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Aliases for CEBPD Gene

Aliases for CEBPD Gene

  • CCAAT/Enhancer Binding Protein Delta 2 3
  • CCAAT/Enhancer Binding Protein (C/EBP), Delta 2 3 5
  • Nuclear Factor NF-IL6-Beta 3 4
  • C/EBP Delta 3 4
  • NF-IL6-Beta 3 4
  • C/EBP-Delta 3
  • CELF 3
  • CRP3 3

External Ids for CEBPD Gene

Previous GeneCards Identifiers for CEBPD Gene

  • GC08M048640
  • GC08M048372
  • GC08M048699
  • GC08M048812
  • GC08M048649
  • GC08M044112

Summaries for CEBPD Gene

Entrez Gene Summary for CEBPD Gene

  • The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages. The cytogenetic location of this locus has been reported as both 8p11 and 8q11. [provided by RefSeq, Sep 2010]

GeneCards Summary for CEBPD Gene

CEBPD (CCAAT/Enhancer Binding Protein Delta) is a Protein Coding gene. Diseases associated with CEBPD include Cardiomyopathy, Dilated, 1M and Cardiomyopathy, Hypertrophic, 12. Among its related pathways are Glucose / Energy Metabolism and IL-2 Pathway. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is CEBPE.

UniProtKB/Swiss-Prot for CEBPD Gene

  • Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers (PubMed:16397300). Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:1741402, PubMed:16397300). Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB (PubMed:1741402).

Gene Wiki entry for CEBPD Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEBPD Gene

Genomics for CEBPD Gene

Regulatory Elements for CEBPD Gene

Enhancers for CEBPD Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CEBPD on UCSC Golden Path with GeneCards custom track

Genomic Location for CEBPD Gene

Chromosome:
8
Start:
47,736,909 bp from pter
End:
47,739,086 bp from pter
Size:
2,178 bases
Orientation:
Minus strand

Genomic View for CEBPD Gene

Genes around CEBPD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEBPD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEBPD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEBPD Gene

Proteins for CEBPD Gene

  • Protein details for CEBPD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49716-CEBPD_HUMAN
    Recommended name:
    CCAAT/enhancer-binding protein delta
    Protein Accession:
    P49716
    Secondary Accessions:
    • Q14937
    • Q2M2X9

    Protein attributes for CEBPD Gene

    Size:
    269 amino acids
    Molecular mass:
    28467 Da
    Quaternary structure:
    • Binds DNA as a homodimer and as a heterodimer (PubMed:1741402). Can form stable heterodimers with CEBPB (PubMed:1741402). Can form stable heterodimers with CEBPA and CEBPE. Interacts with SPI1/PU.1. Interacts with PRDM16.

neXtProt entry for CEBPD Gene

Proteomics data for CEBPD Gene at MOPED

Post-translational modifications for CEBPD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CEBPD Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CEBPD Gene

Domains & Families for CEBPD Gene

Protein Domains for CEBPD Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CEBPD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P49716

UniProtKB/Swiss-Prot:

CEBPD_HUMAN :
  • Contains 1 bZIP (basic-leucine zipper) domain.
  • Belongs to the bZIP family. C/EBP subfamily.
Domain:
  • Contains 1 bZIP (basic-leucine zipper) domain.
Family:
  • Belongs to the bZIP family. C/EBP subfamily.
genes like me logo Genes that share domains with CEBPD: view

Function for CEBPD Gene

Molecular function for CEBPD Gene

GENATLAS Biochemistry:
CCAAT enhancer binding protein delta (C/EBP),expressed in preadipocytes and inducing,conjointly with CEBPD,the induction of CEBPB and PPARG,required for adipocyte differentiation.
UniProtKB/Swiss-Prot Function:
Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers (PubMed:16397300). Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:1741402, PubMed:16397300). Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB (PubMed:1741402).

Gene Ontology (GO) - Molecular Function for CEBPD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA --
GO:0005515 protein binding IPI 20102225
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with CEBPD: view
genes like me logo Genes that share phenotypes with CEBPD: view

Animal Models for CEBPD Gene

MGI Knock Outs for CEBPD:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CEBPD Gene

Localization for CEBPD Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEBPD Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CEBPD Gene COMPARTMENTS Subcellular localization image for CEBPD gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for CEBPD Gene

Pathways & Interactions for CEBPD Gene

genes like me logo Genes that share pathways with CEBPD: view

Pathways by source for CEBPD Gene

1 GeneGo (Thomson Reuters) pathway for CEBPD Gene
1 R&D Systems pathway for CEBPD Gene
1 Qiagen pathway for CEBPD Gene

SIGNOR curated interactions for CEBPD Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CEBPD Gene

None

Drugs & Compounds for CEBPD Gene

(1) Additional Compounds for CEBPD Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CEBPD: view

Transcripts for CEBPD Gene

mRNA/cDNA for CEBPD Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(93) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CEBPD Gene

CCAAT/enhancer binding protein (C/EBP), delta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CEBPD Gene

