Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KLF2 Gene

Aliases for KLF2 Gene

  • Kruppel-Like Factor 2 2 3 5
  • Kruppel-Like Factor 2 (Lung) 2 3
  • Lung Krueppel-Like Factor 3 4
  • LKLF 3 4
  • Lung Kruppel-Like Zinc Finger Transcription Factor 3
  • Kruppel-Like Factor LKLF 3

External Ids for KLF2 Gene

Previous GeneCards Identifiers for KLF2 Gene

  • GC19P016929
  • GC19P016827
  • GC19P016280
  • GC19P016296
  • GC19P016435
  • GC19P016007
  • GC19P016576
  • GC19P016814

Summaries for KLF2 Gene

Entrez Gene Summary for KLF2 Gene

  • Kruppel-like factors (KLFs) are a family of broadly expressed zinc finger transcription factors. KLF2 regulates T-cell trafficking by promoting expression of the lipid-binding receptor S1P1 (S1PR1; MIM 601974) and the selectin CD62L (SELL; MIM 153240) (summary by Weinreich et al., 2009 [PubMed 19592277]).[supplied by OMIM, Feb 2011]

GeneCards Summary for KLF2 Gene

KLF2 (Kruppel-Like Factor 2) is a Protein Coding gene. Diseases associated with KLF2 include splenic marginal zone lymphoma. Among its related pathways are FoxO signaling pathway and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is KLF8.

UniProtKB/Swiss-Prot for KLF2 Gene

  • Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription.

Gene Wiki entry for KLF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLF2 Gene

Genomics for KLF2 Gene

Regulatory Elements for KLF2 Gene

Enhancers for KLF2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KLF2 on UCSC Golden Path with GeneCards custom track

Promoters for KLF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KLF2 on UCSC Golden Path with GeneCards custom track

Genomic Location for KLF2 Gene

Chromosome:
19
Start:
16,324,817 bp from pter
End:
16,327,874 bp from pter
Size:
3,058 bases
Orientation:
Plus strand

Genomic View for KLF2 Gene

Genes around KLF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLF2 Gene

Proteins for KLF2 Gene

  • Protein details for KLF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5W3-KLF2_HUMAN
    Recommended name:
    Krueppel-like factor 2
    Protein Accession:
    Q9Y5W3
    Secondary Accessions:
    • Q6IPC4
    • Q9UJS5
    • Q9UKR6

    Protein attributes for KLF2 Gene

    Size:
    355 amino acids
    Molecular mass:
    37420 Da
    Quaternary structure:
    • Interacts with WWP1.

neXtProt entry for KLF2 Gene

Proteomics data for KLF2 Gene at MOPED

Post-translational modifications for KLF2 Gene

  • Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLF2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLF2 Gene

Domains & Families for KLF2 Gene

Protein Domains for KLF2 Gene

Suggested Antigen Peptide Sequences for KLF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y5W3

UniProtKB/Swiss-Prot:

KLF2_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 3 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 3 C2H2-type zinc fingers.
genes like me logo Genes that share domains with KLF2: view

Function for KLF2 Gene

Molecular function for KLF2 Gene

GENATLAS Biochemistry:
Kruppel-like factor 2 (lung),zinc finger transcription factor,homolog of a mouse gene,predominantly expressed in developing lung,spleen and vascular system,putatively involved in programming the quiescent state of single positive T cells and blood wall morphogenesis
UniProtKB/Swiss-Prot Function:
Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription.

Gene Ontology (GO) - Molecular Function for KLF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 21382345
genes like me logo Genes that share ontologies with KLF2: view
genes like me logo Genes that share phenotypes with KLF2: view

Animal Models for KLF2 Gene

MGI Knock Outs for KLF2:

Animal Model Products

miRNA for KLF2 Gene

miRTarBase miRNAs that target KLF2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KLF2 Gene

Localization for KLF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLF2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLF2 Gene COMPARTMENTS Subcellular localization image for KLF2 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for KLF2 Gene

Pathways & Interactions for KLF2 Gene

genes like me logo Genes that share pathways with KLF2: view

Pathways by source for KLF2 Gene

SIGNOR curated interactions for KLF2 Gene

Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for KLF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis IEA --
GO:0001701 in utero embryonic development IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0032715 negative regulation of interleukin-6 production IEA --
GO:0034101 erythrocyte homeostasis IEA --
genes like me logo Genes that share ontologies with KLF2: view

Drugs & Compounds for KLF2 Gene

(2) Drugs for KLF2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with KLF2: view

Transcripts for KLF2 Gene

mRNA/cDNA for KLF2 Gene

Unigene Clusters for KLF2 Gene

Kruppel-like factor 2 (lung):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLF2 Gene

No ASD Table

Relevant External Links for KLF2 Gene

GeneLoc Exon Structure for
KLF2
ECgene alternative splicing isoforms for
KLF2

Expression for KLF2 Gene

mRNA expression in normal human tissues for KLF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLF2 Gene

This gene is overexpressed in Whole Blood (x6.8).

