Aliases for KLF2 Gene
External Ids for KLF2 Gene
Previous GeneCards Identifiers for KLF2 Gene
Kruppel-like factors (KLFs) are a family of broadly expressed zinc finger transcription factors. KLF2 regulates T-cell trafficking by promoting expression of the lipid-binding receptor S1P1 (S1PR1; MIM 601974) and the selectin CD62L (SELL; MIM 153240) (summary by Weinreich et al., 2009 [PubMed 19592277]).[supplied by OMIM, Feb 2011]
GeneCards Summary for KLF2 Gene
KLF2 (Kruppel-Like Factor 2) is a Protein Coding gene. Diseases associated with KLF2 include splenic marginal zone lymphoma. Among its related pathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and FoxO signaling pathway. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is KLF8.
UniProtKB/Swiss-Prot for KLF2 Gene
Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription.