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Aliases for PEMT Gene

Aliases for PEMT Gene

  • Phosphatidylethanolamine N-Methyltransferase 2 3 5
  • PEAMT 3 4
  • PEMPT 3 4
  • PEMT2 3 4
  • PNMT 3 4
  • EC 2.1.1.17 4
  • EC 2.1.1.71 4

External Ids for PEMT Gene

Previous GeneCards Identifiers for PEMT Gene

  • GC17M017723
  • GC17M018781
  • GC17M017347
  • GC17M017609
  • GC17M017349
  • GC17M017161

Summaries for PEMT Gene

Entrez Gene Summary for PEMT Gene

  • Phosphatidylcholine (PC) is the most abundant mammalian phospholipid. This gene encodes an enzyme which converts phosphatidylethanolamine to phosphatidylcholine by sequential methylation in the liver. Another distinct synthetic pathway in nucleated cells converts intracellular choline to phosphatidylcholine by a three-step process. The protein isoforms encoded by this gene localize to the endoplasmic reticulum and mitochondria-associated membranes. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2012]

GeneCards Summary for PEMT Gene

PEMT (Phosphatidylethanolamine N-Methyltransferase) is a Protein Coding gene. Diseases associated with PEMT include choline deficiency disease and whiplash. Among its related pathways are Metabolism and Viral mRNA Translation. GO annotations related to this gene include N-methyltransferase activity and phosphatidylethanolamine N-methyltransferase activity.

UniProtKB/Swiss-Prot for PEMT Gene

  • Catalyzes three sequential methylation reactions of phosphatidylethanolamine (PE) by AdoMet, thereby producing phosphatidylcholine (PC).

Gene Wiki entry for PEMT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PEMT Gene

Genomics for PEMT Gene

Regulatory Elements for PEMT Gene

Transcription factor binding sites by QIAGEN in the PEMT gene promoter:

Genomic Location for PEMT Gene

Chromosome:
17
Start:
17,505,563 bp from pter
End:
17,591,708 bp from pter
Size:
86,146 bases
Orientation:
Minus strand

Genomic View for PEMT Gene

Genes around PEMT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PEMT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PEMT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PEMT Gene

Proteins for PEMT Gene

  • Protein details for PEMT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBM1-PEMT_HUMAN
    Recommended name:
    Phosphatidylethanolamine N-methyltransferase
    Protein Accession:
    Q9UBM1
    Secondary Accessions:
    • A8MZ66
    • B4DY41
    • D3DXC3
    • Q6IAQ5
    • Q86VL3
    • Q9BW86
    • Q9UHY6
    • Q9Y6V9

    Protein attributes for PEMT Gene

    Size:
    199 amino acids
    Molecular mass:
    22134 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF14867.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PEMT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PEMT Gene

Proteomics data for PEMT Gene at MOPED

Post-translational modifications for PEMT Gene

Antibody Products

No data available for DME Specific Peptides for PEMT Gene

Domains & Families for PEMT Gene

Protein Domains for PEMT Gene

Suggested Antigen Peptide Sequences for PEMT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UBM1

UniProtKB/Swiss-Prot:

PEMT_HUMAN :
  • Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.
Family:
  • Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.
genes like me logo Genes that share domains with PEMT: view

No data available for Gene Families for PEMT Gene

Function for PEMT Gene

Molecular function for PEMT Gene

GENATLAS Biochemistry:
phosphatidylethanolamine N-methyltransferase,converting phosphatidylethanolamine to phosphatidylcholine,involved in hepatocyte proliferation and liver cancer,with three isoforms differing from each other in the 5 region
UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-dimethylethanolamine.
UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + phosphatidyl-N-dimethylethanolamine = S-adenosyl-L-homocysteine + phosphatidylcholine.
UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + phosphatidylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine.
UniProtKB/Swiss-Prot EnzymeRegulation:
The first methylation is rate-limiting.
UniProtKB/Swiss-Prot Function:
Catalyzes three sequential methylation reactions of phosphatidylethanolamine (PE) by AdoMet, thereby producing phosphatidylcholine (PC).

