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Aliases for TLR6 Gene

Aliases for TLR6 Gene

  • Toll Like Receptor 6 2 3 5
  • Toll-Like Receptor 6 2 3
  • CD286 Antigen 4
  • CD286 3

External Ids for TLR6 Gene

Previous GeneCards Identifiers for TLR6 Gene

  • GC04P039066
  • GC04M038992
  • GC04M038663
  • GC04M038725
  • GC04M038650
  • GC04M038504
  • GC04M038149

Summaries for TLR6 Gene

Entrez Gene Summary for TLR6 Gene

  • The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins. A Ser249Pro polymorphism in the extracellular domain of the encoded protein may be associated with an increased of asthma is some populations.[provided by RefSeq, Jan 2011]

GeneCards Summary for TLR6 Gene

TLR6 (Toll Like Receptor 6) is a Protein Coding gene. Diseases associated with TLR6 include Neurosyphilis and Penicilliosis. Among its related pathways are TRAF Pathway and Activated TLR4 signalling. GO annotations related to this gene include protein heterodimerization activity and transmembrane signaling receptor activity. An important paralog of this gene is TLR1.

UniProtKB/Swiss-Prot for TLR6 Gene

  • Participates in the innate immune response to Gram-positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides (PubMed:20037584). In response to diacylated lipopeptides, forms the activation cluster TLR2:TLR6:CD14:CD36, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2 (PubMed:11441107). In complex with TLR4, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion (PubMed:11441107, PubMed:20037584).

Tocris Summary for TLR6 Gene

  • Toll-like receptors (TLRs) are single transmembrane cell-surface receptors, which have a key role in the innate immune system. TLRs generally exist as homodimers (heterodimers have been reported) and are found on immune cells; macrophages, B lymphocytes and mast cells.

Gene Wiki entry for TLR6 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLR6 Gene

Genomics for TLR6 Gene

Regulatory Elements for TLR6 Gene

Enhancers for TLR6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G038855 1.7 FANTOM5 ENCODE dbSUPER 46.4 +0.4 415 4.0 ATF1 PKNOX1 CREB3L1 ARNT SIN3A TCF12 GTF3C2 ZNF766 GATA2 CBX5 TLR6 TLR1 ZBTB12BP HNRNPRP3 FAM114A1 KLF3 KLHL5
GH04G038785 1.6 FANTOM5 Ensembl ENCODE dbSUPER 37.5 +71.6 71580 2.1 ELF3 FOXA2 THRB YY1 RARA ZNF143 ETV6 CREM MIXL1 CBFB TLR1 TLR6 MIR574 FAM114A1 KLF3 TLR10
GH04G038803 1.4 Ensembl ENCODE dbSUPER 26.4 +52.4 52388 3.4 TBP PKNOX1 TBL1XR1 WRNIP1 YBX1 RAD21 ZBTB40 CBX5 ZNF143 ZNF207 TLR1 TLR6 TLR10 FAM114A1 MIR574 ENSG00000249207 ENSG00000249685
GH04G038528 1.6 FANTOM5 Ensembl ENCODE 22.3 +328.0 328011 1.8 HDGF PKNOX1 CREB3L1 ARNT ZNF766 CBX5 KLF13 JUNB REST ZNF592 TLR6 TLR1 KLF3 LINC01258 LINC02278
GH04G038888 1.1 Ensembl ENCODE 31.1 -32.6 -32563 3.3 PKNOX1 FOXA2 SIN3A BMI1 FOS RELB IKZF2 CREM JUNB TBX21 TLR6 TLR1 MIR574 FAM114A1 GC04P038912
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TLR6 on UCSC Golden Path with GeneCards custom track

Promoters for TLR6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000167561 1311 1201 ATF1 PKNOX1 ARNT SIN3A TCF12 ZNF766 CBX5 ZNF143 FOS JUNB

Genomic Location for TLR6 Gene

Chromosome:
4
Start:
38,823,704 bp from pter
End:
38,857,711 bp from pter
Size:
34,008 bases
Orientation:
Minus strand

Genomic View for TLR6 Gene

Genes around TLR6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TLR6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TLR6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLR6 Gene

Proteins for TLR6 Gene

  • Protein details for TLR6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2C9-TLR6_HUMAN
    Recommended name:
    Toll-like receptor 6
    Protein Accession:
    Q9Y2C9
    Secondary Accessions:
    • B3Y640
    • B6CH35
    • B6RFS4
    • B6RFS5
    • Q2NKL3

    Protein attributes for TLR6 Gene

    Size:
    796 amino acids
    Molecular mass:
    91880 Da
    Quaternary structure:
    • Heterodimer with TLR2 via their respective extracellular domains (PubMed:16880211). Binds MYD88 via their respective TIR domains (Probable). Interacts with CD36, following CD36 stimulation by oxLDL or amyloid-beta 42, and forms a heterodimer with TLR4. The trimeric complex is internalized and triggers inflammatory response. LYN kinase activity facilitates TLR4:TLR6 heterodimerization and signal initiation (PubMed:20037584). The heterodimer TLR2:TLR6 interacts with CD14 and CD36 in response to triacylated lipopeptides (PubMed:16880211).

