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Aliases for BTN2A2 Gene

Aliases for BTN2A2 Gene

  • Butyrophilin, Subfamily 2, Member A2 2 3
  • BTF2 3 4 6
  • BT2.2 3 4
  • Butyrophilin Subfamily 2 Member A2 3
  • Butyrophilin 2 3
  • BTN2.2 3

External Ids for BTN2A2 Gene

Previous GeneCards Identifiers for BTN2A2 Gene

  • GC06P026440
  • GC06P026445
  • GC06P026491
  • GC06P026383
  • GC06P026332

Summaries for BTN2A2 Gene

Entrez Gene Summary for BTN2A2 Gene

  • Butyrophilin is the major protein associated with fat droplets in the milk. This gene is a member of the BTN2 subfamily of genes, which encode proteins belonging to the butyrophilin protein family. The gene is located in a cluster on chromosome 6, consisting of seven genes belonging to the expanding B7/butyrophilin-like group, a subset of the immunoglobulin gene superfamily. The encoded protein is a type I receptor glycoprotein involved in lipid, fatty-acid and sterol metabolism. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

GeneCards Summary for BTN2A2 Gene

BTN2A2 (Butyrophilin, Subfamily 2, Member A2) is a Protein Coding gene. An important paralog of this gene is BTNL9.

UniProtKB/Swiss-Prot for BTN2A2 Gene

  • Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion.

Gene Wiki entry for BTN2A2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BTN2A2 Gene

Genomics for BTN2A2 Gene

Regulatory Elements for BTN2A2 Gene

Genomic Location for BTN2A2 Gene

26,382,870 bp from pter
26,394,874 bp from pter
12,005 bases
Plus strand

Genomic View for BTN2A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BTN2A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BTN2A2 Gene

Proteins for BTN2A2 Gene

  • Protein details for BTN2A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Butyrophilin subfamily 2 member A2
    Protein Accession:
    Secondary Accessions:
    • A6NM84
    • B4DE97
    • B4DQ01
    • E9PH07
    • O00480

    Protein attributes for BTN2A2 Gene

    523 amino acids
    Molecular mass:
    59070 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BTN2A2 Gene


neXtProt entry for BTN2A2 Gene

Proteomics data for BTN2A2 Gene at MOPED

Post-translational modifications for BTN2A2 Gene

Antibody Products

  • R&D Systems Antibodies for BTN2A2 (BTN2A2/Butyrophilin 2)

No data available for DME Specific Peptides for BTN2A2 Gene

Domains for BTN2A2 Gene

Gene Families for BTN2A2 Gene

  • BTN :Butyrophilins
  • C2SET :Immunoglobulin superfamily / C2-set domain containing
  • VSET :Immunoglobulin superfamily / V-set domain containing

Graphical View of Domain Structure for InterPro Entry



  • Q8WVV5
  • Contains 1 B30.2/SPRY domain.
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
genes like me logo Genes that share domains with BTN2A2: view

Function for BTN2A2 Gene

Molecular function for BTN2A2 Gene

GENATLAS Biochemistry:
butyrophilin subfamily 2,member A2,B box family of proteins,involved in cell proliferation and development
UniProtKB/Swiss-Prot Function:
Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion.

Gene Ontology (GO) - Molecular Function for BTN2A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with BTN2A2: view

Phenotypes for BTN2A2 Gene

genes like me logo Genes that share phenotypes with BTN2A2: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BTN2A2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for BTN2A2 Gene

Localization for BTN2A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BTN2A2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for BTN2A2 Gene COMPARTMENTS Subcellular localization image for BTN2A2 gene
Compartment Confidence
plasma membrane 3
extracellular 2
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for BTN2A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with BTN2A2: view

Pathways for BTN2A2 Gene

SuperPathways for BTN2A2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BTN2A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031324 negative regulation of cellular metabolic process ISS --
GO:0046007 negative regulation of activated T cell proliferation ISS --
GO:0050710 negative regulation of cytokine secretion ISS --
genes like me logo Genes that share ontologies with BTN2A2: view

