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Aliases for SLC25A17 Gene

Aliases for SLC25A17 Gene

  • Solute Carrier Family 25 Member 17 2 3 4 5
  • Solute Carrier Family 25 (Mitochondrial Carrier; Peroxisomal Membrane Protein, 34kDa), Member 17 2 3
  • PMP34 3 4
  • Solute Carrier Family 25 (Mitochondrial Carrier; Peroxisomal Membrane Protein, 34kD), Member 17 2
  • Peroxisomal Membrane Protein (34kD) 2
  • 34 KDa Peroxisomal Membrane Protein 4
  • Peroxisomal Membrane Protein PMP34 3

External Ids for SLC25A17 Gene

Previous GeneCards Identifiers for SLC25A17 Gene

  • GC22M037780
  • GC22M039408
  • GC22M039409
  • GC22M039490
  • GC22M041165
  • GC22M024127
  • GC22M040771
  • GC22M040772
  • GC22M040774
  • GC22M040918
  • GC22M040920
  • GC22M041089

Summaries for SLC25A17 Gene

Entrez Gene Summary for SLC25A17 Gene

  • This gene encodes a peroxisomal membrane protein that belongs to the family of mitochondrial solute carriers. It is expressed in the liver, and is likely involved in transport. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for SLC25A17 Gene

SLC25A17 (Solute Carrier Family 25 Member 17) is a Protein Coding gene. Diseases associated with SLC25A17 include Adrenomyeloneuropathy and Peroxisome Disorders. Among its related pathways are Metabolism and Peroxisomal lipid metabolism. GO annotations related to this gene include transporter activity and ATP transmembrane transporter activity.

UniProtKB/Swiss-Prot for SLC25A17 Gene

  • Peroxisomal transporter for multiple cofactors like coenzyme A (CoA), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN) and nucleotide adenosine monophosphate (AMP), and to a lesser extent for nicotinamide adenine dinucleotide (NAD(+)), adenosine diphosphate (ADP) and adenosine 3,5-diphosphate (PAP). May catalyze the transport of free CoA, FAD and NAD(+) from the cytosol into the peroxisomal matrix by a counter-exchange mechanism. Inhibited by pyridoxal 5-phosphate and bathophenanthroline in vitro.

Gene Wiki entry for SLC25A17 Gene

Additional gene information for SLC25A17 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A17 Gene

Genomics for SLC25A17 Gene

Regulatory Elements for SLC25A17 Gene

Enhancers for SLC25A17 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22H041444 1.8 FANTOM5 ENCODE dbSUPER 32 -627.3 -627317 5 MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 NFYC L3MBTL2 EP300 ZC3H7B PHF5A SLC25A17 XRCC6 POLR3H NDUFA6-AS1 MEI1 TEF
GH22H040709 2 FANTOM5 Ensembl ENCODE dbSUPER 22 +107.2 107227 6 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 ZNF2 ZNF416 FOS EP300 XRCC6 PHF5A SLC25A17 L3MBTL2 DNAJB7 HMGN2P10 SNU13 ZC3H7B ENSG00000235513
GH22H041666 1.4 Ensembl ENCODE 23.6 -848.0 -848045 2 HDGF PKNOX1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 RN7SKP80 EP300 PHF5A POLDIP3 RRP7BP EP300-AS1 ENSG00000232754 XRCC6 SLC25A17 MEI1
GH22H041815 1.1 ENCODE dbSUPER 23.6 -998.2 -998165 3 ZNF493 ZFP64 ZNF121 ZNF138 ZNF354C ZNF654 ZNF680 ZC3H11A OVOL3 REST EP300 RN7SKP80 PHF5A POLDIP3 RPL5P34 DNAJB7 ENSG00000232754 SLC25A17 MEI1 RRP7BP
GH22H041409 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.9 -593.6 -593577 6 HDGF FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 EP300 ENSG00000272834 MEI1 POLR3H PHF5A CYP2D8P TCF20 XRCC6 SLC25A17 NAGA
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC25A17 on UCSC Golden Path with GeneCards custom track

Promoters for SLC25A17 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000146564 299 1401 ARID4B SIN3A ZNF2 ZNF121 ZNF143 ZNF207 KLF7 RUNX3 SP3 SP5

Genomic Location for SLC25A17 Gene

Chromosome:
22
Start:
40,769,630 bp from pter
End:
40,819,399 bp from pter
Size:
49,770 bases
Orientation:
Minus strand

Genomic View for SLC25A17 Gene

Genes around SLC25A17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A17 Gene

Proteins for SLC25A17 Gene

  • Protein details for SLC25A17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43808-PM34_HUMAN
    Recommended name:
    Peroxisomal membrane protein PMP34
    Protein Accession:
    O43808
    Secondary Accessions:
    • A8KA59
    • Q5TFL0
    • Q9UGW8
    • Q9UGY7

