Aliases for RAPGEF3 Gene
- Rap Guanine Nucleotide Exchange Factor (GEF) 3 2 3
- Exchange Protein Directly Activated By CAMP 1 2 3 4
- EPAC 3 4 6
- Rap1 Guanine-Nucleotide-Exchange Factor Directly Activated By CAMP 3 4
- CAMP-Regulated Guanine Nucleotide Exchange Factor I 3 4
- Exchange Factor Directly Activated By CAMP 1 3 4
- CAMP-GEFI 3 4
- EPAC 1 3 4
External Ids for RAPGEF3 Gene
GeneCards Summary for RAPGEF3 Gene
RAPGEF3 (Rap Guanine Nucleotide Exchange Factor (GEF) 3) is a Protein Coding gene. Among its related pathways are Ras signaling pathway and Signaling by GPCR. GO annotations related to this gene include guanyl-nucleotide exchange factor activity and cAMP binding. An important paralog of this gene is RASGEF1B.
UniProtKB/Swiss-Prot for RAPGEF3 Gene
Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin.
GTPases are a group of enzymes that catalyze hydrolysis of the gamma phosphate bond in guanine triphosphate (GTP) to form guanine diphosphate (GDP). Mg2+ is essential for catalytic activity. GTPases are often coupled to G proteins and have essential roles in signal transduction, protein synthesis and translocation, control of cell growth and differentiation and vesicular transport regulation.