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Aliases for DDX17 Gene

Aliases for DDX17 Gene

  • DEAD-Box Helicase 17 2 3 5
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 17 (72kD) 2 3
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 17 2 3
  • DEAD (Asp-Glu-Ala-Asp) Box Helicase 17 2 3
  • RNA-Dependent Helicase P72 3 4
  • DEAD Box Protein P72 3 4
  • DEAD Box Protein P82 3 4
  • Probable ATP-Dependent RNA Helicase DDX17 3
  • DEAD Box Protein 17 4
  • EC 3.6.4.13 4
  • EC 3.6.1 61
  • RH70 3
  • P72 3

External Ids for DDX17 Gene

Previous GeneCards Identifiers for DDX17 Gene

  • GC22M035496
  • GC22M037122
  • GC22M037124
  • GC22M037203
  • GC22M038879
  • GC22M021845

Summaries for DDX17 Gene

Entrez Gene Summary for DDX17 Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and splicesosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an ATPase activated by a variety of RNA species, but not by dsDNA. This protein, and that encoded by DDX5 gene, are more closely related to each other than to any other member of the DEAD box family. This gene can encode multiple isoforms due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) start codon. [provided by RefSeq, Apr 2011]

GeneCards Summary for DDX17 Gene

DDX17 (DEAD-Box Helicase 17) is a Protein Coding gene. Among its related pathways are GPCR Pathway and RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is DDX5.

UniProtKB/Swiss-Prot for DDX17 Gene

  • As an RNA helicase, unwinds RNA and alters RNA structures through ATP binding and hydrolysis. Involved in multiple cellular processes, including pre-mRNA splicing, alternative splicing, ribosomal RNA processing and miRNA processing, as well as transcription regulation. Regulates the alternative splicing of exons exhibiting specific features (PubMed:12138182, PubMed:23022728, PubMed:24910439, PubMed:22266867). For instance, promotes the inclusion of AC-rich alternative exons in CD44 transcripts (PubMed:12138182). This function requires the RNA helicase activity (PubMed:12138182, PubMed:23022728, PubMed:24910439, PubMed:22266867). Affects NFAT5 and histone macro-H2A.1/H2AFY alternative splicing in a CDK9-dependent manner (PubMed:26209609, PubMed:22266867). In NFAT5, promotes the introduction of alternative exon 4, which contains 2 stop codons and may target NFAT5 exon 4-containing transcripts to nonsense-mediated mRNA decay, leading to the down-regulation of NFAT5 protein (PubMed:22266867). Affects splicing of mediators of steroid hormone signaling pathway, including kinases that phosphorylates ESR1, such as CDK2, MAPK1 and GSK3B, and transcriptional regulators, such as CREBBP, MED1, NCOR1 and NCOR2. By affecting GSK3B splicing, participates in ESR1 and AR stabilization (PubMed:24275493). In myoblasts and epithelial cells, cooperates with HNRNPH1 to control the splicing of specific subsets of exons (PubMed:24910439). In addition to binding mature mRNAs, also interacts with certain pri-microRNAs, including MIR663/miR-663a, MIR99B/miR-99b, and MIR6087/miR-6087 (PubMed:25126784). Binds pri-microRNAs on the 3 segment flanking the stem loop via the 5-[ACG]CAUC[ACU]-3 consensus sequence (PubMed:24581491). Required for the production of subsets of microRNAs, including MIR21 and MIR125B1 (PubMed:24581491, PubMed:27478153). May be involved not only in microRNA primary transcript processing, but also stabilization (By similarity). Participates in MYC down-regulation at high cell density through the production of MYC-targeting microRNAs (PubMed:24581491). Along with DDX5, may be involved in the processing of the 32S intermediate into the mature 28S ribosomal RNA (PubMed:17485482). Promoter-specific transcription regulator, functioning as a coactivator or corepressor depending on the context of the promoter and the transcriptional complex in which it exists (PubMed:15298701). Enhances NFAT5 transcriptional activity (PubMed:22266867). Synergizes with TP53 in the activation of the MDM2 promoter; this activity requires acetylation on lysine residues (PubMed:17226766, PubMed:20663877, PubMed:19995069). May also coactivate MDM2 transcription through a TP53-independent pathway (PubMed:17226766). Coactivates MMP7 transcription (PubMed:17226766). Along with CTNNB1, coactivates MYC, JUN, FOSL1 and cyclin D1/CCND1 transcription (PubMed:17699760). Alone or in combination with DDX5 and/or SRA1 non-coding RNA, plays a critical role in promoting the assembly of proteins required for the formation of the transcription initiation complex and chromatin remodeling leading to coactivation of MYOD1-dependent transcription. This helicase-independent activity is required for skeletal muscle cells to properly differentiate into myotubes (PubMed:17011493, PubMed:24910439). During epithelial-to-mesenchymal transition, coregulates SMAD-dependent transcriptional activity, directly controlling key effectors of differentiation, including miRNAs which in turn directly repress its expression (PubMed:24910439). Plays a role in estrogen and testosterone signaling pathway at several levels. Mediates the use of alternative promoters in estrogen-responsive genes and regulates transcription and splicing of a large number of steroid hormone target genes (PubMed:24275493, PubMed:20406972, PubMed:20663877, PubMed:19995069). Contrary to splicing regulation activity, transcriptional coregulation of the estrogen receptor ESR1 is helicase-independent (PubMed:19718048, PubMed:24275493). Plays a role in innate immunity. Specifically restricts bunyavirus infection, including Rift Valley fever virus (RVFV) or La Crosse virus (LACV), but not vesicular stomatitis virus (VSV), in an interferon- and DROSHA-independent manner (PubMed:25126784). Binds to RVFV RNA, likely via structured viral RNA elements (PubMed:25126784). Promotes mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1, in an ATPase-dependent manner (PubMed:18334637).

Gene Wiki entry for DDX17 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX17 Gene

Genomics for DDX17 Gene

Regulatory Elements for DDX17 Gene

Enhancers for DDX17 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22G039462 1.9 FANTOM5 Ensembl ENCODE dbSUPER 4.4 -961.6 -961614 14.4 HDGF PKNOX1 MLX ZFP64 ARID4B DMAP1 YY1 ZNF143 ZNF207 SP5 TAB1 ENSG00000228274 MGAT3 ENSG00000272834 CBY1 SNORD83B PRDX3P1 SYNGR1 ENSG00000227413 MIEF1
GH22G038951 1.9 FANTOM5 Ensembl ENCODE dbSUPER 4.2 -445.8 -445771 4.9 HDGF PKNOX1 ZNF2 GLIS2 ZNF766 ELK1 ZNF143 ZNF263 SP3 NFIL3 APOBEC3B SUN2 APOBEC3A GTPBP1 APOBEC3B-AS1 DNAL4 JOSD1 APOBEC3D DDX17 LOC105373033
GH22G038966 1.7 FANTOM5 Ensembl ENCODE dbSUPER 3.8 -459.7 -459689 2.0 HDAC1 PKNOX1 ATF1 TCF12 CREM SMARCA4 IKZF1 GLIS1 KDM1A ZNF18 APOBEC3A GTPBP1 SUN2 APOBEC3B-AS1 JOSD1 DDX17 LOC105373033
GH22G038422 1.1 ENCODE dbSUPER 4.7 +83.8 83798 3.0 ZSCAN4 KLF17 FEZF1 BMI1 RARA ZNF366 ZSCAN5C SCRT2 ETV6 EGR2 CSNK1E KDELR3 LOC400927 KCNJ4 TAB1 CBY1 SOX10 POLR2F ENSG00000230912 ENSG00000228274
GH22G038428 1 dbSUPER 4.9 +77.4 77405 3.7 HDGF ZFP64 ARID4B SIN3A ZNF121 SLC30A9 ZNF766 ELK1 ZNF143 ZNF548 KDELR3 KCNJ4 ANKRD54 SNORD83B CSNK1E PICK1 TMEM184B DDX17 LOC105373029 LOC101927183
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DDX17 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the DDX17 gene promoter:

Genomic Location for DDX17 Gene

Chromosome:
22
Start:
38,483,438 bp from pter
End:
38,507,660 bp from pter
Size:
24,223 bases
Orientation:
Minus strand

Genomic View for DDX17 Gene

Genes around DDX17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDX17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDX17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX17 Gene

