Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ATP5H Gene

Aliases for ATP5H Gene

  • ATP Synthase, H+ Transporting, Mitochondrial Fo Complex, Subunit D 2 3
  • ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit D 2 3
  • ATPase Subunit D 3 4
  • ATP Synthase, H+ Transporting, Mitochondrial F1F0, Subunit D 3
  • ATP Synthase Subunit D, Mitochondrial 3
  • ATP Synthase D Chain, Mitochondrial 3
  • My032 Protein 3
  • ATPQ 3

External Ids for ATP5H Gene

Previous GeneCards Identifiers for ATP5H Gene

  • GC17P072954
  • GC17M076094
  • GC17M073499
  • GC17M073632
  • GC17M070546
  • GC17M073034
  • GC17M068445

Summaries for ATP5H Gene

Entrez Gene Summary for ATP5H Gene

  • Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the d subunit of the Fo complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. In addition, three pseudogenes are located on chromosomes 9, 12 and 15. [provided by RefSeq, Jun 2010]

GeneCards Summary for ATP5H Gene

ATP5H (ATP Synthase, H+ Transporting, Mitochondrial Fo Complex, Subunit D) is a Protein Coding gene. Diseases associated with ATP5H include body dysmorphic disorder. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include ATPase activity and hydrogen ion transmembrane transporter activity.

UniProtKB/Swiss-Prot for ATP5H Gene

  • Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements

Gene Wiki entry for ATP5H Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP5H Gene

Genomics for ATP5H Gene

Regulatory Elements for ATP5H Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ATP5H Gene

Start:
75,038,860 bp from pter
End:
75,046,985 bp from pter
Size:
8,126 bases
Orientation:
Minus strand

Genomic View for ATP5H Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATP5H Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP5H Gene

Proteins for ATP5H Gene

  • Protein details for ATP5H Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75947-ATP5H_HUMAN
    Recommended name:
    ATP synthase subunit d, mitochondrial
    Protein Accession:
    O75947
    Secondary Accessions:
    • B2R5L6
    • Q9H3J4

    Protein attributes for ATP5H Gene

    Size:
    161 amino acids
    Molecular mass:
    18491 Da
    Quaternary structure:
    • F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity).

    Alternative splice isoforms for ATP5H Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATP5H Gene

Proteomics data for ATP5H Gene at MOPED

Post-translational modifications for ATP5H Gene

  • Ubiquitination at Lys32
  • Modification sites at PhosphoSitePlus

Other Protein References for ATP5H Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ATP5H Gene

Domains for ATP5H Gene

Gene Families for ATP5H Gene

HGNC:
  • F1ATP :ATPases / F-type
  • FATP :Mitochondrial respiratory chain complex / Complex V
IUPHAR :

Protein Domains for ATP5H Gene

Suggested Antigen Peptide Sequences for ATP5H Gene

Graphical View of Domain Structure for InterPro Entry

O75947

UniProtKB/Swiss-Prot:

ATP5H_HUMAN :
  • O75947
Family:
  • Belongs to the ATPase d subunit family.
genes like me logo Genes that share domains with ATP5H: view

Function for ATP5H Gene

Molecular function for ATP5H Gene

UniProtKB/Swiss-Prot Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements

Gene Ontology (GO) - Molecular Function for ATP5H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015078 hydrogen ion transmembrane transporter activity IEA --
GO:0016887 contributes_to ATPase activity IDA 12110673
GO:0022857 transmembrane transporter activity IC 12110673
genes like me logo Genes that share ontologies with ATP5H: view

Phenotypes for ATP5H Gene

genes like me logo Genes that share phenotypes with ATP5H: view

Animal Model Products

CRISPR Products

miRNA for ATP5H Gene

miRTarBase miRNAs that target ATP5H

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATP5H

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ATP5H Gene

Localization for ATP5H Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP5H Gene

Mitochondrion. Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATP5H Gene COMPARTMENTS Subcellular localization image for ATP5H gene
Compartment Confidence
mitochondrion 5
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for ATP5H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
genes like me logo Genes that share ontologies with ATP5H: view

Pathways for ATP5H Gene

genes like me logo Genes that share pathways with ATP5H: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Mitochondrial Energy Metabolism in human,mouse,rat

Gene Ontology (GO) - Biological Process for ATP5H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0015986 ATP synthesis coupled proton transport --
GO:0022904 respiratory electron transport chain TAS --
GO:0042776 mitochondrial ATP synthesis coupled proton transport TAS --
GO:0044237 cellular metabolic process TAS --
genes like me logo Genes that share ontologies with ATP5H: view

