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Aliases for HMG20B Gene

Aliases for HMG20B Gene

  • High Mobility Group 20B 2 3
  • BRAF35 3 4 6
  • Structural DNA-Binding Protein BRAF35 3 4
  • HMG Domain-Containing Protein HMGX2 3 4
  • HMG Domain-Containing Protein 2 3 4
  • Sox-Like Transcriptional Factor 3 4
  • HMG Box-Containing Protein 20B 3 4
  • HMG Box Domain Containing 2 2 3
  • BRCA2-Associated Factor 35 3 4
  • High-Mobility Group 20B 2 3
  • SMARCE1-Related Protein 3 4
  • SMARCE1r 3 4
  • HMGXB2 3 4
  • HMGX2 3 4
  • SWI/SNF-Related Matrix-Associated Actin-Dependent Regulator Of Chromatin Subfamily E, Member 1-Related 3
  • SWI/SNF-Related Matrix-Associated Actin-Dependent Regulator Of Chromatin Subfamily E Member 1-Related 3
  • BRAF25 3
  • PP7706 3
  • Pp8857 3
  • SOXL 3

External Ids for HMG20B Gene

Previous GeneCards Identifiers for HMG20B Gene

  • GC19P003665
  • GC19P003642
  • GC19P003512
  • GC19P003523
  • GC19P003338

Summaries for HMG20B Gene

GeneCards Summary for HMG20B Gene

HMG20B (High Mobility Group 20B) is a Protein Coding gene. Among its related pathways are Hemostasis and Factors involved in megakaryocyte development and platelet production. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and protein heterodimerization activity. An important paralog of this gene is HMG20A.

UniProtKB/Swiss-Prot for HMG20B Gene

  • Required for correct progression through G2 phase of the cell cycle and entry into mitosis. Required for RCOR1/CoREST mediated repression of neuronal specific gene promoters

Gene Wiki entry for HMG20B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HMG20B Gene

Genomics for HMG20B Gene

Regulatory Elements for HMG20B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HMG20B Gene

Start:
3,572,777 bp from pter
End:
3,579,088 bp from pter
Size:
6,312 bases
Orientation:
Plus strand

Genomic View for HMG20B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HMG20B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HMG20B Gene

Proteins for HMG20B Gene

  • Protein details for HMG20B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P0W2-HM20B_HUMAN
    Recommended name:
    SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related
    Protein Accession:
    Q9P0W2
    Secondary Accessions:
    • A6NMS5
    • D6W616
    • Q6IBP8
    • Q8NBD5
    • Q9HD21
    • Q9Y491
    • Q9Y4A2

    Protein attributes for HMG20B Gene

    Size:
    317 amino acids
    Molecular mass:
    35813 Da
    Quaternary structure:
    • Component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST and PHF21A/BHC80. The BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Interacts with the BRCA2 tumor suppressor protein.
    SequenceCaution:
    • Sequence=AAC26860.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAC26860.1; Type=Frameshift; Positions=223; Evidence={ECO:0000305}; Sequence=AAH21585.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for HMG20B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HMG20B Gene

Proteomics data for HMG20B Gene at MOPED

Post-translational modifications for HMG20B Gene

  • Ubiquitination at Lys208
  • Modification sites at PhosphoSitePlus

Other Protein References for HMG20B Gene

No data available for DME Specific Peptides for HMG20B Gene

Domains for HMG20B Gene

Gene Families for HMG20B Gene

HGNC:
  • HMGX :High mobility group / Non-canonical

Protein Domains for HMG20B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HMG20B Gene

Graphical View of Domain Structure for InterPro Entry

Q9P0W2

UniProtKB/Swiss-Prot:

HM20B_HUMAN :
  • Q9P0W2
Domain:
  • Contains 1 HMG box DNA-binding domain.
genes like me logo Genes that share domains with HMG20B: view

Function for HMG20B Gene

Molecular function for HMG20B Gene

UniProtKB/Swiss-Prot Function: Required for correct progression through G2 phase of the cell cycle and entry into mitosis. Required for RCOR1/CoREST mediated repression of neuronal specific gene promoters

Gene Ontology (GO) - Molecular Function for HMG20B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IBA --
GO:0005515 protein binding IPI 21399666
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with HMG20B: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HMG20B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HMG20B Gene

Localization for HMG20B Gene

Subcellular locations from UniProtKB/Swiss-Prot for HMG20B Gene

Nucleus. Chromosome. Note=Localized to condensed chromosomes in mitosis in conjunction with BRCA2.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HMG20B Gene COMPARTMENTS Subcellular localization image for HMG20B gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for HMG20B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with HMG20B: view

Pathways for HMG20B Gene

genes like me logo Genes that share pathways with HMG20B: view

Pathways by source for HMG20B Gene

Gene Ontology (GO) - Biological Process for HMG20B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization TAS --
GO:0006338 chromatin remodeling IBA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with HMG20B: view

