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Aliases for CDX2 Gene

Aliases for CDX2 Gene

  • Caudal Type Homeobox 2 2 3
  • CDX3 3 4 6
  • Caudal Type Homeo Box Transcription Factor 2 2 3
  • Caudal-Type Homeobox Protein 2 3 4
  • CDX-3 3 4
  • Caudal Type Homeobox Transcription Factor 2 3
  • Homeobox Protein CDX-2 3
  • CDX2/AS 3

External Ids for CDX2 Gene

Previous Symbols for CDX2 Gene

  • CDX3

Summaries for CDX2 Gene

Entrez Gene Summary for CDX2 Gene

  • This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis. [provided by RefSeq, Jan 2012]

GeneCards Summary for CDX2 Gene

CDX2 (Caudal Type Homeobox 2) is a Protein Coding gene. Diseases associated with CDX2 include chronic cholangitis and bladder adenocarcinoma. Among its related pathways are Oct4 in Mammalian ESC Pluripotency and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription regulatory region sequence-specific DNA binding. An important paralog of this gene is CDX4.

UniProtKB/Swiss-Prot for CDX2 Gene

  • Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine

Gene Wiki entry for CDX2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDX2 Gene

Genomics for CDX2 Gene

Genomic Location for CDX2 Gene

Start:
27,962,068 bp from pter
End:
27,971,139 bp from pter
Size:
9,072 bases
Orientation:
Minus strand

Genomic View for CDX2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDX2 Gene

Regulatory Elements for CDX2 Gene

Proteins for CDX2 Gene

  • Protein details for CDX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99626-CDX2_HUMAN
    Recommended name:
    Homeobox protein CDX-2
    Protein Accession:
    Q99626
    Secondary Accessions:
    • O00503
    • Q5VTU7
    • Q969L8
    • Q9UD92

    Protein attributes for CDX2 Gene

    Size:
    313 amino acids
    Molecular mass:
    33520 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CDX2 Gene

Proteomics data for CDX2 Gene at MOPED

Post-translational modifications for CDX2 Gene

  • Phosphorylation of Ser-60 mediates the transactivation capacity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDX2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CDX2 Gene

Domains for CDX2 Gene

Gene Families for CDX2 Gene

HGNC:
  • HOXL :Homeoboxes / ANTP class : HOXL subclass

UniProtKB/Swiss-Prot:

CDX2_HUMAN
Domain:
  • Contains 1 homeobox DNA-binding domain.:
    • Q99626
Family:
  • Belongs to the Caudal homeobox family.:
    • Q99626
genes like me logo Genes that share domains with CDX2: view

Function for CDX2 Gene

Molecular function for CDX2 Gene

GENATLAS Biochemistry: Drosophila caudal family member 2,murine Cdx2 homolog,homeo domain encoding gene,expressed in the intestine,involved in the proliferation and differentiation of intestinal epithelial cells,mutated in colorectal carcinoma with normal APC/CTNNB signaling pathway,fused with ETV6 in acute myeloid leukemia,
UniProtKB/Swiss-Prot Function: Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine

Gene Ontology (GO) - Molecular Function for CDX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA 15677472
GO:0001227 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IDA 15677472
GO:0003677 DNA binding --
GO:0003690 double-stranded DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 9459001
genes like me logo Genes that share ontologies with CDX2: view
genes like me logo Genes that share phenotypes with CDX2: view

Animal Models for CDX2 Gene

MGI Knock Outs for CDX2:
Targeting motifs for CDX2 Gene
HOMER Transcription Factor Regulatory Elements motif CDX2
  • Consensus sequence: GTCATAAAAN Submotif: canonical Cell Type: mES GeoId: GSE14586

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targeting for CDX2 Gene

Localization for CDX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDX2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDX2 Gene COMPARTMENTS Subcellular localization image for CDX2 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CDX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000794 condensed nuclear chromosome IEA --
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0017053 transcriptional repressor complex IEA --
GO:0043234 protein complex --
genes like me logo Genes that share ontologies with CDX2: view

Pathways for CDX2 Gene

genes like me logo Genes that share pathways with CDX2: view

Gene Ontology (GO) - Biological Process for CDX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 15677472
GO:0001568 blood vessel development IEA --
GO:0001824 blastocyst development --
GO:0001829 trophectodermal cell differentiation IEA --
GO:0001890 placenta development --
genes like me logo Genes that share ontologies with CDX2: view

Compounds for CDX2 Gene

(15) Novoseek inferred chemical compound relationships for CDX2 Gene

Compound -log(P) Hits PubMed IDs
vitamin d 51.9 10
5-aza-2deoxycytidine 40.2 3
apai 40.2 4
deoxycholic acid 39.1 13
butyrate 20.7 3
genes like me logo Genes that share compounds with CDX2: view

Transcripts for CDX2 Gene

mRNA/cDNA for CDX2 Gene

Unigene Clusters for CDX2 Gene

Caudal type homeobox 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDX2 Gene

No ASD Table

Relevant External Links for CDX2 Gene

GeneLoc Exon Structure for
CDX2
ECgene alternative splicing isoforms for
CDX2

Expression for CDX2 Gene

mRNA expression in normal human tissues for CDX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDX2 Gene

This gene is overexpressed in Colon - Transverse (37.2) and Small Intestine - Terminal Ileum (12.6).