    Three dimensional structures from OCA and Proteopedia for TLR6 Gene

    Alternative splice isoforms for TLR6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TLR6 Gene

Post-translational modifications for TLR6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TLR6 (TLR6)

No data available for DME Specific Peptides for TLR6 Gene

Domains & Families for TLR6 Gene

Gene Families for TLR6 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y2C9

UniProtKB/Swiss-Prot:

TLR6_HUMAN :
  • Belongs to the Toll-like receptor family.
Family:
  • Belongs to the Toll-like receptor family.
genes like me logo Genes that share domains with TLR6: view

Function for TLR6 Gene

Molecular function for TLR6 Gene

GENATLAS Biochemistry:
Drosophila transmembrane receptor Toll homolog 6,predominantly expressed in spleen,thymus,ovary and lung
UniProtKB/Swiss-Prot Function:
Participates in the innate immune response to Gram-positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides (PubMed:20037584). In response to diacylated lipopeptides, forms the activation cluster TLR2:TLR6:CD14:CD36, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2 (PubMed:11441107). In complex with TLR4, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion (PubMed:11441107, PubMed:20037584).

Gene Ontology (GO) - Molecular Function for TLR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 10426995
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0005515 protein binding IPI 16880211
GO:0035663 Toll-like receptor 2 binding IPI 16880211
GO:0071723 lipopeptide binding ISS 11431423
genes like me logo Genes that share ontologies with TLR6: view
genes like me logo Genes that share phenotypes with TLR6: view

Animal Models for TLR6 Gene

MGI Knock Outs for TLR6:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TLR6

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TLR6 Gene

Localization for TLR6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLR6 Gene

Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, phagosome membrane; Single-pass type I membrane protein. Membrane raft. Golgi apparatus. Note=Upon complex formation with CD36 and TLR4, internalized through dynamin-dependent endocytosis. Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to diacylated lipoproteins, TLR2:TLR6 heterodimers are recruited in lipid rafts, this recruitment determine the intracellular targeting to the Golgi apparatus (PubMed:16880211). {ECO:0000269 PubMed:16880211, ECO:0000269 PubMed:20037584}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TLR6 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 5
extracellular 2
endosome 2
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TLR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IEA,IDA 16880211
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 10231569
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TLR6: view

Pathways & Interactions for TLR6 Gene

genes like me logo Genes that share pathways with TLR6: view

Gene Ontology (GO) - Biological Process for TLR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001774 microglial cell activation IEA --
GO:0001775 cell activation IDA 15294986
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002376 immune system process IEA --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with TLR6: view

No data available for SIGNOR curated interactions for TLR6 Gene

Drugs & Compounds for TLR6 Gene

(7) Drugs for TLR6 Gene - From: Tocris and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
CU CPT 22 Pharma Selective TLR1/2 inhibitor 0
CU CPT 4a Pharma Selective TLR3 inhibitor 0
Pam3CSK4 Pharma TLR1/2 agonist; induces cytokine production 0
Poly(I:C) Pharma TLR3 agonist 0
Resiquimod Pharma Toll-like receptor 7 (TLR7) agonist 0

(2) Additional Compounds for TLR6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(5) Tocris Compounds for TLR6 Gene

Compound Action Cas Number
CU CPT 22 Selective TLR1/2 inhibitor 1416324-85-0
CU CPT 4a Selective TLR3 inhibitor 1279713-77-7
Pam3CSK4 TLR1/2 agonist; induces cytokine production 112208-00-1
Poly(I:C) TLR3 agonist 24939-03-5
Resiquimod Toll-like receptor 7 (TLR7) agonist 144875-48-9
genes like me logo Genes that share compounds with TLR6: view

Transcripts for TLR6 Gene

mRNA/cDNA for TLR6 Gene

Unigene Clusters for TLR6 Gene

Toll-like receptor 6:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TLR6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TLR6 Gene

No ASD Table

Relevant External Links for TLR6 Gene

GeneLoc Exon Structure for
TLR6
ECgene alternative splicing isoforms for
TLR6

Expression for TLR6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TLR6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TLR6 Gene

This gene is overexpressed in Whole Blood (x20.4).

