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Aliases for B3GNT3 Gene

Aliases for B3GNT3 Gene

  • UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 3 2 3 4 5
  • Transmembrane Protein 3 2 3 4
  • Beta-1,3-Galactosyl-O-Glycosyl-Glycoprotein Beta-1,3-N-Acetylglucosaminyltransferase 3 4
  • UDP-Galactose:Beta-N-Acetylglucosamine Beta-1,3-Galactosyltransferase 8 3 4
  • Core 1 Extending Beta-1,3-N-Acetylglucosaminyltransferase 3 4
  • UDP-Gal:Beta-GlcNAc Beta-1,3-Galactosyltransferase 8 3 4
  • Beta-1,3-N-Acetylglucosaminyltransferase BGnT-3 2 3
  • Putative Type II Membrane Protein 2 3
  • Beta-1,3-GalTase 8 3 4
  • Core1-Beta3GlcNAcT 3 4
  • Beta-1,3-Gn-T3 3 4
  • Beta-3-Gx-T8 3 4
  • Beta3GalT8 3 4
  • Beta3Gn-T3 3 4
  • B3GAL-T8 3 4
  • TMEM3 3 4
  • N-Acetyllactosaminide Beta-1,3-N-Acetylglucosaminyltransferase 3 3
  • Beta-1,3-N-Acetylglucosaminyltransferase 3 4
  • Beta-1,3-Galactosyltransferase 8 4
  • EC 2.4.1.149 4
  • EC 2.4.1.146 4
  • Beta3Gal-T8 4
  • EC 2.4.1 58
  • B3GN-T3 3
  • B3GNT-3 3
  • HP10328 3
  • B3GALT8 4
  • BGnT-3 4

External Ids for B3GNT3 Gene

Previous HGNC Symbols for B3GNT3 Gene

  • TMEM3

Previous GeneCards Identifiers for B3GNT3 Gene

  • GC19P018399
  • GC19P018298
  • GC19P017751
  • GC19P017766
  • GC19P017905
  • GC19P017471

Summaries for B3GNT3 Gene

Entrez Gene Summary for B3GNT3 Gene

  • This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein and contains a signal anchor that is not cleaved. It prefers the substrates of lacto-N-tetraose and lacto-N-neotetraose, and is involved in the biosynthesis of poly-N-acetyllactosamine chains and the biosynthesis of the backbone structure of dimeric sialyl Lewis a. It plays dominant roles in L-selectin ligand biosynthesis, lymphocyte homing and lymphocyte trafficking. [provided by RefSeq, Jul 2008]

GeneCards Summary for B3GNT3 Gene

B3GNT3 (UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 3) is a Protein Coding gene. Among its related pathways are O-linked glycosylation and Glycosaminoglycan metabolism. GO annotations related to this gene include galactosyltransferase activity and beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity. An important paralog of this gene is B3GNT6.

UniProtKB/Swiss-Prot for B3GNT3 Gene

  • Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Has activity for type 2 oligosaccharides (PubMed:11042166). Also acts as a core1-1,3-N-acetylglucosaminyltransferase (Core1-beta3GlcNAcT) to form the 6-sulfo sialyl Lewis x on extended core1 O-glycans (PubMed:11439191).

Gene Wiki entry for B3GNT3 Gene

Additional gene information for B3GNT3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for B3GNT3 Gene

Genomics for B3GNT3 Gene

Regulatory Elements for B3GNT3 Gene

Enhancers for B3GNT3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H017794 1.6 Ensembl ENCODE dbSUPER 26.9 +2.1 2079 5 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZBTB7B YY1 B3GNT3 ENSG00000268030 MVB12A ENSG00000268938 HAUS8 COLGALT1 ENSG00000269191 KIAA1683 PLVAP KXD1
GH19H017790 1.1 ENCODE dbSUPER 18.1 -3.6 -3560 2 TAL1 ETV1 ZIC2 TCF12 E2F1 CTBP1 FOS ZNF600 PRDM10 RCOR1 B3GNT3 GC19M017755
GH19H017764 1.5 Ensembl ENCODE dbSUPER 13 -29.0 -28990 3 PKNOX1 FOXA2 ATF1 MLX ARID4B DMAP1 ZNF2 GTF3C2 SLC30A9 GLIS2 MVB12A ENSG00000268030 B3GNT3 UNC13A MAP1S GTPBP3 INSL3 HAUS8 PLVAP ENSG00000268938
GH19H017829 1.4 Ensembl ENCODE dbSUPER 13 +36.1 36065 2 ZNF76 ZEB1 GLIS2 ZNF366 RCOR1 SP3 USF2 SP1 NFIC ZNF341 MVB12A ENSG00000268030 ENSG00000268938 COLGALT1 ENSG00000269191 B3GNT3 HAUS8 KIAA1683 ELL BST2
GH19H017762 1.4 Ensembl ENCODE dbSUPER 12.4 -32.1 -32118 1 HDAC1 YBX3 HDGF PKNOX1 BMI1 RFX5 ZNF366 RCOR1 FOS SP3 MAP1S B3GNT3 INSL3 PLVAP NXNL1 F2RL3 GC19M017755 GC19P019904
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around B3GNT3 on UCSC Golden Path with GeneCards custom track