SOURCE GeneReport for Unigene cluster for CDX2 Gene Hs.174249

genes like me logo Genes that share expressions with CDX2: view

Orthologs for CDX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CDX2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDX2 37
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDX2 36
  • 89 (n)
  • 94.77 (a)
CDX2 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDX2 36
  • 90.2 (n)
  • 96.17 (a)
CDX2 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdx2 36
  • 87.03 (n)
  • 91.64 (a)
Cdx2 16
Cdx2 37
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDX2 37
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDX2 37
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdx2 36
  • 86.67 (n)
  • 92.58 (a)
chicken
(Gallus gallus)
Aves CDX2 36
  • 79.44 (n)
  • 75.83 (a)
CDX2 37
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDX2 37
  • 77 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia xCAD2 36
tropical clawed frog
(Silurana tropicalis)
Amphibia cdx2 36
  • 63.41 (n)
  • 62.93 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1956 36
zebrafish
(Danio rerio)
Actinopterygii -- 36
cdx1a 37
  • 60 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea pal-1 37
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 21 (a)
OneToMany
Species with no ortholog for CDX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDX2 Gene

ENSEMBL:
Gene Tree for CDX2 (if available)
TreeFam:
Gene Tree for CDX2 (if available)

Paralogs for CDX2 Gene

Paralogs for CDX2 Gene

Selected SIMAP similar genes for CDX2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CDX2: view

Variants for CDX2 Gene

Sequence variations from dbSNP and Humsavar for CDX2 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs1050194 -- 27,969,018(-) CCCGG(A/T)CCCTC utr-variant-5-prime
rs1050196 -- 27,963,238(-) CCAGG(C/T)CCTCT synonymous-codon, reference
rs1805106 -- 27,968,824(-) TCCCC(C/G)GGGCC synonymous-codon, reference
rs1805108 -- 27,963,105(-) CCGGG(G/T)TCTGC utr-variant-3-prime
rs2481952 -- 27,962,764(+) AGGTG(C/T)AGCCT utr-variant-3-prime

Relevant External Links for CDX2 Gene

HapMap Linkage Disequilibrium report
CDX2
Human Gene Mutation Database (HGMD)
CDX2

No data available for Structural Variations from Database of Genomic Variants (DGV) for CDX2 Gene

Disorders for CDX2 Gene

(6) University of Copenhagen DISEASES for CDX2 Gene

(80) Novoseek inferred disease relationships for CDX2 Gene

Disease -log(P) Hits PubMed IDs
metaplasia 83.9 123
adenocarcinoma 77.6 171
carcinoma mucinous 77.4 15
barrett esophagus 75.5 25
adenocarcinoma bladder 70.8 2

Relevant External Links for CDX2

Genetic Association Database (GAD)
CDX2
Human Genome Epidemiology (HuGE) Navigator
CDX2
genes like me logo Genes that share disorders with CDX2: view

No data available for UniProtKB/Swiss-Prot for CDX2 Gene

Publications for CDX2 Gene

  1. Cloning and chromosome assignment of the human CDX2 gene. (PMID: 9459001) Drummond F.J. … Edwards Y.H. (Ann. Hum. Genet. 1997) 3 4 23
  2. Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis. (PMID: 9036867) Mallo G.V. … Iovanna J.L. (Int. J. Cancer 1997) 3 4 23
  3. CDX2 polymorphisms, RNA expression, and risk of colorectal cancer. (PMID: 15994917) Rozek L.S. … Gruber S.B. (Cancer Res. 2005) 3 23 49
  4. No association between the polymorphisms in CDX2 coding regions and colorectal cancer in Chinese. (PMID: 19421714) Xia X. … Lai M. (Mol. Cell. Biochem. 2009) 3 23 49
  5. Inhibition of nucleostemin upregulates CDX2 expression in HT29 cells in response to bile acid exposure: implications in the pathogenesis of Barrett's esophagus. (PMID: 19449081) Sun Y.G. … Fang D.C. (J. Gastrointest. Surg. 2009) 3 23

Products for CDX2 Gene

  • Addgene plasmids for CDX2

Sources for CDX2 Gene

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