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Aliases for TAB1 Gene

Aliases for TAB1 Gene

  • TGF-Beta Activated Kinase 1/MAP3K7 Binding Protein 1 2 3 5
  • TAK1-Binding Protein 1 2 3 4
  • Mitogen-Activated Protein Kinase Kinase Kinase 7 Interacting Protein 1 2 2
  • Mitogen-Activated Protein Kinase Kinase Kinase 7-Interacting Protein 1 3 4
  • MAP3K7IP1 3 4
  • Transforming Growth Factor Beta-Activated Kinase-Binding Protein 1 3
  • TGF-Beta-Activated Kinase 1-Binding Protein 1 4
  • 3-Tab1 3

External Ids for TAB1 Gene

Previous HGNC Symbols for TAB1 Gene

  • MAP3K7IP1

Previous GeneCards Identifiers for TAB1 Gene

  • GC22P039796
  • GC22P022760

Summaries for TAB1 Gene

Entrez Gene Summary for TAB1 Gene

  • The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAB1 Gene

TAB1 (TGF-Beta Activated Kinase 1/MAP3K7 Binding Protein 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Immune System. GO annotations related to this gene include protein complex binding and kinase activator activity.

UniProtKB/Swiss-Prot for TAB1 Gene

  • May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.

Gene Wiki entry for TAB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAB1 Gene

Genomics for TAB1 Gene

Regulatory Elements for TAB1 Gene

Promoters for TAB1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TAB1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TAB1 Gene

Chromosome:
22
Start:
39,399,741 bp from pter
End:
39,437,127 bp from pter
Size:
37,387 bases
Orientation:
Plus strand

Genomic View for TAB1 Gene

Genes around TAB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAB1 Gene

Proteins for TAB1 Gene

  • Protein details for TAB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15750-TAB1_HUMAN
    Recommended name:
    TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
    Protein Accession:
    Q15750
    Secondary Accessions:
    • Q2PP09
    • Q8IZW2

    Protein attributes for TAB1 Gene

    Size:
    504 amino acids
    Molecular mass:
    54644 Da
    Quaternary structure:
    • Interacts with XIAP and BIRC7. Interacts with TRAF6 and MAP3K7; during IL-1 signaling. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2.

    Three dimensional structures from OCA and Proteopedia for TAB1 Gene

    Alternative splice isoforms for TAB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAB1 Gene

Proteomics data for TAB1 Gene at MOPED

Post-translational modifications for TAB1 Gene

  • Monoubiquitinated. Deubiquitinated by Y.enterocolitica YopP.
  • Ubiquitination at Lys 150 and Lys 264
  • Modification sites at PhosphoSitePlus

Other Protein References for TAB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TAB1 (TAB1)

No data available for DME Specific Peptides for TAB1 Gene

Domains & Families for TAB1 Gene

Protein Domains for TAB1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q15750

UniProtKB/Swiss-Prot:

TAB1_HUMAN :
  • Contains 1 PPM-type phosphatase domain.
Domain:
  • Contains 1 PPM-type phosphatase domain.
genes like me logo Genes that share domains with TAB1: view

No data available for Gene Families for TAB1 Gene

Function for TAB1 Gene

Molecular function for TAB1 Gene

GENATLAS Biochemistry:
transforming growth factor beta activated kinase (TAK)-binding protein 1,widely expressed,involved in the BMP signaling through binding with API3 (XIAP)
UniProtKB/Swiss-Prot Function:
May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.

Gene Ontology (GO) - Molecular Function for TAB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019209 kinase activator activity IEA --
genes like me logo Genes that share ontologies with TAB1: view
genes like me logo Genes that share phenotypes with TAB1: view

Animal Models for TAB1 Gene

MGI Knock Outs for TAB1:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TAB1 Gene

Localization for TAB1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAB1 Gene COMPARTMENTS Subcellular localization image for TAB1 gene
Compartment Confidence
cytosol 5
nucleus 5
endosome 4
chloroplast 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TAB1 Gene

Pathways & Interactions for TAB1 Gene

SuperPathways for TAB1 Gene

Superpath Contained pathways
1 MyD88 cascade initiated on plasma membrane
2 Toll-Like receptor Signaling Pathways
3 Bacterial infections in CF airways
4 Interleukin-3, 5 and GM-CSF signaling
5 RANK Signaling in Osteoclasts
genes like me logo Genes that share pathways with TAB1: view

SIGNOR curated interactions for TAB1 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for TAB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000185 activation of MAPKKK activity IEA --
GO:0000187 activation of MAPK activity TAS --
GO:0001701 in utero embryonic development IEA --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002224 toll-like receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with TAB1: view

Drugs & Compounds for TAB1 Gene

(1) Drugs for TAB1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for TAB1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TAB1: view

Transcripts for TAB1 Gene

Unigene Clusters for TAB1 Gene

TGF-beta activated kinase 1/MAP3K7 binding protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TAB1 Gene

No ASD Table

Relevant External Links for TAB1 Gene

GeneLoc Exon Structure for
TAB1
ECgene alternative splicing isoforms for
TAB1

Expression for TAB1 Gene

mRNA expression in normal human tissues for TAB1 Gene

Protein differential expression in normal tissues from HIPED for TAB1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.7) and Fetal Brain (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TAB1 Gene



SOURCE GeneReport for Unigene cluster for TAB1 Gene Hs.507681

mRNA Expression by UniProt/SwissProt for TAB1 Gene

Q15750-TAB1_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with TAB1: view

Protein tissue co-expression partners for TAB1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TAB1 Gene

Orthologs for TAB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TAB1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia TAB1 35
  • 90.03 (n)
  • 97.39 (a)
TAB1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tab1 35
  • 88.71 (n)
  • 97.61 (a)
Tab1 16
Tab1 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TAB1 35
  • 99.53 (n)
  • 100 (a)
TAB1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tab1 35
  • 87.45 (n)
  • 96.61 (a)
cow
(Bos Taurus)
Mammalia MAP3K7IP1 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TAB1 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TAB1 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves TAB1 35
  • 80.09 (n)
  • 89.02 (a)
TAB1 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAB1 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tab1 35
  • 71.07 (n)
  • 77.24 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398025 35
zebrafish
(Danio rerio)
Actinopterygii Dr.16754 35
tab1 35
  • 66 (n)
  • 65.91 (a)
tab1 36
  • 64 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002953 35
  • 49.07 (n)
  • 40.93 (a)
worm
(Caenorhabditis elegans)
Secernentea tap-1 36
  • 26 (a)
OneToOne
Species with no ortholog for TAB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TAB1 Gene

ENSEMBL:
Gene Tree for TAB1 (if available)
TreeFam:
Gene Tree for TAB1 (if available)

Paralogs for TAB1 Gene

(1) SIMAP similar genes for TAB1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TAB1: view

No data available for Paralogs for TAB1 Gene

Variants for TAB1 Gene

Sequence variations from dbSNP and Humsavar for TAB1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs17001096 - 39,419,526(+) TTGGA(G/T)GCTGG reference, missense
rs1297236 -- 39,401,056(+) aaaaa(A/C)Cgaaa intron-variant
rs739141 -- 39,428,445(+) GGTTT(C/T)CTTTC intron-variant
rs743838 -- 39,428,702(-) TTCTA(A/C)GGAAG intron-variant
rs2105894 -- 39,423,345(+) catgc(C/T)tgtaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TAB1 Gene

Variant ID Type Subtype PubMed ID
nsv834198 CNV Loss 17160897
nsv834199 CNV Loss 17160897
nsv915098 CNV Loss 21882294
nsv915099 CNV Loss 21882294
esv2724254 CNV Deletion 23290073
nsv471200 CNV Loss 18288195
esv2724255 CNV Deletion 23290073
nsv3628 CNV Insertion 18451855

Variation tolerance for TAB1 Gene

Residual Variation Intolerance Score: 10.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.72; 57.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAB1 Gene

HapMap Linkage Disequilibrium report
TAB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAB1 Gene

Disorders for TAB1 Gene

Relevant External Links for TAB1

Human Genome Epidemiology (HuGE) Navigator
TAB1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAB1

No disorders were found for TAB1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAB1 Gene

Publications for TAB1 Gene

  1. TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction. (PMID: 8638164) Shibuya H. … Matsumoto K. (Science 1996) 2 3 4 23 67
  2. Functional interactions of transforming growth factor beta-activated kinase 1 with IkappaB kinases to stimulate NF-kappaB activation. (PMID: 10187861) Sakurai H. … Sugita T. (J. Biol. Chem. 1999) 2 3 23
  3. Cross interference with TNF-alpha-induced TAK1 activation via EGFR-mediated p38 phosphorylation of TAK1-binding protein 1. (PMID: 19393267) Shin M.S. … Sakurai H. (Biochim. Biophys. Acta 2009) 3 23
  4. Suppression of cell invasiveness by periostin via TAB1/TAK1. (PMID: 19578758) Isono T. … Inoue H. (Int. J. Oncol. 2009) 3 23
  5. Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex. (PMID: 18021073) Mendoza H. … Cohen P. (Biochem. J. 2008) 3 23

Products for TAB1 Gene

Sources for TAB1 Gene

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