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Aliases for PIBF1 Gene

Aliases for PIBF1 Gene

  • Progesterone Immunomodulatory Binding Factor 1 2 3
  • Progesterone-Induced Blocking Factor 1 2 3
  • C13orf24 3 4
  • PIBF 3 4
  • Progesterone-Induced-Blocking Factor 1 3
  • Chromosome 13 Open Reading Frame 24 2
  • CEP90 3

External Ids for PIBF1 Gene

Previous Symbols for PIBF1 Gene

  • C13orf24

Summaries for PIBF1 Gene

GeneCards Summary for PIBF1 Gene

PIBF1 (Progesterone Immunomodulatory Binding Factor 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for PIBF1 Gene

  • Mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling NK activity exerts an anti-abortive effect

Gene Wiki entry for PIBF1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIBF1 Gene

Genomics for PIBF1 Gene

Genomic Location for PIBF1 Gene

Start:
72,782,059 bp from pter
End:
73,016,461 bp from pter
Size:
234,403 bases
Orientation:
Plus strand

Genomic View for PIBF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PIBF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIBF1 Gene

Regulatory Elements for PIBF1 Gene

Proteins for PIBF1 Gene

  • Protein details for PIBF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXW3-PIBF1_HUMAN
    Recommended name:
    Progesterone-induced-blocking factor 1
    Protein Accession:
    Q8WXW3
    Secondary Accessions:
    • O95664
    • Q6U9V2
    • Q6UG50
    • Q86V07
    • Q96SF4

    Protein attributes for PIBF1 Gene

    Size:
    757 amino acids
    Molecular mass:
    89805 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PIBF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PIBF1 Gene

Proteomics data for PIBF1 Gene at MOPED

Post-translational modifications for PIBF1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys490

Other Protein References for PIBF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PIBF1 Gene

Domains for PIBF1 Gene

Protein Domains for PIBF1 Gene

Blocks:
InterPro:
ProtoNet:
genes like me logo Genes that share domains with PIBF1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for PIBF1 Gene

Function for PIBF1 Gene

Molecular function for PIBF1 Gene

UniProtKB/Swiss-Prot Function: Mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling NK activity exerts an anti-abortive effect
UniProtKB/Swiss-Prot Induction: By progesterone

Gene Ontology (GO) - Molecular Function for PIBF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17500595
genes like me logo Genes that share ontologies with PIBF1: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PIBF1 Gene

Localization for PIBF1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PIBF1 Gene COMPARTMENTS Subcellular localization image for PIBF1 gene
Compartment Confidence
cytoskeleton 5
nucleus 3
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PIBF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005813 centrosome IDA 21399614
GO:0016020 membrane --
genes like me logo Genes that share ontologies with PIBF1: view

Pathways for PIBF1 Gene

SuperPathways for PIBF1 Gene

No Data Available

Interacting Proteins for PIBF1 Gene

Gene Ontology (GO) - Biological Process for PIBF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016192 vesicle-mediated transport --
genes like me logo Genes that share ontologies with PIBF1: view

No data available for Pathways by source for PIBF1 Gene

Compounds for PIBF1 Gene

(4) Novoseek inferred chemical compound relationships for PIBF1 Gene

Compound -log(P) Hits PubMed IDs
dydrogesterone 83.2 5
progesterone 75.9 61
mifepristone 62.3 7
arachidonic acid 27.6 4
genes like me logo Genes that share compounds with PIBF1: view

Transcripts for PIBF1 Gene

Unigene Clusters for PIBF1 Gene

Progesterone immunomodulatory binding factor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PIBF1 Gene

No ASD Table

Relevant External Links for PIBF1 Gene

GeneLoc Exon Structure for
PIBF1
ECgene alternative splicing isoforms for
PIBF1

Expression for PIBF1 Gene

mRNA expression in normal human tissues for PIBF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PIBF1 Gene

