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CREB3 Gene(Protein Coding)

CAMP Responsive Element Binding Protein 3

GCID:
GC09P035722
GIFtS:
57
Genes Participants
UDN Logo

Aliases for CREB3 Gene

Aliases for CREB3 Gene

  • CAMP Responsive Element Binding Protein 3 2 3 5
  • Transcription Factor LZIP-Alpha 3 4
  • Small Leucine Zipper Protein 2 3
  • LUMAN 3 4
  • LZIP 3 4
  • Cyclic AMP Response Element (CRE)-Binding Protein/Activating Transcription Factor 1 3
  • CAMP Responsive Element Binding Protein 3 (Luman) 2
  • Cyclic AMP-Responsive Element-Binding Protein 3 3
  • CAMP-Responsive Element-Binding Protein 3 4
  • Basic Leucine Zipper Protein 3
  • Leucin Zipper Proitein 3
  • Leucine Zipper Protein 4
  • CREB-3 4
  • SLZIP 3

External Ids for CREB3 Gene

Previous GeneCards Identifiers for CREB3 Gene

  • GC09P036044
  • GC09P035901

Summaries for CREB3 Gene

Entrez Gene Summary for CREB3 Gene

  • This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-response element and regulates cell proliferation. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. This protein also plays a role in leukocyte migration, tumor suppression, and endoplasmic reticulum stress-associated protein degradation. Additional transcript variants have been identified, but their biological validity has not been determined.[provided by RefSeq, Nov 2009]

GeneCards Summary for CREB3 Gene

CREB3 (CAMP Responsive Element Binding Protein 3) is a Protein Coding gene. Diseases associated with CREB3 include Herpes Simplex and Hypertrophy Of Breast. Among its related pathways are PEDF Induced Signaling and Phospholipase-C Pathway. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is CREB3L3.

UniProtKB/Swiss-Prot for CREB3 Gene

  • Endoplasmic reticulum (ER)-bound transcription factor that plays a role in the unfolded protein response (UPR). Involved in cell proliferation and migration, tumor suppression and inflammatory gene expression. Plays also a role in the human immunodeficiency virus type 1 (HIV-1) virus protein expression and in the herpes simplex virus-1 (HSV-1) latent infection and reactivation from latency. Isoform 2 plays a role in the unfolded protein response (UPR). Isoform 2 acts as a positive regulator of LKN-1/CCL15-induced chemotaxis signaling of leukocyte cell migration. Isoform 2 may play a role as a cellular tumor suppressor that is targeted by the hepatitis C virus (HSV) core protein. Isoform 2 represses the VP16-mediated transactivation of immediate early genes of the HSV-1 virus by sequestring host cell factor-1 HCFC1 in the ER membrane of sensory neurons, thereby preventing the initiation of the replicative cascade leading to latent infection. Isoform 3 functions as a negative transcriptional regulator in ligand-induced transcriptional activation of the glucocorticoid receptor NR3C1 by recruiting and activating histone deacetylases (HDAC1, HDAC2 and HDAC6). Isoform 3 decreases the acetylation level of histone H4. Isoform 3 does not promote the chemotactic activity of leukocyte cells.

  • Processed cyclic AMP-responsive element-binding protein 3: acts as a transcription factor that activates unfolded protein response (UPR) target genes during endoplasmic reticulum (ER) stress response. Promotes cell survival against ER stress-induced apoptotic cell death during UPR. Activates transcription from CRE and C/EBP-containing reporter genes. Induces transcriptional activation of chemokine receptors. Activates transcription of genes required for reactivation of the latent HSV-1 virus. Down-regulates Tat-dependent transcription of the HIV-1 LTR by interacting with HIV-1 Tat. Its transcriptional activity is inhibited by CREBZF in a HCFC1-dependent manner, by the viral transactivator protein VP16 and by the HCV core protein. Binds DNA to the cAMP response element (CRE) (consensus: 5-GTGACGT[AG][AG]-3) and C/EBP sequences present in many viral and cellular promoters. Binds to the unfolded protein respons element (UPRE) consensus sequences sites. Binds DNA to the 5-CCAC[GA]-3half of ERSE II (5-ATTGG-N-CCACG-3). Associates with chromatin to the HERPUD1 promoter.

