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Aliases for DDX17 Gene

Aliases for DDX17 Gene

  • DEAD (Asp-Glu-Ala-Asp) Box Helicase 17 2 3
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 17 (72kD) 2 3
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 17 2 3
  • RNA-Dependent Helicase P72 3 4
  • DEAD Box Protein P72 3 4
  • RH70 3 6
  • P72 3 6
  • Probable ATP-Dependent RNA Helicase DDX17 3
  • DEAD Box Protein 17 4
  • EC 3.6.4.13 4
  • EC 3.6.1 64

External Ids for DDX17 Gene

Summaries for DDX17 Gene

Entrez Gene Summary for DDX17 Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and splicesosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an ATPase activated by a variety of RNA species, but not by dsDNA. This protein, and that encoded by DDX5 gene, are more closely related to each other than to any other member of the DEAD box family. This gene can encode multiple isoforms due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) start codon. [provided by RefSeq, Apr 2011]

GeneCards Summary for DDX17 Gene

DDX17 (DEAD (Asp-Glu-Ala-Asp) Box Helicase 17) is a Protein Coding gene. Among its related pathways are GPCR Pathway. GO annotations related to this gene include RNA binding and ATP-dependent helicase activity. An important paralog of this gene is DDX53.

UniProtKB/Swiss-Prot for DDX17 Gene

  • RNA-dependent ATPase activity. Involved in transcriptional regulation. Transcriptional coactivator for estrogen receptor ESR1. Increases ESR1 AF-1 domain-mediated transactivation. Synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and probably involved in skeletal muscle differentiation. Required for zinc-finger antiviral protein ZC3HAV1-mediated mRNA degradation.

Gene Wiki entry for DDX17 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX17 Gene

Genomics for DDX17 Gene

Genomic Location for DDX17 Gene

Start:
38,483,438 bp from pter
End:
38,507,660 bp from pter
Size:
24,223 bases
Orientation:
Minus strand

Genomic View for DDX17 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DDX17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX17 Gene

Regulatory Elements for DDX17 Gene

Transcription factor binding sites by QIAGEN in the DDX17 gene promoter:

Proteins for DDX17 Gene

  • Protein details for DDX17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92841-DDX17_HUMAN
    Recommended name:
    Probable ATP-dependent RNA helicase DDX17
    Protein Accession:
    Q92841
    Secondary Accessions:
    • B1AHM0
    • Q69YT1
    • Q6ICD6

    Protein attributes for DDX17 Gene

    Size:
    729 amino acids
    Molecular mass:
    80272 Da
    Quaternary structure:
    • Interacts with ESR1. Interacts with NCOA1, NCOA2, NCOA3, TP53 and HDAC1. Self-associates. Interacts with DDX5. Interacts with DCP1A in an RNA-independent manner. Interacts with DCP2 in an RNA-dependent manner. Interacts with ZC3HAV1 (via N-terminal domain) in an RNA-independent manner. Interacts with EXOSC3 and EXOSC5 only in the presence of ZC3HAV1 in an RNA-independent manner.

    Alternative splice isoforms for DDX17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DDX17 Gene

Proteomics data for DDX17 Gene at MOPED

Post-translational modifications for DDX17 Gene

  • Sumoylation significantly increases stability, it also promotes interaction with HDAC1.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys42, Lys50, Lys53, Lys190, Lys195, Lys205, Lys282, Lys373, Lys389, Lys436, Lys449, and Lys468

Other Protein References for DDX17 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for DDX17 Gene

Gene Families for DDX17 Gene

HGNC:
  • DDX :DEAD-boxes

UniProtKB/Swiss-Prot:

DDX17_HUMAN
Domain:
  • Contains 1 helicase ATP-binding domain.:
    • Q92841
  • Contains 1 helicase C-terminal domain.:
    • Q92841
Family:
  • Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.:
    • Q92841
genes like me logo Genes that share domains with DDX17: view

Function for DDX17 Gene

Molecular function for DDX17 Gene

GENATLAS Biochemistry: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 17 (72kD)
UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function: RNA-dependent ATPase activity. Involved in transcriptional regulation. Transcriptional coactivator for estrogen receptor ESR1. Increases ESR1 AF-1 domain-mediated transactivation. Synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and probably involved in skeletal muscle differentiation. Required for zinc-finger antiviral protein ZC3HAV1-mediated mRNA degradation.

Enzyme Numbers (IUBMB) for DDX17 Gene

Gene Ontology (GO) - Molecular Function for DDX17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003713 transcription coactivator activity IDA --
GO:0003723 RNA binding TAS 8871553
GO:0003724 RNA helicase activity TAS 8871553
GO:0004004 ATP-dependent RNA helicase activity IBA --
genes like me logo Genes that share ontologies with DDX17: view
genes like me logo Genes that share phenotypes with DDX17: view

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for DDX17 Gene

Localization for DDX17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX17 Gene

Nucleus. Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DDX17 Gene COMPARTMENTS Subcellular localization image for DDX17 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for DDX17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IBA --
GO:0005737 cytoplasm IBA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with DDX17: view

Pathways for DDX17 Gene

SuperPathways for DDX17 Gene

Superpath Contained pathways
1 GPCR Pathway
genes like me logo Genes that share pathways with DDX17: view

Pathways by source for DDX17 Gene

1 Qiagen pathway for DDX17 Gene

Gene Ontology (GO) - Biological Process for DDX17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IBA --
GO:0006200 obsolete ATP catabolic process --
GO:0006351 transcription, DNA-templated IEA --
GO:0006396 RNA processing TAS 8871553
GO:0009791 post-embryonic development --
genes like me logo Genes that share ontologies with DDX17: view