Protein differential expression in normal tissues from HIPED for KLF2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (25.0), Blymphocyte (22.4), and CD8 Tcells (21.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KLF2 Gene



SOURCE GeneReport for Unigene cluster for KLF2 Gene Hs.744182

genes like me logo Genes that share expression patterns with KLF2: view

Protein tissue co-expression partners for KLF2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for KLF2 Gene

Orthologs for KLF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLF2 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Klf2 35
  • 81.87 (n)
  • 86.69 (a)
Klf2 16
Klf2 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KLF2 35
  • 99.25 (n)
  • 98.87 (a)
KLF2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Klf2 35
  • 81.62 (n)
  • 85.71 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 14 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia KLF2 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KLF2 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves KLF2 36
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 56 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii -- 35
klf2a 36
  • 46 (a)
OneToMany
klf2b 36
  • 48 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5981 35
fruit fly
(Drosophila melanogaster)
Insecta CG9895 37
  • 72 (a)
worm
(Caenorhabditis elegans)
Secernentea F53F8.1 37
  • 59 (a)
F56F11.3 37
  • 79 (a)
mua-1 37
  • 62 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
OneToMany
Species with no ortholog for KLF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KLF2 Gene

ENSEMBL:
Gene Tree for KLF2 (if available)
TreeFam:
Gene Tree for KLF2 (if available)

Paralogs for KLF2 Gene

Paralogs for KLF2 Gene

(9) SIMAP similar genes for KLF2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for KLF2 Gene

genes like me logo Genes that share paralogs with KLF2: view

Variants for KLF2 Gene

Sequence variations from dbSNP and Humsavar for KLF2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs3745318 - 16,325,451(+) GCCGC(C/T)GGGGC reference, missense
rs45586032 - 16,325,574(+) ACCGC(C/G)CGGCC reference, missense
rs7258799 -- 16,326,424(+) GGCTC(A/T)GGTAG intron-variant
rs8102266 -- 16,324,422(+) AAGCC(C/G)GGTGC upstream-variant-2KB
rs8106384 -- 16,324,906(+) TCCTT(C/T)CTCCC utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for KLF2 Gene

Variant ID Type Subtype PubMed ID
nsv833767 CNV Loss 17160897
nsv911159 CNV Loss 21882294
dgv3753n71 CNV Loss 21882294
nsv911162 CNV Loss 21882294
nsv911163 CNV Loss 21882294
dgv3754n71 CNV Loss 21882294

Variation tolerance for KLF2 Gene

Gene Damage Index Score: 0.59; 12.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLF2 Gene

HapMap Linkage Disequilibrium report
KLF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLF2 Gene

Disorders for KLF2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KLF2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
splenic marginal zone lymphoma
  • smzl
- elite association - COSMIC cancer census association via MalaCards
Search KLF2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KLF2

Genetic Association Database (GAD)
KLF2
Human Genome Epidemiology (HuGE) Navigator
KLF2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLF2
genes like me logo Genes that share disorders with KLF2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KLF2 Gene

Publications for KLF2 Gene

  1. cDNA isolation, genomic structure, regulation, and chromosomal localization of human lung kruppel-like factor. (PMID: 10458913) Wani M.A. … Lingrel J.B. (Genomics 1999) 2 3 4 23 67
  2. Structure of the human CpG-island-containing lung Kruppel-like factor (LKLF) gene and its location in chromosome 19p13.11-13 locus. (PMID: 10217429) Kozyrev S.V. … Kisselev L.L. (FEBS Lett. 1999) 2 3 23
  3. Defining the regulation of KLF4 expression and its downstream transcriptional targets in vascular endothelial cells. (PMID: 19968965) Villarreal G. … GarcA-a-CardeA+a G. (Biochem. Biophys. Res. Commun. 2010) 3 23
  4. Simvastatin has an anti-inflammatory effect on macrophages via upregulation of an atheroprotective transcription factor, Kruppel-like factor 2. (PMID: 18192240) Tuomisto T.T. … YlAo-Herttuala S. (Cardiovasc. Res. 2008) 3 23
  5. Abrogation of anti-inflammatory transcription factor LKLF in neutrophil-dominated airways. (PMID: 18218994) Saavedra M.T. … Dinarello C.A. (Am. J. Respir. Cell Mol. Biol. 2008) 3 23

Products for KLF2 Gene

Sources for KLF2 Gene

Content