Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KLF2 Gene

Aliases for KLF2 Gene

  • Kruppel-Like Factor 2 2 3
  • LKLF 3 4 6
  • Kruppel-Like Factor 2 (Lung) 2 3
  • Lung Krueppel-Like Factor 3 4
  • Lung Kruppel-Like Zinc Finger Transcription Factor 3
  • Kruppel-Like Factor LKLF 3
  • Krueppel-Like Factor 2 3

External Ids for KLF2 Gene

Previous GeneCards Identifiers for KLF2 Gene

  • GC19P016929
  • GC19P016827
  • GC19P016280
  • GC19P016296
  • GC19P016435
  • GC19P016007

Summaries for KLF2 Gene

Entrez Gene Summary for KLF2 Gene

  • Kruppel-like factors (KLFs) are a family of broadly expressed zinc finger transcription factors. KLF2 regulates T-cell trafficking by promoting expression of the lipid-binding receptor S1P1 (S1PR1; MIM 601974) and the selectin CD62L (SELL; MIM 153240) (summary by Weinreich et al., 2009 [PubMed 19592277]).[supplied by OMIM, Feb 2011]

GeneCards Summary for KLF2 Gene

KLF2 (Kruppel-Like Factor 2) is a Protein Coding gene. Among its related pathways are FoxO signaling pathway. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is KLF8.

UniProtKB/Swiss-Prot for KLF2 Gene

  • Binds to the CACCC box in the beta-globin gene promoter and activates transcription.

Gene Wiki entry for KLF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLF2 Gene

Genomics for KLF2 Gene

Regulatory Elements for KLF2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KLF2 Gene

Start:
16,324,817 bp from pter
End:
16,327,874 bp from pter
Size:
3,058 bases
Orientation:
Plus strand

Genomic View for KLF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLF2 Gene

Proteins for KLF2 Gene

  • Protein details for KLF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5W3-KLF2_HUMAN
    Recommended name:
    Krueppel-like factor 2
    Protein Accession:
    Q9Y5W3
    Secondary Accessions:
    • Q6IPC4
    • Q9UJS5
    • Q9UKR6

    Protein attributes for KLF2 Gene

    Size:
    355 amino acids
    Molecular mass:
    37420 Da
    Quaternary structure:
    • Interacts with WWP1.

neXtProt entry for KLF2 Gene

Proteomics data for KLF2 Gene at MOPED

Post-translational modifications for KLF2 Gene

  • Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLF2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLF2 Gene

Domains for KLF2 Gene

Gene Families for KLF2 Gene

HGNC:
  • KLF :Kruppel-like transcription factors
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for KLF2 Gene

Suggested Antigen Peptide Sequences for KLF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y5W3

UniProtKB/Swiss-Prot:

KLF2_HUMAN :
  • Q9Y5W3
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 3 C2H2-type zinc fingers.
genes like me logo Genes that share domains with KLF2: view

Function for KLF2 Gene

Molecular function for KLF2 Gene

GENATLAS Biochemistry: Kruppel-like factor 2 (lung),zinc finger transcription factor,homolog of a mouse gene,predominantly expressed in developing lung,spleen and vascular system,putatively involved in programming the quiescent state of single positive T cells and blood wall morphogenesis
UniProtKB/Swiss-Prot Function: Binds to the CACCC box in the beta-globin gene promoter and activates transcription.

Gene Ontology (GO) - Molecular Function for KLF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0005515 protein binding IPI 21382345
GO:0043565 sequence-specific DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with KLF2: view
genes like me logo Genes that share phenotypes with KLF2: view

Animal Models for KLF2 Gene

MGI Knock Outs for KLF2:

Animal Model Products

CRISPR Products

miRNA for KLF2 Gene

miRTarBase miRNAs that target KLF2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for KLF2 Gene

Localization for KLF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLF2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLF2 Gene COMPARTMENTS Subcellular localization image for KLF2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for KLF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with KLF2: view

Pathways for KLF2 Gene

SuperPathways for KLF2 Gene

Superpath Contained pathways
1 FoxO signaling pathway
genes like me logo Genes that share pathways with KLF2: view

Pathways by source for KLF2 Gene

1 KEGG pathway for KLF2 Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for KLF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis IEA --
GO:0001701 in utero embryonic development IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0032715 negative regulation of interleukin-6 production IEA --
GO:0034101 erythrocyte homeostasis --
genes like me logo Genes that share ontologies with KLF2: view

Compounds for KLF2 Gene

(2) Novoseek inferred chemical compound relationships for KLF2 Gene

Compound -log(P) Hits PubMed IDs
zinc 40.3 9
nitric oxide 32.5 8
genes like me logo Genes that share compounds with KLF2: view

