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Aliases for CEACAM5 Gene

Aliases for CEACAM5 Gene

  • Carcinoembryonic Antigen Related Cell Adhesion Molecule 5 2 3
  • Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5 2 5
  • Meconium Antigen 100 3 4
  • CEA 3 4
  • Carcinoembryonic Antigen 4
  • CD66e Antigen 4
  • CD66e 3

External Ids for CEACAM5 Gene

Previous HGNC Symbols for CEACAM5 Gene

  • CEA

Previous GeneCards Identifiers for CEACAM5 Gene

  • GC19P042852
  • GC19P042604
  • GC19P046888
  • GC19P046904
  • GC19P042212
  • GC19P038644
  • GC19P041576

Summaries for CEACAM5 Gene

Entrez Gene Summary for CEACAM5 Gene

  • This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

GeneCards Summary for CEACAM5 Gene

CEACAM5 (Carcinoembryonic Antigen Related Cell Adhesion Molecule 5) is a Protein Coding gene. Diseases associated with CEACAM5 include colorectal cancer and urachal cancer. Among its related pathways are Cell adhesion_Cell-matrix glycoconjugates and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. GO annotations related to this gene include protein homodimerization activity and GPI anchor binding. An important paralog of this gene is CEACAM8.

UniProtKB/Swiss-Prot for CEACAM5 Gene

  • Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins.

Gene Wiki entry for CEACAM5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEACAM5 Gene

Genomics for CEACAM5 Gene

Regulatory Elements for CEACAM5 Gene

Promoters for CEACAM5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CEACAM5 on UCSC Golden Path with GeneCards custom track

Genomic Location for CEACAM5 Gene

Chromosome:
19
Start:
41,708,585 bp from pter
End:
41,730,433 bp from pter
Size:
21,849 bases
Orientation:
Plus strand

Genomic View for CEACAM5 Gene

Genes around CEACAM5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEACAM5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEACAM5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEACAM5 Gene

Proteins for CEACAM5 Gene

  • Protein details for CEACAM5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06731-CEAM5_HUMAN
    Recommended name:
    Carcinoembryonic antigen-related cell adhesion molecule 5
    Protein Accession:
    P06731
    Secondary Accessions:
    • H9KVA7

    Protein attributes for CEACAM5 Gene

    Size:
    702 amino acids
    Molecular mass:
    76795 Da
    Quaternary structure:
    • Homodimer. Binding of E.coli Dr adhesins leads to dissociation of the homodimer.
    SequenceCaution:
    • Sequence=AAA62835.1; Type=Frameshift; Positions=359, 361; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CEACAM5 Gene

    Alternative splice isoforms for CEACAM5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CEACAM5 Gene

Proteomics data for CEACAM5 Gene at MOPED

Post-translational modifications for CEACAM5 Gene

  • Complex immunoreactive glycoprotein with a MW of 180 kDa comprising 60% carbohydrate.
  • Glycosylation at Asn 104, Asn 115, Asn 152, Asn 182, Asn 197, Asn 204, Asn 208, Asn 246, Asn 256, Asn 274, Asn 288, Asn 292, Asn 309, Asn 330, Asn 351, Asn 360, Asn 375, Asn 432, Asn 466, Asn 480, Asn 508, Asn 529, Asn 553, Asn 560, Asn 580, Asn 612, Asn 650, and Asn 665
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CEACAM5 Gene

Domains & Families for CEACAM5 Gene

Graphical View of Domain Structure for InterPro Entry

P06731

UniProtKB/Swiss-Prot:

CEAM5_HUMAN :
  • Contains 7 Ig-like (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily. CEA family.
Domain:
  • Contains 7 Ig-like (immunoglobulin-like) domains.
Family:
  • Belongs to the immunoglobulin superfamily. CEA family.
genes like me logo Genes that share domains with CEACAM5: view

Function for CEACAM5 Gene

Molecular function for CEACAM5 Gene

GENATLAS Biochemistry:
carcinoembryonic antigen-related cell adhesion molecule 5
UniProtKB/Swiss-Prot Function:
Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins.

Gene Ontology (GO) - Molecular Function for CEACAM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042803 protein homodimerization activity IDA 18086185
genes like me logo Genes that share ontologies with CEACAM5: view

Phenotypes for CEACAM5 Gene

genes like me logo Genes that share phenotypes with CEACAM5: view

Human Phenotype Ontology for CEACAM5 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CEACAM5 Gene

Localization for CEACAM5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEACAM5 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CEACAM5 Gene COMPARTMENTS Subcellular localization image for CEACAM5 gene
Compartment Confidence
extracellular 5
plasma membrane 5
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CEACAM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0071575 integral component of external side of plasma membrane IDA 10864933
genes like me logo Genes that share ontologies with CEACAM5: view

Pathways & Interactions for CEACAM5 Gene

genes like me logo Genes that share pathways with CEACAM5: view

Gene Ontology (GO) - Biological Process for CEACAM5 Gene

None

No data available for SIGNOR curated interactions for CEACAM5 Gene

Drugs & Compounds for CEACAM5 Gene

(24) Drugs for CEACAM5 Gene - From: Novoseek, DGIdb, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
2,2,5,5-TETRAMETHYL-3-(SULFANYLMETHYL)-2,5-DIHYDRO-1H-PYRROL-1-OL Experimental Pharma Target 0
CEA/MUC-1/VF/TRICOM Pharma 0
TF2 Pharma 0