Transcripts for HMG20B Gene

Unigene Clusters for HMG20B Gene

High mobility group 20B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HMG20B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HMG20B Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d · 10e ^
SP1: - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - -
SP6: - - - - - - -
SP7: - - - - - -
SP8: - - -
SP9: - -
SP10: - - -
SP11:
SP12: - -
SP13: -
SP14:

ExUns: 11a · 11b · 11c ^ 12a · 12b
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for HMG20B Gene

GeneLoc Exon Structure for
HMG20B
ECgene alternative splicing isoforms for
HMG20B

Expression for HMG20B Gene

mRNA expression in normal human tissues for HMG20B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HMG20B Gene

SOURCE GeneReport for Unigene cluster for HMG20B Gene Hs.406534

mRNA Expression by UniProt/SwissProt for HMG20B Gene

Q9P0W2-HM20B_HUMAN
Tissue specificity: Ubiquitously expressed in adult tissues.
genes like me logo Genes that share expressions with HMG20B: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for HMG20B Gene

Orthologs for HMG20B Gene

This gene was present in the common ancestor of animals.

Orthologs for HMG20B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HMG20B 36
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 58 (a)
OneToMany
HMG20B 36
  • 96 (a)
OneToMany
dog
(Canis familiaris)
Mammalia HMG20B 35
  • 86.73 (n)
  • 89.49 (a)
HMG20B 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hmg20b 35
  • 85.49 (n)
  • 93.69 (a)
Hmg20b 16
Hmg20b 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HMG20B 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HMG20B 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hmg20b 35
  • 86.54 (n)
  • 93.69 (a)
chicken
(Gallus gallus)
Aves HMG20B 35
  • 81.96 (n)
  • 84.25 (a)
HMG20B 36
  • 80 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68625 35
tropical clawed frog
(Silurana tropicalis)
Amphibia hmg20b 35
  • 66.55 (n)
  • 76.69 (a)
MGC75938 35
zebrafish
(Danio rerio)
Actinopterygii hmg20b 35
  • 62.5 (n)
  • 63.19 (a)
hmg20b 36
  • 59 (a)
OneToOne
wufc85b02 35
fruit fly
(Drosophila melanogaster)
Insecta CG9418 36
  • 20 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hmg-20 36
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToMany
Species with no ortholog for HMG20B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HMG20B Gene

ENSEMBL:
Gene Tree for HMG20B (if available)
TreeFam:
Gene Tree for HMG20B (if available)

Paralogs for HMG20B Gene

Paralogs for HMG20B Gene

genes like me logo Genes that share paralogs with HMG20B: view

Variants for HMG20B Gene

Sequence variations from dbSNP and Humsavar for HMG20B Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1443 -- 3,579,002(-) CCCTC(A/C/G)GCTGG utr-variant-3-prime
rs13269 -- 3,578,775(+) CTCCT(C/T)GGAGG utr-variant-3-prime
rs939209 -- 3,578,655(-) TTTTA(A/G)GGGGG utr-variant-3-prime
rs1476786 -- 3,573,504(+) CTCGG(C/T)CTCCA intron-variant
rs3217053 -- 3,576,321(+) CCTTC(-/TTC)CTCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HMG20B Gene

Variant ID Type Subtype PubMed ID
nsv910722 CNV Loss 21882294
nsv910723 CNV Loss 21882294
dgv3651n71 CNV Loss 21882294
nsv470114 CNV Loss 18288195
dgv3652n71 CNV Loss 21882294
dgv3655n71 CNV Loss 21882294
dgv3656n71 CNV Loss 21882294
dgv3657n71 CNV Loss 21882294
nsv910748 CNV Loss 21882294
nsv833713 CNV Loss 17160897
dgv3658n71 CNV Loss 21882294
nsv910752 CNV Loss 21882294
dgv3659n71 CNV Loss 21882294
dgv3660n71 CNV Loss 21882294

Relevant External Links for HMG20B Gene

HapMap Linkage Disequilibrium report
HMG20B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HMG20B Gene

Disorders for HMG20B Gene

No disorders were found for HMG20B Gene.

No data available for UniProtKB/Swiss-Prot for HMG20B Gene

Publications for HMG20B Gene

  1. A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression. (PMID: 11207365) Marmorstein L.Y. … Shiekhattar R. (Cell 2001) 3 4 23
  2. HMG20A and HMG20B map to human chromosomes 15q24 and 19p13.3 and constitute a distinct class of HMG-box genes with ubiquitous expression. (PMID: 10773667) Sumoy L. … Peral B. (Cytogenet. Cell Genet. 2000) 2 3 4
  3. Characterization of human SMARCE1r high-mobility-group protein. (PMID: 11997092) Lee Y.M. … Kim W. (Biochim. Biophys. Acta 2002) 3 4
  4. A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes. (PMID: 12032298) Hakimi M.-A. … Shiekhattar R. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 4
  5. Cloning a cDNA encoding an alternatively spliced protein of BRCA2- associated factor 35. (PMID: 12083779) Wang C. … Steiner M.S. (Biochem. Biophys. Res. Commun. 2002) 3 4

Products for HMG20B Gene

Sources for HMG20B Gene

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