Compounds for ATP5H Gene

(4) HMDB Compounds for ATP5H Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Phosphate
  • NFB Orthophosphate
14265-44-2
Water
  • Dihydrogen oxide
7732-18-5
genes like me logo Genes that share compounds with ATP5H: view

Transcripts for ATP5H Gene

Unigene Clusters for ATP5H Gene

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATP5H

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATP5H Gene

No ASD Table

Relevant External Links for ATP5H Gene

GeneLoc Exon Structure for
ATP5H
ECgene alternative splicing isoforms for
ATP5H

Expression for ATP5H Gene

mRNA expression in normal human tissues for ATP5H Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATP5H Gene

SOURCE GeneReport for Unigene cluster for ATP5H Gene Hs.514465

genes like me logo Genes that share expressions with ATP5H: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ATP5H Gene

Orthologs for ATP5H Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ATP5H Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATP5H 35
  • 100 (n)
  • 100 (a)
ATP5H 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 80 (a)
OneToMany
ATP5H 35
  • 89.03 (n)
  • 88.2 (a)
ATP5H 36
  • 88 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 85 (a)
OneToMany
-- 36
  • 89 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
-- 36
  • 90 (a)
OneToMany
-- 36
  • 87 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
-- 36
  • 87 (a)
OneToMany
-- 36
  • 89 (a)
OneToMany
-- 36
  • 89 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
-- 36
  • 77 (a)
OneToMany
-- 36
  • 80 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
-- 36
  • 87 (a)
OneToMany
-- 36
  • 89 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
-- 36
  • 89 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
-- 36
  • 85 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
-- 36
  • 90 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
-- 36
  • 87 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
LOC102154055 35
  • 90.48 (n)
  • 90.68 (a)
mouse
(Mus musculus)
Mammalia Atp5h 35
  • 80.54 (n)
  • 81.37 (a)
Atp5h 16
Atp5h 36
  • 81 (a)
OneToMany
Gm10250 36
  • 81 (a)
OneToMany
Gm4953 36
  • 75 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia ATP5H 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 67 (a)
OneToMany
-- 36
  • 78 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Atp5h 35
  • 78.88 (n)
  • 78.26 (a)
chicken
(Gallus gallus)
Aves ATP5H 35
  • 68.53 (n)
  • 60.25 (a)
ATP5H 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATP5H 36
  • 58 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.23901 35
tropical clawed frog
(Silurana tropicalis)
Amphibia atp5h 35
  • 61.9 (n)
  • 56.52 (a)
Str.1257 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8409 35
zebrafish
(Danio rerio)
Actinopterygii atp5h 35
  • 65.22 (n)
  • 60.25 (a)
atp5h 36
  • 60 (a)
OneToOne
zgc73071 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011131 35
  • 55.35 (n)
  • 43.4 (a)
fruit fly
(Drosophila melanogaster)
Insecta ATPsyn-d 35
  • 53.21 (n)
  • 45.34 (a)
ATPsyn-d 36
  • 41 (a)
OneToOne
ATPsyn-d 37
  • 45 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATP7 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7968 36
  • 29 (a)
OneToOne
Species with no ortholog for ATP5H:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ATP5H Gene

ENSEMBL:
Gene Tree for ATP5H (if available)
TreeFam:
Gene Tree for ATP5H (if available)

Paralogs for ATP5H Gene

Pseudogenes.org Pseudogenes for ATP5H Gene

genes like me logo Genes that share paralogs with ATP5H: view

No data available for Paralogs for ATP5H Gene

Variants for ATP5H Gene

Structural Variations from Database of Genomic Variants (DGV) for ATP5H Gene

Variant ID Type Subtype PubMed ID
nsv908744 CNV Loss 21882294
nsv908753 CNV Loss 21882294
esv2566082 CNV Deletion 19546169
esv2716235 CNV Deletion 23290073
esv1720628 CNV Deletion 17803354
nsv112456 CNV Loss 16902084

Relevant External Links for ATP5H Gene

HapMap Linkage Disequilibrium report
ATP5H

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for ATP5H Gene

Disorders for ATP5H Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ATP5H Gene including...

Search for ATP5H Gene in MalaCards »

(1) University of Copenhagen DISEASES for ATP5H Gene

Relevant External Links for ATP5H

Genetic Association Database (GAD)
ATP5H
Human Genome Epidemiology (HuGE) Navigator
ATP5H
genes like me logo Genes that share disorders with ATP5H: view

No data available for UniProtKB/Swiss-Prot for ATP5H Gene

Publications for ATP5H Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for ATP5H Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Mitochondrial Energy Metabolism in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ATP5H
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ATP5H
    • Block miRNA regulation of ATP5H using miScript Target Protectors

    Sources for ATP5H Gene

    Back to Top

    Content