Aliases for CDX2 Gene
External Ids for CDX2 Gene
Previous Symbols for CDX2 Gene
This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis. [provided by RefSeq, Jan 2012]
GeneCards Summary for CDX2 Gene
CDX2 (Caudal Type Homeobox 2) is a Protein Coding gene. Diseases associated with CDX2 include chronic cholangitis and bladder adenocarcinoma. Among its related pathways are Oct4 in Mammalian ESC Pluripotency and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription regulatory region sequence-specific DNA binding. An important paralog of this gene is CDX4.
UniProtKB/Swiss-Prot for CDX2 Gene
Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine