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Aliases for CEBPD Gene

Aliases for CEBPD Gene

  • CCAAT/Enhancer Binding Protein Delta 2 3 5
  • CCAAT/Enhancer Binding Protein (C/EBP), Delta 2 3
  • Nuclear Factor NF-IL6-Beta 3 4
  • C/EBP Delta 3 4
  • NF-IL6-Beta 3 4
  • CCAAT/Enhancer-Binding Protein Delta 3
  • C/EBP-Delta 3
  • CELF 3
  • CRP3 3

External Ids for CEBPD Gene

Previous GeneCards Identifiers for CEBPD Gene

  • GC08M048640
  • GC08M048372
  • GC08M048699
  • GC08M048812
  • GC08M048649
  • GC08M044112

Summaries for CEBPD Gene

Entrez Gene Summary for CEBPD Gene

  • The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages. The cytogenetic location of this locus has been reported as both 8p11 and 8q11. [provided by RefSeq, Sep 2010]

GeneCards Summary for CEBPD Gene

CEBPD (CCAAT/Enhancer Binding Protein Delta) is a Protein Coding gene. Diseases associated with CEBPD include Leukoencephalopathy With Vanishing White Matter. Among its related pathways are Transcription factor regulation in adipogenesis and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is CEBPE.

UniProtKB/Swiss-Prot for CEBPD Gene

  • Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers (PubMed:16397300). Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:1741402, PubMed:16397300). Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB (PubMed:1741402).

Gene Wiki entry for CEBPD Gene

Additional gene information for CEBPD Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEBPD Gene

Genomics for CEBPD Gene

Regulatory Elements for CEBPD Gene

Enhancers for CEBPD Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H047351 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12.4 +383.2 383245 8 ATF1 FOXA2 MLX YY1 ZNF121 FOS ATF7 SP5 REST PPARG CEBPD PRKDC SPIDR MCM4 LOC100420054 RPL10AP2 PIR60563 GC08M047258
GH08H047506 1.5 Ensembl ENCODE dbSUPER 11.2 +227.9 227948 10 HDGF FOXA2 PKNOX1 ATF1 SIN3A BRCA1 YY1 FOS ATF7 RUNX3 SPIDR CEBPD MCM4 RPL29P19 ATP6V1G1P2 LOC100420054 PIR56974
GH08H047675 1.1 Ensembl ENCODE dbSUPER 11.1 +62.4 62386 2 SOX13 SMARCE1 SAP130 RAD21 ATF2 ZNF766 POLR2A GATA2 ATF7 CEBPD SPIDR RNU6-665P PIR54596
GH08H047682 1 Ensembl ENCODE dbSUPER 10.9 +55.9 55907 0 ZFHX2 RFX1 PRDM1 EGR2 CEBPD SPIDR PIR54596 RNU6-665P
GH08H047683 0.9 Ensembl ENCODE dbSUPER 10.9 +54.8 54759 1 JUND FOS CEBPD SPIDR MCM4 RNU6-665P PIR54596
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CEBPD on UCSC Golden Path with GeneCards custom track

Promoters for CEBPD Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000224260 1986 4601 HDGF FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF143

Genomic Location for CEBPD Gene

Chromosome:
8
Start:
47,736,909 bp from pter
End:
47,739,086 bp from pter
Size:
2,178 bases
Orientation:
Minus strand

Genomic View for CEBPD Gene

Genes around CEBPD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEBPD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEBPD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEBPD Gene

Proteins for CEBPD Gene

  • Protein details for CEBPD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49716-CEBPD_HUMAN
    Recommended name:
    CCAAT/enhancer-binding protein delta
    Protein Accession:
    P49716
    Secondary Accessions:
    • Q14937
    • Q2M2X9

    Protein attributes for CEBPD Gene

    Size:
    269 amino acids
    Molecular mass:
    28467 Da
    Quaternary structure:
    • Binds DNA as a homodimer and as a heterodimer (PubMed:1741402). Can form stable heterodimers with CEBPB (PubMed:1741402). Can form stable heterodimers with CEBPA and CEBPE. Interacts with SPI1/PU.1. Interacts with PRDM16.

neXtProt entry for CEBPD Gene

Post-translational modifications for CEBPD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CEBPD Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CEBPD (C/EBP-delta)
  • Cloud-Clone Corp. Antibodies for CEBPD

No data available for DME Specific Peptides for CEBPD Gene

Domains & Families for CEBPD Gene

Gene Families for CEBPD Gene

Protein Domains for CEBPD Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CEBPD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P49716

UniProtKB/Swiss-Prot:

CEBPD_HUMAN :
  • Belongs to the bZIP family. C/EBP subfamily.
Family:
  • Belongs to the bZIP family. C/EBP subfamily.
genes like me logo Genes that share domains with CEBPD: view

Function for CEBPD Gene

Molecular function for CEBPD Gene

GENATLAS Biochemistry:
CCAAT enhancer binding protein delta (C/EBP),expressed in preadipocytes and inducing,conjointly with CEBPD,the induction of CEBPB and PPARG,required for adipocyte differentiation.
UniProtKB/Swiss-Prot Function:
Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers (PubMed:16397300). Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:1741402, PubMed:16397300). Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB (PubMed:1741402).

