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Aliases for PPIH Gene

Aliases for PPIH Gene

  • Peptidylprolyl Isomerase H (Cyclophilin H) 2 3
  • Small Nuclear Ribonucleoprotein Particle-Specific Cyclophilin H 2 3 4
  • Rotamase H 2 3 4
  • PPIase H 2 3 4
  • U-SnRNP-Associated Cyclophilin SunCyp-20 2 3
  • U-SnRNP-Associated Cyclophilin SnuCyp-20 3 4
  • Peptidyl-Prolyl Cis-Trans Isomerase H 2 3
  • USA-CyP SnuCyp-20 2 3
  • Cyclophilin H 2 3
  • EC 4 63
  • USA-CYP 3 4
  • CYPH 3 4
  • Peptidyl Prolyl Isomerase H (Cyclophilin H) 2
  • SnuCyp-20 3
  • CYP-20 3
  • CYP20 4

External Ids for PPIH Gene

Previous GeneCards Identifiers for PPIH Gene

  • GC01P043097
  • GC01P042127
  • GC01P042537
  • GC01P042793
  • GC01P042897
  • GC01P041244

Summaries for PPIH Gene

Entrez Gene Summary for PPIH Gene

  • The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is a specific component of the complex that includes pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP. This protein has been shown to possess PPIase activity and may act as a protein chaperone that mediates the interactions between different proteins inside the spliceosome. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPIH Gene

PPIH (Peptidylprolyl Isomerase H (Cyclophilin H)) is a Protein Coding gene. Among its related pathways are Spliceosome. GO annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity and cyclosporin A binding. An important paralog of this gene is PPIB.

UniProtKB/Swiss-Prot for PPIH Gene

  • PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. May act as a chaperone.

Gene Wiki entry for PPIH Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPIH Gene

Genomics for PPIH Gene

Regulatory Elements for PPIH Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PPIH Gene

42,658,358 bp from pter
42,676,758 bp from pter
18,401 bases
Plus strand

Genomic View for PPIH Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPIH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPIH Gene

Proteins for PPIH Gene

  • Protein details for PPIH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase H
    Protein Accession:
    Secondary Accessions:
    • A6NNE7

    Protein attributes for PPIH Gene

    177 amino acids
    Molecular mass:
    19208 Da
    Quaternary structure:
    • Interacts directly with PRPF4. Part of a heteromeric complex containing PPIH, PRPF3 and PRPF4 that is stable in the absence of RNA. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, DDX23, CD2BP2, PPIH, NHP2L1, EFTUD2, SART1 and USP39. Heterodimer with PRPF18.

    Three dimensional structures from OCA and Proteopedia for PPIH Gene

    Alternative splice isoforms for PPIH Gene


neXtProt entry for PPIH Gene

Proteomics data for PPIH Gene at MOPED

Selected DME Specific Peptides for PPIH Gene

Post-translational modifications for PPIH Gene

  • Ubiquitination at Lys38, Lys61, and Lys101
  • Modification sites at PhosphoSitePlus

Other Protein References for PPIH Gene

Antibody Products

Domains for PPIH Gene

Graphical View of Domain Structure for InterPro Entry



  • O43447
  • Contains 1 PPIase cyclophilin-type domain.
  • Belongs to the cyclophilin-type PPIase family. PPIase H subfamily.
genes like me logo Genes that share domains with PPIH: view

No data available for Gene Families for PPIH Gene

Function for PPIH Gene

Molecular function for PPIH Gene

UniProtKB/Swiss-Prot CatalyticActivity: Peptidylproline (omega=180) = peptidylproline (omega=0)
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by cyclosporin A
UniProtKB/Swiss-Prot Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. May act as a chaperone.

Enzyme Numbers (IUBMB) for PPIH Gene

Gene Ontology (GO) - Molecular Function for PPIH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IDA 9570313
GO:0005515 protein binding IPI 19615732
GO:0016018 cyclosporin A binding TAS 9570313
GO:0043021 ribonucleoprotein complex binding IDA 9570313
genes like me logo Genes that share ontologies with PPIH: view

Phenotypes for PPIH Gene

GenomeRNAi human phenotypes for PPIH:
genes like me logo Genes that share phenotypes with PPIH: view

Animal Model Products

CRISPR Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PPIH Gene

Localization for PPIH Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPIH Gene

Nucleus speckle. Cytoplasm. Note=Colocalizes with spliceosomal snRNPs. A small proportion may also be cytoplasmic.

Subcellular locations from

Jensen Localization Image for PPIH Gene COMPARTMENTS Subcellular localization image for PPIH gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PPIH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005681 spliceosomal complex IC 9570313
GO:0005737 cytoplasm IDA 9570313
GO:0016607 nuclear speck IDA 9570313
GO:0046540 U4/U6 x U5 tri-snRNP complex IDA 9570313
GO:0071001 U4/U6 snRNP IDA 9570313
genes like me logo Genes that share ontologies with PPIH: view

Pathways for PPIH Gene

SuperPathways for PPIH Gene

Superpath Contained pathways
1 Spliceosome
genes like me logo Genes that share pathways with PPIH: view

Pathways by source for PPIH Gene

1 KEGG pathway for PPIH Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PPIH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IC 9570313
GO:0000413 protein peptidyl-prolyl isomerization IEA --
GO:0006457 protein folding IEA --
GO:0006461 protein complex assembly TAS 9570313
GO:0045070 positive regulation of viral genome replication IMP 19932913
genes like me logo Genes that share ontologies with PPIH: view

