following DNA damage, part of a differentiation checkpoint that limits self-renewal of hematopoietic stem cells (HSCs): up-regulated by STAT3, leading to differentiation of HSCs, thereby restricting self-renewal of HSCs (By similarity).

Gene Wiki entry for BATF Gene

Additional gene information for BATF Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BATF Gene

Genomics for BATF Gene

Regulatory Elements for BATF Gene

Enhancers for BATF Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H075535 1.9 FANTOM5 Ensembl ENCODE dbSUPER 17.1 +13.9 13905 2 PKNOX1 FOXA2 MLX SIN3A FEZF1 YY1 ZNF207 FOS DEK REST BATF TTLL5 FOS PIR35535
GH14H075519 1.6 FANTOM5 ENCODE dbSUPER 17.7 +0.0 8 5 HDGF PKNOX1 FOXA2 SIN3A ZNF766 ZNF143 FOS ATF7 RUNX3 REST BATF LOC102724153 FLVCR2 JDP2 TTLL5 FOS PIR35535
GH14H075549 1.3 FANTOM5 ENCODE dbSUPER 21.7 +26.9 26890 0 PKNOX1 ZNF687 TBL1XR1 CBFB MAX JUNB EBF1 RELA IKZF1 EED BATF FLVCR2 LOC102724153 JDP2 TTLL5 PIR35535
GH14H075497 1 FANTOM5 ENCODE 25.5 -25.0 -24959 0 MAX BATF RELA EED ETV6 RUNX3 IKZF2 CREM ZNF687 CBFB BATF JDP2 ERG28 LOC105370572 LOC101928377
GH14H075340 1.4 FANTOM5 Ensembl ENCODE 14.8 -181.1 -181125 3 ZNF175 MAX BATF RAD21 ZNF316 NFE2 MAFK MAFG USF2 NR3C1 BATF JDP2 FLVCR2 FOS LINC01220
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BATF on UCSC Golden Path with GeneCards custom track

Promoters for BATF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000070938 175 401 HDGF PKNOX1 FOXA2 TBL1XR1 RB1 SIN3A ZNF766 ZNF143 ATF7 ETV6

Genomic Location for BATF Gene

Chromosome:
14
Start:
75,522,425 bp from pter
End:
75,547,015 bp from pter
Size:
24,591 bases
Orientation:
Plus strand

Genomic View for BATF Gene

Genes around BATF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BATF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BATF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BATF Gene

Proteins for BATF Gene

  • Protein details for BATF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16520-BATF_HUMAN
    Recommended name:
    Basic leucine zipper transcriptional factor ATF-like
    Protein Accession:
    Q16520

    Protein attributes for BATF Gene

    Size:
    125 amino acids
    Molecular mass:
    14120 Da
    Quaternary structure:
    • Heterodimer; mainly heterodimerizes with JUNB. The BATF-JUNB heterodimer interacts with IRF4 and IRF8. Interacts (via bZIP domain) with IRF4 and IRF8; the interaction is direct (By similarity). Also forms heterodimers with JUN and JUND. Also interacts with IFI35.

neXtProt entry for BATF Gene

Post-translational modifications for BATF Gene

  • Phosphorylated on serine and threonine residues and at least one tyrosine residue. Phosphorylation at Ser-43 inhibit DNA binding activity and transforms it as a negative regulator of AP-1 mediated transcription (By similarity).
  • Phosphorylated.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BATF Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BATF Gene

Domains & Families for BATF Gene

Gene Families for BATF Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for BATF Gene

Suggested Antigen Peptide Sequences for BATF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16520

UniProtKB/Swiss-Prot:

BATF_HUMAN :
  • Belongs to the bZIP family.
Family:
  • Belongs to the bZIP family.
genes like me logo Genes that share domains with BATF: view