No ASD Table

Relevant External Links for CEBPD Gene

GeneLoc Exon Structure for
CEBPD
ECgene alternative splicing isoforms for
CEBPD

Expression for CEBPD Gene

mRNA expression in normal human tissues for CEBPD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CEBPD Gene

This gene is overexpressed in Blymphocyte (38.7), Monocytes (12.7), and Bone marrow stromal cell (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CEBPD Gene



SOURCE GeneReport for Unigene cluster for CEBPD Gene Hs.440829

genes like me logo Genes that share expression patterns with CEBPD: view

Protein tissue co-expression partners for CEBPD Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CEBPD Gene

Orthologs for CEBPD Gene

This gene was present in the common ancestor of animals.

Orthologs for CEBPD Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CEBPD 35
  • 88.02 (n)
  • 89.84 (a)
dog
(Canis familiaris)
Mammalia CEBPD 35
  • 87.52 (n)
  • 83.41 (a)
mouse
(Mus musculus)
Mammalia Cebpd 35
  • 86.19 (n)
  • 86.19 (a)
Cebpd 16
chimpanzee
(Pan troglodytes)
Mammalia CEBPD 35
  • 99.5 (n)
  • 99.26 (a)
CEBPD 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cebpd 35
  • 85.07 (n)
  • 87.31 (a)
oppossum
(Monodelphis domestica)
Mammalia CEBPD 36
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CEBPD 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CEBPD 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cebpd 35
  • 67.56 (n)
  • 63.39 (a)
Str.2213 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
cebpd 35
  • 61.41 (n)
  • 56.43 (a)
cebpd 36
  • 48 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea cebp-2 36
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
OneToMany
Species with no ortholog for CEBPD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CEBPD Gene

ENSEMBL:
Gene Tree for CEBPD (if available)
TreeFam:
Gene Tree for CEBPD (if available)

Paralogs for CEBPD Gene

Paralogs for CEBPD Gene

(2) SIMAP similar genes for CEBPD Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CEBPD: view

Variants for CEBPD Gene

Sequence variations from dbSNP and Humsavar for CEBPD Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs34948549 - 47,737,379(-) GCCTC(C/T)GGCAG reference, missense
rs11539253 -- 47,737,072(-) TCTTA(C/T)TCCTG utr-variant-3-prime
rs11539254 -- 47,737,471(-) CAACC(A/T)GGAGA reference, missense
rs11539255 -- 47,737,449(-) TTGGT(G/T)GAGCT reference, synonymous-codon
rs15955 -- 47,737,332(-) GCCGC(C/T)GGGAC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for CEBPD Gene

Variant ID Type Subtype PubMed ID
nsv890849 CNV Loss 21882294

Variation tolerance for CEBPD Gene

Gene Damage Index Score: 1.77; 33.43% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CEBPD Gene

Disorders for CEBPD Gene

MalaCards: The human disease database

(2) MalaCards diseases for CEBPD Gene - From: OMIM

Disorder Aliases PubMed IDs
cardiomyopathy, dilated, 1m
  • cmd1m
cardiomyopathy, hypertrophic, 12
  • cardiomyopathy, familial hypertrophic, 12
- elite association - COSMIC cancer census association via MalaCards
Search CEBPD in MalaCards View complete list of genes associated with diseases

Relevant External Links for CEBPD

Genetic Association Database (GAD)
CEBPD
Human Genome Epidemiology (HuGE) Navigator
CEBPD
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CEBPD
genes like me logo Genes that share disorders with CEBPD: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CEBPD Gene

Publications for CEBPD Gene

  1. Genetic variations at the CCAAT/enhancer-binding protein delta are associated with metabolic phenotypes in the Japanese population. (PMID: 18370833) Kaji H. … Tanida K. (Metab Syndr Relat Disord 2008) 3 23 48 67
  2. Epigenetic silencing of CCAAT/enhancer-binding protein delta activity by YY1/polycomb group/DNA methyltransferase complex. (PMID: 18753137) Ko C.Y. … Wang J.M. (J. Biol. Chem. 2008) 3 23
  3. Proteasome-mediated CCAAT/enhancer-binding protein delta (C/EBPdelta) degradation is ubiquitin-independent. (PMID: 17373909) Zhou S. … Dewille J.W. (Biochem. J. 2007) 3 23
  4. Interleukin-6 and mevastatin regulate plasminogen activator inhibitor-1 through CCAAT/enhancer-binding protein-delta. (PMID: 15718495) Dong J. … Kitabatake A. (Arterioscler. Thromb. Vasc. Biol. 2005) 3 23
  5. Induction of human NF-IL6beta by epidermal growth factor is mediated through the p38 signaling pathway and cAMP response element-binding protein activation in A431 cells. (PMID: 15901830) Wang J.M. … Chang W.C. (Mol. Biol. Cell 2005) 3 23

Products for CEBPD Gene

Sources for CEBPD Gene

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