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Aliases for PIBF1 Gene

Aliases for PIBF1 Gene

  • Progesterone Immunomodulatory Binding Factor 1 2 3
  • Progesterone-Induced Blocking Factor 1 2 3
  • C13orf24 3 4
  • PIBF 3 4
  • Chromosome 13 Open Reading Frame 24 2
  • CEP90 3

External Ids for PIBF1 Gene

Previous HGNC Symbols for PIBF1 Gene

  • C13orf24

Previous GeneCards Identifiers for PIBF1 Gene

  • GC13P071323
  • GC13P067351
  • GC13P072292
  • GC13P071154
  • GC13P072255
  • GC13P073356
  • GC13P054053

Summaries for PIBF1 Gene

GeneCards Summary for PIBF1 Gene

PIBF1 (Progesterone Immunomodulatory Binding Factor 1) is a Protein Coding gene. Diseases associated with PIBF1 include pregnancy loss, recurrent 1.

UniProtKB/Swiss-Prot for PIBF1 Gene

  • Mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling NK activity exerts an anti-abortive effect

Gene Wiki entry for PIBF1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIBF1 Gene

Genomics for PIBF1 Gene

Regulatory Elements for PIBF1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PIBF1 Gene

Chromosome:
13
Start:
72,782,059 bp from pter
End:
73,016,461 bp from pter
Size:
234,403 bases
Orientation:
Plus strand

Genomic View for PIBF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PIBF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIBF1 Gene

Proteins for PIBF1 Gene

  • Protein details for PIBF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXW3-PIBF1_HUMAN
    Recommended name:
    Progesterone-induced-blocking factor 1
    Protein Accession:
    Q8WXW3
    Secondary Accessions:
    • O95664
    • Q6U9V2
    • Q6UG50
    • Q86V07
    • Q96SF4

    Protein attributes for PIBF1 Gene

    Size:
    757 amino acids
    Molecular mass:
    89805 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PIBF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PIBF1 Gene

Proteomics data for PIBF1 Gene at MOPED

Post-translational modifications for PIBF1 Gene

  • Ubiquitination at Lys 490
  • Modification sites at PhosphoSitePlus

Other Protein References for PIBF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PIBF1 Gene

Domains & Families for PIBF1 Gene

Protein Domains for PIBF1 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PIBF1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PIBF1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for PIBF1 Gene

Function for PIBF1 Gene

Molecular function for PIBF1 Gene

UniProtKB/Swiss-Prot Function:
Mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling NK activity exerts an anti-abortive effect
UniProtKB/Swiss-Prot Induction:
By progesterone

Gene Ontology (GO) - Molecular Function for PIBF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005136 interleukin-4 receptor binding IDA 16393965
GO:0005515 protein binding IPI 17500595
genes like me logo Genes that share ontologies with PIBF1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PIBF1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PIBF1 Gene

Localization for PIBF1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PIBF1 Gene COMPARTMENTS Subcellular localization image for PIBF1 gene
Compartment Confidence
cytoskeleton 5

Gene Ontology (GO) - Cellular Components for PIBF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 14634107
GO:0005634 nucleus IDA 14634107
GO:0005813 centrosome IDA 21399614
GO:0034451 centriolar satellite IDA 21224392
genes like me logo Genes that share ontologies with PIBF1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PIBF1 Gene

Pathways & Interactions for PIBF1 Gene

SuperPathways for PIBF1 Gene

No Data Available

Interacting Proteins for PIBF1 Gene

Gene Ontology (GO) - Biological Process for PIBF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007080 mitotic metaphase plate congression IMP 21224392
GO:0010531 activation of JAK1 kinase activity IDA 16393965
GO:0031393 negative regulation of prostaglandin biosynthetic process IDA 3863495
GO:0032695 negative regulation of interleukin-12 production IDA 14634107
GO:0032733 positive regulation of interleukin-10 production IDA 14634107
genes like me logo Genes that share ontologies with PIBF1: view

No data available for Pathways by source and SIGNOR curated interactions for PIBF1 Gene

Drugs & Compounds for PIBF1 Gene

(4) Drugs for PIBF1 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dydrogesterone Approved, Withdrawn Pharma Agonist 17
Mifepristone Approved, Investigational Pharma Antagonist Progesterone receptor antagonist, Progesterone and glucocorticoid receptor antagonist 132
Progesterone Approved Pharma Inhibition, Pore Blocker Endogenous progesterone receptor agonist 473
arachidonic acid Experimental Nutra Potentiation, Activator 27
genes like me logo Genes that share compounds with PIBF1: view

Transcripts for PIBF1 Gene

Unigene Clusters for PIBF1 Gene

Progesterone immunomodulatory binding factor 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PIBF1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PIBF1 Gene