Compounds for DDX17 Gene

(1) Novoseek inferred chemical compound relationships for DDX17 Gene

Compound -log(P) Hits PubMed IDs
atp 15.8 3
genes like me logo Genes that share compounds with DDX17: view

Transcripts for DDX17 Gene

Unigene Clusters for DDX17 Gene

DEAD (Asp-Glu-Ala-Asp) box helicase 17:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DDX17 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d ^ 13a · 13b · 13c
SP1: - - - - - -
SP2: - - - - - -
SP3: - -
SP4: -
SP5: - - - - -
SP6:
SP7:
SP8:

Relevant External Links for DDX17 Gene

GeneLoc Exon Structure for
DDX17
ECgene alternative splicing isoforms for
DDX17

Expression for DDX17 Gene

mRNA expression in normal human tissues for DDX17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDX17 Gene

SOURCE GeneReport for Unigene cluster for DDX17 Gene Hs.528305

mRNA Expression by UniProt/SwissProt for DDX17 Gene

Q92841-DDX17_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with DDX17: view

Orthologs for DDX17 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DDX17 36
  • 99.79 (n)
  • 100 (a)
DDX17 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DDX17 36
  • 94.87 (n)
  • 99.69 (a)
DDX17 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DDX17 36
  • 95.3 (n)
  • 99.3 (a)
DDX17 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ddx17 36
  • 90.15 (n)
  • 98.77 (a)
Ddx17 16
Ddx17 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DDX17 37
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DDX17 37
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves DDX17 36
  • 79.42 (n)
  • 90.64 (a)
DDX17 37
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DDX17 37
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx17 36
  • 73.96 (n)
  • 85.36 (a)
zebrafish
(Danio rerio)
Actinopterygii DDX17 37
  • 73 (a)
OneToOne
LOC556764 36
  • 69.93 (n)
  • 79.07 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005652 36
  • 61.95 (n)
  • 67.58 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10077 37
  • 43 (a)
ManyToMany
CG10777 37
  • 37 (a)
ManyToMany
Rm62 37
  • 45 (a)
ManyToMany
Rm62 38
  • 65 (a)
CG14443 38
  • 32 (a)
CG10077 38
  • 67 (a)
CG10777 38
  • 59 (a)
worm
(Caenorhabditis elegans)
Secernentea ddx-17 37
  • 52 (a)
OneToMany
F58E10.3 36
  • 59.56 (n)
  • 60.77 (a)
F58E10.3 38
  • 60 (a)
F58G11.2 38
  • 31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DBP2 37
  • 55 (a)
OneToMany
soybean
(Glycine max)
eudicotyledons Gma.6121 36
corn
(Zea mays)
Liliopsida Zm.5411 36
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1847 36
Species with no ortholog for DDX17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DDX17 Gene

ENSEMBL:
Gene Tree for DDX17 (if available)
TreeFam:
Gene Tree for DDX17 (if available)

Paralogs for DDX17 Gene

Paralogs for DDX17 Gene

genes like me logo Genes that share paralogs with DDX17: view

Variants for DDX17 Gene

Sequence variations from dbSNP and Humsavar for DDX17 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs13996 -- 38,486,022(-) CCTCC(A/G)GGAGC synonymous-codon, reference
rs15530 -- 38,488,261(+) AGAAA(A/C)AAAAA intron-variant
rs86796 -- 38,485,449(+) GGGCA(A/C)TCCCT utr-variant-3-prime
rs138437 -- 38,484,682(+) ATTAC(C/T)ATGAA utr-variant-3-prime
rs138438 -- 38,485,696(+) TATAT(A/T)TTTTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DDX17 Gene

Variant ID Type Subtype PubMed ID
nsv834195 CNV Loss 17160897
nsv915066 CNV Loss 21882294

Relevant External Links for DDX17 Gene

HapMap Linkage Disequilibrium report
DDX17

Disorders for DDX17 Gene

No disorders were found for DDX17 Gene.

No data available for UniProtKB/Swiss-Prot for DDX17 Gene

Publications for DDX17 Gene

  1. p72: a human nuclear DEAD box protein highly related to p68. (PMID: 8871553) Lamm G.M. … Lamond A.I. (Nucleic Acids Res. 1996) 2 3 4 23
  2. Concerted activation of the Mdm2 promoter by p72 RNA helicase and the coactivators p300 and P/CAF. (PMID: 17226766) Shin S. … Janknecht R. (J. Cell. Biochem. 2007) 2 3 4 23
  3. The DEAD-box protein p72 regulates ERalpha-/oestrogen-dependent transcription and cell growth, and is associated with improved survival in ERalpha-positive breast cancer. (PMID: 19718048) Wortham N.C. … Fuller-Pace F.V. (Oncogene 2009) 3 4 23
  4. Sumoylation of p68 and p72 RNA helicases affects protein stability and transactivation potential. (PMID: 19995069) Mooney S.M. … Janknecht R. (Biochemistry 2010) 3 4 23
  5. The p68 and p72 DEAD box RNA helicases interact with HDAC1 and repress transcription in a promoter-specific manner. (PMID: 15298701) Wilson B.J. … Fuller-Pace F.V. (BMC Mol. Biol. 2004) 3 4 23

Products for DDX17 Gene

  • Addgene plasmids for DDX17

Sources for DDX17 Gene

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