Function for BATF Gene

Molecular function for BATF Gene

GENATLAS Biochemistry:
activation transcription factor expressed on B and T cells after induction respectively by EB virus and HTLV1,ATF/AP-1 family
UniProtKB/Swiss-Prot Function:
AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5-TGA[CG]TCA-3. The BATF-JUNB heterodimer also forms a complex with IRF4 (or IRF8) in immune cells, leading to recognition of AICE sequence (5-TGAnTCA/GAAA-3), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 (or IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells) by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and RORC target genes such as IL17 (IL17A or IL17B). Also involved in differentiation of follicular T-helper cells (TfH) by directing expression of BCL6 and MAF. In B-cells, involved in class-switch recombination (CSR) by controlling the expression of both AICDA and of germline transcripts of the intervening heavy-chain region and constant heavy-chain region (I(H)-C(H)). Following infection, can participate in CD8(+) dendritic cell differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation. Regulates effector CD8(+) T-cell differentiation by regulating expression of SIRT1. Following DNA damage, part of a differentiation checkpoint that limits self-renewal of hematopoietic stem cells (HSCs): up-regulated by STAT3, leading to differentiation of HSCs, thereby restricting self-renewal of HSCs (By similarity).
UniProtKB/Swiss-Prot Induction:
Up-regulated by PDCD1 following infection by HIV-1 virus, leading to inhibit T-cell functions and exhaust T-cells. Up-regulated by Epstein-Barr virus (EBV) protein EBNA2 following infection by EBV.

Phenotypes From GWAS Catalog for BATF Gene

Gene Ontology (GO) - Molecular Function for BATF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA --
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA,ISS --
GO:0005515 protein binding IPI 8954125
genes like me logo Genes that share ontologies with BATF: view
genes like me logo Genes that share phenotypes with BATF: view

Animal Models for BATF Gene

MGI Knock Outs for BATF:

Animal Model Products

CRISPR Products

miRNA for BATF Gene

miRTarBase miRNAs that target BATF
Targeted motifs for BATF Gene
HOMER Transcription Factor Regulatory Elements motif BATF
  • Consensus sequence: DATGASTCAT Submotif: canonical Cell Type: Th17 GEO ID: GSE39756

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for BATF
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for BATF Gene

Localization for BATF Gene

Subcellular locations from UniProtKB/Swiss-Prot for BATF Gene

Nucleus. Cytoplasm. Note=Present in the nucleus and cytoplasm, but shows increased nuclear translocation after activation of T-cells. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BATF gene
Compartment Confidence
nucleus 5
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for BATF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm IDA,TAS --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with BATF: view

Pathways & Interactions for BATF Gene

genes like me logo Genes that share pathways with BATF: view

Pathways by source for BATF Gene

Gene Ontology (GO) - Biological Process for BATF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001816 cytokine production IEA,ISS --
GO:0002320 lymphoid progenitor cell differentiation IEA,ISS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with BATF: view

No data available for SIGNOR curated interactions for BATF Gene

Drugs & Compounds for BATF Gene

(3) Drugs for BATF Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
genes like me logo Genes that share compounds with BATF: view

Transcripts for BATF Gene

mRNA/cDNA for BATF Gene

Unigene Clusters for BATF Gene

Basic leucine zipper transcription factor, ATF-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for BATF
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for BATF Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1: -
SP2:

Relevant External Links for BATF Gene

GeneLoc Exon Structure for
BATF
ECgene alternative splicing isoforms for
BATF

Expression for BATF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BATF Gene

mRNA differential expression in normal tissues according to GTEx for BATF Gene

This gene is overexpressed in Whole Blood (x13.4) and Spleen (x4.4).