Genomic Location for B3GNT3 Gene

Chromosome:
19
Start:
17,794,828 bp from pter
End:
17,813,576 bp from pter
Size:
18,749 bases
Orientation:
Plus strand

Genomic View for B3GNT3 Gene

Genes around B3GNT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
B3GNT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for B3GNT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for B3GNT3 Gene

Proteins for B3GNT3 Gene

  • Protein details for B3GNT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2A9-B3GN3_HUMAN
    Recommended name:
    N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3
    Protein Accession:
    Q9Y2A9
    Secondary Accessions:
    • B2RAS4
    • Q6NWU9
    • Q6NXU9
    • Q8WWR6
    • Q9C0J2

    Protein attributes for B3GNT3 Gene

    Size:
    372 amino acids
    Molecular mass:
    42534 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAC82374.1; Type=Frameshift; Positions=194, 196, 202, 204, 209, 215; Evidence={ECO:0000305};

neXtProt entry for B3GNT3 Gene

Selected DME Specific Peptides for B3GNT3 Gene

Q9Y2A9:
  • PIDDVFLGMCL
  • DILQWDF

Post-translational modifications for B3GNT3 Gene

  • Glycosylation at posLast=6464, Asn184, Asn202, posLast=362362, and Asn367
  • Modification sites at PhosphoSitePlus

Other Protein References for B3GNT3 Gene

Domains & Families for B3GNT3 Gene

Gene Families for B3GNT3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted secreted proteins

Protein Domains for B3GNT3 Gene

Suggested Antigen Peptide Sequences for B3GNT3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y2A9

UniProtKB/Swiss-Prot:

B3GN3_HUMAN :
  • Belongs to the glycosyltransferase 31 family.
Family:
  • Belongs to the glycosyltransferase 31 family.
genes like me logo Genes that share domains with B3GNT3: view

Function for B3GNT3 Gene

Molecular function for B3GNT3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->3)-(N-acetyl-D-glucosaminyl-(1->6))-N-acetyl-D-galactosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-(N-acetyl-D-glucosaminyl-(1->6))-N-acetyl-D-galactosaminyl-R.
UniProtKB/Swiss-Prot CatalyticActivity:
UDP-N-acetyl-alpha-D-glucosamine + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R.
UniProtKB/Swiss-Prot Function:
Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Has activity for type 2 oligosaccharides (PubMed:11042166). Also acts as a core1-1,3-N-acetylglucosaminyltransferase (Core1-beta3GlcNAcT) to form the 6-sulfo sialyl Lewis x on extended core1 O-glycans (PubMed:11439191).

Enzyme Numbers (IUBMB) for B3GNT3 Gene

Phenotypes From GWAS Catalog for B3GNT3 Gene

Gene Ontology (GO) - Molecular Function for B3GNT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008378 galactosyltransferase activity IEA --
GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity TAS --
GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity TAS,IEA --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with B3GNT3: view
genes like me logo Genes that share phenotypes with B3GNT3: view

Animal Models for B3GNT3 Gene

MGI Knock Outs for B3GNT3:

Animal Model Products

CRISPR Products

miRNA for B3GNT3 Gene

miRTarBase miRNAs that target B3GNT3

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for B3GNT3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for B3GNT3 Gene

Localization for B3GNT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for B3GNT3 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for B3GNT3 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 4
extracellular 2
endosome 2
mitochondrion 1
peroxisome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for B3GNT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IEA --
GO:0005887 integral component of plasma membrane TAS 10072769
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with B3GNT3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for B3GNT3 Gene

Pathways & Interactions for B3GNT3 Gene

genes like me logo Genes that share pathways with B3GNT3: view

UniProtKB/Swiss-Prot Q9Y2A9-B3GN3_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for B3GNT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IEA --
GO:0016266 O-glycan processing TAS --
GO:0018146 keratan sulfate biosynthetic process TAS --
GO:0030311 poly-N-acetyllactosamine biosynthetic process IDA 11042166
genes like me logo Genes that share ontologies with B3GNT3: view

No data available for SIGNOR curated interactions for B3GNT3 Gene

Drugs & Compounds for B3GNT3 Gene

No Compound Related Data Available

Transcripts for B3GNT3 Gene

Unigene Clusters for B3GNT3 Gene

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for B3GNT3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for B3GNT3 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c
SP1: - - -
SP2: -
SP3:
SP4: -

Relevant External Links for B3GNT3 Gene

GeneLoc Exon Structure for
B3GNT3
ECgene alternative splicing isoforms for
B3GNT3

Expression for B3GNT3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for B3GNT3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for B3GNT3 Gene

This gene is overexpressed in Colon - Transverse (x11.3), Stomach (x8.6), Minor Salivary Gland (x7.2), Esophagus - Mucosa (x6.5), and Small Intestine - Terminal Ileum (x4.6).