Gene Wiki entry for CREB3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CREB3 Gene

Genomics for CREB3 Gene

Products:

  1. Regulatory Element

Regulatory Elements for CREB3 Gene

Enhancers for CREB3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G035904 1.8 FANTOM5 Ensembl ENCODE dbSUPER 9.6 +175.8 175848 7.4 FOXA2 SIN3A ZNF48 YY1 SLC30A9 ZNF121 GLIS2 GATA2 ZNF143 FOS HRCT1 SPAAR TMEM8B OR13J1 FAM221B NDUFA5P4 ENSG00000227388 NPR2 SPAG8 OR2S1P
GH09G035679 1.5 Ensembl ENCODE dbSUPER 11.2 -46.2 -46203 12.8 PKNOX1 ARID4B SIN3A GLIS2 ELK1 FOS ZNF263 SP3 SMARCB1 MBD2 TPM2 GBA2 TMEM8B TLN1 NPR2 CCDC107 SIT1 CREB3 RGP1 MSMP
GH09G035913 1.6 Ensembl ENCODE dbSUPER 9.5 +184.9 184922 7.7 HDGF PKNOX1 ARNT ARID4B YBX1 ZBTB7B YY1 ZNF766 ZNF207 ZNF548 YBX1P10 GBA2 SPAAR RECK NDUFA5P4 OR13J1 FAM221B TMEM8B SPAG8 ENSG00000227388
GH09G035616 1.2 ENCODE dbSUPER 10.9 -113.1 -113066 6.4 HDGF PKNOX1 ATF1 WRNIP1 ZBTB40 RFX5 ETS1 EGR1 SCRT2 ZNF143 CCDC107 RN7SL22P ARHGEF39 SIT1 CA9 FAM166B TLN1 CREB3 GBA2 CD72
GH09G035694 1 ENCODE dbSUPER 11.1 -36.2 -36234 2.6 CTCF FOXA2 ARID4B RAD21 ZBTB48 POLR2A ZNF143 SMC3 FOS THAP11 TPM2 RN7SL22P ARHGEF39 CCDC107 SIT1 CA9 TLN1 CREB3 GBA2 RGP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CREB3 on UCSC Golden Path with GeneCards custom track

Promoters for CREB3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000234675 -120 2401 CREB3L1 MLX AGO1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC

Transcription factor binding sites by QIAGEN in the CREB3 gene promoter:

Genomic Location for CREB3 Gene

Chromosome:
9
Start:
35,732,320 bp from pter
End:
35,737,008 bp from pter
Size:
4,689 bases
Orientation:
Plus strand

Genomic View for CREB3 Gene

Genes around CREB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CREB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CREB3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CREB3 Gene

Proteins for CREB3 Gene

Products:

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  2. Protein
  3. Assay

  • Protein details for CREB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43889-CREB3_HUMAN
    Recommended name:
    Cyclic AMP-responsive element-binding protein 3
    Protein Accession:
    O43889
    Secondary Accessions:
    • D0PTW6
    • O14671
    • O14919
    • Q5TCV1
    • Q96GK8
    • Q9H2W3
    • Q9UE77

    Protein attributes for CREB3 Gene

    Size:
    395 amino acids
    Molecular mass:
    43917 Da
    Quaternary structure:
    • Homodimer; homodimerization is prevented by the HCV core protein. Interacts with HCFC1; the interaction is required to stimulate CREB3 transcriptional activity. Isoform 2 interacts with CREBZF; the interaction occurs only in combination with HCFC1. Isoform 2 interacts (via central part and transmembrane region) with TM7SF4 (via C-terminus cytoplasmic domain). Isoform 2 interacts with OS9. Isoform 2 interacts (via leucine-zipper domain) with CREBRF (via leucine-zipper domain); the interaction occurs only after CREB3 activation and promotes CREB3 degradation. Isoform 2 interacts (via C-terminal domain) with CCR1. Isoform 2 interacts (via leucine-zipper and transmembrane domains) with HIV-1 ENV (via cytoplasmic domain). Isoform 2 interacts (via leucine-zipper and transmembrane domains) with HIV-1 TMgp41 (via cytoplasmic domain); the interaction reduces CREB3 stability. Interacts with the HCV core protein. Processed cyclic AMP-responsive element-binding protein 3 interacts with HIV-1 Tat.