Proteins for DDX17 Gene

  • Protein details for DDX17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92841-DDX17_HUMAN
    Recommended name:
    Probable ATP-dependent RNA helicase DDX17
    Protein Accession:
    Q92841
    Secondary Accessions:
    • B1AHM0
    • H3BLZ8
    • Q69YT1
    • Q6ICD6

    Protein attributes for DDX17 Gene

    Size:
    729 amino acids
    Molecular mass:
    80272 Da
    Quaternary structure:
    • Interacts with DDX5 in an RNA-independent manner (PubMed:12595555, PubMed:19995069). Interacts with CDK9 transcription elongation complex under basal conditions. Following cell stimulation with poly(I:C), a synthetic double-stranded RNA mimicking viral infection, the interaction with CDK9 is decreased (PubMed:26209609). Interacts with ESR1 in an estrogen-independent manner (PubMed:19718048, PubMed:20663877). Interacts with HNRNPH1; this interaction is important for the regulation of alternative splicing on G-quadruplex structures (PubMed:24910439). At high, but not low, cell density, interacts with DROSHA and DGCR8, the core components of the microprocessor complex involved in the maturation of primary microRNAs (pri-miRNAs) into pre-miRNAs. The interaction with DGCR8 is reduced during mitosis (PubMed:24589731, PubMed:24581491). At low, but not high, cell density, interacts with YAP1 and with its paralog, WWTR1/TAZ. Interactions with DROSHA and YAP1 are mutually exclusive (PubMed:24581491). In vitro, the pre-miRNA processing activity of the DDX17-containing microprocessor complex is weaker than that of the DROSHA/DGCR8 microprocessor complex devoid of DDX17 (PubMed:15531877). Interacts with UPF3B (PubMed:23788676). Interacts with NFAT5; this interaction leads to DDX17 recruitment to LNC2 and S100A4 promoters and NFAT5-mediated DDX17-enhanced transactivation (PubMed:22266867). Interacts with HDAC1, HDAC2 and HDAC3; this interaction with HDAC1 and HDAC3, but not HDAC2, depends upon DDX17 acetylation (PubMed:15298701, PubMed:20663877). Interacts with ZC3HAV1 (via N-terminal domain) in an RNA-independent manner. Interacts with EXOSC3/RRP40 and EXOSC5/RRP46; this interaction may be indirect and mediated by ZC3HAV1-binding (PubMed:18334637). Interacts with EP300; this interaction leads to acetylation at lysine residues (PubMed:17226766, PubMed:19995069). Interacts with CREBBP/CBP and KAT2B/P/CAF (PubMed:17226766). Directly interacts with CTNNB1 (PubMed:17699760). Interacts with MYOD1 (PubMed:17011493). Interacts with TP53 (PubMed:15660129). Interacts with DCP1A in an RNA-independent manner. Interacts with DCP2 in an RNA-dependent manner (PubMed:21876179).

    Alternative splice isoforms for DDX17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DDX17 Gene

Selected DME Specific Peptides for DDX17 Gene

Q92841:
  • EDYVHRIGRT
  • MRRDGWPAM
  • DMGFEPQ
  • YGGAPKG
  • DEADRML
  • VASRGLD
  • PTRELAQQ
  • TGSGKTLA
  • VLDEADRM
  • TDVASRG
  • QLAEDFL
  • KKFGNPGE
  • LPAIVHIN
  • AQTGSGKT
  • FVETKRRCD
  • GKTLAYL
  • FEKNFYVE
  • LAPTREL
  • HRIGRTAR
  • LELSANHNILQIVDVC
  • TPGRLID
  • ILIATDVA
  • LVLDEADR
  • MWSATWPK
  • QIRPDRQT
  • IHGDKSQ
  • SATWPKEV
  • APTRELA
  • GPQIRDL
  • GKTNLRR
  • IATPGRL
  • KSQPERD
  • PKFEKNFY
  • EANQAINPKL

Post-translational modifications for DDX17 Gene

  • Acetylation at lysine residues stabilizes the protein, stimulates interaction with HDAC1 and HDAC3, but not HDAC2, and represses ESR1 and TP53 coactivation activity.
  • Sumoylation significantly increases stability. It also promotes interaction specifically with HDAC1 (but not HDAC2, nor HDAC3) and strongly stimulates ESR1 and TP53 coactivation.
  • Ubiquitination at isoforms=4, 2, 342, Lys50, Lys53, isoforms=4, 2, 3190, isoforms=4, 2, 3373, Lys389, Lys436, Lys449, and Lys468
  • Modification sites at PhosphoSitePlus