Protein differential expression in normal tissues from HIPED for B3GNT3 Gene

This gene is overexpressed in Nasal epithelium (66.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for B3GNT3 Gene



NURSA nuclear receptor signaling pathways regulating expression of B3GNT3 Gene:

B3GNT3

SOURCE GeneReport for Unigene cluster for B3GNT3 Gene:

Hs.69009

mRNA Expression by UniProt/SwissProt for B3GNT3 Gene:

Q9Y2A9-B3GN3_HUMAN
Tissue specificity: Expressed in colon, jejunum, stomach, esophagus, placenta and trachea.

Evidence on tissue expression from TISSUES for B3GNT3 Gene

  • Stomach(4.3)
  • Intestine(3.3)
genes like me logo Genes that share expression patterns with B3GNT3: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for B3GNT3 Gene

Orthologs for B3GNT3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for B3GNT3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia B3GNT3 33 34
  • 99.28 (n)
cow
(Bos Taurus)
Mammalia B3GNT3 33 34
  • 80.37 (n)
dog
(Canis familiaris)
Mammalia B3GNT3 33 34
  • 79.66 (n)
rat
(Rattus norvegicus)
Mammalia B3gnt3 33
  • 70.74 (n)
mouse
(Mus musculus)
Mammalia B3gnt3 33 16 34
  • 70.46 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia B3GNT3 34
  • 60 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia B3GNT3 34
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 34
  • 47 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100145701 33
  • 56.7 (n)
zebrafish
(Danio rerio)
Actinopterygii b3gnt3 33 34
  • 59.34 (n)
si:ch211-126g16.10 34
  • 46 (a)
ManyToMany
si:ch211-126g16.11 34
  • 46 (a)
ManyToMany
zgc:86586 34
  • 44 (a)
ManyToMany
Species where no ortholog for B3GNT3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for B3GNT3 Gene

ENSEMBL:
Gene Tree for B3GNT3 (if available)
TreeFam:
Gene Tree for B3GNT3 (if available)

Paralogs for B3GNT3 Gene

(10) SIMAP similar genes for B3GNT3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with B3GNT3: view

Variants for B3GNT3 Gene

Sequence variations from dbSNP and Humsavar for B3GNT3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000149153 -- 17,795,651(+) GTTCC(A/G)GTGCT intron-variant
rs1000182016 -- 17,795,938(+) GAGTG(C/G)ATAGG intron-variant
rs1000418679 -- 17,813,016(+) TCTGC(C/T)AGTCA utr-variant-3-prime
rs1000477609 -- 17,794,248(+) CATAT(C/G)TAGAA upstream-variant-2KB
rs1000867466 -- 17,807,104(+) AGCAG(C/T)GGCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for B3GNT3 Gene

Variant ID Type Subtype PubMed ID
dgv50n68 CNV loss 17160897

Variation tolerance for B3GNT3 Gene

Residual Variation Intolerance Score: 38% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.76; 47.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for B3GNT3 Gene

Human Gene Mutation Database (HGMD)
B3GNT3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
B3GNT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for B3GNT3 Gene

Disorders for B3GNT3 Gene

Relevant External Links for B3GNT3

Genetic Association Database (GAD)
B3GNT3
Human Genome Epidemiology (HuGE) Navigator
B3GNT3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
B3GNT3

No disorders were found for B3GNT3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for B3GNT3 Gene

Publications for B3GNT3 Gene

  1. Identification and characterization of three novel beta 1,3-N-acetylglucosaminyltransferases structurally related to the beta 1,3-galactosyltransferase family. (PMID: 11042166) Shiraishi N … Sasaki K (The Journal of biological chemistry 2001) 2 3 4 60
  2. Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bank. (PMID: 10072769) Yokoyama-Kobayashi M … Kato S (Gene 1999) 2 3 4 60
  3. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PMID: 20424473) Yokoyama K … Hosoya T (Nephron. Clinical practice 2010) 3 45 60
  4. Genetic variation in 1253 immune and inflammation genes and risk of non-Hodgkin lymphoma. (PMID: 17827388) Cerhan JR … Slager SL (Blood 2007) 3 45 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for B3GNT3 Gene

Sources for B3GNT3 Gene

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