No data available for Pathways by source for BTN2A2 Gene

Transcripts for BTN2A2 Gene

Unigene Clusters for BTN2A2 Gene

Butyrophilin, subfamily 2, member A2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BTN2A2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BTN2A2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
SP1: - - - - - - -
SP2: - - - - -
SP5: -
SP6: - - -
SP7: - -

Relevant External Links for BTN2A2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BTN2A2 Gene

mRNA expression in normal human tissues for BTN2A2 Gene

Protein differential expression in normal tissues for BTN2A2 Gene

This gene is overexpressed in Urine (57.2) and Heart (11.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for BTN2A2 Gene

SOURCE GeneReport for Unigene cluster for BTN2A2 Gene Hs.373938

mRNA Expression by UniProt/SwissProt for BTN2A2 Gene

Tissue specificity: Highly expressed in brain, bone marrow, small intestine, muscle, spleen and pancreas. Moderate expression was seen in lung, liver and kidney.
genes like me logo Genes that share expressions with BTN2A2: view

Expression partners for BTN2A2 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for BTN2A2 Gene

Orthologs for BTN2A2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for BTN2A2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia BTN2A1 35
  • 73.69 (n)
  • 63.43 (a)
-- 36
  • 58 (a)
(Canis familiaris)
Mammalia BTN2A2 35
  • 80.37 (n)
  • 73.12 (a)
-- 36
  • 72 (a)
(Mus musculus)
Mammalia Btn2a2 35
  • 77.36 (n)
  • 72.75 (a)
Btn2a2 16
Btn2a2 36
  • 70 (a)
(Pan troglodytes)
Mammalia BTN2A2 35
  • 99.36 (n)
  • 98.85 (a)
BTN2A2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Btn2a2 35
  • 76.08 (n)
  • 70.78 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 40 (a)
Species with no ortholog for BTN2A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BTN2A2 Gene

Gene Tree for BTN2A2 (if available)
Gene Tree for BTN2A2 (if available)

Paralogs for BTN2A2 Gene

Paralogs for BTN2A2 Gene

genes like me logo Genes that share paralogs with BTN2A2: view

Variants for BTN2A2 Gene

Sequence variations from dbSNP and Humsavar for BTN2A2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs7355 -- 26,393,931(+) taatg(A/T)agata utr-variant-3-prime, intron-variant
rs1131936 -- 26,394,092(+) aggtc(A/G)tgtta utr-variant-3-prime, intron-variant, downstream-variant-500B
rs1614887 -- 26,392,793(+) AGATC(A/G)CACAT synonymous-codon, reference, intron-variant, utr-variant-3-prime, downstream-variant-500B
rs1796518 -- 26,388,444(+) TCTCC(C/T)CTCCT intron-variant
rs1804836 -- 26,393,559(+) CACAC(A/C)CACAG utr-variant-3-prime, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BTN2A2 Gene

Variant ID Type Subtype PubMed ID
nsv883491 CNV Loss 21882294
dgv6440n71 CNV Loss 21882294
nsv883496 CNV Gain 21882294
nsv883499 CNV Gain 21882294
esv2731728 CNV Deletion 23290073
esv2731730 CNV Deletion 23290073

Relevant External Links for BTN2A2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BTN2A2 Gene

Disorders for BTN2A2 Gene

Relevant External Links for BTN2A2

Genetic Association Database (GAD)

No disorders were found for BTN2A2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for BTN2A2 Gene

Publications for BTN2A2 Gene

  1. A 1.1-Mb transcript map of the hereditary hemochromatosis locus. (PMID: 9149941) Ruddy D.A. … Feder J.N. (Genome Res. 1997) 2 3 4
  2. Structure and evolution of the extended B7 family. (PMID: 10354554) Henry J. … Pontarotti P. (Immunol. Today 1999) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Common variants on chromosome 6p22.1 are associated with schizophrenia. (PMID: 19571809) Shi J. … Gejman P.V. (Nature 2009) 3 48
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4

Products for BTN2A2 Gene

Sources for BTN2A2 Gene

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