    Protein attributes for SLC25A17 Gene

    Size:
    307 amino acids
    Molecular mass:
    34567 Da
    Quaternary structure:
    • Interacts (via N- and C-terminus peroxisomal targeting regions) with PEX19; the interaction occurs with the newly synthesized SLC25A17 in the cytosol.

neXtProt entry for SLC25A17 Gene

Post-translational modifications for SLC25A17 Gene

  • Ubiquitination at isoforms=268
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC25A17 Gene

Domains & Families for SLC25A17 Gene

Gene Families for SLC25A17 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC25A17 Gene

Suggested Antigen Peptide Sequences for SLC25A17 Gene

Graphical View of Domain Structure for InterPro Entry

O43808

UniProtKB/Swiss-Prot:

PM34_HUMAN :
  • The N- and C-terminal portions are exposed to the cytoplasm. Lacks a typical peroxisomal sorting signal. A region between helical transmembrane domains (TM) 4 and 5 and TM1-TM3 or TM4-TM6 are necessary for the peroxisome-targeting activity.
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Domain:
  • The N- and C-terminal portions are exposed to the cytoplasm. Lacks a typical peroxisomal sorting signal. A region between helical transmembrane domains (TM) 4 and 5 and TM1-TM3 or TM4-TM6 are necessary for the peroxisome-targeting activity.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
genes like me logo Genes that share domains with SLC25A17: view

Function for SLC25A17 Gene

Molecular function for SLC25A17 Gene

GENATLAS Biochemistry:
solute carrier protein family 25,member A17,mitochondrial carrier,peroxisomal protein,34kDa,widely expressed
UniProtKB/Swiss-Prot Function:
Peroxisomal transporter for multiple cofactors like coenzyme A (CoA), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN) and nucleotide adenosine monophosphate (AMP), and to a lesser extent for nicotinamide adenine dinucleotide (NAD(+)), adenosine diphosphate (ADP) and adenosine 3,5-diphosphate (PAP). May catalyze the transport of free CoA, FAD and NAD(+) from the cytosol into the peroxisomal matrix by a counter-exchange mechanism. Inhibited by pyridoxal 5-phosphate and bathophenanthroline in vitro.

Phenotypes From GWAS Catalog for SLC25A17 Gene

Gene Ontology (GO) - Molecular Function for SLC25A17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000295 adenine nucleotide transmembrane transporter activity TAS --
GO:0005215 transporter activity IEA --
GO:0005347 ATP transmembrane transporter activity IGI 12445829
GO:0005515 protein binding IPI 10704444
GO:0015217 ADP transmembrane transporter activity IDA 22185573
genes like me logo Genes that share ontologies with SLC25A17: view
genes like me logo Genes that share phenotypes with SLC25A17: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC25A17

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SLC25A17
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC25A17 Gene

Localization for SLC25A17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A17 Gene

Cytoplasm. Peroxisome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC25A17 gene
Compartment Confidence
peroxisome 5
mitochondrion 4
plasma membrane 2
endoplasmic reticulum 2
cytosol 2
extracellular 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SLC25A17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane IBA,IEA --
GO:0005777 peroxisome IDA 9874197
GO:0005778 peroxisomal membrane TAS --
genes like me logo Genes that share ontologies with SLC25A17: view

Pathways & Interactions for SLC25A17 Gene

genes like me logo Genes that share pathways with SLC25A17: view

Pathways by source for SLC25A17 Gene

1 KEGG pathway for SLC25A17 Gene

Gene Ontology (GO) - Biological Process for SLC25A17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001561 fatty acid alpha-oxidation TAS --
GO:0006635 fatty acid beta-oxidation IGI 12445829
GO:0006810 transport IEA --
GO:0006839 mitochondrial transport IBA --
GO:0015866 ADP transport IEA --
genes like me logo Genes that share ontologies with SLC25A17: view

No data available for SIGNOR curated interactions for SLC25A17 Gene

Drugs & Compounds for SLC25A17 Gene

(1) Drugs for SLC25A17 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for SLC25A17 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLC25A17: view

Transcripts for SLC25A17 Gene

Unigene Clusters for SLC25A17 Gene

Solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SLC25A17
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A17 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1: - - - -
SP2: - - -
SP3: - - - - - -
SP4: - - - -
SP5: - - - - - - - -
SP6: - - - - -
SP7:
SP8:

Relevant External Links for SLC25A17 Gene

GeneLoc Exon Structure for
SLC25A17
ECgene alternative splicing isoforms for
SLC25A17

Expression for SLC25A17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC25A17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC25A17 Gene

This gene is overexpressed in Plasma (35.4), Adrenal (10.8), and Fetal ovary (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC25A17 Gene



NURSA nuclear receptor signaling pathways regulating expression of SLC25A17 Gene:

SLC25A17

SOURCE GeneReport for Unigene cluster for SLC25A17 Gene:

Hs.474938

mRNA Expression by UniProt/SwissProt for SLC25A17 Gene:

O43808-PM34_HUMAN
Tissue specificity: Ubiquitous. Expressed in liver.

