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Aliases for MYBBP1A Gene

Aliases for MYBBP1A Gene

  • MYB Binding Protein (P160) 1a 2 3
  • P160 3 4 6
  • P53-Activated Protein-2 2 3
  • Myb-Binding Protein 1A 3
  • PAP2 3

External Ids for MYBBP1A Gene

Summaries for MYBBP1A Gene

Entrez Gene Summary for MYBBP1A Gene

  • This gene encodes a nucleolar transcriptional regulator that was first identified by its ability to bind specifically to the Myb proto-oncogene protein. The encoded protein is thought to play a role in many cellular processes including response to nucleolar stress, tumor suppression and synthesis of ribosomal DNA. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for MYBBP1A Gene

MYBBP1A (MYB Binding Protein (P160) 1a) is a Protein Coding gene. Diseases associated with MYBBP1A include brain glioma. Among its related pathways are Energy Metabolism. GO annotations related to this gene include sequence-specific DNA binding and DNA-directed DNA polymerase activity.

UniProtKB/Swiss-Prot for MYBBP1A Gene

  • May activate or repress transcription via interactions with sequence specific DNA-binding proteins. Repression may be mediated at least in part by histone deacetylase activity (HDAC activity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2. Preferentially binds to dimethylated histone H3 Lys-9 (H3K9me2) on the PER2 promoter.

Gene Wiki entry for MYBBP1A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYBBP1A Gene

Genomics for MYBBP1A Gene

Genomic Location for MYBBP1A Gene

Start:
4,538,896 bp from pter
End:
4,555,631 bp from pter
Size:
16,736 bases
Orientation:
Minus strand

Genomic View for MYBBP1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYBBP1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYBBP1A Gene

Regulatory Elements for MYBBP1A Gene

Proteins for MYBBP1A Gene

  • Protein details for MYBBP1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQG0-MBB1A_HUMAN
    Recommended name:
    Myb-binding protein 1A
    Protein Accession:
    Q9BQG0
    Secondary Accessions:
    • Q86VM3
    • Q9BW49
    • Q9P0V5
    • Q9UF99

    Protein attributes for MYBBP1A Gene

    Size:
    1328 amino acids
    Molecular mass:
    148855 Da
    Quaternary structure:
    • Binds to and represses JUN and MYB via the leucine zipper regions present in these proteins. Also binds to and represses PPARGC1A: this interaction is abrogated when PPARGC1A is phosphorylated by MAPK1/ERK. Binds to and stimulates transcription by AHR. Binds to KPNA2. Interacts wih CLOCK and CRY1 (By similarity). Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21.
    SequenceCaution:
    • Sequence=CAB66530.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MYBBP1A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYBBP1A Gene

Proteomics data for MYBBP1A Gene at MOPED

Post-translational modifications for MYBBP1A Gene

  • Citrullinated by PADI4.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys56, Lys161, Lys179, Lys231, Lys988, Lys1036, and Lys1140

Other Protein References for MYBBP1A Gene

No data available for DME Specific Peptides for MYBBP1A Gene

Domains for MYBBP1A Gene

Protein Domains for MYBBP1A Gene

genes like me logo Genes that share domains with MYBBP1A: view

No data available for Gene Families and UniProtKB/Swiss-Prot for MYBBP1A Gene

Function for MYBBP1A Gene

Molecular function for MYBBP1A Gene

GENATLAS Biochemistry: MYB binding protein 1A,expressed in pancreas,kidney,brain,colon,prostate,nuclear predominantly localized in the nucleolus
UniProtKB/Swiss-Prot Function: May activate or repress transcription via interactions with sequence specific DNA-binding proteins. Repression may be mediated at least in part by histone deacetylase activity (HDAC activity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2. Preferentially binds to dimethylated histone H3 Lys-9 (H3K9me2) on the PER2 promoter.

Gene Ontology (GO) - Molecular Function for MYBBP1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001047 core promoter binding ISS --
GO:0003677 DNA binding --
GO:0003714 transcription corepressor activity ISS --
GO:0003887 DNA-directed DNA polymerase activity IEA --
GO:0005488 binding --
genes like me logo Genes that share ontologies with MYBBP1A: view

Phenotypes for MYBBP1A Gene

genes like me logo Genes that share phenotypes with MYBBP1A: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MYBBP1A Gene

Localization for MYBBP1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYBBP1A Gene

Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Shuttles between the nucleus and cytoplasm. Nuclear import may be mediated by KPNA2, while export appears to depend partially on XPO1/CRM1 (By similarity). Predominantly nucleolar. {ECO:0000250 UniProtKB:Q7TPV4}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYBBP1A Gene COMPARTMENTS Subcellular localization image for MYBBP1A gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for MYBBP1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005730 nucleolus ISS --
GO:0005737 cytoplasm ISS --
GO:0016020 membrane IDA 16210410
GO:0042564 NLS-dependent protein nuclear import complex ISS --
genes like me logo Genes that share ontologies with MYBBP1A: view

Pathways for MYBBP1A Gene

SuperPathways for MYBBP1A Gene

Superpath Contained pathways
1 Energy Metabolism
genes like me logo Genes that share pathways with MYBBP1A: view

Pathways by source for MYBBP1A Gene

1 BioSystems pathway for MYBBP1A Gene

Gene Ontology (GO) - Biological Process for MYBBP1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation IDA 16210410
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated TAS 10644447
GO:0006913 nucleocytoplasmic transport ISS --
GO:0022904 respiratory electron transport chain IEA --
genes like me logo Genes that share ontologies with MYBBP1A: view