Other Protein References for DDX17 Gene

Antibody Products

Domains & Families for DDX17 Gene

Gene Families for DDX17 Gene

Graphical View of Domain Structure for InterPro Entry

Q92841

UniProtKB/Swiss-Prot:

DDX17_HUMAN :
  • Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.
Family:
  • Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.
genes like me logo Genes that share domains with DDX17: view

Function for DDX17 Gene

Molecular function for DDX17 Gene

GENATLAS Biochemistry:
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 17 (72kD)
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=170 uM for ATP {ECO:0000269 PubMed:8871553};
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
As an RNA helicase, unwinds RNA and alters RNA structures through ATP binding and hydrolysis. Involved in multiple cellular processes, including pre-mRNA splicing, alternative splicing, ribosomal RNA processing and miRNA processing, as well as transcription regulation. Regulates the alternative splicing of exons exhibiting specific features (PubMed:12138182, PubMed:23022728, PubMed:24910439, PubMed:22266867). For instance, promotes the inclusion of AC-rich alternative exons in CD44 transcripts (PubMed:12138182). This function requires the RNA helicase activity (PubMed:12138182, PubMed:23022728, PubMed:24910439, PubMed:22266867). Affects NFAT5 and histone macro-H2A.1/H2AFY alternative splicing in a CDK9-dependent manner (PubMed:26209609, PubMed:22266867). In NFAT5, promotes the introduction of alternative exon 4, which contains 2 stop codons and may target NFAT5 exon 4-containing transcripts to nonsense-mediated mRNA decay, leading to the down-regulation of NFAT5 protein (PubMed:22266867). Affects splicing of mediators of steroid hormone signaling pathway, including kinases that phosphorylates ESR1, such as CDK2, MAPK1 and GSK3B, and transcriptional regulators, such as CREBBP, MED1, NCOR1 and NCOR2. By affecting GSK3B splicing, participates in ESR1 and AR stabilization (PubMed:24275493). In myoblasts and epithelial cells, cooperates with HNRNPH1 to control the splicing of specific subsets of exons (PubMed:24910439). In addition to binding mature mRNAs, also interacts with certain pri-microRNAs, including MIR663/miR-663a, MIR99B/miR-99b, and MIR6087/miR-6087 (PubMed:25126784). Binds pri-microRNAs on the 3 segment flanking the stem loop via the 5-[ACG]CAUC[ACU]-3 consensus sequence (PubMed:24581491). Required for the production of subsets of microRNAs, including MIR21 and MIR125B1 (PubMed:24581491, PubMed:27478153). May be involved not only in microRNA primary transcript processing, but also stabilization (By similarity). Participates in MYC down-regulation at high cell density through the production of MYC-targeting microRNAs (PubMed:24581491). Along with DDX5, may be involved in the processing of the 32S intermediate into the mature 28S ribosomal RNA (PubMed:17485482). Promoter-specific transcription regulator, functioning as a coactivator or corepressor depending on the context of the promoter and the transcriptional complex in which it exists (PubMed:15298701). Enhances NFAT5 transcriptional activity (PubMed:22266867). Synergizes with TP53 in the activation of the MDM2 promoter; this activity requires acetylation on lysine residues (PubMed:17226766, PubMed:20663877, PubMed:19995069). May also coactivate MDM2 transcription through a TP53-independent pathway (PubMed:17226766). Coactivates MMP7 transcription (PubMed:17226766). Along with CTNNB1, coactivates MYC, JUN, FOSL1 and cyclin D1/CCND1 transcription (PubMed:17699760). Alone or in combination with DDX5 and/or SRA1 non-coding RNA, plays a critical role in promoting the assembly of proteins required for the formation of the transcription initiation complex and chromatin remodeling leading to coactivation of MYOD1-dependent transcription. This helicase-independent activity is required for skeletal muscle cells to properly differentiate into myotubes (PubMed:17011493, PubMed:24910439). During epithelial-to-mesenchymal transition, coregulates SMAD-dependent transcriptional activity, directly controlling key effectors of differentiation, including miRNAs which in turn directly repress its expression (PubMed:24910439). Plays a role in estrogen and testosterone signaling pathway at several levels. Mediates the use of alternative promoters in estrogen-responsive genes and regulates transcription and splicing of a large number of steroid hormone target genes (PubMed:24275493, PubMed:20406972, PubMed:20663877, PubMed:19995069). Contrary to splicing regulation activity, transcriptional coregulation of the estrogen receptor ESR1 is helicase-independent (PubMed:19718048, PubMed:24275493). Plays a role in innate immunity. Specifically restricts bunyavirus infection, including Rift Valley fever virus (RVFV) or La Crosse virus (LACV), but not vesicular stomatitis virus (VSV), in an interferon- and DROSHA-independent manner (PubMed:25126784). Binds to RVFV RNA, likely via structured viral RNA elements (PubMed:25126784). Promotes mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1, in an ATPase-dependent manner (PubMed:18334637).