Evidence on tissue expression from TISSUES for SLC25A17 Gene

  • Liver(4.4)
  • Skin(4.3)
  • Nervous system(4.1)
  • Adrenal gland(2.2)
genes like me logo Genes that share expression patterns with SLC25A17: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC25A17 Gene

Orthologs for SLC25A17 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC25A17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC25A17 33 34
  • 99.26 (n)
dog
(Canis familiaris)
Mammalia SLC25A17 33 34
  • 93.7 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC25A17 34
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC25A17 33 34
  • 90.77 (n)
mouse
(Mus musculus)
Mammalia Slc25a17 33 16 34
  • 88.17 (n)
rat
(Rattus norvegicus)
Mammalia Slc25a17 33
  • 87.51 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SLC25A17 34
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC25A17 33 34
  • 80.78 (n)
lizard
(Anolis carolinensis)
Reptilia SLC25A17 34
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a17 33
  • 70.89 (n)
Str.1440 33
African clawed frog
(Xenopus laevis)
Amphibia LOC398157 33
zebrafish
(Danio rerio)
Actinopterygii slc25a17 33 34
  • 67 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007520 33
  • 56.69 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG32250 33 34
  • 54.58 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E02817g 33
  • 46.31 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR147C 33
  • 45.93 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YEA6 34
  • 24 (a)
ManyToMany
YIA6 34
  • 21 (a)
ManyToMany
ANT1 36
rice
(Oryza sativa)
Liliopsida Os09g0508900 33
  • 47.79 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU03556 33
  • 46.45 (n)
Species where no ortholog for SLC25A17 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC25A17 Gene

ENSEMBL:
Gene Tree for SLC25A17 (if available)
TreeFam:
Gene Tree for SLC25A17 (if available)

Paralogs for SLC25A17 Gene

genes like me logo Genes that share paralogs with SLC25A17: view

No data available for Paralogs for SLC25A17 Gene

Variants for SLC25A17 Gene

Sequence variations from dbSNP and Humsavar for SLC25A17 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000016799 -- 40,776,856(+) ACCAC(G/T)GTACT intron-variant
rs1000228802 -- 40,783,375(+) TCAGT(A/G)GAGAA intron-variant
rs1000241273 -- 40,821,121(+) TCGAG(C/T)AGCTG upstream-variant-2KB
rs1000345503 -- 40,816,171(+) CCAGC(C/T)TGGGC intron-variant
rs1000413574 -- 40,819,408(+) GCGGG(A/G)AAGCG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SLC25A17 Gene

Variant ID Type Subtype PubMed ID
esv3568414 CNV loss 25503493
nsv1062438 CNV gain 25217958
nsv1066802 CNV gain 25217958
nsv834205 CNV gain+loss 17160897
nsv834206 CNV gain 17160897

Variation tolerance for SLC25A17 Gene

Residual Variation Intolerance Score: 51.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.64; 31.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC25A17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC25A17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A17 Gene

Disorders for SLC25A17 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SLC25A17 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
adrenomyeloneuropathy
  • amn
peroxisome disorders
  • peroxisomal disease
cerebral degeneration
  • brain degeneration
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC25A17

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC25A17
genes like me logo Genes that share disorders with SLC25A17: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC25A17 Gene

Publications for SLC25A17 Gene

  1. Identification and characterization of human PMP34, a protein closely related to the peroxisomal integral membrane protein PMP47 of Candida boidinii. (PMID: 9874197) Wylin T … Van Veldhoven PP (European journal of biochemistry 1998) 2 3 4 22 60
  2. Identification of human PMP34 as a peroxisomal ATP transporter. (PMID: 12445829) Visser WF … Wanders RJ (Biochemical and biophysical research communications 2002) 3 4 22 60
  3. Multiple distinct targeting signals in integral peroxisomal membrane proteins. (PMID: 11402059) Jones JM … Gould SJ (The Journal of cell biology 2001) 3 4 22 60
  4. Topogenesis of peroxisomal membrane protein requires a short, positively charged intervening-loop sequence and flanking hydrophobic segments. study using human membrane protein PMP34. (PMID: 11121399) Honsho M … Fujiki Y (The Journal of biological chemistry 2001) 3 4 22 60
  5. PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis. (PMID: 10704444) Sacksteder KA … Gould SJ (The Journal of cell biology 2000) 3 4 22 60

Products for SLC25A17 Gene

Sources for SLC25A17 Gene

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