Compounds for PPIH Gene

(1) HMDB Compounds for PPIH Gene

Compound Synonyms Cas Number PubMed IDs
  • (-)-(S)-Proline

(1) Drugbank Compounds for PPIH Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
  • (-)-2-Pyrrolidinecarboxylic acid
147-85-3 target
genes like me logo Genes that share compounds with PPIH: view

Transcripts for PPIH Gene

Unigene Clusters for PPIH Gene

Peptidylprolyl isomerase H (cyclophilin H):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPIH

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPIH Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: - - - -
SP2: - - -
SP3: - -

Relevant External Links for PPIH Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPIH Gene

mRNA expression in normal human tissues for PPIH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPIH Gene

SOURCE GeneReport for Unigene cluster for PPIH Gene Hs.256639

genes like me logo Genes that share expressions with PPIH: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PPIH Gene

Orthologs for PPIH Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPIH Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PPIH 35
  • 99.81 (n)
  • 100 (a)
  • 100 (a)
(Bos Taurus)
Mammalia PPIH 35
  • 92.66 (n)
  • 100 (a)
  • 100 (a)
(Canis familiaris)
Mammalia PPIH 35
  • 93.79 (n)
  • 100 (a)
  • 100 (a)
(Mus musculus)
Mammalia Ppih 35
  • 92.66 (n)
  • 100 (a)
Ppih 16
Ppih 36
  • 84 (a)
(Monodelphis domestica)
Mammalia PPIH 36
  • 99 (a)
(Ornithorhynchus anatinus)
Mammalia PPIH 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Ppih 35
  • 93.56 (n)
  • 100 (a)
(Gallus gallus)
Aves PPIH 35
  • 80.41 (n)
  • 95.48 (a)
  • 95 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76244 35
ppih 35
  • 79.66 (n)
  • 91.53 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8742 35
(Danio rerio)
Actinopterygii ppih 35
  • 76.27 (n)
  • 87.57 (a)
ppih 36
  • 65 (a)
zgc55766 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007392 35
  • 69.01 (n)
  • 79.53 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17266 35
  • 68.62 (n)
  • 78.36 (a)
CG17266 36
  • 73 (a)
ninaA 37
  • 46 (a)
CG17266 37
  • 79 (a)
(Caenorhabditis elegans)
Secernentea cyn-11 35
  • 63.92 (n)
  • 70.59 (a)
cyn-11 36
  • 66 (a)
cyp-8 37
  • 55 (a)
cyp-11 37
  • 70 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CPR2 36
  • 43 (a)
CPR5 36
  • 37 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.2140 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G38730 35
  • 68.81 (n)
  • 73.68 (a)
(Zea mays)
Liliopsida Zm.2051 35
(Oryza sativa)
Liliopsida Os.27981 35
Os03g0811600 35
  • 66.86 (n)
  • 71.93 (a)
(Triticum aestivum)
Liliopsida Ta.18236 35
bread mold
(Neurospora crassa)
Ascomycetes NCU02614 35
  • 62.3 (n)
  • 65.48 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cyp3 35
  • 58.78 (n)
  • 62.13 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4482 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.534 36
  • 72 (a)
Species with no ortholog for PPIH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PPIH Gene

Gene Tree for PPIH (if available)
Gene Tree for PPIH (if available)

Paralogs for PPIH Gene

Paralogs for PPIH Gene Pseudogenes for PPIH Gene

genes like me logo Genes that share paralogs with PPIH: view

Variants for PPIH Gene

Sequence variations from dbSNP and Humsavar for PPIH Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs12244 -- 42,665,982(+) CAGGC(A/C/G)AACAG synonymous-codon, reference, nc-transcript-variant
rs1198099 -- 42,671,335(-) ttctc(C/G)tgcct intron-variant
rs1198100 -- 42,671,276(-) taatt(C/T)ttgta intron-variant
rs1198101 -- 42,671,270(-) ttgta(A/T)tttta intron-variant
rs1198102 -- 42,671,250(-) ggttt(C/T)accat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPIH Gene

Variant ID Type Subtype PubMed ID
nsv829682 CNV Loss 17160897
esv2671740 CNV Deletion 23128226

Relevant External Links for PPIH Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPIH Gene

Disorders for PPIH Gene

No disorders were found for PPIH Gene.

No data available for UniProtKB/Swiss-Prot for PPIH Gene

Publications for PPIH Gene

  1. A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a complex associated with U4/U6 snRNPs. (PMID: 9404889) Horowitz D.S. … Krainer A.R. (RNA 1997) 2 3 4
  2. The 20kD protein of human [U4/U6.U5] tri-snRNPs is a novel cyclophilin that forms a complex with the U4/U6-specific 60kD and 90kD proteins. (PMID: 9570313) Teigelkamp S. … Luehrmann R. (RNA 1998) 2 3 4
  3. Crystal structure of the human U4/U6 small nuclear ribonucleoprotein particle-specific SnuCyp-20, a nuclear cyclophilin. (PMID: 10713041) Reidt U. … Ficner R. (J. Biol. Chem. 2000) 3 4
  4. A cyclophilin functions in pre-mRNA splicing. (PMID: 11823439) Horowitz D.S. … Misteli T. (EMBO J. 2002) 3 4
  5. Crystal structure of a complex between human spliceosomal cyclophilin H and a U4/U6 snRNP-60K peptide. (PMID: 12875835) Reidt U. … Ficner R. (J. Mol. Biol. 2003) 3 4

Products for PPIH Gene

Sources for PPIH Gene

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