SOURCE GeneReport for Unigene cluster for PIBF1 Gene Hs.441926

mRNA Expression by UniProt/SwissProt for PIBF1 Gene

Q8WXW3-PIBF1_HUMAN
Tissue specificity: Expressed at highest levels in testis. Moderate expression is detected in spleen, thymus, prostate, ovary, small intestine, and colon.
genes like me logo Genes that share expressions with PIBF1: view

Orthologs for PIBF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PIBF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PIBF1 36
  • 99.52 (n)
  • 99.34 (a)
PIBF1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PIBF1 36
  • 91.19 (n)
  • 89.7 (a)
PIBF1 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PIBF1 36
  • 92.03 (n)
  • 91.15 (a)
PIBF1 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pibf1 36
  • 86.42 (n)
  • 88.89 (a)
Pibf1 16
Pibf1 37
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PIBF1 37
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pibf1 36
  • 86.66 (n)
  • 88.51 (a)
chicken
(Gallus gallus)
Aves PIBF1 36
  • 75.17 (n)
  • 75.56 (a)
PIBF1 37
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PIBF1 37
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pibf1 36
  • 70.41 (n)
  • 71.52 (a)
Str.19453 36
zebrafish
(Danio rerio)
Actinopterygii pibf1 36
  • 65.5 (n)
  • 66.04 (a)
pibf1 37
  • 65 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 40 (a)
OneToOne
Species with no ortholog for PIBF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PIBF1 Gene

ENSEMBL:
Gene Tree for PIBF1 (if available)
TreeFam:
Gene Tree for PIBF1 (if available)

Paralogs for PIBF1 Gene

No data available for Paralogs for PIBF1 Gene

Variants for PIBF1 Gene

Sequence variations from dbSNP and Humsavar for PIBF1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs8867 -- 73,016,102(-) AAAAA(A/T)TAAAG utr-variant-3-prime
rs722478 -- 72,856,410(-) AAGGC(C/T)TTACT intron-variant
rs723944 -- 72,805,546(+) CTCAT(A/G)CTTAT intron-variant
rs997186 -- 72,839,362(+) TGATA(C/T)AGTTT intron-variant
rs1000973 -- 72,981,494(+) GAATA(A/G)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PIBF1 Gene

Variant ID Type Subtype PubMed ID
nsv1085 CNV Insertion 18451855
nsv900551 CNV Loss 21882294
nsv517408 CNV Loss 19592680

Relevant External Links for PIBF1 Gene

HapMap Linkage Disequilibrium report
PIBF1
Human Gene Mutation Database (HGMD)
PIBF1

Disorders for PIBF1 Gene

(5) Novoseek inferred disease relationships for PIBF1 Gene

Disease -log(P) Hits PubMed IDs
abortion threatened 81.1 1
miscarriage recurrent 70 1
miscarriage 66.6 7
preterm delivery 48.1 1
tumors 0 8

Relevant External Links for PIBF1

Genetic Association Database (GAD)
PIBF1
Human Genome Epidemiology (HuGE) Navigator
PIBF1
genes like me logo Genes that share disorders with PIBF1: view

No data available for UniProtKB/Swiss-Prot for PIBF1 Gene

Publications for PIBF1 Gene

  1. Progesterone as an immunomodulatory molecule. (PMID: 11407300) Szekeres-Bartho J. … Szereday L. (Int. Immunopharmacol. 2001) 3 4 23
  2. PIBF (progesterone induced blocking factor) is overexpressed in highly proliferating cells and associated with the centrosome. (PMID: 15305375) Lachmann M. … Nagy E. (Int. J. Cancer 2004) 3 4 23
  3. A genomic map of a 6-Mb region at 13q21-q22 implicated in cancer development: identification and characterization of candidate genes. (PMID: 11935316) Rozenblum E. … Kallioniemi O.-P. (Hum. Genet. 2002) 2 3 4
  4. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for PIBF1 Gene

Sources for PIBF1 Gene

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