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Aliases for AKR1A1 Gene

Aliases for AKR1A1 Gene

  • Aldo-Keto Reductase Family 1, Member A1 (Aldehyde Reductase) 2 3
  • ALR 3 4 6
  • Aldo-Keto Reductase Family 1 Member A1 3 4
  • Dihydrodiol Dehydrogenase 3 2 3
  • Aldehyde Reductase 3 4
  • EC 1.1.1.2 4 63
  • ALDR1 3 4
  • Epididymis Secretory Sperm Binding Protein Li 165mP 3
  • Epididymis Secretory Protein Li 6 3
  • Alcohol Dehydrogenase [NADP(+)] 3
  • Alcohol Dehydrogenase 3
  • HEL-S-165mP 3
  • EC 1.1.1 63
  • HEL-S-6 3
  • ARM 3
  • DD3 3

External Ids for AKR1A1 Gene

Previous GeneCards Identifiers for AKR1A1 Gene

  • GC01P045743
  • GC01P045016
  • GC01P045446
  • GC01P045429
  • GC01P045685
  • GC01P045789
  • GC01P046017
  • GC01P044128

Summaries for AKR1A1 Gene

Entrez Gene Summary for AKR1A1 Gene

  • This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. Multiple alternatively spliced transcript variants of this gene exist, all encoding the same protein. [provided by RefSeq, Jan 2011]

GeneCards Summary for AKR1A1 Gene

AKR1A1 (Aldo-Keto Reductase Family 1, Member A1 (Aldehyde Reductase)) is a Protein Coding gene. Diseases associated with AKR1A1 include ethylene glycol poisoning and methanol poisoning. Among its related pathways are Metabolism and Doxorubicin Pathway (Cardiomyocyte Cell), Pharmacodynamics. GO annotations related to this gene include electron carrier activity and L-glucuronate reductase activity. An important paralog of this gene is AKR1B1.

UniProtKB/Swiss-Prot for AKR1A1 Gene

  • Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN).

Gene Wiki entry for AKR1A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKR1A1 Gene

Genomics for AKR1A1 Gene

Regulatory Elements for AKR1A1 Gene

Genomic Location for AKR1A1 Gene

Start:
45,550,543 bp from pter
End:
45,570,051 bp from pter
Size:
19,509 bases
Orientation:
Plus strand

Genomic View for AKR1A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AKR1A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKR1A1 Gene

Proteins for AKR1A1 Gene

  • Protein details for AKR1A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14550-AK1A1_HUMAN
    Recommended name:
    Alcohol dehydrogenase [NADP(+)]
    Protein Accession:
    P14550
    Secondary Accessions:
    • A8KAL8
    • D3DQ04
    • Q6IAZ4

    Protein attributes for AKR1A1 Gene

    Size:
    325 amino acids
    Molecular mass:
    36573 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for AKR1A1 Gene

neXtProt entry for AKR1A1 Gene

Proteomics data for AKR1A1 Gene at MOPED

Post-translational modifications for AKR1A1 Gene

  • Ubiquitination at Lys153
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains for AKR1A1 Gene

Gene Families for AKR1A1 Gene

HGNC:
  • AKR :Aldo-keto reductases

Protein Domains for AKR1A1 Gene

Suggested Antigen Peptide Sequences for AKR1A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P14550

UniProtKB/Swiss-Prot:

AK1A1_HUMAN :
  • P14550
Family:
  • Belongs to the aldo/keto reductase family.
genes like me logo Genes that share domains with AKR1A1: view

Function for AKR1A1 Gene

Molecular function for AKR1A1 Gene

GENATLAS Biochemistry: aldehyde reductase 1,monomeric NADPH dependent,expressed in many organs predominantly in kidney,cortex,liver,thyroid,small intestine,cytosolic reducing various biogenic and xenobiotic aldehyde compounds,with two alternatively spliced transcripts encoding the same protein
UniProtKB/Swiss-Prot CatalyticActivity: An alcohol + NADP(+) = an aldehyde + NADPH
UniProtKB/Swiss-Prot Function: Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN).

Enzyme Numbers (IUBMB) for AKR1A1 Gene

Gene Ontology (GO) - Molecular Function for AKR1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004032 alditol:NADP+ 1-oxidoreductase activity TAS 2498333
GO:0009055 electron carrier activity TAS 2498333
GO:0016491 oxidoreductase activity --
GO:0047939 L-glucuronate reductase activity IEA --
genes like me logo Genes that share ontologies with AKR1A1: view
genes like me logo Genes that share phenotypes with AKR1A1: view

Animal Models for AKR1A1 Gene

MGI Knock Outs for AKR1A1:

Animal Model Products

CRISPR Products

miRNA for AKR1A1 Gene

miRTarBase miRNAs that target AKR1A1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AKR1A1

