Aliases for SEMA4D Gene
External Ids for SEMA4D Gene
Previous HGNC Symbols for SEMA4D Gene
Previous GeneCards Identifiers for SEMA4D Gene
GeneCards Summary for SEMA4D Gene
SEMA4D (Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) And Short Cytoplasmic Domain, (Semaphorin) 4D) is a Protein Coding gene. Diseases associated with SEMA4D include hemorrhagic fever with renal syndrome. Among its related pathways are Developmental Biology and Guidance Cues and Growth Cone Motility. GO annotations related to this gene include receptor binding and transmembrane signaling receptor activity. An important paralog of this gene is SEMA4G.
UniProtKB/Swiss-Prot for SEMA4D Gene
Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system. Regulates dendrite and axon branching and morphogenesis. Promotes the migration of cerebellar granule cells and of endothelial cells. Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro). Promotes signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Interaction with PLXNB1 mediates activation of RHOA.