Aliases for SEC23B Gene
External Ids for SEC23B Gene
Previous HGNC Symbols for SEC23B Gene
Previous GeneCards Identifiers for SEC23B Gene
The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The function of this gene product has been implicated in cargo selection and concentration. Multiple alternatively spliced transcript variants have been identified in this gene. [provided by RefSeq, Feb 2010]
GeneCards Summary for SEC23B Gene
SEC23B (Sec23 Homolog B, Coat Complex II Component) is a Protein Coding gene. Diseases associated with SEC23B include Dyserythropoietic Anemia, Congenital, Type Ii and Cowden Disease. Among its related pathways are Normal wtCFTR traffic / ER-to-Golgi and Regulation of cholesterol biosynthesis by SREBP (SREBF). An important paralog of this gene is SEC23A.
UniProtKB/Swiss-Prot for SEC23B Gene
Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex (By similarity).