(37) Additional Compounds for CEACAM5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CEACAM5: view

Transcripts for CEACAM5 Gene

Unigene Clusters for CEACAM5 Gene

Carcinoembryonic antigen-related cell adhesion molecule 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CEACAM5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c · 12d
SP1:
SP2: - - - - - - - - - - - - - - -
SP3:
SP4:
SP5: -
SP6: - - - - - - - - -
SP7:
SP8: - - - - -
SP9:

Relevant External Links for CEACAM5 Gene

GeneLoc Exon Structure for
CEACAM5
ECgene alternative splicing isoforms for
CEACAM5

Expression for CEACAM5 Gene

mRNA expression in normal human tissues for CEACAM5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CEACAM5 Gene

This gene is overexpressed in Colon - Transverse (x30.9) and Esophagus - Mucosa (x11.7).

Protein differential expression in normal tissues from HIPED for CEACAM5 Gene

This gene is overexpressed in Nasal epithelium (44.1) and Cervix (13.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CEACAM5 Gene



SOURCE GeneReport for Unigene cluster for CEACAM5 Gene Hs.709196

mRNA Expression by UniProt/SwissProt for CEACAM5 Gene

P06731-CEAM5_HUMAN
Tissue specificity: Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.
genes like me logo Genes that share expression patterns with CEACAM5: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for CEACAM5 Gene

Orthologs for CEACAM5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CEACAM5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CEACAM5 35
  • 98.77 (n)
  • 97.44 (a)
-- 36
  • 97 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 36
  • 36 (a)
ManyToMany
CEACAM1 36
  • 43 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Ceacam1 36
  • 43 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 39 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii si:ch211-264f5.6 35
  • 44.03 (n)
  • 32.35 (a)
Species with no ortholog for CEACAM5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CEACAM5 Gene

ENSEMBL:
Gene Tree for CEACAM5 (if available)
TreeFam:
Gene Tree for CEACAM5 (if available)

Paralogs for CEACAM5 Gene

genes like me logo Genes that share paralogs with CEACAM5: view

Variants for CEACAM5 Gene

Sequence variations from dbSNP and Humsavar for CEACAM5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs7249230 - 41,717,688(+) AGAAC(A/G)AATTA intron-variant, reference, missense
rs10407503 - 41,717,515(+) GGATG(A/C/G)TGTAG intron-variant, reference, missense
rs10423171 - 41,721,140(+) CTGGC(A/C/T)GCAAT intron-variant, reference, missense
rs3815780 - 41,710,025(+) TGGCC(A/C)GTTCC reference, missense
VAR_056029 -

Structural Variations from Database of Genomic Variants (DGV) for CEACAM5 Gene

Variant ID Type Subtype PubMed ID
esv2718577 CNV Deletion 23290073
nsv522854 CNV Gain 19592680
nsv482220 CNV Gain 20164927

Variation tolerance for CEACAM5 Gene

Residual Variation Intolerance Score: 91.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.68; 65.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CEACAM5 Gene

HapMap Linkage Disequilibrium report
CEACAM5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEACAM5 Gene

Disorders for CEACAM5 Gene

MalaCards: The human disease database

(7) MalaCards diseases for CEACAM5 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
colorectal cancer
  • colorectal cancer, somatic
urachal cancer
  • urachal carcinoma
urachal adenocarcinoma
  • adenocarcinoma of the urachus
vaccinia
lung cancer
  • lung cancer, protection against
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CEACAM5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CEACAM5
genes like me logo Genes that share disorders with CEACAM5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CEACAM5 Gene

Publications for CEACAM5 Gene

  1. Binding of Dr adhesins of Escherichia coli to carcinoembryonic antigen triggers receptor dissociation. (PMID: 18086185) Korotkova N. … Matthews S. (Mol. Microbiol. 2008) 3 4 67
  2. Survival and prognostic factors in small cell lung cancer. (PMID: 19214813) Li J. … Li X.Q. (Med. Oncol. 2010) 3 23
  3. Carcinoembryonic antigen surge in metastatic colorectal cancer patients responding to irinotecan combination chemotherapy. (PMID: 20121626) An X. … Li Y.H. (Biomarkers 2010) 3 23
  4. The impact of carcinoembryonic antigen flare in patients with advanced colorectal cancer receiving first-line chemotherapy. (PMID: 19861580) Strimpakos A.S. … Chau I. (Ann. Oncol. 2010) 3 23
  5. DC-SIGN and SRCL bind glycans of carcinoembryonic antigen (CEA) and CEA-related cell adhesion molecule 1 (CEACAM1): recombinant human glycan-binding receptors as analytical tools. (PMID: 20034698) Samsen A. … Wagener C. (Eur. J. Cell Biol. 2010) 3 23

Products for CEACAM5 Gene

Sources for CEACAM5 Gene

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