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for AKR1A1 Gene

Localization for AKR1A1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AKR1A1 Gene COMPARTMENTS Subcellular localization image for AKR1A1 gene
Compartment Confidence
cytosol 3
nucleus 2
plasma membrane 2
cytoskeleton 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for AKR1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 23580065
GO:0005829 cytosol IEA --
GO:0016324 apical plasma membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with AKR1A1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for AKR1A1 Gene

Pathways for AKR1A1 Gene

genes like me logo Genes that share pathways with AKR1A1: view

Gene Ontology (GO) - Biological Process for AKR1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006006 glucose metabolic process TAS 2498333
GO:0006081 cellular aldehyde metabolic process TAS 2498333
GO:0019853 L-ascorbic acid biosynthetic process IEA --
GO:0042840 D-glucuronate catabolic process IEA --
GO:0046185 aldehyde catabolic process IEA --
genes like me logo Genes that share ontologies with AKR1A1: view

Compounds for AKR1A1 Gene

(17) HMDB Compounds for AKR1A1 Gene

Compound Synonyms Cas Number PubMed IDs
1-Butanol
  • 1-Butanol
71-36-3
1-Hexanol
  • 1-Hexyl alcohol
111-27-3
1-Pentanol
  • 1-Pentol
71-41-0
6-Hydroxyhexanoic acid
  • 6-Hydroxyhexanoate
1191-25-9
Acetaldehyde
  • acetaldehyde
75-07-0

(5) Drugbank Compounds for AKR1A1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
2'-Monophosphoadenosine 5'-Diphosphoribose
target
Doxorubicin
  • Adria
23214-92-8 enzyme substrate
NADH
  • beta-DPNH
606-68-8 enzyme substrate
Nicotinamide-Adenine-Dinucleotide
53-84-9 target
Tolrestat
82964-04-3 target

(129) Novoseek inferred chemical compound relationships for AKR1A1 Gene

Compound -log(P) Hits PubMed IDs
4-methylpyrazole 93.9 54
acetaldehyde 91.9 106
m-nitrobenzaldehyde 91.1 1
ethanol 87.6 127
nad+ 82.1 47
genes like me logo Genes that share compounds with AKR1A1: view

Transcripts for AKR1A1 Gene

Unigene Clusters for AKR1A1 Gene

Aldo-keto reductase family 1, member A1 (aldehyde reductase):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AKR1A1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AKR1A1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b · 7c ^
SP1: - - -
SP2: - - - - - -
SP3: - - -
SP4: - - -
SP5: -
SP6: - - - - - - -
SP7: - - - - - -
SP8: - - -
SP9: - - - -
SP10: - - - -
SP11: - - - - - - - - -
SP12: - - - - -
SP13: - - - - - - -
SP14: - - - - - -
SP15:
SP16: - - -
SP17: - -
SP18:
SP19: - - - - -

ExUns: 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11
SP1: -
SP2: -
SP3: - - - -
SP4: - - - -
SP5:
SP6:
SP7:
SP8: - - -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18: - - - -
SP19:

Relevant External Links for AKR1A1 Gene

GeneLoc Exon Structure for
AKR1A1
ECgene alternative splicing isoforms for
AKR1A1

Expression for AKR1A1 Gene

mRNA expression in normal human tissues for AKR1A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AKR1A1 Gene

SOURCE GeneReport for Unigene cluster for AKR1A1 Gene Hs.474584

mRNA Expression by UniProt/SwissProt for AKR1A1 Gene

P14550-AK1A1_HUMAN
Tissue specificity: Widely expressed. Highly expressed in kidney, salivary gland and liver. Detected in trachea, stomach, brain, lung, prostate, placenta, mammary gland, small intestine and lung.
genes like me logo Genes that share expressions with AKR1A1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for AKR1A1 Gene