Phenotypes From GWAS Catalog for CEBPD Gene

Gene Ontology (GO) - Molecular Function for CEBPD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA --
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0005515 protein binding IPI 20102225
genes like me logo Genes that share ontologies with CEBPD: view
genes like me logo Genes that share phenotypes with CEBPD: view

Animal Models for CEBPD Gene

MGI Knock Outs for CEBPD:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CEBPD
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CEBPD Gene

Localization for CEBPD Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEBPD Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CEBPD gene
Compartment Confidence
nucleus 5
peroxisome 2
cytosol 2
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CEBPD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with CEBPD: view

Pathways & Interactions for CEBPD Gene

genes like me logo Genes that share pathways with CEBPD: view

Pathways by source for CEBPD Gene

SIGNOR curated interactions for CEBPD Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CEBPD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS 8314590
genes like me logo Genes that share ontologies with CEBPD: view

Drugs & Compounds for CEBPD Gene

(1) Additional Compounds for CEBPD Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CEBPD: view

Transcripts for CEBPD Gene

mRNA/cDNA for CEBPD Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(93) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CEBPD Gene

CCAAT/enhancer binding protein (C/EBP), delta:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CEBPD
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CEBPD Gene

No ASD Table

Relevant External Links for CEBPD Gene

GeneLoc Exon Structure for
CEBPD
ECgene alternative splicing isoforms for
CEBPD

Expression for CEBPD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CEBPD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CEBPD Gene

This gene is overexpressed in Blymphocyte (38.7), Monocytes (12.7), and Bone marrow stromal cell (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CEBPD Gene



Protein tissue co-expression partners for CEBPD Gene

NURSA nuclear receptor signaling pathways regulating expression of CEBPD Gene:

CEBPD

SOURCE GeneReport for Unigene cluster for CEBPD Gene:

Hs.440829

Evidence on tissue expression from TISSUES for CEBPD Gene

  • Kidney(4.7)
  • Nervous system(4.7)
  • Lung(4.6)
  • Liver(3.6)
  • Muscle(3.4)
  • Blood(2.8)
  • Intestine(2.8)
  • Heart(2.6)
  • Eye(2)
genes like me logo Genes that share expression patterns with CEBPD: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CEBPD Gene

Orthologs for CEBPD Gene

This gene was present in the common ancestor of animals.

Orthologs for CEBPD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CEBPD 33 34
  • 99.5 (n)
cow
(Bos Taurus)
Mammalia CEBPD 33
  • 88.02 (n)
dog
(Canis familiaris)
Mammalia CEBPD 33
  • 87.52 (n)
mouse
(Mus musculus)
Mammalia Cebpd 33 16
  • 86.19 (n)
rat
(Rattus norvegicus)
Mammalia Cebpd 33
  • 85.07 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CEBPD 34
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CEBPD 34
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CEBPD 34
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cebpd 33
  • 67.56 (n)
Str.2213 33
zebrafish
(Danio rerio)
Actinopterygii cebpd 33 34
  • 61.41 (n)
-- 33
worm
(Caenorhabditis elegans)
Secernentea cebp-2 34
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 22 (a)
OneToMany
Species where no ortholog for CEBPD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CEBPD Gene

ENSEMBL:
Gene Tree for CEBPD (if available)
TreeFam:
Gene Tree for CEBPD (if available)

Paralogs for CEBPD Gene

Paralogs for CEBPD Gene

(2) SIMAP similar genes for CEBPD Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CEBPD: view

Variants for CEBPD Gene

Sequence variations from dbSNP and Humsavar for CEBPD Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000925679 -- 47,738,417(+) GCCCG(A/G)GCCGG upstream-variant-2KB
rs1000988488 -- 47,738,875(+) TGCGT(C/T)CTGGC upstream-variant-2KB
rs1002346085 -- 47,738,941(+) CACGA(-/CACCGC)GTCCT upstream-variant-2KB
rs1002377249 -- 47,738,675(+) GCCCC(A/G)CGCCT upstream-variant-2KB
rs1002417459 -- 47,737,165(+) CCAGG(C/G)TGTAG utr-variant-3-prime

Variation tolerance for CEBPD Gene

Gene Damage Index Score: 1.77; 33.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CEBPD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CEBPD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CEBPD Gene

Disorders for CEBPD Gene

MalaCards: The human disease database

(1) MalaCards diseases for CEBPD Gene - From: DISEASES

Disorder Aliases PubMed IDs
leukoencephalopathy with vanishing white matter
  • ovarioleukodystrophy
- elite association - COSMIC cancer census association via MalaCards
Search CEBPD in MalaCards View complete list of genes associated with diseases

Relevant External Links for CEBPD

Genetic Association Database (GAD)
CEBPD
Human Genome Epidemiology (HuGE) Navigator
CEBPD
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CEBPD
genes like me logo Genes that share disorders with CEBPD: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CEBPD Gene

Publications for CEBPD Gene

  1. Genetic variations at the CCAAT/enhancer-binding protein delta are associated with metabolic phenotypes in the Japanese population. (PMID: 18370833) Kaji H … Tanida K (Metabolic syndrome and related disorders 2008) 3 22 45 60
  2. The human C/EBP delta (CRP3/CELF) gene: structure and chromosomal localization. (PMID: 8314590) Cleutjens CB … Trapman J (Genomics 1993) 3 4 22 60
  3. CCAAT/enhancer binding protein alpha, beta and delta gene variants: associations with obesity related phenotypes in the Leeds Family Study. (PMID: 20460359) Bennett CE … Carter AM (Diabetes & vascular disease research 2010) 3 45 60
  4. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PMID: 18660489) Lu Y … Boer JM (Journal of lipid research 2008) 3 45 60
  5. Epigenetic silencing of CCAAT/enhancer-binding protein delta activity by YY1/polycomb group/DNA methyltransferase complex. (PMID: 18753137) Ko CY … Wang JM (The Journal of biological chemistry 2008) 3 22 60

Products for CEBPD Gene

Sources for CEBPD Gene

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