    Alternative splice isoforms for CREB3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CREB3 Gene

Post-translational modifications for CREB3 Gene

  • N-glycosylated.
  • The ER membrane embedded cyclic AMP-responsive element-binding protein 3 form is first proteolytically cleaved by site-1 protease (S1P) that generates membrane-associated N-terminus and a luminal C-terminus forms. The membrane-associated N-terminus form is further proteolytically processed probably by the site-2 protease (S2P) through a regulated intramembrane proteolysis (RIP), releasing the transcriptional active processed cyclic AMP-responsive element-binding protein 3 form, which is transported to the nucleus. The proteolytic cleavage is strongly induced during dendritic cell (DC) maturation and inhibited by TM7SF4.
  • The processed cyclic AMP-responsive element-binding protein 3 is rapidly degraded.
  • Ubiquitination at isoforms=2, 3376
  • Modification sites at PhosphoSitePlus

Other Protein References for CREB3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for CREB3

No data available for DME Specific Peptides for CREB3 Gene

Domains & Families for CREB3 Gene

Gene Families for CREB3 Gene

HGNC:

Protein Domains for CREB3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CREB3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43889

UniProtKB/Swiss-Prot:

CREB3_HUMAN :
  • Belongs to the bZIP family. ATF subfamily.
Family:
  • Belongs to the bZIP family. ATF subfamily.
genes like me logo Genes that share domains with CREB3: view

Function for CREB3 Gene

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Molecular function for CREB3 Gene

UniProtKB/Swiss-Prot Function:
Endoplasmic reticulum (ER)-bound transcription factor that plays a role in the unfolded protein response (UPR). Involved in cell proliferation and migration, tumor suppression and inflammatory gene expression. Plays also a role in the human immunodeficiency virus type 1 (HIV-1) virus protein expression and in the herpes simplex virus-1 (HSV-1) latent infection and reactivation from latency. Isoform 2 plays a role in the unfolded protein response (UPR). Isoform 2 acts as a positive regulator of LKN-1/CCL15-induced chemotaxis signaling of leukocyte cell migration. Isoform 2 may play a role as a cellular tumor suppressor that is targeted by the hepatitis C virus (HSV) core protein. Isoform 2 represses the VP16-mediated transactivation of immediate early genes of the HSV-1 virus by sequestring host cell factor-1 HCFC1 in the ER membrane of sensory neurons, thereby preventing the initiation of the replicative cascade leading to latent infection. Isoform 3 functions as a negative transcriptional regulator in ligand-induced transcriptional activation of the glucocorticoid receptor NR3C1 by recruiting and activating histone deacetylases (HDAC1, HDAC2 and HDAC6). Isoform 3 decreases the acetylation level of histone H4. Isoform 3 does not promote the chemotactic activity of leukocyte cells.
UniProtKB/Swiss-Prot Function:
Processed cyclic AMP-responsive element-binding protein 3: acts as a transcription factor that activates unfolded protein response (UPR) target genes during endoplasmic reticulum (ER) stress response. Promotes cell survival against ER stress-induced apoptotic cell death during UPR. Activates transcription from CRE and C/EBP-containing reporter genes. Induces transcriptional activation of chemokine receptors. Activates transcription of genes required for reactivation of the latent HSV-1 virus. Down-regulates Tat-dependent transcription of the HIV-1 LTR by interacting with HIV-1 Tat. Its transcriptional activity is inhibited by CREBZF in a HCFC1-dependent manner, by the viral transactivator protein VP16 and by the HCV core protein. Binds DNA to the cAMP response element (CRE) (consensus: 5-GTGACGT[AG][AG]-3) and C/EBP sequences present in many viral and cellular promoters. Binds to the unfolded protein respons element (UPRE) consensus sequences sites. Binds DNA to the 5-CCAC[GA]-3half of ERSE II (5-ATTGG-N-CCACG-3). Associates with chromatin to the HERPUD1 promoter.
UniProtKB/Swiss-Prot Induction:
Up-regulated upon differentiation of monocytes towards immature dendritic cells (DC). Down-regulated upon DC maturation. Up-regulated by endoplasmic reticulum stress triggered by thapsigargin (Tg) or tunicamycin (Tm). Up-regulated by CCR1-dependent chemokines in an immediate early response and biphasic manner and by NF-kappa-B.

