External Ids for TESK2 Gene
Previous GeneCards Identifiers for TESK2 Gene
This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain that is structurally similar to the kinase domains of testis-specific protein kinase-1 and the LIM motif-containing protein kinases (LIMKs). Its overall structure is most related to the former, indicating that it belongs to the TESK subgroup of the LIMK/TESK family of protein kinases. This gene is predominantly expressed in testis and prostate. The developmental expression pattern of the rat gene in testis suggests an important role for this gene in meitoic stages and/or early stages of spermiogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
GeneCards Summary for TESK2 Gene
TESK2 (Testis-Specific Kinase 2) is a Protein Coding gene. Among its related pathways are Regulation of Microtubule Cytoskeleton and Focal Adhesion. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TESK1.
UniProtKB/Swiss-Prot for TESK2 Gene
Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at Ser-3. May play an important role in spermatogenesis.