Enzyme Numbers (IUBMB) for PEMT Gene

Gene Ontology (GO) - Molecular Function for PEMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008429 phosphatidylethanolamine binding IEA --
GO:0080101 phosphatidyl-N-dimethylethanolamine N-methyltransferase activity IBA --
genes like me logo Genes that share ontologies with PEMT: view
genes like me logo Genes that share phenotypes with PEMT: view

Animal Models for PEMT Gene

MGI Knock Outs for PEMT:

Animal Model Products

miRNA for PEMT Gene

miRTarBase miRNAs that target PEMT

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PEMT Gene

Localization for PEMT Gene

Subcellular locations from UniProtKB/Swiss-Prot for PEMT Gene

Isoform 1: Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein. Note=Found in endoplasmic reticulum where most PEMT activity is generated and in mitochondria. {ECO:0000250}.
Isoform 2: Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PEMT Gene COMPARTMENTS Subcellular localization image for PEMT gene
Compartment Confidence
endoplasmic reticulum 4
mitochondrion 4
plasma membrane 4
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for PEMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042383 sarcolemma IEA --
genes like me logo Genes that share ontologies with PEMT: view

Pathways & Interactions for PEMT Gene

genes like me logo Genes that share pathways with PEMT: view

UniProtKB/Swiss-Prot Q9UBM1-PEMT_HUMAN

  • Pathway: Phospholipid metabolism; phosphatidylcholine biosynthesis.

Gene Ontology (GO) - Biological Process for PEMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process TAS 9989271
GO:0006650 glycerophospholipid metabolic process IEA --
GO:0006656 phosphatidylcholine biosynthetic process TAS --
GO:0007584 response to nutrient IEA --
GO:0008285 negative regulation of cell proliferation IEA --
genes like me logo Genes that share ontologies with PEMT: view

No data available for SIGNOR curated interactions for PEMT Gene

Drugs & Compounds for PEMT Gene

(9) Drugs for PEMT Gene - From: Novoseek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra 0
Phosphatidylethanolamine Experimental Pharma 0
s-adenosylhomocysteine Experimental Pharma 0

(9) Additional Compounds for PEMT Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PC(18:1(9Z)e/2:0)
  • (2-acetyloxy-3-octadec-9-enoxypropyl) 2-trimethylazaniumylethyl phosphate
  • 2-Acetyl-1-(9Z-octadecenyl)-sn-glycero-3-phosphocholine
  • PC(O-18:1(9Z)/2:0)
Phosphatidylcholines Group A
  • (R)-4-hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxohexadecyl)oxy]-3,5,9-Trioxa-4-phosphapentacosan-1-aminium 4-oxide hydroxide inner salt
  • (R)-4-hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxohexadecyl)oxy]-3,5,9-Trioxa-4-phosphapentacosan-1-aminium 4-oxide inner salt
  • 1,2-Bis(hexadecanoyl)-sn-glycero-3-phosphocholine
  • 1,2-Bis(palmitoyl)-sn-glycero-3-phosphocholine
  • 1,2-Dihexadecanoyl-sn-glycerol-3-phosphorylcholine
63-89-8, 68737-67-7
Phosphatidylcholines Group B
  • 1-(1-Enyl-palmitoyl)-2-stearidonoyl-sn-glycero-3-phosphocholine
  • GPCho(16:0/18:4)
  • GPCho(16:0/18:4n3)
  • GPCho(16:0/18:4w3)
  • GPCho(34:4)
88542-95-4
Phosphatidylethanolamines Group A
  • 1-(1-Enyl-stearoyl)-2-arachidonoyl-sn-glycero-3-phosphoethanolamine
  • 1-(1Z-Octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine
  • 1-Alkenyl-2-acyl-glycerophosphoethanolamine
  • GPEtn(18:0/20:4)
  • GPEtn(18:0/20:4n6)
103597-60-0
genes like me logo Genes that share compounds with PEMT: view

Transcripts for PEMT Gene

Unigene Clusters for PEMT Gene

Phosphatidylethanolamine N-methyltransferase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PEMT Gene

No ASD Table

Relevant External Links for PEMT Gene

GeneLoc Exon Structure for
PEMT
ECgene alternative splicing isoforms for
PEMT

Expression for PEMT Gene

mRNA expression in normal human tissues for PEMT Gene

mRNA differential expression in normal tissues according to GTEx for PEMT Gene

This gene is overexpressed in Liver (x7.7).

Protein differential expression in normal tissues from HIPED for PEMT Gene

This gene is overexpressed in Liver (30.4), Ovary (12.6), Retina (7.0), and Fetal ovary (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PEMT Gene



SOURCE GeneReport for Unigene cluster for PEMT Gene Hs.714193

genes like me logo Genes that share expression patterns with PEMT: view

Protein tissue co-expression partners for PEMT Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for PEMT Gene

Orthologs for PEMT Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PEMT Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PEMT 35
  • 84.42 (n)
  • 80.4 (a)
PEMT 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PEMT 35
  • 86.31 (n)
  • 83.93 (a)
PEMT 36
  • 84 (a)
OneToOne