No ASD Table

Relevant External Links for PIBF1 Gene

GeneLoc Exon Structure for
PIBF1
ECgene alternative splicing isoforms for
PIBF1

Expression for PIBF1 Gene

mRNA expression in normal human tissues for PIBF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PIBF1 Gene

This gene is overexpressed in Cerebrospinal fluid (23.9), Liver, secretome (17.7), Testis (10.0), and Urine (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PIBF1 Gene



SOURCE GeneReport for Unigene cluster for PIBF1 Gene Hs.441926

mRNA Expression by UniProt/SwissProt for PIBF1 Gene

Q8WXW3-PIBF1_HUMAN
Tissue specificity: Expressed at highest levels in testis. Moderate expression is detected in spleen, thymus, prostate, ovary, small intestine, and colon.
genes like me logo Genes that share expression patterns with PIBF1: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for PIBF1 Gene

Orthologs for PIBF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PIBF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PIBF1 36
  • 99 (a)
OneToOne
PIBF1 35
  • 99.52 (n)
  • 99.34 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia PIBF1 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pibf1 36
  • 89 (a)
OneToOne
Pibf1 16
Pibf1 35
  • 86.42 (n)
  • 88.89 (a)
dog
(Canis familiaris)
Mammalia PIBF1 36
  • 91 (a)
OneToOne
PIBF1 35
  • 92.03 (n)
  • 91.15 (a)
cow
(Bos Taurus)
Mammalia PIBF1 36
  • 88 (a)
OneToOne
PIBF1 35
  • 91.19 (n)
  • 89.7 (a)
rat
(Rattus norvegicus)
Mammalia Pibf1 35
  • 86.66 (n)
  • 88.51 (a)
chicken
(Gallus gallus)
Aves PIBF1 36
  • 75 (a)
OneToOne
PIBF1 35
  • 75.17 (n)
  • 75.56 (a)
lizard
(Anolis carolinensis)
Reptilia PIBF1 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.19453 35
pibf1 35
  • 70.41 (n)
  • 71.52 (a)
zebrafish
(Danio rerio)
Actinopterygii pibf1 36
  • 65 (a)
OneToOne
pibf1 35
  • 65.5 (n)
  • 66.04 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToOne
Species with no ortholog for PIBF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PIBF1 Gene

ENSEMBL:
Gene Tree for PIBF1 (if available)
TreeFam:
Gene Tree for PIBF1 (if available)

Paralogs for PIBF1 Gene

No data available for Paralogs for PIBF1 Gene

Variants for PIBF1 Gene

Sequence variations from dbSNP and Humsavar for PIBF1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
VAR_051279 -
VAR_051280 -
VAR_051281 -

Structural Variations from Database of Genomic Variants (DGV) for PIBF1 Gene

Variant ID Type Subtype PubMed ID
nsv1085 CNV Insertion 18451855
nsv900551 CNV Loss 21882294
nsv517408 CNV Loss 19592680

Variation tolerance for PIBF1 Gene

Residual Variation Intolerance Score: 26.12% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.08; 68.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PIBF1 Gene

HapMap Linkage Disequilibrium report
PIBF1
Human Gene Mutation Database (HGMD)
PIBF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIBF1 Gene

Disorders for PIBF1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PIBF1 Gene - From: NovoSeek

Disorder Aliases PubMed IDs
pregnancy loss, recurrent 1
  • pregnancy loss, recurrent, susceptibility to, 1
- elite association
Search PIBF1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PIBF1

Genetic Association Database (GAD)
PIBF1
Human Genome Epidemiology (HuGE) Navigator
PIBF1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PIBF1
genes like me logo Genes that share disorders with PIBF1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PIBF1 Gene

Publications for PIBF1 Gene

  1. Mifepristone treatment improves length and quality of survival of mice with spontaneous lung cancer. (PMID: 20150625) Check J.H. … Dix E. (Anticancer Res. 2010) 23 67
  2. Neuroendocrine circuitry and endometriosis: progesterone derivative dampens corticotropin-releasing hormone-induced inflammation by peritoneal cells in vitro. (PMID: 19898767) Tariverdian N. … Arck P.C. (J. Mol. Med. 2010) 23 67
  3. Progesterone - induced blocking factor (PIBF) and Th(1)/Th(2) cytokine in women with threatened spontaneous abortion. (PMID: 19290853) HudiA8 I. … FatusiA8 Z. (J Perinat Med 2009) 23 67
  4. Progesterone-induced blocking factor and cytokine profile in women with threatened pre-term delivery. (PMID: 19343831) HudiA8 I. … DizdareviA8-HudiA8 L. (Am. J. Reprod. Immunol. 2009) 23 67
  5. Support for the hypothesis that successful immunotherapy of various cancers can be achieved by inhibiting a progesterone associated immunomodulatory protein. (PMID: 18842348) Check J.H. … Sansoucie L. (Med. Hypotheses 2009) 23 67

Products for PIBF1 Gene

Sources for PIBF1 Gene

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