Gene Ontology (GO) - Molecular Function for CREB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 16940180
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 16940180
GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 16940180
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IMP 16940180
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with CREB3: view
genes like me logo Genes that share phenotypes with CREB3: view

Animal Models for CREB3 Gene

MGI Knock Outs for CREB3:

Animal Model Products

miRNA for CREB3 Gene

miRTarBase miRNAs that target CREB3

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CREB3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CREB3 Gene

Localization for CREB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CREB3 Gene

Isoform 2: Endoplasmic reticulum membrane; Single-pass type II membrane protein. Membrane. Note=Colocalizes with HCFC1 in neuronal cell bodies of the trigeminal ganglia (By similarity). Colocalizes with TM7SF4 in the ER membrane of immature dendritic cell (DC). Colocalizes with CANX, CCR1, HCFC1 in the ER membrane. Sequestred into the cytoplasm by the HCV core protein. {ECO:0000250}.
Isoform 3: Nucleus. Cytoplasm. Note=Predominantly in the nucleus.
Processed cyclic AMP-responsive element-binding protein 3: Nucleus. Note=Upon RIP activation the transcriptional active processed cyclic AMP-responsive element-binding protein 3 form translocates into the nucleus. Detected in the nucleus upon dendritic cell maturation and RIP activation. Colocalizes with CREBRF in nuclear foci. Colocalizes with CREBZF in promyelocytic leukemia protein nuclear bodies (PML-NB).

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CREB3 gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 5
cytosol 5
golgi apparatus 5

Gene Ontology (GO) - Cellular Components for CREB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005634 nucleus IC,IDA 20546900
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IDA 16236796
genes like me logo Genes that share ontologies with CREB3: view

Pathways & Interactions for CREB3 Gene

genes like me logo Genes that share pathways with CREB3: view

SIGNOR curated interactions for CREB3 Gene

Activates:

Gene Ontology (GO) - Biological Process for CREB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0006935 chemotaxis IEA --
GO:0006986 response to unfolded protein IEA --
genes like me logo Genes that share ontologies with CREB3: view

Drugs & Compounds for CREB3 Gene

Products:

  1. Drug

(5) Drugs for CREB3 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0

(5) Additional Compounds for CREB3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CREB3: view

Transcripts for CREB3 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for CREB3 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(297) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CREB3 Gene

CAMP responsive element binding protein 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CREB3

Alternative Splicing Database (ASD) splice patterns (SP) for CREB3 Gene

No ASD Table

Relevant External Links for CREB3 Gene

GeneLoc Exon Structure for
CREB3
ECgene alternative splicing isoforms for
CREB3

Expression for CREB3 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CREB3 Gene

mRNA expression in normal human tissues for CREB3 Gene
mRNA expression by BioGPS for CREB3 GenemRNA expression by GTEx for CREB3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of CREB3 Gene:

CREB3

SOURCE GeneReport for Unigene cluster for CREB3 Gene:

Hs.522110

mRNA Expression by UniProt/SwissProt for CREB3 Gene:

O43889-CREB3_HUMAN
Tissue specificity: Expressed in dendritic cells (DC). Weakly expressed in monocytes (at protein level). Ubiquitous.

Evidence on tissue expression from TISSUES for CREB3 Gene

  • Nervous system(4.8)
  • Pancreas(4.2)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with CREB3: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CREB3 Gene

Orthologs for CREB3 Gene

This gene was present in the common ancestor of animals.