Orthologs for AKR1A1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AKR1A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AKR1A1 35
  • 99.59 (n)
  • 99.69 (a)
AKR1A1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AKR1A1 35
  • 90.56 (n)
  • 93.23 (a)
AKR1A1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AKR1A1 35
  • 90.05 (n)
  • 94.77 (a)
AKR1A1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Akr1a1 35
  • 87.79 (n)
  • 93.23 (a)
Akr1a1 16
Akr1a1 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AKR1A1 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AKR1A1 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Akr1a1 35
  • 87.59 (n)
  • 94.15 (a)
chicken
(Gallus gallus)
Aves AKR1A1 35
  • 71.79 (n)
  • 78.46 (a)
AKR1A1 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AKR1A1 36
  • 68 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.10170 35
tropical clawed frog
(Silurana tropicalis)
Amphibia akr1a1 35
  • 69.18 (n)
  • 74.53 (a)
Str.11963 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1439 35
zebrafish
(Danio rerio)
Actinopterygii akr1a1b 35
  • 65.62 (n)
  • 72.1 (a)
akr1a1b 36
  • 70 (a)
OneToOne
Dr.13132 35
fruit fly
(Drosophila melanogaster)
Insecta ARY 36
  • 31 (a)
OneToMany
CG10638 36
  • 41 (a)
OneToMany
CG10863 36
  • 40 (a)
OneToMany
CG12766 36
  • 39 (a)
OneToMany
CG6083 36
  • 45 (a)
OneToMany
CG9436 36
  • 42 (a)
OneToMany
CG6084 37
  • 49 (a)
CG10638 37
  • 40 (a)
CG6083 37
  • 47 (a)
CG9436 37
  • 41 (a)
CG2767 37
  • 42 (a)
CG12766 37
  • 40 (a)
worm
(Caenorhabditis elegans)
Secernentea C07D8.5 36
  • 28 (a)
OneToMany
C07D8.6 36
  • 39 (a)
OneToMany
T08H10.1 36
  • 41 (a)
OneToMany
Y39G8B.1 36
  • 46 (a)
OneToMany
Y39G8B.2 36
  • 32 (a)
OneToMany
T08H10.1 37
  • 41 (a)
C07D8.6 37
  • 38 (a)
Y39G8B.1b 37
  • 45 (a)
C01G5.5 37
  • 31 (a)
F53F1.2 37
  • 34 (a)
ZC443.1 37
  • 37 (a)
Y39G8B.2 37
  • 34 (a)
K07C5.2 37
  • 31 (a)
F53F1.3 37
  • 35 (a)
C35D10.6 37
  • 31 (a)
Y39G8B.1a 37
  • 45 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GCY1 38
GRE3 36
  • 37 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3560 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G37760 35
  • 51.14 (n)
  • 48.11 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.12012 35
bread mold
(Neurospora crassa)
Ascomycetes NCU04510 35
  • 48.86 (n)
  • 41.67 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC26F1.07 35
  • 49.94 (n)
  • 47 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 19 (a)
ManyToMany
CSA.5991 36
  • 15 (a)
ManyToMany
Species with no ortholog for AKR1A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AKR1A1 Gene

ENSEMBL:
Gene Tree for AKR1A1 (if available)
TreeFam:
Gene Tree for AKR1A1 (if available)

Paralogs for AKR1A1 Gene

Paralogs for AKR1A1 Gene

Selected SIMAP similar genes for AKR1A1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for AKR1A1 Gene

genes like me logo Genes that share paralogs with AKR1A1: view

Variants for AKR1A1 Gene

Sequence variations from dbSNP and Humsavar for AKR1A1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs9147 -- 45,551,015(+) TCCTT(C/T)ATGCC utr-variant-5-prime
rs486346 -- 45,561,189(+) CTTCT(C/G)TGTGG intron-variant
rs500636 -- 45,557,598(+) CATGC(A/G)TGCTG intron-variant
rs505175 -- 45,551,536(+) AGTGG(A/G)GAGAA intron-variant
rs505207 -- 45,558,109(+) tcgcc(A/T)tgttg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AKR1A1 Gene

Variant ID Type Subtype PubMed ID
nsv829726 CNV Loss 17160897
nsv871928 CNV Gain 21882294

Relevant External Links for AKR1A1 Gene

HapMap Linkage Disequilibrium report
AKR1A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AKR1A1 Gene

Disorders for AKR1A1 Gene

(52) Novoseek inferred disease relationships for AKR1A1 Gene

Disease -log(P) Hits PubMed IDs
alcoholism 75 44
liver diseases alcoholic 67.9 6
metabolic acidosis 59.4 3
fetal alcohol syndrome 58.4 3
alcohol abuse 55.7 2

Relevant External Links for AKR1A1

Genetic Association Database (GAD)
AKR1A1
Human Genome Epidemiology (HuGE) Navigator
AKR1A1
genes like me logo Genes that share disorders with AKR1A1: view

No data available for UniProtKB/Swiss-Prot for AKR1A1 Gene

Publications for AKR1A1 Gene

  1. The structural organization of the human aldehyde reductase gene, AKR1A1, and mapping to chromosome 1p33-->p32. (PMID: 10393438) Fujii J. … Taniguchi N. (Cytogenet. Cell Genet. 1999) 2 3 4 23
  2. The aldo-keto reductase superfamily. cDNAs and deduced amino acid sequences of human aldehyde and aldose reductases. (PMID: 2498333) Bohren K.M. … Gabbay K.H. (J. Biol. Chem. 1989) 2 3 4
  3. Major differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members. (PMID: 10510318) O'Connor T. … Hayes J.D. (Biochem. J. 1999) 3 4 23
  4. Genetic polymorphisms in the oxidative stress pathway and susceptibility to non-Hodgkin lymphoma. (PMID: 17149600) Lan Q. … Chanock S. (Hum. Genet. 2007) 3 23 48
  5. Two allelic variants of aldo-keto reductase 1A1 exhibit reduced in vitro metabolism of daunorubicin. (PMID: 18276838) Bains O.S. … Riggs K.W. (Drug Metab. Dispos. 2008) 4 23

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