Compounds for MYBBP1A Gene

(6) HMDB Compounds for MYBBP1A Gene

Compound Synonyms Cas Number PubMed IDs
dATP
  • 2'-Deoxy-5'-ATP
1927-31-7
dCTP
  • 2'-deoxycytidine-5'-triphosphate
2056-98-6
dGTP
  • 2'-Deoxyguanosine 5'-triphosphate
2564-35-4
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8
genes like me logo Genes that share compounds with MYBBP1A: view

Transcripts for MYBBP1A Gene

Unigene Clusters for MYBBP1A Gene

MYB binding protein (P160) 1a:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYBBP1A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: - - - - - -
SP12:
SP13:
SP14:

ExUns: 21a · 21b ^ 22 ^ 23a · 23b · 23c · 23d ^ 24a · 24b ^ 25 ^ 26 ^ 27a · 27b · 27c
SP1:
SP2: - -
SP3: - -
SP4: - -
SP5: - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: - - - - - - - - - -
SP12: - -
SP13:
SP14:

Relevant External Links for MYBBP1A Gene

GeneLoc Exon Structure for
MYBBP1A
ECgene alternative splicing isoforms for
MYBBP1A

Expression for MYBBP1A Gene

mRNA expression in normal human tissues for MYBBP1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MYBBP1A Gene

SOURCE GeneReport for Unigene cluster for MYBBP1A Gene Hs.701718

genes like me logo Genes that share expressions with MYBBP1A: view

Orthologs for MYBBP1A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MYBBP1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYBBP1A 36
  • 96.75 (n)
  • 96.16 (a)
MYBBP1A 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MYBBP1A 36
  • 82.35 (n)
  • 77.23 (a)
MYBBP1A 37
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYBBP1A 36
  • 82.09 (n)
  • 78.08 (a)
MYBBP1A 37
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mybbp1a 36
  • 76.27 (n)
  • 70.72 (a)
Mybbp1a 16
Mybbp1a 37
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MYBBP1A 37
  • 43 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MYBBP1A 37
  • 52 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mybbp1a 36
  • 75.77 (n)
  • 69.71 (a)
chicken
(Gallus gallus)
Aves MYBBP1A 36
  • 60.08 (n)
  • 53.97 (a)
MYBBP1A 37
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYBBP1A 37
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mybbp1a 36
  • 54.03 (n)
  • 47.52 (a)
Str.18801 36
zebrafish
(Danio rerio)
Actinopterygii Dr.25251 36
mybbp1a 37
  • 41 (a)
OneToMany
MYBBP1A (2 of 2) 37
  • 48 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1017 37
  • 26 (a)
OneToOne
Species with no ortholog for MYBBP1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYBBP1A Gene

ENSEMBL:
Gene Tree for MYBBP1A (if available)
TreeFam:
Gene Tree for MYBBP1A (if available)

Paralogs for MYBBP1A Gene

No data available for Paralogs for MYBBP1A Gene

Variants for MYBBP1A Gene

Sequence variations from dbSNP and Humsavar for MYBBP1A Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs749028 -- 4,545,955(-) GTCCT(A/G)CCCTG intron-variant
rs751670 -- 4,543,162(+) AGGTG(A/G)TGCCT reference, synonymous-codon
rs879797 - 4,542,932(+) GCATG(G/T)GGCTG reference, missense
rs899439 -- 4,543,963(+) GGTGC(A/G)GGGGT intron-variant
rs899440 - 4,545,645(+) CAGGT(A/G)GGAGC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MYBBP1A Gene

Variant ID Type Subtype PubMed ID
nsv907605 CNV Loss 21882294
dgv3049n71 CNV Loss 21882294
dgv3050n71 CNV Loss 21882294
dgv3051n71 CNV Loss 21882294
esv2715555 CNV Deletion 23290073

Relevant External Links for MYBBP1A Gene

HapMap Linkage Disequilibrium report
MYBBP1A
Human Gene Mutation Database (HGMD)
MYBBP1A

Disorders for MYBBP1A Gene

(1) MalaCards Diseases for MYBBP1A Gene

Search for MYBBP1A Gene in MalaCards »

Relevant External Links for MYBBP1A

Genetic Association Database (GAD)
MYBBP1A
Human Genome Epidemiology (HuGE) Navigator
MYBBP1A
genes like me logo Genes that share disorders with MYBBP1A: view

No data available for UniProtKB/Swiss-Prot for MYBBP1A Gene

Publications for MYBBP1A Gene

  1. Molecular cloning and chromosomal mapping of the human homologue of MYB binding protein (P160) 1A (MYBBP1A) to 17p13.3. (PMID: 10644447) Keough R. … Gonda T.J. (Genomics 1999) 2 3 4 23
  2. MYBBP1a is a novel repressor of NF-kappaB. (PMID: 17196614) Owen H.R. … Hottiger M.O. (J. Mol. Biol. 2007) 3 23
  3. Identification of Myb-binding protein 1A (MYBBP1A) as a novel substrate for aurora B kinase. (PMID: 20177074) Perrera C. … Rusconi L. (J. Biol. Chem. 2010) 3 23
  4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  5. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A. … Diaz J.-J. (Mol. Biol. Cell 2002) 3 4

Products for MYBBP1A Gene

Sources for MYBBP1A Gene

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