Enzyme Numbers (IUBMB) for DDX17 Gene

Gene Ontology (GO) - Molecular Function for DDX17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003713 transcription coactivator activity IDA 17226766
GO:0003723 RNA binding IDA,TAS 22658674
GO:0003724 RNA helicase activity TAS 8871553
GO:0004004 ATP-dependent RNA helicase activity IBA --
genes like me logo Genes that share ontologies with DDX17: view
genes like me logo Genes that share phenotypes with DDX17: view

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DDX17 Gene

Localization for DDX17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX17 Gene

Nucleus. Nucleus, nucleolus. Cytoplasm, cytosol. Note=In the course of bunyavirus infection, relocalizes from the nucleus to the cytosol where it binds viral RNA to antagonize replication. {ECO:0000269 PubMed:25126784}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DDX17 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 1
extracellular 1
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for DDX17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS,IDA 24910439
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IEA --
GO:0005829 cytosol IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with DDX17: view

Pathways & Interactions for DDX17 Gene

genes like me logo Genes that share pathways with DDX17: view

Pathways by source for DDX17 Gene

1 BioSystems pathway for DDX17 Gene
1 Qiagen pathway for DDX17 Gene

Gene Ontology (GO) - Biological Process for DDX17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000380 alternative mRNA splicing, via spliceosome IMP 24275493
GO:0000381 regulation of alternative mRNA splicing, via spliceosome IMP 23022728
GO:0001837 epithelial to mesenchymal transition IMP 24910439
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with DDX17: view

No data available for SIGNOR curated interactions for DDX17 Gene

Drugs & Compounds for DDX17 Gene

(4) Drugs for DDX17 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for DDX17 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with DDX17: view

Transcripts for DDX17 Gene

Unigene Clusters for DDX17 Gene

DEAD (Asp-Glu-Ala-Asp) box helicase 17:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DDX17 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d ^ 13a · 13b · 13c
SP1: - - - - - -
SP2: - - - - - -
SP3: - -
SP4: -
SP5: - - - - -
SP6:
SP7:
SP8:

Relevant External Links for DDX17 Gene

GeneLoc Exon Structure for
DDX17
ECgene alternative splicing isoforms for
DDX17

Expression for DDX17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DDX17 Gene

Protein differential expression in normal tissues from HIPED for DDX17 Gene

This gene is overexpressed in Lymph node (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DDX17 Gene



Protein tissue co-expression partners for DDX17 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DDX17 Gene:

DDX17

SOURCE GeneReport for Unigene cluster for DDX17 Gene:

Hs.528305

mRNA Expression by UniProt/SwissProt for DDX17 Gene:

Q92841-DDX17_HUMAN
Tissue specificity: Widely expressed (PubMed:8871553). Low expression, if any, in normal colonic epithelial cells (at protein level). Levels tend to increase during colon cancer progression, from very low in benign hyperplastic polyps to very high in tubular and villous adenomas (PubMed:17699760).