Orthologs for CREB3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CREB3 35
  • 99 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia CREB3 34 35
  • 83.48 (n)
cow
(Bos Taurus)
 Mammalia CREB3 34 35
  • 82.88 (n)
mouse
(Mus musculus)
 Mammalia Creb3 34 16 35
  • 76.26 (n)
rat
(Rattus norvegicus)
 Mammalia Creb3 34
  • 72.92 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia CREB3 35
  • 50 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia CREB3 35
  • 49 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves CREB3 34 35
  • 60.64 (n)
lizard
(Anolis carolinensis)
 Reptilia CREB3 35
  • 66 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia creb3 34
  • 59.45 (n)
African clawed frog
(Xenopus laevis)
 Amphibia Xl.16347 34
zebrafish
(Danio rerio)
 Actinopterygii creb3l3l 34 35
  • 59.76 (n)
wufj05f07 34
worm
(Caenorhabditis elegans)
 Secernentea let-607 35
  • 14 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 35
  • 21 (a)
 OneToMany
Species where no ortholog for CREB3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CREB3 Gene

ENSEMBL:
Gene Tree for CREB3 (if available)
TreeFam:
Gene Tree for CREB3 (if available)

Paralogs for CREB3 Gene

Paralogs for CREB3 Gene

genes like me logo Genes that share paralogs with CREB3: view

Variants for CREB3 Gene

Sequence variations from dbSNP and Humsavar for CREB3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs398123015 Pathogenic 35,737,335(-) GTTCC(A/G)CTCAC downstream-variant-500B, reference, missense, utr-variant-3-prime
rs752274637 Likely pathogenic 35,737,405(+) GGTAC(A/G)GTAGC downstream-variant-500B, reference, missense, utr-variant-3-prime
rs869025236 Uncertain significance 35,736,433(+) ACCCT(G/T)ACCAG downstream-variant-500B, reference, missense
rs1000622693 -- 35,730,746(+) ATGGG(G/T)GTGAA intron-variant, upstream-variant-2KB
rs1000779511 -- 35,730,392(+) CCAGT(G/T)TCCTC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CREB3 Gene

Variant ID Type Subtype PubMed ID
esv25437 CNV loss 19812545
nsv1125318 OTHER inversion 24896259

Variation tolerance for CREB3 Gene

Residual Variation Intolerance Score: 74.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.15; 23.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CREB3 Gene

Human Gene Mutation Database (HGMD)
CREB3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CREB3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CREB3 Gene

Disorders for CREB3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CREB3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
herpes simplex
  • herpesvirus hominis disease
hypertrophy of breast
  • breasts enlarged
hiv-1
  • aids, slow progression to
- elite association - COSMIC cancer census association via MalaCards
Search CREB3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CREB3

Genetic Association Database (GAD)
CREB3
Human Genome Epidemiology (HuGE) Navigator
CREB3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CREB3
genes like me logo Genes that share disorders with CREB3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CREB3 Gene

Publications for CREB3 Gene

  1. Luman, a new member of the CREB/ATF family, binds to herpes simplex virus VP16-associated host cellular factor. (PMID: 9271389) Lu R. … Misra V. (Mol. Cell. Biol. 1997) 2 3 4 22 64
  2. A novel isoform of human LZIP negatively regulates the transactivation of the glucocorticoid receptor. (PMID: 19779205) Kang H. … Ko J. (Mol. Endocrinol. 2009) 3 4 22 64
  3. Regulation of human LZIP expression by NF-kappaB and its involvement in monocyte cell migration induced by Lkn-1. (PMID: 17296613) Jang S.W. … Ko J. (J. Biol. Chem. 2007) 3 4 22 64
  4. Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response element. (PMID: 16940180) Liang G. … Lu R. (Mol. Cell. Biol. 2006) 3 4 22 64
  5. Zhangfei is a potent and specific inhibitor of the host cell factor- binding transcription factor Luman. (PMID: 15705566) Misra V. … Korchinski P. (J. Biol. Chem. 2005) 3 4 22 64

Products for CREB3 Gene

  • Addgene plasmids for CREB3

Sources for CREB3 Gene

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