Transcripts for KLF2 Gene

mRNA/cDNA for KLF2 Gene

Unigene Clusters for KLF2 Gene

Kruppel-like factor 2 (lung):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLF2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLF2 Gene

No ASD Table

Relevant External Links for KLF2 Gene

GeneLoc Exon Structure for
KLF2
ECgene alternative splicing isoforms for
KLF2

Expression for KLF2 Gene

mRNA expression in normal human tissues for KLF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLF2 Gene

This gene is overexpressed in Whole Blood (6.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KLF2 Gene

SOURCE GeneReport for Unigene cluster for KLF2 Gene Hs.744182

genes like me logo Genes that share expressions with KLF2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for KLF2 Gene

Orthologs for KLF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLF2 35
  • 99.25 (n)
  • 98.87 (a)
KLF2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 14 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Klf2 35
  • 81.87 (n)
  • 86.69 (a)
Klf2 16
Klf2 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KLF2 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KLF2 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Klf2 35
  • 81.62 (n)
  • 85.71 (a)
chicken
(Gallus gallus)
Aves KLF2 36
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 56 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5981 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
klf2a 36
  • 46 (a)
OneToMany
klf2b 36
  • 48 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG9895 37
  • 72 (a)
worm
(Caenorhabditis elegans)
Secernentea F53F8.1 37
  • 59 (a)
mua-1 37
  • 62 (a)
F56F11.3 37
  • 79 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
OneToMany
Species with no ortholog for KLF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KLF2 Gene

ENSEMBL:
Gene Tree for KLF2 (if available)
TreeFam:
Gene Tree for KLF2 (if available)

Paralogs for KLF2 Gene

Selected SIMAP similar genes for KLF2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for KLF2 Gene

genes like me logo Genes that share paralogs with KLF2: view

Variants for KLF2 Gene

Sequence variations from dbSNP and Humsavar for KLF2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs8810 -- 16,327,504(-) TTAAT(A/T)AAAAA utr-variant-3-prime
rs15336 -- 16,327,202(-) ACGGG(G/T)GCTGG utr-variant-3-prime
rs1003669 -- 16,326,278(-) CTCGT(A/C)CTAAG intron-variant
rs1063905 -- 16,325,389(-) CTGTA(G/T)GGCGG synonymous-codon, reference
rs2293811 -- 16,327,087(+) gggcg(C/T)ggccc utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for KLF2 Gene

Variant ID Type Subtype PubMed ID
nsv833767 CNV Loss 17160897
nsv911159 CNV Loss 21882294
dgv3753n71 CNV Loss 21882294
nsv911162 CNV Loss 21882294
nsv911163 CNV Loss 21882294
dgv3754n71 CNV Loss 21882294

Relevant External Links for KLF2 Gene

HapMap Linkage Disequilibrium report
KLF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLF2 Gene

Disorders for KLF2 Gene

(4) Novoseek inferred disease relationships for KLF2 Gene

Disease -log(P) Hits PubMed IDs
leukemia t-cell 32.1 2
vascular diseases 29.9 1
necrosis 7.38 1
tumors 0 1

Relevant External Links for KLF2

Genetic Association Database (GAD)
KLF2
Human Genome Epidemiology (HuGE) Navigator
KLF2
genes like me logo Genes that share disorders with KLF2: view

No data available for UniProtKB/Swiss-Prot for KLF2 Gene

Publications for KLF2 Gene

  1. cDNA isolation, genomic structure, regulation, and chromosomal localization of human lung kruppel-like factor. (PMID: 10458913) Wani M.A. … Lingrel J.B. (Genomics 1999) 2 3 4 23
  2. Structure of the human CpG-island-containing lung Kruppel-like factor (LKLF) gene and its location in chromosome 19p13.11-13 locus. (PMID: 10217429) Kozyrev S.V. … Kisselev L.L. (FEBS Lett. 1999) 2 3 4 23
  3. A study of the relationships between KLF2 polymorphisms and body weight control in a French population. (PMID: 16542423) Meirhaeghe A. … Amouyel P. (BMC Med. Genet. 2006) 3 23 48
  4. Kruppel-like factor 2 (KLF2) regulates proinflammatory activation of monocytes. (PMID: 16617118) Das H. … Jain M.K. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3 23
  5. KrA1ppel-like factor 2, a novel immediate-early transcriptional factor, regulates IL-2 expression in T lymphocyte activation. (PMID: 16116194) Wu J. … Lingrel J.B. (J. Immunol. 2005) 3 23

Products for KLF2 Gene

  • Addgene plasmids for KLF2

Sources for KLF2 Gene

Back to Top

Content