Aliases for NOD1 Gene
- Nucleotide-Binding Oligomerization Domain Containing 1 2 3
- Caspase Recruitment Domain-Containing Protein 4 3 4
- Caspase Recruitment Domain Family, Member 4 2 3
- CARD4 3 4
- Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And CARD Domain Containing 1 3
- Leucine Rich Repeat And CARD Domain Containing 1 2
- Nucleotide-Binding Oligomerization Domain 2
External Ids for NOD1 Gene
Previous HGNC Symbols for NOD1 Gene
Previous GeneCards Identifiers for NOD1 Gene
This gene encodes a member of the NOD (nucleotide-binding oligomerization domain) family. This member is a cytosolic protein. It contains an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. This protein is an intracellular pattern-recognition receptor (PRR) that initiates inflammation in response to a subset of bacteria through the detection of bacterial diaminopimelic acid. Multiple alternatively spliced transcript variants differring in the 5' UTR have been described, but the full-length nature of these variants has not been determined. [provided by RefSeq, Oct 2009]
GeneCards Summary for NOD1 Gene
NOD1 (Nucleotide-Binding Oligomerization Domain Containing 1) is a Protein Coding gene. Diseases associated with NOD1 include progressive relapsing multiple sclerosis and blau syndrome. Among its related pathways are Immune System and Interleukin receptor SHC signaling. GO annotations related to this gene include protein homodimerization activity and cysteine-type endopeptidase activator activity involved in apoptotic process. An important paralog of this gene is NLRX1.
UniProtKB/Swiss-Prot for NOD1 Gene
Enhances caspase-9-mediated apoptosis. Induces NF-kappa-B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathway activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB. Recruits NLRP10 to the cell membrane following bacterial infection.