Protein differential expression in normal tissues from HIPED for TLR6 Gene

This gene is overexpressed in Stomach (34.1) and Cardia (19.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TLR6 Gene



NURSA nuclear receptor signaling pathways regulating expression of TLR6 Gene:

TLR6

SOURCE GeneReport for Unigene cluster for TLR6 Gene:

Hs.575090

mRNA Expression by UniProt/SwissProt for TLR6 Gene:

Q9Y2C9-TLR6_HUMAN
Tissue specificity: Detected in monocytes, CD11c+ immature dendritic cells, plasmacytoid pre-dendritic cells and dermal microvessel endothelial cells.

Evidence on tissue expression from TISSUES for TLR6 Gene

  • Blood(2.4)
  • Spleen(2.3)
  • Lymph node(2.2)
genes like me logo Genes that share expression patterns with TLR6: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TLR6 Gene

Orthologs for TLR6 Gene

This gene was present in the common ancestor of animals.

Orthologs for TLR6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TLR6 34 35
  • 98.79 (n)
cow
(Bos Taurus)
Mammalia TLR6 34 35
  • 85.25 (n)
dog
(Canis familiaris)
Mammalia TLR6 34 35
  • 84.59 (n)
rat
(Rattus norvegicus)
Mammalia Tlr6 34
  • 77.86 (n)
mouse
(Mus musculus)
Mammalia Tlr6 34 16 35
  • 77.74 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 62 (a)
OneToMany
chicken
(Gallus gallus)
Aves TLR1LB 34 35
  • 60.84 (n)
TLR1LA 35
  • 47 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 49 (a)
ManyToMany
-- 35
  • 48 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493946 34
  • 55.72 (n)
zebrafish
(Danio rerio)
Actinopterygii tlr1 35
  • 34 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Toll-9 35
  • 18 (a)
OneToMany
Species where no ortholog for TLR6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TLR6 Gene

ENSEMBL:
Gene Tree for TLR6 (if available)
TreeFam:
Gene Tree for TLR6 (if available)

Paralogs for TLR6 Gene

Variants for TLR6 Gene

Sequence variations from dbSNP and Humsavar for TLR6 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs863223364 Benign 38,827,744(-) TTCAC(-/AT)GTCTG reference, frameshift-variant
rs137853178 untested 38,829,092(-) TAGAT(A/C/G)TCTCA reference, missense
rs137853179 untested 38,828,846(-) TATTC(A/G)CTATC reference, missense
rs137853180 untested 38,828,845(-) ATTCG(C/G)TATCC reference, missense
rs137853181 untested 38,828,627(-) TCAAT(A/G)TTTAC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TLR6 Gene

Variant ID Type Subtype PubMed ID
esv2672127 CNV deletion 23128226
esv2762427 CNV loss 21179565
esv3600267 CNV loss 21293372
nsv594010 CNV loss 21841781
nsv818227 CNV gain 17921354
nsv950576 CNV duplication 24416366
nsv980195 CNV duplication 23825009

Variation tolerance for TLR6 Gene

Residual Variation Intolerance Score: 84.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.55; 72.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TLR6 Gene

Human Gene Mutation Database (HGMD)
TLR6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TLR6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TLR6 Gene

Disorders for TLR6 Gene

MalaCards: The human disease database

(15) MalaCards diseases for TLR6 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
neurosyphilis
penicilliosis
pelvic inflammatory disease
  • pid
invasive aspergillosis
  • aspergillosis invasive
tuberculosis
  • kochs disease
- elite association - COSMIC cancer census association via MalaCards
Search TLR6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TLR6

Genetic Association Database (GAD)
TLR6
Human Genome Epidemiology (HuGE) Navigator
TLR6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TLR6
genes like me logo Genes that share disorders with TLR6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TLR6 Gene

Publications for TLR6 Gene

  1. TLR6: a novel member of an expanding Toll-like receptor family. (PMID: 10231569) Takeuchi O. … Akira S. (Gene 1999) 2 3 4 22 64
  2. Gene polymorphisms of Toll-like and related recognition receptors in relation to the vaginal carriage of Gardnerella vaginalis and Atopobium vaginae. (PMID: 19200604) Verstraelen H. … Temmerman M. (J. Reprod. Immunol. 2009) 3 22 46 64
  3. Toll-like receptor heterodimer variants protect from childhood asthma. (PMID: 18547625) Kormann M.S. … Kabesch M. (J. Allergy Clin. Immunol. 2008) 3 22 46 64
  4. Genetic variation in the toll-like receptor gene cluster (TLR10-TLR1-TLR6) and prostate cancer risk. (PMID: 18752252) Stevens V.L. … Rodriguez C. (Int. J. Cancer 2008) 3 22 46 64
  5. Mutations in pattern recognition receptor genes modulate seroreactivity to microbial antigens in patients with inflammatory bowel disease. (PMID: 17595233) Henckaerts L. … Vermeire S. (Gut 2007) 3 22 46 64

Products for TLR6 Gene

Sources for TLR6 Gene

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