Evidence on tissue expression from TISSUES for DDX17 Gene

  • Nervous system(5)
  • Skin(4.8)
  • Liver(4.6)
  • Lung(4.4)
  • Intestine(4)
  • Eye(3.9)
  • Blood(3.8)
  • Kidney(3.8)
  • Pancreas(3.5)
  • Stomach(3.1)
  • Heart(3)
  • Bone(2.8)
  • Muscle(2.4)
  • Thyroid gland(2.4)
  • Lymph node(2.3)
  • Spleen(2.3)
  • Gall bladder(2.2)
  • Adrenal gland(2.1)
genes like me logo Genes that share expression patterns with DDX17: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DDX17 Gene

Orthologs for DDX17 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DDX17 34 35
  • 99.79 (n)
dog
(Canis familiaris)
Mammalia DDX17 35 34
  • 95.3 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DDX17 35
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DDX17 35
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DDX17 34 35
  • 94.87 (n)
mouse
(Mus musculus)
Mammalia Ddx17 34 16 35
  • 90.15 (n)
chicken
(Gallus gallus)
Aves DDX17 34 35
  • 79.42 (n)
lizard
(Anolis carolinensis)
Reptilia DDX17 35
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx17 34
  • 73.96 (n)
zebrafish
(Danio rerio)
Actinopterygii DDX17 35
  • 73 (a)
OneToOne
LOC556764 34
  • 69.93 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10077 36 35
  • 67 (a)
CG10777 36 35
  • 59 (a)
Rm62 35 36
  • 45 (a)
ManyToMany
CG14443 36
  • 32 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005652 34
  • 61.95 (n)
worm
(Caenorhabditis elegans)
Secernentea F58E10.3 36 34
  • 59.56 (n)
ddx-17 35
  • 52 (a)
OneToMany
F58G11.2 36
  • 31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DBP2 35
  • 55 (a)
OneToMany
soybean
(Glycine max)
eudicotyledons Gma.6121 34
corn
(Zea mays)
Liliopsida Zm.5411 34
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1847 34
Species where no ortholog for DDX17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DDX17 Gene

ENSEMBL:
Gene Tree for DDX17 (if available)
TreeFam:
Gene Tree for DDX17 (if available)

Paralogs for DDX17 Gene

Paralogs for DDX17 Gene

genes like me logo Genes that share paralogs with DDX17: view

Variants for DDX17 Gene

Sequence variations from dbSNP and Humsavar for DDX17 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000072115 -- 38,501,663(+) AATAA(C/T)ACCAC intron-variant
rs1000411664 -- 38,483,710(+) AGAAG(C/T)AGCCC downstream-variant-500B, utr-variant-3-prime
rs1000427810 -- 38,489,668(+) AGGGG(A/C)ATTAT intron-variant
rs1000502419 -- 38,495,594(+) CTTAT(-/GTACA)GTACA intron-variant
rs1000507383 -- 38,501,484(+) GAATA(C/T)AGCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DDX17 Gene

Variant ID Type Subtype PubMed ID
nsv834195 CNV loss 17160897

Variation tolerance for DDX17 Gene

Residual Variation Intolerance Score: 9.76% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.23; 24.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DDX17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DDX17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX17 Gene

Disorders for DDX17 Gene

Relevant External Links for DDX17

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DDX17

No disorders were found for DDX17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DDX17 Gene

Publications for DDX17 Gene

  1. Concerted activation of the Mdm2 promoter by p72 RNA helicase and the coactivators p300 and P/CAF. (PMID: 17226766) Shin S. … Janknecht R. (J. Cell. Biochem. 2007) 2 3 4 22 64
  2. p72: a human nuclear DEAD box protein highly related to p68. (PMID: 8871553) Lamm G.M. … Lamond A.I. (Nucleic Acids Res. 1996) 2 3 4 22 64
  3. Sumoylation of p68 and p72 RNA helicases affects protein stability and transactivation potential. (PMID: 19995069) Mooney S.M. … Janknecht R. (Biochemistry 2010) 3 4 22 64
  4. The DEAD-box protein p72 regulates ERalpha-/oestrogen-dependent transcription and cell growth, and is associated with improved survival in ERalpha-positive breast cancer. (PMID: 19718048) Wortham N.C. … Fuller-Pace F.V. (Oncogene 2009) 3 4 22 64
  5. p72 DEAD box RNA helicase is required for optimal function of the zinc-finger antiviral protein. (PMID: 18334637) Chen G. … Gao G. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 4 22 64

Products for DDX17 Gene

Sources for DDX17 Gene

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