Protein differential expression in normal tissues from HIPED for BATF Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BATF Gene



Protein tissue co-expression partners for BATF Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BATF Gene:

BATF

SOURCE GeneReport for Unigene cluster for BATF Gene:

Hs.509964

mRNA Expression by UniProt/SwissProt for BATF Gene:

Q16520-BATF_HUMAN
Tissue specificity: Expressed at highest levels in lung, and at lower levels in placenta, liver, kidney, spleen, and peripheral blood. Detected in SW480 colorectal cancer cell line and several hematopoietic tumor cell lines, including Raji Burkitts lymphoma. Strongly expressed in mature B- and T-lymphocytes. Also expressed in moderate levels in lymph node and appendix and at low levels in thymus and bone marrow (PubMed:10777209).

Evidence on tissue expression from TISSUES for BATF Gene

  • Lymph node(2.2)
  • Spleen(2.1)
  • Blood(2)
genes like me logo Genes that share expression patterns with BATF: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for BATF Gene

Orthologs for BATF Gene

This gene was present in the common ancestor of chordates.

Orthologs for BATF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BATF 33 34
  • 99.73 (n)
dog
(Canis familiaris)
Mammalia BATF 33 34
  • 92.21 (n)
cow
(Bos Taurus)
Mammalia BATF 33 34
  • 91.59 (n)
rat
(Rattus norvegicus)
Mammalia Batf 33
  • 88.79 (n)
mouse
(Mus musculus)
Mammalia Batf 33 16 34
  • 88.47 (n)
oppossum
(Monodelphis domestica)
Mammalia BATF 34
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves BATF 33 34
  • 79.68 (n)
lizard
(Anolis carolinensis)
Reptilia BATF 34
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia batf 33
  • 65.25 (n)
zebrafish
(Danio rerio)
Actinopterygii batf 33 34
  • 69.18 (n)
Species where no ortholog for BATF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BATF Gene

ENSEMBL:
Gene Tree for BATF (if available)
TreeFam:
Gene Tree for BATF (if available)

Paralogs for BATF Gene

Paralogs for BATF Gene

(7) SIMAP similar genes for BATF Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with BATF: view

Variants for BATF Gene

Sequence variations from dbSNP and Humsavar for BATF Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000042581 -- 75,530,461(+) TATAG(C/G)AAAGA intron-variant
rs1000241022 -- 75,546,499(+) TCTAC(A/G)CAAGG reference, missense
rs1000318056 -- 75,533,402(+) CAGCC(A/T)AGGCA intron-variant
rs1000454172 -- 75,527,464(+) CAGAA(G/T)AGTCT intron-variant
rs1000520201 -- 75,532,459(+) CTATA(G/T)ATAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BATF Gene

Variant ID Type Subtype PubMed ID
esv3634966 CNV loss 21293372
nsv1037822 CNV gain 25217958

Variation tolerance for BATF Gene

Residual Variation Intolerance Score: 41.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.48; 10.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BATF Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BATF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BATF Gene

Disorders for BATF Gene

Relevant External Links for BATF

Genetic Association Database (GAD)
BATF
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BATF

No disorders were found for BATF Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BATF Gene

Publications for BATF Gene

  1. SFA-2, a novel bZIP transcription factor induced by human T-cell leukemia virus type I, is highly expressed in mature lymphocytes. (PMID: 8630063) Hasegawa H … Fujita S (Biochemical and biophysical research communications 1996) 2 3 4 22 60
  2. B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family. (PMID: 8570175) Dorsey MJ … Taparowsky EJ (Oncogene 1995) 2 3 4 22 60
  3. EBNA2 and activated Notch induce expression of BATF. (PMID: 12719594) Johansen LM … Taparowsky EJ (Journal of virology 2003) 3 4 22 60
  4. B-ATF functions as a negative regulator of AP-1 mediated transcription and blocks cellular transformation by Ras and Fos. (PMID: 10777209) Echlin DR … Taparowsky EJ (Oncogene 2000) 3 4 22 60
  5. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PMID: 21833088) International Multiple Sclerosis Genetics Consortium … Compston A (Nature 2011) 3 45 60

Products for BATF Gene

Sources for BATF Gene

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